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Items: 1 to 50 of 57

1.

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition.

Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D, Kuusisto S, Sormunen R, Heljasvaara R, Jones EL, Muilu M, Jauhiainen M, Pihlajamäki J, Savolainen MJ, Shoulders CC, Pihlajaniemi T.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3043-52. doi: 10.1073/pnas.1405879111. Epub 2014 Jul 14.

2.

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

Fryer LG, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M, Townley AK, Mensenkamp AR, Stephens DJ, Dallinga-Thie GM, Shoulders CC.

J Biol Chem. 2014 Feb 14;289(7):4244-61. doi: 10.1074/jbc.M113.479980. Epub 2013 Dec 13.

3.

CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients.

Horswell SD, Fryer LG, Hutchison CE, Zindrou D, Speedy HE, Town MM, Duncan EJ, Sivapackianathan R, Patel HN, Jones EL, Braithwaite A, Salm MP, Neuwirth CK, Potter E, Anderson JR, Taylor KM, Seed M, Betteridge DJ, Crook MA, Wierzbicki AS, Scott J, Naoumova RP, Shoulders CC.

J Lipid Res. 2013 Dec;54(12):3491-505. doi: 10.1194/jlr.M041814. Epub 2013 Oct 8.

4.

Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels.

Motazacker MM, Peter J, Treskes M, Shoulders CC, Kuivenhoven JA, Hovingh GK.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1521-8. doi: 10.1161/ATVBAHA.113.301505. Epub 2013 May 16. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):e128.

PMID:
23685560
5.

The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism.

Salm MP, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO, Wierzbicki AS, Naoumova RP, Shoulders CC.

Genome Res. 2012 Jun;22(6):1144-53. doi: 10.1101/gr.126037.111. Epub 2012 Mar 7.

6.

Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

Calandra S, Tarugi P, Speedy HE, Dean AF, Bertolini S, Shoulders CC.

J Lipid Res. 2011 Nov;52(11):1885-926. doi: 10.1194/jlr.R017855. Epub 2011 Aug 23. Review.

7.

A new Thematic Series: genetics of human lipid diseases.

Shoulders CC.

J Lipid Res. 2010 Jul;51(7):1621-3. doi: 10.1194/jlr.E006833. Epub 2010 Mar 15. No abstract available.

8.

New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia.

Horswell SD, Ringham HE, Shoulders CC.

J Lipid Res. 2009 Apr;50 Suppl:S370-5. doi: 10.1194/jlr.R800081-JLR200. Epub 2008 Nov 20. Review.

9.

The FTO (fat mass and obesity-associated) gene: big in adipocyte lipolysis?

Shoulders CC.

J Lipid Res. 2008 Mar;49(3):495-6. doi: 10.1194/jlr.E700013-JLR200. No abstract available.

10.

Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.

Lelliott CJ, Ljungberg A, Ahnmark A, William-Olsson L, Ekroos K, Elmgren A, Arnerup G, Shoulders CC, Oscarsson J, Lindén D.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2707-13. Epub 2007 Oct 11.

PMID:
17932310
11.

Current biology of MTP: implications for selective inhibition.

Shoulders CC, Shelness GS.

Curr Top Med Chem. 2005;5(3):283-300. Review.

PMID:
15857311
12.

USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome.

Shoulders CC, Naoumova RP.

Trends Mol Med. 2004 Aug;10(8):362-5. Review.

PMID:
15310455
13.

USF1 on trial.

Shoulders CC.

Nat Genet. 2004 Apr;36(4):322-3. No abstract available.

PMID:
15054483
14.

The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice.

Mensenkamp AR, Van Luyn MJ, Havinga R, Teusink B, Waterman IJ, Mann CJ, Elzinga BM, Verkade HJ, Zammit VA, Havekes LM, Shoulders CC, Kuipers F.

J Hepatol. 2004 Apr;40(4):599-606.

PMID:
15030975
15.

The intracellular transport of chylomicrons requires the small GTPase, Sar1b.

Shoulders CC, Stephens DJ, Jones B.

Curr Opin Lipidol. 2004 Apr;15(2):191-7. Review.

PMID:
15017362
16.

Genetics of familial combined hyperlipidemia and risk of coronary heart disease.

Shoulders CC, Jones EL, Naoumova RP.

Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R149-60. Epub 2004 Feb 5. Review.

PMID:
14764618
17.

The genes and proteins of atherogenic lipoprotein production.

Shoulders CC, Naoumova RP.

Biochem Soc Trans. 2004 Feb;32(Pt 1):70-4. Review.

PMID:
14748715
18.

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

Griffin JL, Bonney SA, Mann C, Hebbachi AM, Gibbons GF, Nicholson JK, Shoulders CC, Scott J.

Physiol Genomics. 2004 Apr 13;17(2):140-9.

PMID:
14747661
19.

Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.

Eichenbaum-Voline S, Olivier M, Jones EL, Naoumova RP, Jones B, Gau B, Patel HN, Seed M, Betteridge DJ, Galton DJ, Rubin EM, Scott J, Shoulders CC, Pennacchio LA.

Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):167-74. Epub 2003 Oct 9.

20.

Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia.

Naoumova RP, Bonney SA, Eichenbaum-Voline S, Patel HN, Jones B, Jones EL, Amey J, Colilla S, Neuwirth CK, Allotey R, Seed M, Betteridge DJ, Galton DJ, Cox NJ, Bell GI, Scott J, Shoulders CC.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2070-7. Epub 2003 Sep 18.

PMID:
14500288
21.

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.

Jones B, Jones EL, Bonney SA, Patel HN, Mensenkamp AR, Eichenbaum-Voline S, Rudling M, Myrdal U, Annesi G, Naik S, Meadows N, Quattrone A, Islam SA, Naoumova RP, Angelin B, Infante R, Levy E, Roy CC, Freemont PS, Scott J, Shoulders CC.

Nat Genet. 2003 May;34(1):29-31.

PMID:
12692552
22.

Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes.

Griffin JL, Mann CJ, Scott J, Shoulders CC, Nicholson JK.

FEBS Lett. 2001 Dec 7;509(2):263-6.

23.

A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein.

Read J, Anderson TA, Ritchie PJ, Vanloo B, Amey J, Levitt D, Rosseneu M, Scott J, Shoulders CC.

J Biol Chem. 2000 Sep 29;275(39):30372-7.

24.

Baculovirus expression and biochemical characterization of the human microsomal triglyceride transfer protein.

Ritchie PJ, Decout A, Amey J, Mann CJ, Read J, Rosseneu M, Scott J, Shoulders CC.

Biochem J. 1999 Mar 1;338 ( Pt 2):305-10.

25.

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J.

Nat Genet. 1999 Jan;21(1):76-83.

PMID:
9916795
26.

A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.

Bradbury P, Mann CJ, Köchl S, Anderson TA, Chester SA, Hancock JM, Ritchie PJ, Amey J, Harrison GB, Levitt DG, Banaszak LJ, Scott J, Shoulders CC.

J Biol Chem. 1999 Jan 29;274(5):3159-64.

27.

Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein.

Nicodeme E, Benoist F, McLeod R, Yao Z, Scott J, Shoulders CC, Grand-Perret T.

J Biol Chem. 1999 Jan 22;274(4):1986-93.

28.

The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins.

Mann CJ, Anderson TA, Read J, Chester SA, Harrison GB, Köchl S, Ritchie PJ, Bradbury P, Hussain FS, Amey J, Vanloo B, Rosseneu M, Infante R, Hancock JM, Levitt DG, Banaszak LJ, Scott J, Shoulders CC.

J Mol Biol. 1999 Jan 8;285(1):391-408.

PMID:
9878414
29.

The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24).

Heath KE, Luong LA, Leonard JV, Chester A, Shoulders CC, Scott J, Middleton-Price HR, Humphries SE, Talmud PJ.

Prenat Diagn. 1997 Dec;17(12):1181-6.

PMID:
9467817
30.

Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children.

Shoulders CC, Grantham TT, North JD, Gaspardone A, Tomai F, de Fazio A, Versaci F, Gioffre PA, Cox NJ.

Hum Genet. 1996 Nov;98(5):557-66.

PMID:
8882875
32.

Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia.

Narcisi TM, Shoulders CC, Chester SA, Read J, Brett DJ, Harrison GB, Grantham TT, Fox MF, Povey S, de Bruin TW, et al.

Am J Hum Genet. 1995 Dec;57(6):1298-310.

33.
34.

The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain.

Shoulders CC, Narcisi TM, Read J, Chester A, Brett DJ, Scott J, Anderson TA, Levitt DG, Banaszak LJ.

Nat Struct Biol. 1994 May;1(5):285-6. No abstract available.

PMID:
7664034
35.

Genetics and molecular biology.

Shoulders CC.

Curr Opin Lipidol. 1994 Feb;5(1):U5-9. No abstract available.

PMID:
15559036
36.

Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein.

Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al.

Hum Mol Genet. 1993 Dec;2(12):2109-16.

PMID:
8111381
37.

Dinucleotide repeat polymorphisms at the lipoprotein lipase (LPL) locus.

Narcisi TM, Schotz MC, Scott J, Shoulders CC.

Hum Genet. 1993 Oct 1;92(3):312-3. No abstract available.

PMID:
8104864
38.

Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance.

Castro Cabezas M, de Bruin TW, de Valk HW, Shoulders CC, Jansen H, Willem Erkelens D.

J Clin Invest. 1993 Jul;92(1):160-8.

39.

Characterization of genetic markers in the 5'flanking region of the apo A1 gene.

Shoulders CC, Narcisi TM, Jarmuz A, Brett DJ, Bayliss JD, Scott J.

Hum Genet. 1993 Mar;91(2):197-8.

PMID:
8096496
40.

Variation at the apo AI/CIII/AIV gene complex is associated with elevated plasma levels of apo CIII.

Shoulders CC, Harry PJ, Lagrost L, White SE, Shah NF, North JD, Gilligan M, Gambert P, Ball MJ.

Atherosclerosis. 1991 Apr;87(2-3):239-47.

PMID:
1906714
41.

Variation in the apo AI/CIII/AIV gene complex: its association with hyperlipidemia.

Shoulders CC, Ball MJ, Baralle FE.

Atherosclerosis. 1989 Dec;80(2):111-8.

PMID:
2514696
42.

Characterization of genetic markers in the 3' end of the apo B gene and their use in family and population studies.

Jenner K, Sidoli A, Ball M, Rodriguez JR, Pagani F, Giudici G, Vergani C, Mann J, Baralle FE, Shoulders CC.

Atherosclerosis. 1988 Jan;69(1):39-49.

PMID:
2895657
43.

Genetic polymorphism in the ApoA-I/C-III complex.

Shoulders CC, Baralle FE.

Methods Enzymol. 1986;128:727-45. No abstract available.

PMID:
3088391
44.

The molecular genetics of hyperlipidemia.

Shoulders CC, Baralle FE.

Horiz Biochem Biophys. 1986;8:299-340. Review. No abstract available.

PMID:
2875933
45.

Molecular cloning of human LDL apolipoprotein B cDNA. Evidence for more than one gene per haploid genome.

Shoulders CC, Myant NB, Sidoli A, Rodriguez JC, Cortese C, Baralle FE, Cortese R.

Atherosclerosis. 1985 Dec;58(1-3):277-89.

PMID:
3841481
46.

Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction.

Shelley CS, Sharpe CR, Baralle FE, Shoulders CC.

J Mol Biol. 1985 Nov 5;186(1):43-51.

PMID:
3935800
47.

Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia.

Rees A, Stocks J, Sharpe CR, Vella MA, Shoulders CC, Katz J, Jowett NI, Baralle FE, Galton DJ.

J Clin Invest. 1985 Sep;76(3):1090-5.

48.

Lipoprotein genes and hyperlipidemia.

Baralle FE, Shoulders CC.

Schweiz Med Wochenschr. 1984 Oct 6;114(40):1351-8.

PMID:
6494870
49.

Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE.

Nucleic Acids Res. 1984 May 11;12(9):3917-32.

50.

Apolipoprotein genes, DNA polymorphisms and hyperlipidemia.

Shoulders CC, Baralle FE.

Agents Actions Suppl. 1984;16:17-33. No abstract available.

PMID:
6091427

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