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Items: 1 to 50 of 69

1.

Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing.

Abayasingam A, Leung P, Eltahla A, Bull RA, Luciani F, Grebely J, Dore GJ, Applegate T, Page K, Bruneau J, Cox AL, Kim AY, Schinkel J, Shoukry NH, Lauer GM, Maher L, Hellard M, Prins M, Lloyd A, Rodrigo C.

Infect Genet Evol. 2019 Mar 7. pii: S1567-1348(18)30936-5. doi: 10.1016/j.meegid.2019.02.032. [Epub ahead of print]

PMID:
30853512
2.

Sex discrepancies in the protective effect of opioid agonist therapy on incident hepatitis C infection.

Geddes L, Iversen J, Wand H, Esmaeili A, Tsui J, Hellard M, Dore G, Grebely J, Dietze P, Bruneau J, Prins M, Morris MD, Shoukry NH, Lloyd AR, Kim AY, Lauer G, Cox AL, Page K, Maher L; InC3 Collaborative.

Clin Infect Dis. 2019 Feb 28. pii: ciz162. doi: 10.1093/cid/ciz162. [Epub ahead of print]

PMID:
30816419
3.

Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC.

Lisovsky I, Kant S, Tremblay-McLean A, Isitman G, Kiani Z, Dupuy FP, Gilbert L, Bruneau J, Shoukry NH, Lebouché B, Bernard NF.

J Leukoc Biol. 2019 Mar;105(3):551-563. doi: 10.1002/JLB.4A0617-242RRR. Epub 2019 Jan 30.

PMID:
30698860
4.

Genomic variability of within-host hepatitis C variants in acute infection.

Rodrigo C, Leung P, Lloyd AR, Bull RA, Luciani F, Grebely J, Dore GJ, Applegate T, Page K, Bruneau J, Cox AL, Osburn W, Kim AY, Shoukry NH, Lauer GM, Maher L, Schinkel J, Prins M, Hellard M, Eltahla AA; InC3 Collaborative.

J Viral Hepat. 2019 Apr;26(4):476-484. doi: 10.1111/jvh.13051. Epub 2019 Jan 22.

PMID:
30578702
5.

Type 3 cytokines IL-17A and IL-22 drive TGF-β-dependent liver fibrosis.

Fabre T, Molina MF, Soucy G, Goulet JP, Willems B, Villeneuve JP, Bilodeau M, Shoukry NH.

Sci Immunol. 2018 Oct 26;3(28). pii: eaar7754. doi: 10.1126/sciimmunol.aar7754.

PMID:
30366940
6.

Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance.

Rosenberg BR, Depla M, Freije CA, Gaucher D, Mazouz S, Boisvert M, Bédard N, Bruneau J, Rice CM, Shoukry NH.

PLoS Pathog. 2018 Sep 17;14(9):e1007290. doi: 10.1371/journal.ppat.1007290. eCollection 2018 Sep.

7.

Type 3 cytokines in liver fibrosis and liver cancer.

Molina MF, Abdelnabi MN, Fabre T, Shoukry NH.

Cytokine. 2018 Aug 7. pii: S1043-4666(18)30326-0. doi: 10.1016/j.cyto.2018.07.028. [Epub ahead of print]

PMID:
30097286
8.

Hepatitis C Vaccines, Antibodies, and T Cells.

Shoukry NH.

Front Immunol. 2018 Jun 28;9:1480. doi: 10.3389/fimmu.2018.01480. eCollection 2018. Review.

9.

Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

Smith LK, Boukhaled GM, Condotta SA, Mazouz S, Guthmiller JJ, Vijay R, Butler NS, Bruneau J, Shoukry NH, Krawczyk CM, Richer MJ.

Immunity. 2018 Feb 20;48(2):299-312.e5. doi: 10.1016/j.immuni.2018.01.006. Epub 2018 Jan 23.

10.

CCDC88B is required for pathogenesis of inflammatory bowel disease.

Fodil N, Moradin N, Leung V, Olivier JF, Radovanovic I, Jeyakumar T, Flores Molina M, McFarquhar A, Cayrol R, Bozec D, Shoukry NH, Kubo M, Dimitrieva J, Louis E, Theatre E, Dahan S, Momozawa Y, Georges M, Yeretssian G, Gros P.

Nat Commun. 2017 Oct 13;8(1):932. doi: 10.1038/s41467-017-01381-y.

11.

The Effect of Female Sex on Hepatitis C Incidence Among People Who Inject Drugs: Results From the International Multicohort InC3 Collaborative.

Esmaeili A, Mirzazadeh A, Morris MD, Hajarizadeh B, Sacks HS, Maher L, Grebely J, Kim AY, Lauer G, Cox AL, Hellard M, Dietze P, Bruneau J, Shoukry NH, Dore GJ, Lloyd AR, Prins M, Page K; InC3 Collaborative.

Clin Infect Dis. 2018 Jan 6;66(1):20-28. doi: 10.1093/cid/cix768.

12.

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

Hart KM, Fabre T, Sciurba JC, Gieseck RL 3rd, Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson RW, White S, Soucy G, Bilodeau M, Ramalingam TR, Arron JR, Shoukry NH, Wynn TA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3694. doi: 10.1126/scitranslmed.aal3694.

PMID:
28659437
13.

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance.

Abdel-Hakeem MS, Boisvert M, Bruneau J, Soudeyns H, Shoukry NH.

PLoS Pathog. 2017 Feb 1;13(2):e1006191. doi: 10.1371/journal.ppat.1006191. eCollection 2017 Feb.

14.

Type III Interferons in Hepatitis C Virus Infection.

Boisvert M, Shoukry NH.

Front Immunol. 2016 Dec 23;7:628. doi: 10.3389/fimmu.2016.00628. eCollection 2016. Review.

15.

Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection.

Rodrigo C, Walker MR, Leung P, Eltahla AA, Grebely J, Dore GJ, Applegate T, Page K, Dwivedi S, Bruneau J, Morris MD, Cox AL, Osburn W, Kim AY, Schinkel J, Shoukry NH, Lauer GM, Maher L, Hellard M, Prins M, Luciani F, Lloyd AR, Bull RA; InC(3) Study Group.

Infect Genet Evol. 2017 Apr;49:88-96. doi: 10.1016/j.meegid.2017.01.006. Epub 2017 Jan 5.

16.

Restrictions for reimbursement of direct-acting antiviral treatment for hepatitis C virus infection in Canada: a descriptive study.

Marshall AD, Saeed S, Barrett L, Cooper CL, Treloar C, Bruneau J, Feld JJ, Gallagher L, Klein MB, Krajden M, Shoukry NH, Taylor LE, Grebely J; Canadian Network on Hepatitis C (CanHepC).

CMAJ Open. 2016 Oct 14;4(4):E605-E614. doi: 10.9778/cmajo.20160008. eCollection 2016 Oct-Dec.

17.

Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells.

Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH, Grakoui A.

J Immunol. 2016 Dec 15;197(12):4848-4858. Epub 2016 Nov 14.

18.

The effects of alcohol on spontaneous clearance of acute hepatitis C virus infection in females versus males.

Tsui JI, Mirzazadeh A, Hahn JA, Maher L, Bruneau J, Grebely J, Hellard M, Kim AY, Shoukry NH, Cox AL, Prins M, Dore GJ, Lauer G, Lloyd AR, Page K.

Drug Alcohol Depend. 2016 Dec 1;169:156-162. doi: 10.1016/j.drugalcdep.2016.10.024. Epub 2016 Oct 26.

19.

Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC3 Study.

Rodrigo C, Eltahla AA, Bull RA, Luciani F, Grebely J, Dore GJ, Applegate T, Page K, Bruneau J, Morris MD, Cox AL, Osburn W, Kim AY, Shoukry NH, Lauer GM, Maher L, Schinkel J, Prins M, Hellard M, Lloyd AR; InC3 Collaborative.

J Viral Hepat. 2017 Jan;24(1):43-52. doi: 10.1111/jvh.12616. Epub 2016 Nov 3.

20.

Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents.

Eltahla AA, Rodrigo C, Betz-Stablein B, Grebely J, Applegate T, Luciani F, Schinkel J, Dore GJ, Page K, Bruneau J, Morris MD, Cox AL, Kim AY, Shoukry NH, Lauer GM, Maher L, Hellard M, Prins M, Lloyd AR, Bull RA; InC3 Study Group.

J Viral Hepat. 2017 Jan;24(1):37-42. doi: 10.1111/jvh.12615. Epub 2016 Sep 25.

21.

IFN-λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection.

Depla M, Pelletier S, Bédard N, Brunaud C, Bruneau J, Shoukry NH.

Immun Inflamm Dis. 2016 Aug 16;4(3):376-88. doi: 10.1002/iid3.122. eCollection 2016 Sep.

22.

IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.

Beltra JC, Bourbonnais S, Bédard N, Charpentier T, Boulangé M, Michaud E, Boufaied I, Bruneau J, Shoukry NH, Lamarre A, Decaluwe H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5444-53. doi: 10.1073/pnas.1604256113. Epub 2016 Aug 29.

23.

Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia.

Rodrigo C, Eltahla AA, Bull RA, Grebely J, Dore GJ, Applegate T, Page K, Bruneau J, Morris MD, Cox AL, Osburn W, Kim AY, Schinkel J, Shoukry NH, Lauer GM, Maher L, Hellard M, Prins M, Estes C, Razavi H, Lloyd AR, Luciani F; International Collaborative of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study Group.

J Infect Dis. 2016 Nov 1;214(9):1383-1389. Epub 2016 Aug 28.

24.

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Page K, Mirzazadeh A, Rice TM, Grebely J, Kim AY, Cox AL, Morris MD, Hellard M, Bruneau J, Shoukry NH, Dore GJ, Maher L, Lloyd AR, Lauer G, Prins M, McGovern BH.

Open Forum Infect Dis. 2016 Feb 8;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan.

25.

A novel role for hepatic stellate cells in pathogenesis of visceral leishmaniasis.

Shoukry NH, Fabre T, Gandhi CR.

Hepatology. 2016 Feb;63(2):375-6. doi: 10.1002/hep.28247. Epub 2015 Nov 30. No abstract available.

PMID:
26403215
26.

Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity.

Isitman G, Lisovsky I, Tremblay-McLean A, Parsons MS, Shoukry NH, Wainberg MA, Bruneau J, Bernard NF.

AIDS. 2015 Jul 31;29(12):1433-43. doi: 10.1097/QAD.0000000000000729.

PMID:
26244383
27.

Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection--the InC3 Study.

Sacks-Davis R, Grebely J, Dore GJ, Osburn W, Cox AL, Rice TM, Spelman T, Bruneau J, Prins M, Kim AY, McGovern BH, Shoukry NH, Schinkel J, Allen TM, Morris M, Hajarizadeh B, Maher L, Lloyd AR, Page K, Hellard M; InC3 study group.

J Infect Dis. 2015 Nov 1;212(9):1407-19. doi: 10.1093/infdis/jiv220. Epub 2015 Apr 15.

28.

A longitudinal study of hepatitis C virus testing and infection status notification on behaviour change in people who inject drugs.

Spelman T, Morris MD, Zang G, Rice T, Page K, Maher L, Lloyd A, Grebely J, Dore GJ, Kim AY, Shoukry NH, Hellard M, Bruneau J; International Collaborative of Incident HIV and Hepatitis C in Injecting Cohorts (InC3 Study).

J Epidemiol Community Health. 2015 Aug;69(8):745-52. doi: 10.1136/jech-2014-205224. Epub 2015 Mar 26.

29.

Erratum to: IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test.

Gélinas JF, Fabre T, Willems P, Leung RC, George J, Willems B, Bruneau J, Shoukry NH.

Immunogenetics. 2015 Apr;67(4):265-6. doi: 10.1007/s00251-015-0831-8. No abstract available.

30.

IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-β receptor on hepatic stellate cells in a JNK-dependent manner.

Fabre T, Kared H, Friedman SL, Shoukry NH.

J Immunol. 2014 Oct 15;193(8):3925-33. doi: 10.4049/jimmunol.1400861. Epub 2014 Sep 10.

31.

Signatures of protective memory immune responses during hepatitis C virus reinfection.

Abdel-Hakeem MS, Bédard N, Murphy D, Bruneau J, Shoukry NH.

Gastroenterology. 2014 Oct;147(4):870-881.e8. doi: 10.1053/j.gastro.2014.07.005. Epub 2014 Jul 16.

32.

CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals.

Kared H, Saeed S, Klein MB, Shoukry NH.

PLoS One. 2014 Jul 9;9(7):e101441. doi: 10.1371/journal.pone.0101441. eCollection 2014.

33.

Protective immunity against hepatitis C: many shades of gray.

Abdel-Hakeem MS, Shoukry NH.

Front Immunol. 2014 Jun 16;5:274. doi: 10.3389/fimmu.2014.00274. eCollection 2014. Review.

34.

Genetics of spontaneous clearance of hepatitis C virus infection: a complex topic with much to learn.

Grebely J, Dore GJ, Kim AY, Lloyd A, Shoukry NH, Prins M, Page K.

Hepatology. 2014 Dec;60(6):2127-8. doi: 10.1002/hep.27163. Epub 2014 May 27. No abstract available.

35.

MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

Fortin JS, Genève L, Gauthier C, Shoukry NH, Azar GA, Younes S, Yassine-Diab B, Sékaly RP, Fremont DH, Thibodeau J.

J Immunol. 2014 Feb 15;192(4):1896-906. doi: 10.4049/jimmunol.1203130. Epub 2014 Jan 22.

36.

The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection.

Grebely J, Page K, Sacks-Davis R, van der Loeff MS, Rice TM, Bruneau J, Morris MD, Hajarizadeh B, Amin J, Cox AL, Kim AY, McGovern BH, Schinkel J, George J, Shoukry NH, Lauer GM, Maher L, Lloyd AR, Hellard M, Dore GJ, Prins M; InC3 Study Group.

Hepatology. 2014 Jan;59(1):109-20. doi: 10.1002/hep.26639. Epub 2013 Nov 22.

37.

Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C.

Kared H, Fabre T, Bédard N, Bruneau J, Shoukry NH.

PLoS Pathog. 2013;9(6):e1003422. doi: 10.1371/journal.ppat.1003422. Epub 2013 Jun 20.

38.

Sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C.

Pelletier S, Bédard N, Said E, Ancuta P, Bruneau J, Shoukry NH.

J Virol. 2013 Jun;87(12):6769-81. doi: 10.1128/JVI.02445-12. Epub 2013 Apr 10.

39.

IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test.

Gélinas JF, Fabre T, Willems P, Leung RC, George J, Willems B, Bruneau J, Shoukry NH.

Immunogenetics. 2013 Jun;65(6):397-403. doi: 10.1007/s00251-013-0688-7. Epub 2013 Mar 3. Erratum in: Immunogenetics. 2015 Apr;67(4):265-6.

40.

Plasma interferon-gamma-inducible protein-10 (IP-10) levels during acute hepatitis C virus infection.

Grebely J, Feld JJ, Applegate T, Matthews GV, Hellard M, Sherker A, Petoumenos K, Zang G, Shaw I, Yeung B, George J, Teutsch S, Kaldor JM, Cherepanov V, Bruneau J, Shoukry NH, Lloyd AR, Dore GJ.

Hepatology. 2013 Jun;57(6):2124-34. doi: 10.1002/hep.26263. Epub 2013 May 8.

41.

Cohort profile: the international collaboration of incident HIV and hepatitis C in injecting cohorts (InC3) study.

Grebely J, Morris MD, Rice TM, Bruneau J, Cox AL, Kim AY, McGovern BH, Shoukry NH, Lauer G, Maher L, Lloyd AR, Hellard M, Prins M, Dore GJ, Page K; InC Study Group.

Int J Epidemiol. 2013 Dec;42(6):1649-59. doi: 10.1093/ije/dys167. Epub 2012 Nov 30.

42.

Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.

Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin SR, Alvarez F, Shoukry NH, Soudeyns H.

J Clin Microbiol. 2012 Jul;50(7):2515-9. doi: 10.1128/JCM.00622-12. Epub 2012 Apr 25.

43.

Altered thymic function during interferon therapy in HCV-infected patients.

Beq S, Rozlan S, Pelletier S, Willems B, Bruneau J, Lelievre JD, Levy Y, Shoukry NH, Cheynier R.

PLoS One. 2012;7(4):e34326. doi: 10.1371/journal.pone.0034326. Epub 2012 Apr 16.

44.

A view to natural killer cells in hepatitis C.

Shoukry NH, Pelletier S, Chang KM.

Gastroenterology. 2011 Oct;141(4):1144-8. doi: 10.1053/j.gastro.2011.08.025. Epub 2011 Aug 27. No abstract available.

PMID:
21875586
45.

Mind the gap: lack of association between KIR3DL1*004/HLA‐Bw4-induced natural killer cell function and protection from HIV infection.

Parsons MS, Boulet S, Song R, Bruneau J, Shoukry NH, Routy JP, Tsoukas CM, Bernard NF.

J Infect Dis. 2010 Nov 1;202 Suppl 3:S356-60. doi: 10.1086/655966.

PMID:
20887224
46.

Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses.

Pelletier S, Drouin C, Bédard N, Khakoo SI, Bruneau J, Shoukry NH.

J Hepatol. 2010 Nov;53(5):805-16. doi: 10.1016/j.jhep.2010.05.013. Epub 2010 Jul 17.

47.

Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus.

Abdel-Hakeem MS, Bédard N, Badr G, Ostrowski M, Sékaly RP, Bruneau J, Willems B, Heathcote EJ, Shoukry NH.

J Virol. 2010 Oct;84(19):10429-35. doi: 10.1128/JVI.01094-10. Epub 2010 Jul 28.

48.

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.

Said EA, Dupuy FP, Trautmann L, Zhang Y, Shi Y, El-Far M, Hill BJ, Noto A, Ancuta P, Peretz Y, Fonseca SG, Van Grevenynghe J, Boulassel MR, Bruneau J, Shoukry NH, Routy JP, Douek DC, Haddad EK, Sekaly RP.

Nat Med. 2010 Apr;16(4):452-9. doi: 10.1038/nm.2106. Epub 2010 Mar 7.

49.

Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.

Radziewicz H, Ibegbu CC, Hon H, Bédard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A.

J Immunol. 2010 Mar 1;184(5):2410-22. doi: 10.4049/jimmunol.0902994. Epub 2010 Jan 25.

50.

HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells.

Boulet S, Song R, Kamya P, Bruneau J, Shoukry NH, Tsoukas CM, Bernard NF.

J Immunol. 2010 Feb 15;184(4):2057-64. doi: 10.4049/jimmunol.0902621. Epub 2010 Jan 8.

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