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Items: 1 to 50 of 52

1.

3-Bromopyruvate: targets and outcomes.

Shoshan MC.

J Bioenerg Biomembr. 2012 Feb;44(1):7-15. doi: 10.1007/s10863-012-9419-2. Review.

PMID:
22298255
2.

Potentiation of anti-cancer treatment by modulators of energy metabolism.

Shoshan MC.

Curr Pharm Biotechnol. 2013;14(3):313-30. Review.

PMID:
22201600
3.

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S.

Int J Cancer. 2009 Nov 15;125(10):2450-5. doi: 10.1002/ijc.24627.

4.

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.

Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H.

Carcinogenesis. 2009 Sep;30(9):1517-27. doi: 10.1093/carcin/bgp165. Epub 2009 Jul 3.

PMID:
19578044
5.

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

Berndtsson M, Hernlund E, Shoshan MC, Linder S.

J Chem Biol. 2009 Jun;2(2):81-7. doi: 10.1007/s12154-009-0017-7. Epub 2009 Mar 31.

6.

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Ihrlund LS, Hernlund E, Khan O, Shoshan MC.

Mol Oncol. 2008 Jun;2(1):94-101. doi: 10.1016/j.molonc.2008.01.003. Epub 2008 Jan 13.

7.

Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.

Pettersson HM, Pietras A, Munksgaard Persson M, Karlsson J, Johansson L, Shoshan MC, Påhlman S.

Mol Cancer Ther. 2009 Jan;8(1):160-70. doi: 10.1158/1535-7163.MCT-08-0595.

8.

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH, Havelka AM, Brnjic S, Shoshan MC, Linder S.

BMC Chem Biol. 2008 Aug 1;8:2. doi: 10.1186/1472-6769-8-2.

9.

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.

Hernlund E, Ihrlund LS, Khan O, Ates YO, Linder S, Panaretakis T, Shoshan MC.

Int J Cancer. 2008 Jul 15;123(2):476-483. doi: 10.1002/ijc.23525.

10.

Target specificity and off-target effects as determinants of cancer drug efficacy.

Shoshan MC, Linder S.

Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):273-80. doi: 10.1517/17425255.4.3.273 . Review.

PMID:
18363542
11.

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S.

Mini Rev Med Chem. 2007 Oct;7(10):1035-9. Review.

PMID:
17979806
12.

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.

Olofsson MH, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S.

Clin Cancer Res. 2007 Jun 1;13(11):3198-206.

13.

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.

Linder S, Shoshan MC, Gupta RS.

Cancer Res. 2007 Mar 15;67(6):2899; author reply 2899-900. No abstract available. Erratum in: Cancer Res. 2007 Jul 1;67(13):6529.

14.

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.

Shoshan MC, Havelka AP, Neumann F, Linder S.

Expert Opin Drug Discov. 2006 Nov;1(6):585-94. doi: 10.1517/17460441.1.6.585.

PMID:
23506068
15.

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.

Berndtsson M, Hägg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S.

Int J Cancer. 2007 Jan 1;120(1):175-80.

16.
17.

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

Ihrlund LS, Hernlund E, Viktorsson K, Panaretakis T, Barna G, Sabapathy K, Linder S, Shoshan MC.

Exp Cell Res. 2006 May 15;312(9):1581-9. Epub 2006 Mar 9.

PMID:
16529740
18.

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy.

Linder S, Shoshan MC.

Drug Resist Updat. 2005 Aug;8(4):199-204. Epub 2005 Aug 1. Review.

PMID:
16055370
19.

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Panaretakis T, Laane E, Pokrovskaja K, Björklund AC, Moustakas A, Zhivotovsky B, Heyman M, Shoshan MC, Grandér D.

Mol Biol Cell. 2005 Aug;16(8):3821-31. Epub 2005 May 25.

20.

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.

Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):192-7. Epub 2004 Dec 23.

21.

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.

Linder S, Havelka AM, Ueno T, Shoshan MC.

Cancer Lett. 2004 Oct 8;214(1):1-9. Review.

PMID:
15331168
22.

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids.

Hägg M, Berndtsson M, Mandic A, Zhou R, Shoshan MC, Linder S.

Mol Cancer Ther. 2004 Apr;3(4):489-97.

23.

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

Kramer G, Erdal H, Mertens HJ, Nap M, Mauermann J, Steiner G, Marberger M, Bivén K, Shoshan MC, Linder S.

Cancer Res. 2004 Mar 1;64(5):1751-6.

24.

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line.

Viktorsson K, Ekedahl J, Lindebro MC, Lewensohn R, Zhivotovsky B, Linder S, Shoshan MC.

Exp Cell Res. 2003 Oct 1;289(2):256-64.

PMID:
14499626
25.

Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax.

Panaretakis T, Pokrovskaja K, Shoshan MC, Grandér D.

Oncogene. 2003 Jul 17;22(29):4543-56.

PMID:
12881711
26.

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera.

Bivén K, Erdal H, Hägg M, Ueno T, Zhou R, Lynch M, Rowley B, Wood J, Zhang C, Toi M, Shoshan MC, Linder S.

Apoptosis. 2003 Jun;8(3):263-8.

PMID:
12766486
27.

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling.

Mandic A, Hansson J, Linder S, Shoshan MC.

J Biol Chem. 2003 Mar 14;278(11):9100-6. Epub 2002 Dec 31.

28.

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

Panaretakis T, Pokrovskaja K, Shoshan MC, Grandér D.

J Biol Chem. 2002 Nov 15;277(46):44317-26. Epub 2002 Aug 21.

29.

Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis.

Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S, Shoshan MC.

Mol Cell Biol. 2002 May;22(9):3003-13.

30.
31.

Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner.

Mandic A, Viktorsson K, Molin M, Akusjärvi G, Eguchi H, Hayashi SI, Toi M, Hansson J, Linder S, Shoshan MC.

Mol Cell Biol. 2001 Jun;21(11):3684-91.

32.

The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis.

Mandic A, Viktorsson K, Heiden T, Hansson J, Shoshan MC.

Melanoma Res. 2001 Feb;11(1):11-9.

PMID:
11254111
33.

Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin.

Viktorsson K, Heiden T, Molin M, Akusjärvi G, Linder S, Shoshan MC.

Apoptosis. 2000 Oct;5(4):355-67.

PMID:
11227217
34.
35.

ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation.

Seddighzadeh M, Zhou JN, Kronenwett U, Shoshan MC, Auer G, Sten-Linder M, Wiman B, Linder S.

Clin Exp Metastasis. 1999;17(8):649-54.

PMID:
10919709
36.

Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments.

Molin M, Shoshan MC, Ohman-Forslund K, Linder S, Akusjärvi G.

J Virol. 1998 Oct;72(10):8358-61.

37.

Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop.

Ljungdahl S, Linder S, Franzén B, Binétruy B, Auer G, Shoshan MC.

Cell Growth Differ. 1998 Jul;9(7):565-73.

38.

Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.

Zhou JN, Ljungdahl S, Shoshan MC, Swedenborg J, Linder S.

Mol Carcinog. 1998 Apr;21(4):234-43.

PMID:
9585253
40.

Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen.

Bergman AC, Linder C, Sakaguchi K, Sten-Linder M, Alaiya AA, Franzén B, Shoshan MC, Bergman T, Wiman B, Auer G, Appella E, Jörnvall H, Linder S.

FEBS Lett. 1997 Nov 3;417(1):17-20.

41.

Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines.

Zhou JN, Ljungdahl S, Röhme D, Levan G, Shoshan MC, Linder S.

Genes Chromosomes Cancer. 1997 Sep;20(1):82-9.

PMID:
9290958
42.

The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.

Fokstuen T, Rabo YB, Zhou JN, Karlson J, Platz A, Shoshan MC, Hansson J, Linder S.

Anticancer Res. 1997 Jul-Aug;17(4A):2347-52.

PMID:
9252645
43.
44.

Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.

Karlson J, Borg-Karlson AK, Unelius R, Shoshan MC, Wilking N, Ringborg U, Linder S.

Anticancer Drugs. 1996 Jun;7(4):422-9.

PMID:
8826611
45.

Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light.

Rabo YB, Shoshan MC, Linder S, Hansson J.

Int J Cancer. 1996 Mar 15;65(6):821-6.

46.
47.

Tumorigenic and metastatic properties of two ras-oncogene transfected rat fibrosarcoma cell lines defective in c-jun.

Marshall-Heyman H, Engel G, Ljungdahl S, Shoshan MC, Svensson C, Wasylyk B, Linder S.

Oncogene. 1994 Dec;9(12):3655-63.

PMID:
7970724
48.

Induction of the collagenase phorbol ester response element by staurosporine.

Shoshan MC, Linder S.

J Cell Biochem. 1994 Aug;55(4):496-502.

PMID:
7962179
49.

Dithiothreitol generates an activated 250,000 mol. wt form of Clostridium difficile toxin B.

Shoshan MC, Bergman T, Thelestam M, Florin I.

Toxicon. 1993 Jul;31(7):845-52.

PMID:
8212030
50.

Activation of cellular phospholipase A2 by Clostridium difficile toxin B.

Shoshan MC, Florin I, Thelestam M.

J Cell Biochem. 1993 May;52(1):116-24.

PMID:
8320270

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