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Dendritic cell development: A personal historical perspective.

Shortman K.

Mol Immunol. 2020 Jan 24;119:64-68. doi: 10.1016/j.molimm.2019.12.016. [Epub ahead of print] Review.


Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells.

Park HY, Tan PS, Kavishna R, Ker A, Lu J, Chan CEZ, Hanson BJ, MacAry PA, Caminschi I, Shortman K, Alonso S, Lahoud MH.

NPJ Vaccines. 2017 Nov 6;2:31. doi: 10.1038/s41541-017-0033-5. eCollection 2017.


Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition.

Tullett KM, Leal Rojas IM, Minoda Y, Tan PS, Zhang JG, Smith C, Khanna R, Shortman K, Caminschi I, Lahoud MH, Radford KJ.

JCI Insight. 2016 May 19;1(7):e87102. doi: 10.1172/jci.insight.87102.


Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan.

Zhan Y, Chow KV, Soo P, Xu Z, Brady JL, Lawlor KE, Masters SL, O'keeffe M, Shortman K, Zhang JG, Lew AM.

Sci Rep. 2016 Apr 26;6:25060. doi: 10.1038/srep25060.


IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection.

Torres D, Köhler A, Delbauve S, Caminschi I, Lahoud MH, Shortman K, Flamand V.

PLoS Pathog. 2016 Apr 13;12(4):e1005561. doi: 10.1371/journal.ppat.1005561. eCollection 2016 Apr.


How does batf3 determine dendritic cell development?

Shortman K.

Immunol Cell Biol. 2015 Sep;93(8):681-2. doi: 10.1038/icb.2015.69. Epub 2015 Aug 25. No abstract available.


Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall.

Kato Y, Zaid A, Davey GM, Mueller SN, Nutt SL, Zotos D, Tarlinton DM, Shortman K, Lahoud MH, Heath WR, Caminschi I.

J Immunol. 2015 Aug 1;195(3):1006-14. doi: 10.4049/jimmunol.1500767. Epub 2015 Jun 22.


What's in a Name? Some Early and Current Issues in Dendritic Cell Nomenclature.

Vremec D, Shortman K.

Front Immunol. 2015 May 29;6:267. doi: 10.3389/fimmu.2015.00267. eCollection 2015. Review. No abstract available.


Professor Donald Metcalf (1929–2014).

Shortman K, Nicola NA, Ng AP.

Immunity. 2015 Jan 20;42(1):1-3. No abstract available.


NOD mice are functionally deficient in the capacity of cross-presentation.

Lee CN, Lew AM, Shortman K, Wu L.

Immunol Cell Biol. 2015 Jul;93(6):548-57. doi: 10.1038/icb.2014.119. Epub 2015 Jan 20.


Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Li J, Ahmet F, Sullivan LC, Brooks AG, Kent SJ, De Rose R, Salazar AM, Reis e Sousa C, Shortman K, Lahoud MH, Heath WR, Caminschi I.

Eur J Immunol. 2015 Mar;45(3):854-64. doi: 10.1002/eji.201445127. Epub 2015 Jan 14.


Maintaining dendritic cell viability in culture.

Vremec D, Hansen J, Strasser A, Acha-Orbea H, Zhan Y, O'Keeffe M, Shortman K.

Mol Immunol. 2015 Feb;63(2):264-7. doi: 10.1016/j.molimm.2014.07.011. Epub 2014 Jul 28.


Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor.

Sathe P, Metcalf D, Vremec D, Naik SH, Langdon WY, Huntington ND, Wu L, Shortman K.

Immunity. 2014 Jul 17;41(1):104-15. doi: 10.1016/j.immuni.2014.05.020.


GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

Ko HJ, Brady JL, Ryg-Cornejo V, Hansen DS, Vremec D, Shortman K, Zhan Y, Lew AM.

J Immunol. 2014 Mar 1;192(5):2202-9. doi: 10.4049/jimmunol.1302040. Epub 2014 Jan 31.


FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo.

Ding Y, Wilkinson A, Idris A, Fancke B, O'Keeffe M, Khalil D, Ju X, Lahoud MH, Caminschi I, Shortman K, Rodwell R, Vuckovic S, Radford KJ.

J Immunol. 2014 Feb 15;192(4):1982-9. doi: 10.4049/jimmunol.1302391. Epub 2014 Jan 22.


Evolution of B cell responses to Clec9A-targeted antigen.

Park HY, Light A, Lahoud MH, Caminschi I, Tarlinton DM, Shortman K.

J Immunol. 2013 Nov 15;191(10):4919-25. doi: 10.4049/jimmunol.1301947. Epub 2013 Oct 11.


Plasmacytoid dendritic cell development.

Shortman K, Sathe P, Vremec D, Naik S, O'Keeffe M.

Adv Immunol. 2013;120:105-26. doi: 10.1016/B978-0-12-417028-5.00004-1. Review.


Another heritage for plasmacytoid dendritic cells.

Shortman K, Sathe P.

Immunity. 2013 May 23;38(5):845-6. doi: 10.1016/j.immuni.2013.05.002. No abstract available.


Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells.

Sathe P, Vremec D, Wu L, Corcoran L, Shortman K.

Blood. 2013 Jan 3;121(1):11-9. doi: 10.1182/blood-2012-02-413336. Epub 2012 Oct 10.


DEC-205 is a cell surface receptor for CpG oligonucleotides.

Lahoud MH, Ahmet F, Zhang JG, Meuter S, Policheni AN, Kitsoulis S, Lee CN, O'Keeffe M, Sullivan LC, Brooks AG, Berry R, Rossjohn J, Mintern JD, Vega-Ramos J, Villadangos JA, Nicola NA, Nussenzweig MC, Stacey KJ, Shortman K, Heath WR, Caminschi I.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16270-5. doi: 10.1073/pnas.1208796109. Epub 2012 Sep 17.


The remembrance of 56 years of research.

Shortman K.

Immunol Cell Biol. 2012 Jul;90(6):565-7. doi: 10.1038/icb.2012.26. No abstract available.


Development of antigen cross-presentation capacity in dendritic cells.

Dresch C, Leverrier Y, Marvel J, Shortman K.

Trends Immunol. 2012 Aug;33(8):381-8. doi: 10.1016/ Epub 2012 Jun 5. Review.


The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.

Zhang JG, Czabotar PE, Policheni AN, Caminschi I, Wan SS, Kitsoulis S, Tullett KM, Robin AY, Brammananth R, van Delft MF, Lu J, O'Reilly LA, Josefsson EC, Kile BT, Chin WJ, Mintern JD, Olshina MA, Wong W, Baum J, Wright MD, Huang DC, Mohandas N, Coppel RL, Colman PM, Nicola NA, Shortman K, Lahoud MH.

Immunity. 2012 Apr 20;36(4):646-57. doi: 10.1016/j.immuni.2012.03.009. Epub 2012 Apr 5.


Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice.

Caminschi I, Vremec D, Ahmet F, Lahoud MH, Villadangos JA, Murphy KM, Heath WR, Shortman K.

Mol Immunol. 2012 Feb;50(1-2):9-17. doi: 10.1016/j.molimm.2011.11.008. Epub 2011 Dec 29.


Boosting antibody responses by targeting antigens to dendritic cells.

Caminschi I, Shortman K.

Trends Immunol. 2012 Feb;33(2):71-7. doi: 10.1016/ Epub 2011 Dec 6. Review.


Ralph Steinman and dendritic cells.

Shortman K.

Immunol Cell Biol. 2012 Jan;90(1):1-2. doi: 10.1038/icb.2011.91. Epub 2011 Oct 25. No abstract available.


Highlights of 10 years of immunology in Nature Reviews Immunology.

Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A.

Nat Rev Immunol. 2011 Sep 23;11(10):693-702. doi: 10.1038/nri3063. Review.


CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen.

Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH, Caminschi I, Shortman K, Henson PM, Jakubzick CV.

J Exp Med. 2011 Aug 29;208(9):1789-97. doi: 10.1084/jem.20110538. Epub 2011 Aug 22.


Thymic but not splenic CD8⁺ DCs can efficiently cross-prime T cells in the absence of licensing factors.

Dresch C, Ackermann M, Vogt B, de Andrade Pereira B, Shortman K, Fraefel C.

Eur J Immunol. 2011 Sep;41(9):2544-55. doi: 10.1002/eji.201041374. Epub 2011 Aug 3.


Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.

Lahoud MH, Ahmet F, Kitsoulis S, Wan SS, Vremec D, Lee CN, Phipson B, Shi W, Smyth GK, Lew AM, Kato Y, Mueller SN, Davey GM, Heath WR, Shortman K, Caminschi I.

J Immunol. 2011 Jul 15;187(2):842-50. doi: 10.4049/jimmunol.1101176. Epub 2011 Jun 15.


Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.

Fuertes Marraco SA, Scott CL, Bouillet P, Ives A, Masina S, Vremec D, Jansen ES, O'Reilly LA, Schneider P, Fasel N, Shortman K, Strasser A, Acha-Orbea H.

PLoS One. 2011;6(6):e20189. doi: 10.1371/journal.pone.0020189. Epub 2011 Jun 2.


Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

Mittag D, Proietto AI, Loudovaris T, Mannering SI, Vremec D, Shortman K, Wu L, Harrison LC.

J Immunol. 2011 Jun 1;186(11):6207-17. doi: 10.4049/jimmunol.1002632. Epub 2011 Apr 22.


The acquisition of antigen cross-presentation function by newly formed dendritic cells.

Sathe P, Pooley J, Vremec D, Mintern J, Jin JO, Wu L, Kwak JY, Villadangos JA, Shortman K.

J Immunol. 2011 May 1;186(9):5184-92. doi: 10.4049/jimmunol.1002683. Epub 2011 Mar 21.


Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber CA, Fejer G, Freudenberg MA, Davey GM, Vremec D, Kallies A, Wu L, Shortman K, Chaplin P, Suter M, O'Keeffe M, Hochrein H.

J Exp Med. 2010 Nov 22;207(12):2703-17. doi: 10.1084/jem.20092720. Epub 2010 Oct 25.


Nomenclature of monocytes and dendritic cells in blood.

Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB.

Blood. 2010 Oct 21;116(16):e74-80. doi: 10.1182/blood-2010-02-258558. Epub 2010 Jul 13.


Found in translation: the human equivalent of mouse CD8+ dendritic cells.

Villadangos JA, Shortman K.

J Exp Med. 2010 Jun 7;207(6):1131-4. doi: 10.1084/jem.20100985. Epub 2010 May 31. Review.


Factors determining the spontaneous activation of splenic dendritic cells in culture.

Vremec D, O'Keeffe M, Wilson A, Ferrero I, Koch U, Radtke F, Scott B, Hertzog P, Villadangos J, Shortman K.

Innate Immun. 2011 Feb;17(3):338-52. doi: 10.1177/1753425910371396. Epub 2010 May 25.


The CD8+ dendritic cell subset.

Shortman K, Heath WR.

Immunol Rev. 2010 Mar;234(1):18-31. doi: 10.1111/j.0105-2896.2009.00870.x. Review.


Regeneration of dendritic cells in aged mice.

van Dommelen SL, Rizzitelli A, Chidgey A, Boyd R, Shortman K, Wu L.

Cell Mol Immunol. 2010 Mar;7(2):108-15. doi: 10.1038/cmi.2009.114. Epub 2010 Feb 1.


The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.

Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID, Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I.

J Immunol. 2009 Jun 15;182(12):7587-94. doi: 10.4049/jimmunol.0900464.


Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.

Bedoui S, Whitney PG, Waithman J, Eidsmo L, Wakim L, Caminschi I, Allan RS, Wojtasiak M, Shortman K, Carbone FR, Brooks AG, Heath WR.

Nat Immunol. 2009 May;10(5):488-95. doi: 10.1038/ni.1724. Epub 2009 Apr 6.


Improving vaccines by targeting antigens to dendritic cells.

Shortman K, Lahoud MH, Caminschi I.

Exp Mol Med. 2009 Feb 28;41(2):61-6. Review.


Enhancing immune responses by targeting antigen to DC.

Caminschi I, Lahoud MH, Shortman K.

Eur J Immunol. 2009 Apr;39(4):931-8. doi: 10.1002/eji.200839035.


The steady-state development of splenic dendritic cells.

Sathe P, Shortman K.

Mucosal Immunol. 2008 Nov;1(6):425-31. doi: 10.1038/mi.2008.56. Epub 2008 Sep 10. Review.


Dendritic cells in the thymus contribute to T-regulatory cell induction.

Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K, Wu L.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19869-74. doi: 10.1073/pnas.0810268105. Epub 2008 Dec 10. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1679.


Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.

Young LJ, Wilson NS, Schnorrer P, Proietto A, ten Broeke T, Matsuki Y, Mount AM, Belz GT, O'Keeffe M, Ohmura-Hoshino M, Ishido S, Stoorvogel W, Heath WR, Shortman K, Villadangos JA.

Nat Immunol. 2008 Nov;9(11):1244-52. doi: 10.1038/ni.1665. Epub 2008 Oct 12.


The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.

Caminschi I, Proietto AI, Ahmet F, Kitsoulis S, Shin Teh J, Lo JC, Rizzitelli A, Wu L, Vremec D, van Dommelen SL, Campbell IK, Maraskovsky E, Braley H, Davey GM, Mottram P, van de Velde N, Jensen K, Lew AM, Wright MD, Heath WR, Shortman K, Lahoud MH.

Blood. 2008 Oct 15;112(8):3264-73. doi: 10.1182/blood-2008-05-155176. Epub 2008 Jul 30.


The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture.

Vremec D, Shortman K.

Methods Mol Biol. 2008;415:163-78. doi: 10.1007/978-1-59745-570-1_10.


Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.

Wilson NS, Young LJ, Kupresanin F, Naik SH, Vremec D, Heath WR, Akira S, Shortman K, Boyle J, Maraskovsky E, Belz GT, Villadangos JA.

Immunol Cell Biol. 2008 Feb;86(2):200-5. Epub 2007 Nov 20.


Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.

Caminschi I, Ahmet F, Heger K, Brady J, Nutt SL, Vremec D, Pietersz S, Lahoud MH, Schofield L, Hansen DS, O'Keeffe M, Smyth MJ, Bedoui S, Davey GM, Villadangos JA, Heath WR, Shortman K.

J Exp Med. 2007 Oct 29;204(11):2579-90. Epub 2007 Oct 8.

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