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Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors.

Guo L, Fare CM, Shorter J.

Trends Cell Biol. 2019 Jan 16. pii: S0962-8924(18)30218-6. doi: 10.1016/j.tcb.2018.12.004. [Epub ahead of print] Review.


Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.

Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A.

Structure. 2018 Nov 21. pii: S0969-2126(18)30420-9. doi: 10.1016/j.str.2018.11.001. [Epub ahead of print]


TDP-43 shapeshifts to encipher FTD severity.

Barbieri EM, Shorter J.

Nat Neurosci. 2019 Jan;22(1):3-5. doi: 10.1038/s41593-018-0299-6. No abstract available.


Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation.

McGurk L, Gomes E, Guo L, Shorter J, Bonini N.

Biochemistry. 2018 Dec 12. doi: 10.1021/acs.biochem.8b00910. [Epub ahead of print]


Correction to: Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Shorter JR, Huang W, Beak JY, Hua K, Gatti DM, de Villena FP, Pomp D, Jensen BC.

Mamm Genome. 2018 Dec 4. doi: 10.1007/s00335-018-9789-9. [Epub ahead of print]


3' UTRs in the Eye of the TIGER.

Portz B, Shorter J.

Dev Cell. 2018 Dec 3;47(5):544-546. doi: 10.1016/j.devcel.2018.11.022.


TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R.

Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31.


Early detection of lung cancer in a population at high risk due to occupation and smoking.

Welch LS, Dement JM, Cranford K, Shorter J, Quinn PS, Madtes DK, Ringen K.

Occup Environ Med. 2018 Nov 10. pii: oemed-2018-105431. doi: 10.1136/oemed-2018-105431. [Epub ahead of print]


Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation.

Shorter J, Houry WA.

Front Mol Biosci. 2018 Oct 2;5:85. doi: 10.3389/fmolb.2018.00085. eCollection 2018. No abstract available.


Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.

McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM.

Acta Neuropathol Commun. 2018 Aug 29;6(1):84. doi: 10.1186/s40478-018-0586-1.


Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.

McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM.

Mol Cell. 2018 Sep 6;71(5):703-717.e9. doi: 10.1016/j.molcel.2018.07.002. Epub 2018 Aug 9.


The molecular language of membraneless organelles.

Gomes E, Shorter J.

J Biol Chem. 2018 Jul 25. pii: jbc.TM118.001192. doi: 10.1074/jbc.TM118.001192. [Epub ahead of print]


Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.


Enhancement of Ebola virus infection by seminal amyloid fibrils.

Bart SM, Cohen C, Dye JM, Shorter J, Bates P.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7410-7415. doi: 10.1073/pnas.1721646115. Epub 2018 Jun 25.


Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.

Tariq A, Lin J, Noll MM, Torrente MP, Mack KL, Murillo OH, Jackrel ME, Shorter J.

FEMS Yeast Res. 2018 Aug 1;18(5). doi: 10.1093/femsyr/foy042.


Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J.

Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002.


Second-trimester surgical abortion practices in the United States.

White KO, Jones HE, Shorter J, Norman WV, Guilbert E, Lichtenberg ES, Paul M.

Contraception. 2018 Apr 14. pii: S0010-7824(18)30140-9. doi: 10.1016/j.contraception.2018.04.004. [Epub ahead of print]


Amyloid assembly and disassembly.

Chuang E, Hori AM, Hesketh CD, Shorter J.

J Cell Sci. 2018 Apr 13;131(8). pii: jcs189928. doi: 10.1242/jcs.189928. Review.


Protein Phase Separation: A New Phase in Cell Biology.

Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M.

Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27. Review.


Ubiquilin 2: Shuttling Clients Out of Phase?

Subudhi I, Shorter J.

Mol Cell. 2018 Mar 15;69(6):919-921. doi: 10.1016/j.molcel.2018.02.030.


FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J.

Mol Cell. 2018 Mar 1;69(5):787-801.e8. doi: 10.1016/j.molcel.2018.02.001.


Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Shorter JR, Huang W, Beak JY, Hua K, Gatti DM, de Villena FP, Pomp D, Jensen BC.

Mamm Genome. 2018 Feb;29(1-2):80-89. doi: 10.1007/s00335-017-9730-7. Epub 2017 Dec 26. Erratum in: Mamm Genome. 2018 Dec 4;:.


Liquidizing FUS via prion-like domain phosphorylation.

Shorter J.

EMBO J. 2017 Oct 16;36(20):2925-2927. doi: 10.15252/embj.201798078. Epub 2017 Sep 28. No abstract available.


Prion-like Domains Program Ewing's Sarcoma.

Shorter J.

Cell. 2017 Sep 21;171(1):30-31. doi: 10.1016/j.cell.2017.09.010.


Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR.

Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15.


Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.

Shorter JR, Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L, O'Brien DA, Villena FP.

Genetics. 2017 Jun;206(2):557-572. doi: 10.1534/genetics.116.199596.


Genomes of the Mouse Collaborative Cross.

Srivastava A, Morgan AP, Najarian ML, Sarsani VK, Sigmon JS, Shorter JR, Kashfeen A, McMullan RC, Williams LH, Giusti-Rodríguez P, Ferris MT, Sullivan P, Hock P, Miller DR, Bell TA, McMillan L, Churchill GA, de Villena FP.

Genetics. 2017 Jun;206(2):537-556. doi: 10.1534/genetics.116.198838.


Neurodegenerative disease: models, mechanisms, and a new hope.

Gitler AD, Dhillon P, Shorter J.

Dis Model Mech. 2017 May 1;10(5):499-502. doi: 10.1242/dmm.030205.


RNA-binding proteins with prion-like domains in health and disease.

Harrison AF, Shorter J.

Biochem J. 2017 Apr 7;474(8):1417-1438. doi: 10.1042/BCJ20160499. Review.


Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL.

Biochemistry. 2017 Apr 18;56(15):2071-2075. doi: 10.1021/acs.biochem.7b00225. Epub 2017 Apr 10.


FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.

Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S.

J Cell Biol. 2017 Apr 3;216(4):1015-1034. doi: 10.1083/jcb.201608022. Epub 2017 Mar 15.


Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

Jackrel ME, Shorter J.

Front Neurosci. 2017 Feb 28;11:99. doi: 10.3389/fnins.2017.00099. eCollection 2017. Review.


Designer protein disaggregases to counter neurodegenerative disease.

Shorter J.

Curr Opin Genet Dev. 2017 Jun;44:1-8. doi: 10.1016/j.gde.2017.01.008. Epub 2017 Feb 14. Review.


Quality Improvement: Changing Patterns of Antibiotic Prophylaxis for Surgical Abortion.

Muramoto OT, Calfee AL, Shorter JM, Creinin MD, Hou MY.

J Healthc Qual. 2017 Sep/Oct;39(5):e79-e83. doi: 10.1097/JHQ.0000000000000074.


Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Guo L, Shorter J.

Cold Spring Harb Perspect Med. 2017 Sep 1;7(9). pii: a024554. doi: 10.1101/cshperspect.a024554. Review.


Susan Lee Lindquist (1949-2016).

Shorter J, Gitler AD.

Nature. 2016 Nov 30;540(7631):40. doi: 10.1038/540040a. No abstract available.


Obp56h Modulates Mating Behavior in Drosophila melanogaster.

Shorter JR, Dembeck LM, Everett LJ, Morozova TV, Arya GH, Turlapati L, St Armour GE, Schal C, Mackay TF, Anholt RR.

G3 (Bethesda). 2016 Oct 13;6(10):3335-3342. doi: 10.1534/g3.116.034595.


Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.

Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR.

Nat Struct Mol Biol. 2016 Sep;23(9):830-7. doi: 10.1038/nsmb.3277. Epub 2016 Aug 1.


Engineering therapeutic protein disaggregases.

Shorter J.

Mol Biol Cell. 2016 May 15;27(10):1556-60. doi: 10.1091/mbc.E15-10-0693. Review.


Membraneless organelles: Phasing in and out.

Shorter J.

Nat Chem. 2016 May 24;8(6):528-30. doi: 10.1038/nchem.2534. No abstract available.


Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity.

Mack KL, Shorter J.

Front Mol Biosci. 2016 Mar 15;3:8. doi: 10.3389/fmolb.2016.00008. eCollection 2016. Review.


Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.

March ZM, King OD, Shorter J.

Brain Res. 2016 Sep 15;1647:9-18. doi: 10.1016/j.brainres.2016.02.037. Epub 2016 Mar 18. Review.


Mechanistic Insights into Hsp104 Potentiation.

Torrente MP, Chuang E, Noll MM, Jackrel ME, Go MS, Shorter J.

J Biol Chem. 2016 Mar 4;291(10):5101-15. doi: 10.1074/jbc.M115.707976. Epub 2016 Jan 8.


Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.

Sweeny EA, Shorter J.

J Mol Biol. 2016 May 8;428(9 Pt B):1870-85. doi: 10.1016/j.jmb.2015.11.016. Epub 2015 Dec 1. Review.


It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles.

Guo L, Shorter J.

Mol Cell. 2015 Oct 15;60(2):189-92. doi: 10.1016/j.molcel.2015.10.006.


Chaperones in Neurodegeneration.

Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ.

J Neurosci. 2015 Oct 14;35(41):13853-9. doi: 10.1523/JNEUROSCI.2600-15.2015. Review.


Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.

Ford AF, Shorter J.

Cell. 2015 Oct 8;163(2):275-6. doi: 10.1016/j.cell.2015.09.049.


Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

Jackrel ME, Yee K, Tariq A, Chen AI, Shorter J.

ACS Chem Biol. 2015 Dec 18;10(12):2672-9. doi: 10.1021/acschembio.5b00765. Epub 2015 Oct 15.


Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils.

Castellano LM, Hammond RM, Holmes VM, Weissman D, Shorter J.

Biol Open. 2015 Aug 28;4(9):1206-12. doi: 10.1242/bio.010215.


A molecular tweezer antagonizes seminal amyloids and HIV infection.

Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J.

Elife. 2015 Aug 18;4. pii: e05397. doi: 10.7554/eLife.05397.

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