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Items: 1 to 50 of 173

1.

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.

Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S.

Neuron. 2019 Sep 19. pii: S0896-6273(19)30776-7. doi: 10.1016/j.neuron.2019.09.003. [Epub ahead of print]

PMID:
31587919
2.

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.

Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J.

Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069.

3.

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.

Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME.

J Biol Chem. 2019 Jul 19;294(29):11286-11296. doi: 10.1074/jbc.RA119.009494. Epub 2019 Jun 5.

PMID:
31171724
4.

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR.

Nat Commun. 2019 Jun 3;10(1):2393. doi: 10.1038/s41467-019-10150-y.

5.

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases.

Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL.

Biophys J. 2019 May 21;116(10):1856-1872. doi: 10.1016/j.bpj.2019.03.035. Epub 2019 Apr 5.

PMID:
31027887
6.

AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.

March ZM, Mack KL, Shorter J.

Biophys J. 2019 Apr 23;116(8):1380-1385. doi: 10.1016/j.bpj.2019.03.007. Epub 2019 Mar 22. Review.

PMID:
30952364
7.

Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series.

Shorter J.

J Biol Chem. 2019 May 3;294(18):7113-7114. doi: 10.1074/jbc.REV119.007944. Epub 2019 Apr 4. Review.

8.

Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution.

Ye X, Lin J, Mayne L, Shorter J, Englander SW.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7333-7342. doi: 10.1073/pnas.1816184116. Epub 2019 Mar 27.

9.

A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size.

Shorter JR, Maurizio PL, Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L, Valdar W, Pardo-Manuel de Villena F.

G3 (Bethesda). 2019 May 7;9(5):1613-1622. doi: 10.1534/g3.118.200847.

10.

Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.

Shorter JR, Najarian ML, Bell TA, Blanchard M, Ferris MT, Hock P, Kashfeen A, Kirchoff KE, Linnertz CL, Sigmon JS, Miller DR, McMillan L, Pardo-Manuel de Villena F.

G3 (Bethesda). 2019 May 7;9(5):1303-1311. doi: 10.1534/g3.119.400039.

11.

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW.

Neuron. 2019 Apr 17;102(2):339-357.e7. doi: 10.1016/j.neuron.2019.02.038. Epub 2019 Mar 7.

PMID:
30853299
12.

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ.

Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27.

PMID:
30826182
13.

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.

14.

Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase.

Shorter J, Southworth DR.

Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8). pii: a034033. doi: 10.1101/cshperspect.a034033. Review.

15.

Management of early pregnancy loss, with a focus on patient centered care.

Shorter JM, Atrio JM, Schreiber CA.

Semin Perinatol. 2019 Mar;43(2):84-94. doi: 10.1053/j.semperi.2018.12.005. Epub 2018 Dec 20. Review.

PMID:
30739750
16.

Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors.

Guo L, Fare CM, Shorter J.

Trends Cell Biol. 2019 Apr;29(4):308-322. doi: 10.1016/j.tcb.2018.12.004. Epub 2019 Jan 16. Review.

PMID:
30660504
17.

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.

Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A.

Structure. 2019 Mar 5;27(3):449-463.e7. doi: 10.1016/j.str.2018.11.001. Epub 2018 Dec 27.

PMID:
30595457
18.

TDP-43 shapeshifts to encipher FTD severity.

Barbieri EM, Shorter J.

Nat Neurosci. 2019 Jan;22(1):3-5. doi: 10.1038/s41593-018-0299-6. No abstract available.

PMID:
30559481
19.

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation.

McGurk L, Gomes E, Guo L, Shorter J, Bonini NM.

Biochemistry. 2018 Dec 26;57(51):6923-6926. doi: 10.1021/acs.biochem.8b00910. Epub 2018 Dec 17.

PMID:
30540446
20.

Correction to: Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Shorter JR, Huang W, Beak JY, Hua K, Gatti DM, de Villena FP, Pomp D, Jensen BC.

Mamm Genome. 2019 Feb;30(1-2):42. doi: 10.1007/s00335-018-9789-9.

PMID:
30515527
21.

3' UTRs in the Eye of the TIGER.

Portz B, Shorter J.

Dev Cell. 2018 Dec 3;47(5):544-546. doi: 10.1016/j.devcel.2018.11.022.

PMID:
30513300
22.

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R.

Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31.

23.

Early detection of lung cancer in a population at high risk due to occupation and smoking.

Welch LS, Dement JM, Cranford K, Shorter J, Quinn PS, Madtes DK, Ringen K.

Occup Environ Med. 2019 Mar;76(3):137-142. doi: 10.1136/oemed-2018-105431. Epub 2018 Nov 10.

PMID:
30415231
24.

Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation.

Shorter J, Houry WA.

Front Mol Biosci. 2018 Oct 2;5:85. doi: 10.3389/fmolb.2018.00085. eCollection 2018. No abstract available.

25.

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.

McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM.

Acta Neuropathol Commun. 2018 Aug 29;6(1):84. doi: 10.1186/s40478-018-0586-1.

26.

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.

McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM.

Mol Cell. 2018 Sep 6;71(5):703-717.e9. doi: 10.1016/j.molcel.2018.07.002. Epub 2018 Aug 9.

27.

The molecular language of membraneless organelles.

Gomes E, Shorter J.

J Biol Chem. 2019 May 3;294(18):7115-7127. doi: 10.1074/jbc.TM118.001192. Epub 2018 Jul 25. Review.

28.

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.

29.

Enhancement of Ebola virus infection by seminal amyloid fibrils.

Bart SM, Cohen C, Dye JM, Shorter J, Bates P.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7410-7415. doi: 10.1073/pnas.1721646115. Epub 2018 Jun 25.

30.

Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.

Tariq A, Lin J, Noll MM, Torrente MP, Mack KL, Murillo OH, Jackrel ME, Shorter J.

FEMS Yeast Res. 2018 Aug 1;18(5). doi: 10.1093/femsyr/foy042.

31.

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J.

Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002.

32.

Second-trimester surgical abortion practices in the United States.

White KO, Jones HE, Shorter J, Norman WV, Guilbert E, Lichtenberg ES, Paul M.

Contraception. 2018 Apr 14. pii: S0010-7824(18)30140-9. doi: 10.1016/j.contraception.2018.04.004. [Epub ahead of print]

PMID:
29665357
33.

Amyloid assembly and disassembly.

Chuang E, Hori AM, Hesketh CD, Shorter J.

J Cell Sci. 2018 Apr 13;131(8). pii: jcs189928. doi: 10.1242/jcs.189928. Review.

34.

Protein Phase Separation: A New Phase in Cell Biology.

Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M.

Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27. Review.

35.

Ubiquilin 2: Shuttling Clients Out of Phase?

Subudhi I, Shorter J.

Mol Cell. 2018 Mar 15;69(6):919-921. doi: 10.1016/j.molcel.2018.02.030.

36.

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J.

Mol Cell. 2018 Mar 1;69(5):787-801.e8. doi: 10.1016/j.molcel.2018.02.001.

37.

Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Shorter JR, Huang W, Beak JY, Hua K, Gatti DM, de Villena FP, Pomp D, Jensen BC.

Mamm Genome. 2018 Feb;29(1-2):80-89. doi: 10.1007/s00335-017-9730-7. Epub 2017 Dec 26. Erratum in: Mamm Genome. 2018 Dec 4;:.

38.

Liquidizing FUS via prion-like domain phosphorylation.

Shorter J.

EMBO J. 2017 Oct 16;36(20):2925-2927. doi: 10.15252/embj.201798078. Epub 2017 Sep 28. No abstract available.

39.

Prion-like Domains Program Ewing's Sarcoma.

Shorter J.

Cell. 2017 Sep 21;171(1):30-31. doi: 10.1016/j.cell.2017.09.010.

40.

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR.

Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15.

41.

Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.

Shorter JR, Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L, O'Brien DA, Villena FP.

Genetics. 2017 Jun;206(2):557-572. doi: 10.1534/genetics.116.199596.

42.

Genomes of the Mouse Collaborative Cross.

Srivastava A, Morgan AP, Najarian ML, Sarsani VK, Sigmon JS, Shorter JR, Kashfeen A, McMullan RC, Williams LH, Giusti-Rodríguez P, Ferris MT, Sullivan P, Hock P, Miller DR, Bell TA, McMillan L, Churchill GA, de Villena FP.

Genetics. 2017 Jun;206(2):537-556. doi: 10.1534/genetics.116.198838.

43.

Neurodegenerative disease: models, mechanisms, and a new hope.

Gitler AD, Dhillon P, Shorter J.

Dis Model Mech. 2017 May 1;10(5):499-502. doi: 10.1242/dmm.030205.

44.

RNA-binding proteins with prion-like domains in health and disease.

Harrison AF, Shorter J.

Biochem J. 2017 Apr 7;474(8):1417-1438. doi: 10.1042/BCJ20160499. Review.

45.

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL.

Biochemistry. 2017 Apr 18;56(15):2071-2075. doi: 10.1021/acs.biochem.7b00225. Epub 2017 Apr 10.

46.

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.

Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S.

J Cell Biol. 2017 Apr 3;216(4):1015-1034. doi: 10.1083/jcb.201608022. Epub 2017 Mar 15.

47.

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

Jackrel ME, Shorter J.

Front Neurosci. 2017 Feb 28;11:99. doi: 10.3389/fnins.2017.00099. eCollection 2017. Review.

48.

Designer protein disaggregases to counter neurodegenerative disease.

Shorter J.

Curr Opin Genet Dev. 2017 Jun;44:1-8. doi: 10.1016/j.gde.2017.01.008. Epub 2017 Feb 14. Review.

49.

Quality Improvement: Changing Patterns of Antibiotic Prophylaxis for Surgical Abortion.

Muramoto OT, Calfee AL, Shorter JM, Creinin MD, Hou MY.

J Healthc Qual. 2017 Sep/Oct;39(5):e79-e83. doi: 10.1097/JHQ.0000000000000074.

50.

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Guo L, Shorter J.

Cold Spring Harb Perspect Med. 2017 Sep 1;7(9). pii: a024554. doi: 10.1101/cshperspect.a024554. Review.

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