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Items: 33

1.

Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe.

Prendergast AJ, Berejena C, Pimundu G, Shonhai A, Bwakura-Dangarembizi M, Musiime V, Szubert AJ, Cook AD, Spyer MJ, Nahirya-Ntege P, Kekitiinwa A, Gibb DM, Klein N, Walker AS.

AIDS. 2019 Apr 16. doi: 10.1097/QAD.0000000000002231. [Epub ahead of print]

PMID:
31008797
2.

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation.

Bourke CD, Gough EK, Pimundu G, Shonhai A, Berejena C, Terry L, Baumard L, Choudhry N, Karmali Y, Bwakura-Dangarembizi M, Musiime V, Lutaakome J, Kekitiinwa A, Mutasa K, Szubert AJ, Spyer MJ, Deayton JR, Glass M, Geum HM, Pardieu C, Gibb DM, Klein N, Edens TJ, Walker AS, Manges AR, Prendergast AJ.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav0537. doi: 10.1126/scitranslmed.aav0537.

PMID:
30944164
3.

Proteomic analysis of Plasmodium falciparum histone deacetylase 1 complex proteins.

Engel JA, Norris EL, Gilson P, Przyborski J, Shonhai A, Blatch GL, Skinner-Adams TS, Gorman J, Headlam M, Andrews KT.

Exp Parasitol. 2019 Mar;198:7-16. doi: 10.1016/j.exppara.2019.01.008. Epub 2019 Jan 22.

PMID:
30682336
4.

Heat Shock Proteins as Immunomodulants.

Zininga T, Ramatsui L, Shonhai A.

Molecules. 2018 Nov 1;23(11). pii: E2846. doi: 10.3390/molecules23112846. Review.

5.

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif.

Mabate B, Zininga T, Ramatsui L, Makumire S, Achilonu I, Dirr HW, Shonhai A.

Proteins. 2018 Nov;86(11):1189-1201. doi: 10.1002/prot.25600. Epub 2018 Sep 29.

6.

(-)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners.

Zininga T, Ramatsui L, Makhado PB, Makumire S, Achilinou I, Hoppe H, Dirr H, Shonhai A.

Molecules. 2017 Dec 5;22(12). pii: E2139. doi: 10.3390/molecules22122139.

7.

Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function.

Zininga T, Anokwuru CP, Sigidi MT, Tshisikhawe MP, Ramaite IID, Traoré AN, Hoppe H, Shonhai A, Potgieter N.

Molecules. 2017 Jul 28;22(8). pii: E1224. doi: 10.3390/molecules22081224.

8.

Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70.

Zininga T, Pooe OJ, Makhado PB, Ramatsui L, Prinsloo E, Achilonu I, Dirr H, Shonhai A.

Cell Stress Chaperones. 2017 Sep;22(5):707-715. doi: 10.1007/s12192-017-0797-6. Epub 2017 Apr 28.

9.

Plasmodium falciparum Heat Shock Protein 70 Lacks Immune Modulatory Activity.

Pooe OJ, Köllisch G, Heine H, Shonhai A.

Protein Pept Lett. 2017;24(6):503-510. doi: 10.2174/0929866524666170214141909.

PMID:
28201964
10.

Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy.

Prendergast AJ, Szubert AJ, Berejena C, Pimundu G, Pala P, Shonhai A, Musiime V, Bwakura-Dangarembizi M, Poulsom H, Hunter P, Musoke P, Kihembo M, Munderi P, Gibb DM, Spyer M, Walker AS, Klein N; ARROW Trial Team.

J Infect Dis. 2016 Jul 15;214(2):226-36. doi: 10.1093/infdis/jiw148. Epub 2016 May 18.

11.

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli.

Makhoba XH, Burger A, Coertzen D, Zininga T, Birkholtz LM, Shonhai A.

PLoS One. 2016 Mar 31;11(3):e0152626. doi: 10.1371/journal.pone.0152626. eCollection 2016.

12.

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion.

Zininga T, Achilonu I, Hoppe H, Prinsloo E, Dirr HW, Shonhai A.

Cell Stress Chaperones. 2016 May;21(3):499-513. doi: 10.1007/s12192-016-0678-4. Epub 2016 Feb 19.

13.

Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.

Zininga T, Makumire S, Gitau GW, Njunge JM, Pooe OJ, Klimek H, Scheurr R, Raifer H, Prinsloo E, Przyborski JM, Hoppe H, Shonhai A.

PLoS One. 2015 Aug 12;10(8):e0135326. doi: 10.1371/journal.pone.0135326. eCollection 2015.

14.

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.

Zininga T, Achilonu I, Hoppe H, Prinsloo E, Dirr HW, Shonhai A.

PLoS One. 2015 Jun 17;10(6):e0129445. doi: 10.1371/journal.pone.0129445. eCollection 2015.

15.

Trends of rubella incidence during a 5-year period of case based surveillance in Zimbabwe.

Chimhuya S, Manangazira P, Mukaratirwa A, Nziramasanga P, Berejena C, Shonhai A, Kamupota M, Gerede R, Munyoro M, Mangwanya D, Tapfumaneyi C, Byabamazima C, Shibeshi EM, Nathoo KJ.

BMC Public Health. 2015 Mar 27;15:294. doi: 10.1186/s12889-015-1642-4.

16.

Investigation of a measles outbreak in Zimbabwe, 2010: potential of a point of care test to replace laboratory confirmation of suspected cases.

Shonhai A, Warrener L, Mangwanya D, Slibinskas R, Brown K, Brown D, Featherstone D, Samuel D.

Epidemiol Infect. 2015 Dec;143(16):3442-50. doi: 10.1017/S0950268815000540. Epub 2015 Apr 13.

PMID:
25865645
17.

DnaK protein alleviates toxicity induced by citrate-coated gold nanoparticles in Escherichia coli.

Makumire S, Revaprasadu N, Shonhai A.

PLoS One. 2015 Apr 2;10(4):e0121243. doi: 10.1371/journal.pone.0121243. eCollection 2015.

18.

Whole-genome analyses of DS-1-like human G2P[4] and G8P[4] rotavirus strains from Eastern, Western and Southern Africa.

Nyaga MM, Stucker KM, Esona MD, Jere KC, Mwinyi B, Shonhai A, Tsolenyanu E, Mulindwa A, Chibumbya JN, Adolfine H, Halpin RA, Roy S, Stockwell TB, Berejena C, Seheri ML, Mwenda JM, Steele AD, Wentworth DE, Mphahlele MJ.

Virus Genes. 2014 Oct;49(2):196-207. doi: 10.1007/s11262-014-1091-7. Epub 2014 Jun 22.

19.

Immunomodulatory activity of zinc peroxide (ZnO₂) and titanium dioxide (TiO₂) nanoparticles and their effects on DNA and protein integrity.

Makumire S, Chakravadhanula VS, Köllisch G, Redel E, Shonhai A.

Toxicol Lett. 2014 May 16;227(1):56-64. doi: 10.1016/j.toxlet.2014.02.027. Epub 2014 Mar 12.

PMID:
24631018
20.

Epidemiologic and genotypic characteristics of rotavirus strains detected in children less than 5 years of age with gastroenteritis treated at 3 pediatric hospitals in Zimbabwe during 2008-2011.

Mukaratirwa A, Berejena C, Nziramasanga P, Shonhai A, Mamvura TS, Chibukira P, Mucheuki I, Mangwanya D, Kamupota M, Manangazira P, Tapfumaneyi C, Gerede R, Munyoro M, Mwenda JM, Mphahlele JM, Seheri ML, Peenze I, Gonah AN, Maruta A, Tengende MB.

Pediatr Infect Dis J. 2014 Jan;33 Suppl 1:S45-8. doi: 10.1097/INF.0000000000000050.

PMID:
24343613
21.

Anti-plasmodial activity of some Zulu medicinal plants and of some triterpenes isolated from them.

Simelane MB, Shonhai A, Shode FO, Smith P, Singh M, Opoku AR.

Molecules. 2013 Oct 8;18(10):12313-23. doi: 10.3390/molecules181012313.

22.

Cysteine-capped gold nanoparticles suppress aggregation of proteins exposed to heat stress.

Luthuli SD, Chili MM, Revaprasadu N, Shonhai A.

IUBMB Life. 2013 May;65(5):454-61. doi: 10.1002/iub.1146. Epub 2013 Feb 22.

23.

An in vitro assessment of the interaction of cadmium selenide quantum dots with DNA, iron, and blood platelets.

Dunpall R, Nejo AA, Pullabhotla VS, Opoku AR, Revaprasadu N, Shonhai A.

IUBMB Life. 2012 Dec;64(12):995-1002. doi: 10.1002/iub.1100.

24.

Characterisation of the Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop).

Gitau GW, Mandal P, Blatch GL, Przyborski J, Shonhai A.

Cell Stress Chaperones. 2012 Mar;17(2):191-202. doi: 10.1007/s12192-011-0299-x. Epub 2011 Oct 18.

25.

Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI.

Stephens LL, Shonhai A, Blatch GL.

Protein Expr Purif. 2011 Jun;77(2):159-65. doi: 10.1016/j.pep.2011.01.005. Epub 2011 Jan 22.

PMID:
21262365
26.

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.

Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL.

Cell Stress Chaperones. 2011 Jul;16(4):389-401. doi: 10.1007/s12192-010-0250-6. Epub 2010 Dec 30.

27.

Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis.

Shonhai A, Maier AG, Przyborski JM, Blatch GL.

Protein Pept Lett. 2011 Feb;18(2):143-57. Review.

PMID:
20955165
28.

Plasmodial heat shock proteins: targets for chemotherapy.

Shonhai A.

FEMS Immunol Med Microbiol. 2010 Feb;58(1):61-74. doi: 10.1111/j.1574-695X.2009.00639.x. Epub 2009 Nov 30. Review.

29.

Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses.

Shonhai A, Botha M, de Beer TA, Boshoff A, Blatch GL.

Protein Pept Lett. 2008;15(10):1117-25.

PMID:
19075824
30.

Heterologous expression of plasmodial proteins for structural studies and functional annotation.

Birkholtz LM, Blatch G, Coetzer TL, Hoppe HC, Human E, Morris EJ, Ngcete Z, Oldfield L, Roth R, Shonhai A, Stephens L, Louw AI.

Malar J. 2008 Oct 1;7:197. doi: 10.1186/1475-2875-7-197. Review.

31.

The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns.

Pesce ER, Acharya P, Tatu U, Nicoll WS, Shonhai A, Hoppe HC, Blatch GL.

Int J Biochem Cell Biol. 2008;40(12):2914-26. doi: 10.1016/j.biocel.2008.06.011. Epub 2008 Jul 12.

PMID:
18674634
32.

The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum.

Shonhai A, Boshoff A, Blatch GL.

Protein Sci. 2007 Sep;16(9):1803-18. Review.

33.

Plasmodium falciparum heat shock protein 70 is able to suppress the thermosensitivity of an Escherichia coli DnaK mutant strain.

Shonhai A, Boshoff A, Blatch GL.

Mol Genet Genomics. 2005 Aug;274(1):70-8. Epub 2005 Jun 23.

PMID:
15973516

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