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Items: 1 to 50 of 77

1.

Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts.

Dale AP, Pandey AK, Hesp RJ, Belogiannis K, Laver JR, Shone CC, Read RC.

J Infect. 2018 Dec;77(6):534-543. doi: 10.1016/j.jinf.2018.10.011. Epub 2018 Nov 2.

2.

The structure of the S-layer of Clostridium difficile.

Bradshaw WJ, Roberts AK, Shone CC, Acharya KR.

J Cell Commun Signal. 2018 Mar;12(1):319-331. doi: 10.1007/s12079-017-0429-z. Epub 2017 Nov 23. Review.

3.

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.

Bradshaw WJ, Kirby JM, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2017 Dec;284(24):4343-4357. doi: 10.1111/febs.14310. Epub 2017 Nov 17.

4.

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin.

Davies AH, McGlashan J, Posner MG, Roberts AK, Shone CC, Acharya KR.

Biochem Biophys Rep. 2016 Aug 11;8:55-61. doi: 10.1016/j.bbrep.2016.08.011. eCollection 2016 Dec.

5.

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Monaghan TM, Negm OH, MacKenzie B, Hamed MR, Shone CC, Humphreys DP, Acharya KR, Wilcox MH.

Clin Exp Gastroenterol. 2017 Jul 19;10:169-175. doi: 10.2147/CEG.S133939. eCollection 2017.

6.

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.

Bradshaw WJ, Kirby JM, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2017 Sep;284(17):2886-2898. doi: 10.1111/febs.14157. Epub 2017 Jul 23.

7.

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.

Negm OH, MacKenzie B, Hamed MR, Ahmad OAJ, Shone CC, Humphreys DP, Ravi Acharya K, Loscher CE, Marszalowska I, Lynch M, Wilcox MH, Monaghan TM.

Clin Exp Immunol. 2017 Jun;188(3):437-443. doi: 10.1111/cei.12946. Epub 2017 Mar 16.

8.

Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2016 Sep 1;115:152. doi: 10.1016/j.bcp.2016.07.006. Epub 2016 Jul 12. No abstract available.

PMID:
27498956
9.

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M.

Sci Rep. 2015 Dec 16;5:17513. doi: 10.1038/srep17513.

10.

Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2015 Dec 1;98(3):522-30. doi: 10.1016/j.bcp.2015.09.023. Epub 2015 Oct 9.

PMID:
26449594
11.

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Negm OH, Hamed MR, Dilnot EM, Shone CC, Marszalowska I, Lynch M, Loscher CE, Edwards LJ, Tighe PJ, Wilcox MH, Monaghan TM.

Clin Vaccine Immunol. 2015 Sep;22(9):1033-9. doi: 10.1128/CVI.00190-15. Epub 2015 Jul 15.

12.

The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles.

Pirazzini M, Azarnia Tehran D, Zanetti G, Lista F, Binz T, Shone CC, Rossetto O, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):32-6. doi: 10.1016/j.toxicon.2015.06.019. Epub 2015 Jun 27.

PMID:
26130523
13.

Molecular features of the sortase enzyme family.

Bradshaw WJ, Davies AH, Chambers CJ, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2015 Jun;282(11):2097-114. doi: 10.1111/febs.13288. Epub 2015 Apr 24. Review.

14.

Structure and function of a Clostridium difficile sortase enzyme.

Chambers CJ, Roberts AK, Shone CC, Acharya KR.

Sci Rep. 2015 Mar 24;5:9449. doi: 10.1038/srep09449.

15.

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide.

Bradshaw WJ, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):295-303. doi: 10.1107/S2053230X15001065. Epub 2015 Feb 19.

16.

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C.

Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15.

17.

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile.

Bradshaw WJ, Kirby JM, Thiyagarajan N, Chambers CJ, Davies AH, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1983-93. doi: 10.1107/S1399004714009997. Epub 2014 Jun 29.

18.

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.

Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):38-42. doi: 10.1016/j.bbrc.2012.11.048. Epub 2012 Nov 27.

PMID:
23200837
19.

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C.

FEBS Lett. 2013 Jan 16;587(2):150-5. doi: 10.1016/j.febslet.2012.11.007. Epub 2012 Nov 21.

20.

Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19.

Kirby JM, Thiyagarajan N, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):762-7. doi: 10.1107/S1744309111016770. Epub 2011 Jun 30.

21.

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

Pirazzini M, Rossetto O, Bolognese P, Shone CC, Montecucco C.

Cell Microbiol. 2011 Nov;13(11):1731-43. doi: 10.1111/j.1462-5822.2011.01654.x. Epub 2011 Aug 25.

PMID:
21790947
22.

Super toxins from a super bug: structure and function of Clostridium difficile toxins.

Davies AH, Roberts AK, Shone CC, Acharya KR.

Biochem J. 2011 Jun 15;436(3):517-26. doi: 10.1042/BJ20110106. Review.

PMID:
21615333
23.

Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile.

Sundriyal A, Roberts AK, Ling R, McGlashan J, Shone CC, Acharya KR.

Protein Expr Purif. 2010 Nov;74(1):42-8. doi: 10.1016/j.pep.2010.04.014. Epub 2010 Apr 28.

PMID:
20433927
24.

Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile.

Kirby JM, Ahern H, Roberts AK, Kumar V, Freeman Z, Acharya KR, Shone CC.

J Biol Chem. 2009 Dec 11;284(50):34666-73. doi: 10.1074/jbc.M109.051177. Epub 2009 Oct 6.

25.

Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from Clostridium difficile.

Sundriyal A, Roberts AK, Shone CC, Acharya KR.

J Biol Chem. 2009 Oct 16;284(42):28713-9. doi: 10.1074/jbc.M109.043018. Epub 2009 Aug 19.

26.

An assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin.

Evans ER, Skipper PJ, Shone CC.

J Appl Microbiol. 2009 Oct;107(4):1384-91. doi: 10.1111/j.1365-2672.2009.04325.x. Epub 2009 Apr 22.

27.

A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins.

Holbourn KP, Shone CC, Acharya KR.

FEBS J. 2006 Oct;273(20):4579-93. Epub 2006 Sep 5. Review.

28.

Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics.

Foster KA, Adams EJ, Durose L, Cruttwell CJ, Marks E, Shone CC, Chaddock JA, Cox CL, Heaton C, Sutton JM, Wayne J, Alexander FC, Rogers DF.

Neurotox Res. 2006 Apr;9(2-3):101-7.

PMID:
16785105
29.

Analysis of the substrate recognition domain determinants of botulinum type B toxin using phage display.

Evans ER, Sutton JM, Gravett A, Shone CC.

Toxicon. 2005 Sep 15;46(4):446-53.

PMID:
16112699
30.

Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase.

Holbourn KP, Sutton JM, Evans HR, Shone CC, Acharya KR.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5357-62. Epub 2005 Apr 4.

31.

Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications.

Sutton JM, Wayne J, Scott-Tucker A, O'Brien SM, Marks PM, Alexander FC, Shone CC, Chaddock JA.

Protein Expr Purif. 2005 Mar;40(1):31-41.

PMID:
15721769
32.

C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure.

Evans HR, Holloway DE, Sutton JM, Ayriss J, Shone CC, Acharya KR.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1502-5. Epub 2004 Jul 21.

PMID:
15272191
33.

Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.

Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Duggan MJ, Quinn CP, Shone CC, Foster KA.

Mov Disord. 2004 Mar;19 Suppl 8:S42-7.

PMID:
15027053
34.

The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD.

Evans HR, Sutton JM, Holloway DE, Ayriss J, Shone CC, Acharya KR.

J Biol Chem. 2003 Nov 14;278(46):45924-30. Epub 2003 Aug 21.

35.

Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin.

Stancombe PR, Alexander FC, Ling R, Matheson MA, Shone CC, Chaddock JA.

Protein Expr Purif. 2003 Aug;30(2):283-92.

PMID:
12880778
36.

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.

Chaddock JA, Herbert MH, Ling RJ, Alexander FC, Fooks SJ, Revell DF, Quinn CP, Shone CC, Foster KA.

Protein Expr Purif. 2002 Jul;25(2):219-28.

PMID:
12135553
37.

Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.

Duggan MJ, Quinn CP, Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Shone CC, Foster KA.

J Biol Chem. 2002 Sep 20;277(38):34846-52. Epub 2002 Jul 8.

38.

Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones.

Sutton JM, Chow-Worn O, Spaven L, Silman NJ, Hallis B, Shone CC.

FEBS Lett. 2001 Mar 23;493(1):45-9.

39.
40.
41.

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A.

Chaddock JA, Purkiss JR, Friis LM, Broadbridge JD, Duggan MJ, Fooks SJ, Shone CC, Quinn CP, Foster KA.

Infect Immun. 2000 May;68(5):2587-93.

42.

Novel assays for the detection of botulinum toxins in foods.

Wictome M, Newton KA, Jameson K, Dunnigan P, Clarke S, Gaze J, Tauk A, Foster KA, Shone CC.

Dev Biol Stand. 1999;101:141-5.

PMID:
10566787
43.

Development of in vitro assays for the detection of botulinum toxins in foods.

Wictome M, Newton KA, Jameson K, Dunnigan P, Clarke S, Gaze J, Tauk A, Foster KA, Shone CC.

FEMS Immunol Med Microbiol. 1999 Jul;24(3):319-23.

44.

Botulinum neurotoxins: mode of action and detection.

Wictome M, Shone CC.

Symp Ser Soc Appl Microbiol. 1998;27:87S-97S. Review. No abstract available.

PMID:
9750365
45.

The interaction of synaptic vesicle-associated membrane protein/synaptobrevin with botulinum neurotoxins D and F.

Pellizzari R, Mason S, Shone CC, Montecucco C.

FEBS Lett. 1997 Jun 16;409(3):339-42.

46.
47.

Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins.

Pellizzari R, Rossetto O, Lozzi L, Giovedi' S, Johnson E, Shone CC, Montecucco C.

J Biol Chem. 1996 Aug 23;271(34):20353-8.

48.
50.

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