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Items: 1 to 50 of 123

1.

Use of VHH antibodies for the development of antigen detection test for visceral leishmaniasis.

Abeijon C, Dilo J, Tremblay JM, Viana AG, Bueno LL, Carvalho SFG, Fujiwara RT, Shoemaker CB, Campos-Neto A.

Parasite Immunol. 2018 Nov;40(11):e12584. doi: 10.1111/pim.12584. Epub 2018 Sep 11.

2.

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec.

3.

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin.

Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HF.

Nat Commun. 2017 Sep 4;8(1):423. doi: 10.1038/s41467-017-00448-0.

4.

Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion.

Barta ML, Shearer JP, Arizmendi O, Tremblay JM, Mehzabeen N, Zheng Q, Battaile KP, Lovell S, Tzipori S, Picking WD, Shoemaker CB, Picking WL.

J Biol Chem. 2017 Oct 6;292(40):16677-16687. doi: 10.1074/jbc.M117.802231. Epub 2017 Aug 25.

5.

mRNA mediates passive vaccination against infectious agents, toxins, and tumors.

Thran M, Mukherjee J, Pönisch M, Fiedler K, Thess A, Mui BL, Hope MJ, Tam YK, Horscroft N, Heidenreich R, Fotin-Mleczek M, Shoemaker CB, Schlake T.

EMBO Mol Med. 2017 Oct;9(10):1434-1447. doi: 10.15252/emmm.201707678.

6.

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R.

Sci Rep. 2017 Aug 7;7(1):7438. doi: 10.1038/s41598-017-07457-5.

7.

Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Jacobson AR, Adler M, Silvaggi NR, Allen KN, Smith GM, Fredenburg RA, Stein RL, Park JB, Feng X, Shoemaker CB, Deshpande SS, Goodnough MC, Malizio CJ, Johnson EA, Pellett S, Tepp WH, Tzipori S.

Toxicon. 2017 Oct;137:36-47. doi: 10.1016/j.toxicon.2017.06.016. Epub 2017 Jul 8.

8.

Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.

Vazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko K.

Sci Rep. 2017 Feb 21;7:42923. doi: 10.1038/srep42923.

9.

Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins.

Krautz-Peterson G, Debatis M, Tremblay JM, Oliveira SC, Da'dara AA, Skelly PJ, Shoemaker CB.

PLoS Negl Trop Dis. 2017 Jan 17;11(1):e0005306. doi: 10.1371/journal.pntd.0005306. eCollection 2017 Jan.

10.

Using Antigen-antibody Binding Kinetic Parameters to Understand Single-Molecule Array Immunoassay Performance.

Dinh TL, Ngan KC, Shoemaker CB, Walt DR.

Anal Chem. 2016 Dec 6;88(23):11335-11339. Epub 2016 Nov 8.

PMID:
27779850
11.

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection.

Vrentas CE, Moayeri M, Keefer AB, Greaney AJ, Tremblay J, O'Mard D, Leppla SH, Shoemaker CB.

J Biol Chem. 2016 Oct 7;291(41):21596-21606. Epub 2016 Aug 18.

12.

A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection.

Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S.

Clin Vaccine Immunol. 2016 Sep 6;23(9):774-84. doi: 10.1128/CVI.00730-15. Print 2016 Sep.

13.

Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Shoemaker CB, Mantis NJ.

Proteins. 2016 Aug;84(8):1162-72. doi: 10.1002/prot.25062. Epub 2016 Jun 15.

14.

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.

15.

Identification of Targeting Peptides for Mucosal Delivery in Sheep and Mice.

Kenngott EE, Cole S, Hein WR, Hoffmann U, Lauer U, Maass D, Moore L, Pfeil J, Rosanowski S, Shoemaker CB, Umair S, Volkmer R, Hamann A, Pernthaner A.

Mol Pharm. 2016 Jan 4;13(1):202-10. doi: 10.1021/acs.molpharmaceut.5b00635. Epub 2015 Dec 1.

PMID:
26568284
16.

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Herrera C, Tremblay JM, Shoemaker CB, Mantis NJ.

J Biol Chem. 2015 Nov 13;290(46):27880-9. doi: 10.1074/jbc.M115.658070. Epub 2015 Sep 22.

17.

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.

Moayeri M, Leysath CE, Tremblay JM, Vrentas C, Crown D, Leppla SH, Shoemaker CB.

J Biol Chem. 2015 Mar 6;290(10):6584-95. doi: 10.1074/jbc.M114.627943. Epub 2015 Jan 6.

18.

Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157:H7 against fatal systemic intoxication.

Sheoran AS, Dmitriev IP, Kashentseva EA, Cohen O, Mukherjee J, Debatis M, Shearer J, Tremblay JM, Beamer G, Curiel DT, Shoemaker CB, Tzipori S.

Infect Immun. 2015 Jan;83(1):286-91. doi: 10.1128/IAI.02360-14. Epub 2014 Nov 3.

19.

Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin.

Barrera DJ, Rosenberg JN, Chiu JG, Chang YN, Debatis M, Ngoi SM, Chang JT, Shoemaker CB, Oyler GA, Mayfield SP.

Plant Biotechnol J. 2015 Jan;13(1):117-24. doi: 10.1111/pbi.12244. Epub 2014 Sep 17.

20.

Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.

Mukherjee J, Dmitriev I, Debatis M, Tremblay JM, Beamer G, Kashentseva EA, Curiel DT, Shoemaker CB.

PLoS One. 2014 Aug 29;9(8):e106422. doi: 10.1371/journal.pone.0106422. eCollection 2014.

21.

Adenoviral targeting using genetically incorporated camelid single variable domains.

Kaliberov SA, Kaliberova LN, Buggio M, Tremblay JM, Shoemaker CB, Curiel DT.

Lab Invest. 2014 Aug;94(8):893-905. doi: 10.1038/labinvest.2014.82. Epub 2014 Jun 16.

22.

Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Herrera C, Vance DJ, Eisele LE, Shoemaker CB, Mantis NJ.

PLoS One. 2014 Jun 11;9(6):e99788. doi: 10.1371/journal.pone.0099788. eCollection 2014.

23.

Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies.

Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ.

J Mol Biol. 2014 Aug 26;426(17):3057-68. doi: 10.1016/j.jmb.2014.05.026. Epub 2014 Jun 4.

24.

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.

Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H.

J Infect Dis. 2014 Sep 15;210(6):964-72. doi: 10.1093/infdis/jiu196. Epub 2014 Mar 27.

25.

On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni.

Farias LP, Krautz-Peterson G, Tararam CA, Araujo-Montoya BO, Fraga TR, Rofatto HK, Silva FP Jr, Isaac L, Da'dara AA, Wilson RA, Shoemaker CB, Leite LC.

PLoS Negl Trop Dis. 2013 Oct 24;7(10):e2482. doi: 10.1371/journal.pntd.0002482. eCollection 2013.

26.

Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

Vance DJ, Tremblay JM, Mantis NJ, Shoemaker CB.

J Biol Chem. 2013 Dec 20;288(51):36538-47. doi: 10.1074/jbc.M113.519207. Epub 2013 Nov 7.

27.

A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Tremblay JM, Mukherjee J, Leysath CE, Debatis M, Ofori K, Baldwin K, Boucher C, Peters R, Beamer G, Sheoran A, Bedenice D, Tzipori S, Shoemaker CB.

Infect Immun. 2013 Dec;81(12):4592-603. doi: 10.1128/IAI.01033-13. Epub 2013 Sep 30.

28.

Generation of a phage-display library of single-domain camelid VH H antibodies directed against Chlamydomonas reinhardtii antigens, and characterization of VH Hs binding cell-surface antigens.

Jiang W, Rosenberg JN, Wauchope AD, Tremblay JM, Shoemaker CB, Weeks DP, Oyler GA.

Plant J. 2013 Nov;76(4):709-17. doi: 10.1111/tpj.12316. Epub 2013 Oct 17.

29.

The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.

Silhár P, Lardy MA, Hixon MS, Shoemaker CB, Barbieri JT, Struss AK, Lively JM, Javor S, Janda KD.

ACS Med Chem Lett. 2013 Feb 14;4(2):283-287. Epub 2012 Dec 23.

30.

Sheep monoclonal antibodies prevent systemic effects of botulinum neurotoxin A1.

Mukherjee J, McCann C, Ofori K, Hill J, Baldwin K, Shoemaker CB, Harrison P, Tzipori S.

Toxins (Basel). 2012 Dec;4(12):1565-81.

31.

Persistence of Botulinum neurotoxin inactivation of nerve function.

Shoemaker CB, Oyler GA.

Curr Top Microbiol Immunol. 2013;364:179-96. doi: 10.1007/978-3-642-33570-9_9.

32.

Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.

Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R.

Science. 2012 Feb 24;335(6071):977-81. doi: 10.1126/science.1214270.

33.

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.

Mukherjee J, Tremblay JM, Leysath CE, Ofori K, Baldwin K, Feng X, Bedenice D, Webb RP, Wright PM, Smith LA, Tzipori S, Shoemaker CB.

PLoS One. 2012;7(1):e29941. doi: 10.1371/journal.pone.0029941. Epub 2012 Jan 6.

34.

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism.

Krautz-Peterson G, Zhang Y, Chen K, Oyler GA, Feng H, Shoemaker CB.

J Toxicol. 2012;2012:760142. doi: 10.1155/2012/760142. Epub 2011 Sep 20.

35.

Accelerated neuronal cell recovery from Botulinum neurotoxin intoxication by targeted ubiquitination.

Kuo CL, Oyler GA, Shoemaker CB.

PLoS One. 2011;6(5):e20352. doi: 10.1371/journal.pone.0020352. Epub 2011 May 24.

36.

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Šilhár P, Alakurtti S, Čapková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2229-31. doi: 10.1016/j.bmcl.2011.02.115. Epub 2011 Mar 4.

37.

Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease.

Eubanks LM, Silhár P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD.

ACS Med Chem Lett. 2010;1(6):268-272.

38.

Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system.

Tsai YC, Maditz R, Kuo CL, Fishman PS, Shoemaker CB, Oyler GA, Weissman AM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16554-9. doi: 10.1073/pnas.1008302107. Epub 2010 Sep 7.

39.

Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases.

Tremblay JM, Kuo CL, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB.

Toxicon. 2010 Nov;56(6):990-8. doi: 10.1016/j.toxicon.2010.07.003. Epub 2010 Jul 14.

40.

Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats.

Sepulveda J, Tremblay JM, DeGnore JP, Skelly PJ, Shoemaker CB.

Int J Parasitol. 2010 Oct;40(12):1407-17. doi: 10.1016/j.ijpara.2010.04.019. Epub 2010 Jun 30.

41.

Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host.

Krautz-Peterson G, Simoes M, Faghiri Z, Ndegwa D, Oliveira G, Shoemaker CB, Skelly PJ.

PLoS Pathog. 2010 Jun 3;6(6):e1000932. doi: 10.1371/journal.ppat.1000932.

42.

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm.

Kvam E, Sierks MR, Shoemaker CB, Messer A.

Protein Eng Des Sel. 2010 Jun;23(6):489-98. doi: 10.1093/protein/gzq022. Epub 2010 Apr 8.

43.

Identification of an abundant allergen from the sheep louse, Bovicola ovis.

Pfeffer A, Shoemaker CB, Shaw RJ, Green RS, Shu D.

Int J Parasitol. 2010 Jul;40(8):911-9. doi: 10.1016/j.ijpara.2010.01.005. Epub 2010 Feb 1.

PMID:
20123101
44.

Efficient serum clearance of botulinum neurotoxin achieved using a pool of small antitoxin binding agents.

Sepulveda J, Mukherjee J, Tzipori S, Simpson LL, Shoemaker CB.

Infect Immun. 2010 Feb;78(2):756-63. doi: 10.1128/IAI.01084-09. Epub 2009 Nov 16.

45.

Lipid and cationic polymer based transduction of botulinum holotoxin, or toxin protease alone, extends the target cell range and improves the efficiency of intoxication.

Kuo CL, Oyler G, Shoemaker CB.

Toxicon. 2010 Feb-Mar;55(2-3):619-29. doi: 10.1016/j.toxicon.2009.10.019. Epub 2009 Oct 21.

46.

Intraspecific epitopic variation in a carbohydrate antigen exposed on the surface of Trichostrongylus colubriformis infective L3 larvae.

Maass DR, Harrison GB, Grant WN, Hein WR, Shoemaker CB.

PLoS Pathog. 2009 Sep;5(9):e1000597. doi: 10.1371/journal.ppat.1000597. Epub 2009 Sep 25.

47.

Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway.

Hu X, Kang S, Chen X, Shoemaker CB, Jin MM.

J Biol Chem. 2009 Jun 12;284(24):16369-76. doi: 10.1074/jbc.M109.001743. Epub 2009 Apr 15.

48.

Identification and characterization of a novel cell-penetrating peptide.

Sheng J, Oyler G, Zhou B, Janda K, Shoemaker CB.

Biochem Biophys Res Commun. 2009 May 1;382(2):236-40. doi: 10.1016/j.bbrc.2008.11.139. Epub 2008 Dec 11.

49.

Antibodies to surface epitopes of the carbohydrate larval antigen CarLA are associated with passive protection in strongylid nematode challenge infections.

Harrison GB, Pulford HD, Doolin EE, Pernthaner A, Shoemaker CB, Hein WR.

Parasite Immunol. 2008 Nov-Dec;30(11-12):577-84. doi: 10.1111/j.1365-3024.2008.01058.x.

50.

Mucosal antibody responses in experimental hookworm infection.

Bungiro RD Jr, Sun T, Harrison LM, Shoemaker CB, Cappello M.

Parasite Immunol. 2008 May;30(5):293-303. doi: 10.1111/j.1365-3024.2008.01023.x. Epub 2008 Feb 28.

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