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Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.

Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H.

Commun Biol. 2019 Feb 25;2:76. doi: 10.1038/s42003-019-0325-6. eCollection 2019.


NFκB Regulates Muscle Development and Mitochondrial Function.

Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N.

J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print]


Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.

Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N.

Aging Cell. 2017 Aug;16(4):847-858. doi: 10.1111/acel.12613. Epub 2017 May 29.


The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization.

Woo JR, Kim SJ, Kim KY, Jang H, Shoelson SE, Park S.

Int J Biol Macromol. 2017 Oct;103:965-971. doi: 10.1016/j.ijbiomac.2017.05.119. Epub 2017 May 22.


Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin-treated cardiovascular disease: A 30-month randomized placebo-controlled trial.

Salastekar N, Desai T, Hauser T, Schaefer EJ, Fowler K, Joseph S, Shoelson SE, Goldfine AB; TINSAL-CVD study team.

Diabetes Obes Metab. 2017 Oct;19(10):1458-1462. doi: 10.1111/dom.12940. Epub 2017 Jul 6.


Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk.

Goldfine AB, Shoelson SE.

J Clin Invest. 2017 Jan 3;127(1):83-93. doi: 10.1172/JCI88884. Epub 2017 Jan 3. Review.


Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function.

Oh J, Sinha I, Tan KY, Rosner B, Dreyfuss JM, Gjata O, Tran P, Shoelson SE, Wagers AJ.

Aging (Albany NY). 2016 Nov 14;8(11):2871-2896. doi: 10.18632/aging.101098.


Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins.

Hauser TH, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM, Weber GM, Welty F, Clouse M, Shoelson SE, Goldfine AB; Targeting Inflammation Using Salsalate in Cardiovascular Disease (TINSAL-CVD) Study Team.

JAMA Cardiol. 2016 Jul 1;1(4):413-23. doi: 10.1001/jamacardio.2016.0605.


Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity.

Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J.

Cell Metab. 2016 Apr 12;23(4):685-98. doi: 10.1016/j.cmet.2016.03.002. Epub 2016 Mar 31.


Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus.

Rubin MR, Goldfine AB, McMahon DJ, Donovan DS, Cremers S, Dworakowski E, Schaefer EJ, Shoelson SE, Silverberg SJ.

Endocrine. 2015 Nov;50(2):504-7. doi: 10.1007/s12020-015-0535-8. Epub 2015 Feb 1. No abstract available.


Muscle-specific inhibition of the classical nuclear factor-κB pathway is protective against diaphragmatic weakness in murine endotoxemia.

Okazaki T, Liang F, Li T, Lemaire C, Danialou G, Shoelson SE, Petrof BJ.

Crit Care Med. 2014 Jul;42(7):e501-9. doi: 10.1097/CCM.0000000000000407.


Insulin receptor activation with transmembrane domain ligands.

Lee J, Miyazaki M, Romeo GR, Shoelson SE.

J Biol Chem. 2014 Jul 11;289(28):19769-77. doi: 10.1074/jbc.M114.578641. Epub 2014 May 27.


Response to comment on Goldfine et al. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes care 2013;36:4132-4139.

Goldfine AB, Jablonski KA, Shoelson SE, Creager MA; TINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team.

Diabetes Care. 2014 May;37(5):e112. doi: 10.2337/dc14-0222. No abstract available.


Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone.

Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J.

PLoS One. 2013 Dec 23;8(12):e82847. doi: 10.1371/journal.pone.0082847. eCollection 2013.


The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.

Barzilay JI, Jablonski KA, Fonseca V, Shoelson SE, Goldfine AB, Strauch C, Monnier VM; TINSAL-T2D Research Consortium.

Diabetes Care. 2014 Apr;37(4):1083-91. doi: 10.2337/dc13-1527. Epub 2013 Nov 19.


Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes.

King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC.

PLoS One. 2013 Oct 18;8(10):e77452. doi: 10.1371/journal.pone.0077452. eCollection 2013.


Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD).

Goldfine AB, Buck JS, Desouza C, Fonseca V, Chen YD, Shoelson SE, Jablonski KA, Creager MA; TINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team.

Diabetes Care. 2013 Dec;36(12):4132-9. doi: 10.2337/dc13-0859. Epub 2013 Oct 15.


Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis.

Romeo GR, Pae M, Eberlé D, Lee J, Shoelson SE.

Diabetes. 2013 Nov;62(11):3718-26. doi: 10.2337/db13-0050. Epub 2013 Jul 24.


Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.

Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE; Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team.

Ann Intern Med. 2013 Jul 2;159(1):1-12. doi: 10.7326/0003-4819-159-1-201307020-00003.


A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance.

Goldfine AB, Conlin PR, Halperin F, Koska J, Permana P, Schwenke D, Shoelson SE, Reaven PD.

Diabetologia. 2013 Apr;56(4):714-23. doi: 10.1007/s00125-012-2819-3. Epub 2013 Jan 31.


Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.

Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL.

Invest Ophthalmol Vis Sci. 2012 Dec 19;53(13):8424-32. doi: 10.1167/iovs.12-10207.


Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.

Romeo GR, Lee J, Shoelson SE.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1771-6. doi: 10.1161/ATVBAHA.111.241869. Review.


Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation.

Schakman O, Dehoux M, Bouchuari S, Delaere S, Lause P, Decroly N, Shoelson SE, Thissen JP.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E729-39. doi: 10.1152/ajpendo.00060.2012. Epub 2012 Jun 26.


PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.

Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D.

Nature. 2012 Jun 28;486(7404):549-53. doi: 10.1038/nature11132.


NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.

Langen RC, Haegens A, Vernooy JH, Wouters EF, de Winther MP, Carlsen H, Steele C, Shoelson SE, Schols AM.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):288-97. doi: 10.1165/rcmb.2011-0119OC. Epub 2012 Apr 26.


NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.

Haegens A, Schols AM, Gorissen SH, van Essen AL, Snepvangers F, Gray DA, Shoelson SE, Langen RC.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L103-10. doi: 10.1152/ajplung.00084.2011. Epub 2011 Oct 14.


Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.

van Diepen JA, Vroegrijk IO, Berbée JF, Shoelson SE, Romijn JA, Havekes LM, Rensen PC, Voshol PJ.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1099-107. doi: 10.1152/ajpendo.00185.2011. Epub 2011 Aug 23.


Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.

Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF.

Atherosclerosis. 2012 Feb;220(2):362-8. doi: 10.1016/j.atherosclerosis.2011.06.055. Epub 2011 Jul 12.


Immunometabolism: an emerging frontier.

Mathis D, Shoelson SE.

Nat Rev Immunol. 2011 Feb;11(2):81. doi: 10.1038/nri2922.


Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.

Park SY, Jin W, Woo JR, Shoelson SE.

J Biol Chem. 2011 May 20;286(20):18130-8. doi: 10.1074/jbc.M110.217323. Epub 2011 Mar 23.


Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice.

van Diepen JA, Wong MC, Guigas B, Bos J, Stienstra R, Hodson L, Shoelson SE, Berbée JF, Rensen PC, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2011 May;52(5):942-50. doi: 10.1194/jlr.M010405. Epub 2011 Feb 28.


Type 2 diabetes as an inflammatory disease.

Donath MY, Shoelson SE.

Nat Rev Immunol. 2011 Feb;11(2):98-107. doi: 10.1038/nri2925. Epub 2011 Jan 14. Review.


Therapeutic approaches to target inflammation in type 2 diabetes.

Goldfine AB, Fonseca V, Shoelson SE.

Clin Chem. 2011 Feb;57(2):162-7. doi: 10.1373/clinchem.2010.148833. Epub 2010 Nov 22. Review.


The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial.

Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE; TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team.

Ann Intern Med. 2010 Mar 16;152(6):346-57. doi: 10.7326/0003-4819-152-6-201003160-00004.


Inflammation and adipose tissue macrophages in lipodystrophic mice.

Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):240-5. doi: 10.1073/pnas.0905310107. Epub 2009 Dec 10.


Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation.

Rha GB, Wu G, Shoelson SE, Chi YI.

J Biol Chem. 2009 Dec 11;284(50):35165-76. doi: 10.1074/jbc.M109.052506. Epub 2009 Oct 21.


Expansion and contraction: treating diabetes with bariatric surgery.

Goldfine AB, Shoelson SE, Aguirre V.

Nat Med. 2009 Jun;15(6):616-7. doi: 10.1038/nm0609-616. No abstract available.


Getting away from glucose: fanning the flames of obesity-induced inflammation.

Shoelson SE, Goldfine AB.

Nat Med. 2009 Apr;15(4):373-4. doi: 10.1038/nm0409-373. No abstract available.


Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes.

Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE.

Clin Transl Sci. 2008 May;1(1):36-43. doi: 10.1111/j.1752-8062.2008.00026.x.


Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. doi: 10.1073/pnas.0808470105. Epub 2008 Oct 7.


When a domain is not a domain.

Park SY, Shoelson SE.

Nat Struct Mol Biol. 2008 Mar;15(3):224-6. doi: 10.1038/nsmb0308-224. No abstract available.


Salsalate improves glycemia and inflammatory parameters in obese young adults.

Fleischman A, Shoelson SE, Bernier R, Goldfine AB.

Diabetes Care. 2008 Feb;31(2):289-94. Epub 2007 Oct 24.


Inflammation and obesity: STAMPing out insulin resistance?

Abedini A, Shoelson SE.

Immunol Cell Biol. 2007 Aug-Sep;85(6):399-400. Epub 2007 Jul 24. No abstract available.


Obesity, inflammation, and insulin resistance.

Shoelson SE, Herrero L, Naaz A.

Gastroenterology. 2007 May;132(6):2169-80. Review.


Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.

Shoelson SE.

J Appl Physiol (1985). 2007 Feb;102(2):820; author reply 825. doi: 10.1152/japplphysiol.01353.2006. No abstract available.


Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.

Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A.

Diabetes. 2007 Feb;56(2):499-505.


Banking on ATM as a new target in metabolic syndrome.

Shoelson SE.

Cell Metab. 2006 Nov;4(5):337-8. Review.


Inflammation and insulin resistance.

Shoelson SE, Lee J, Goldfine AB.

J Clin Invest. 2006 Jul;116(7):1793-801. Review. Erratum in: J Clin Invest. 2006 Aug;116(8):2308.


Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle.

Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ.

Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.


Kinase activation through dimerization by human SH2-B.

Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE.

Mol Cell Biol. 2005 Apr;25(7):2607-21.

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