Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 60


Response to Letter to the Editor.

Smith-Roe SL, Shockley KR, Bucher JR, Witt KL.

Environ Mol Mutagen. 2020 Feb;61(2):294-295. doi: 10.1002/em.22352. Epub 2020 Jan 9. No abstract available.


Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure.

Dunnick JK, Shockley KR, Morgan DL, Travlos GS, Gerrish K, Ton TT, Wilson R, Brar SS, Brix AE, Waidyanatha S, Mutlu E, Pandiri AKR.

Toxicol Pathol. 2020 Feb;48(2):338-349. doi: 10.1177/0192623319888433. Epub 2019 Dec 12.


Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure.

Smith-Roe SL, Wyde ME, Stout MD, Winters JW, Hobbs CA, Shepard KG, Green AS, Kissling GE, Shockley KR, Tice RR, Bucher JR, Witt KL.

Environ Mol Mutagen. 2020 Feb;61(2):276-290. doi: 10.1002/em.22343. Epub 2019 Nov 13.


Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies.

Moore RR, Nagai H, Miller RA, Hardisty JF, Allison N, Shockley KR, Malarkey DE.

Toxicol Pathol. 2019 Oct;47(7):833-841. doi: 10.1177/0192623319863119. Epub 2019 Aug 8.


Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Hsieh JH, Smith-Roe SL, Huang R, Sedykh A, Shockley KR, Auerbach SS, Merrick BA, Xia M, Tice RR, Witt KL.

Chem Res Toxicol. 2019 Jul 15;32(7):1384-1401. doi: 10.1021/acs.chemrestox.9b00053. Epub 2019 Jun 18.


Quality Control of Quantitative High Throughput Screening Data.

Shockley KR, Gupta S, Harris SF, Lahiri SN, Peddada SD.

Front Genet. 2019 May 9;10:387. doi: 10.3389/fgene.2019.00387. eCollection 2019.


PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat.

Dunnick JK, Shockley KR, Pandiri AR, Kissling GE, Gerrish KE, Ton TV, Wilson RE, Brar SS, Brix AE, Waidyanatha S, Mutlu E, Morgan DL.

Arch Toxicol. 2018 Nov;92(11):3415-3433. doi: 10.1007/s00204-018-2292-y. Epub 2018 Sep 5.


Statistical Guidance for Reviewers of Toxicologic Pathology.

Shockley KR, Kissling GE.

Toxicol Pathol. 2018 Aug;46(6):647-652. doi: 10.1177/0192623318785097. Epub 2018 Jul 2. Review.


Erratum: "Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity".

French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA.

Environ Health Perspect. 2018 Jun 27;126(6):069003. doi: 10.1289/EHP3950. eCollection 2018 Jun.


Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats.

Yamashita H, Hoenerhoff MJ, Shockley KR, Peddada SD, Gerrish KE, Sutton D, Cummings CA, Wang Y, Julie FF, Behl M, Waidyanatha S, Sills RC, Pandiri AR.

Toxicol Pathol. 2018 Jul;46(5):564-573. doi: 10.1177/0192623318778796. Epub 2018 May 27.


Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: Isolating independent associations with diet/energy balance and body weight.

Perron IJ, Keenan BT, Chellappa K, Lahens NF, Yohn NL, Shockley KR, Pack AI, Veasey SC.

PLoS One. 2018 May 10;13(5):e0196743. doi: 10.1371/journal.pone.0196743. eCollection 2018.


Tetrabromobisphenol A activates the hepatic interferon pathway in rats.

Dunnick JK, Morgan DL, Elmore SA, Gerrish K, Pandiri A, Ton TV, Shockley KR, Merrick BA.

Toxicol Lett. 2017 Jan 15;266:32-41. doi: 10.1016/j.toxlet.2016.11.019. Epub 2016 Nov 30.


Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats.

Dunnick JK, Shockley KR, Morgan DL, Brix A, Travlos GS, Gerrish K, Michael Sanders J, Ton TV, Pandiri AR.

Arch Toxicol. 2017 Apr;91(4):1685-1696. doi: 10.1007/s00204-016-1831-7. Epub 2016 Sep 16.


Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure.

Dunnick JK, Merrick BA, Brix A, Morgan DL, Gerrish K, Wang Y, Flake G, Foley J, Shockley KR.

Toxicol Pathol. 2016 Aug;44(6):835-47. doi: 10.1177/0192623316637708. Epub 2016 Apr 20.


Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2016 Jan;44(1):71-87. doi: 10.1177/0192623315610820. Epub 2015 Dec 17.


Developmental Effects of the ToxCastâ„¢ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits.

Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH.

Environ Health Perspect. 2016 May;124(5):586-93. doi: 10.1289/ehp.1409645. Epub 2015 Oct 23.


Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Dec;43(8):1114-26. doi: 10.1177/0192623315599853. Epub 2015 Aug 18.


Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.

Pei Y, Peng J, Behl M, Sipes NS, Shockley KR, Rao MS, Tice RR, Zeng X.

Brain Res. 2016 May 1;1638(Pt A):57-73. doi: 10.1016/j.brainres.2015.07.048. Epub 2015 Aug 5.


Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library.

Chen S, Hsieh JH, Huang R, Sakamuru S, Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR.

Toxicol Sci. 2015 Oct;147(2):446-57. doi: 10.1093/toxsci/kfv141. Epub 2015 Jul 3.


Quantitative high-throughput screening data analysis: challenges and recent advances.

Shockley KR.

Drug Discov Today. 2015 Mar;20(3):296-300. doi: 10.1016/j.drudis.2014.10.005. Epub 2014 Oct 23.


Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity.

French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA.

Environ Health Perspect. 2015 Mar;123(3):237-45. doi: 10.1289/ehp.1408202. Epub 2014 Nov 6. Erratum in: Environ Health Perspect. 2018 Jun 27;126(6):069003.


Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans.

George-Raizen JB, Shockley KR, Trojanowski NF, Lamb AL, Raizen DM.

Biol Open. 2014 Oct 31;3(11):1139-49. doi: 10.1242/bio.20147500.


Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.

Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi RC, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI.

Sleep. 2014 Oct 1;37(10):1589-600. doi: 10.5665/sleep.4064.


Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M.

Sci Rep. 2014 Jul 11;4:5664. doi: 10.1038/srep05664.


Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways.

Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Feb;43(2):171-85. doi: 10.1177/0192623314537885. Epub 2014 Jun 23.


Using weighted entropy to rank chemicals in quantitative high-throughput screening experiments.

Shockley KR.

J Biomol Screen. 2014 Mar;19(3):344-53. doi: 10.1177/1087057113505325. Epub 2013 Sep 20.


Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways.

Blackshear PE, Pandiri AR, Ton TV, Clayton NP, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014 Jul;42(5):863-76. doi: 10.1177/0192623313501894. Epub 2013 Aug 26.


Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues.

Anafi RC, Pellegrino R, Shockley KR, Romer M, Tufik S, Pack AI.

BMC Genomics. 2013 May 30;14:362. doi: 10.1186/1471-2164-14-362.


Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.

Pandiri AR, Sills RC, Ziglioli V, Ton TV, Hong HH, Lahousse SA, Gerrish KE, Auerbach SS, Shockley KR, Bushel PR, Peddada SD, Hoenerhoff MJ.

Toxicol Pathol. 2012 Dec;40(8):1141-59. doi: 10.1177/0192623312447543. Epub 2012 Jun 11.


A three-stage algorithm to make toxicologically relevant activity calls from quantitative high throughput screening data.

Shockley KR.

Environ Health Perspect. 2012 Aug;120(8):1107-15. doi: 10.1289/ehp.1104688. Epub 2012 May 10.


Characterization of polybrominated diphenyl ether toxicity in Wistar Han rats and use of liver microarray data for predicting disease susceptibilities.

Dunnick JK, Brix A, Cunny H, Vallant M, Shockley KR.

Toxicol Pathol. 2012;40(1):93-106. doi: 10.1177/0192623311429973.


Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.

Hoenerhoff MJ, Pandiri AR, Lahousse SA, Hong HH, Ton TV, Masinde T, Auerbach SS, Gerrish K, Bushel PR, Shockley KR, Peddada SD, Sills RC.

Toxicol Pathol. 2011 Jun;39(4):678-99. doi: 10.1177/0192623311407213. Epub 2011 May 13.


Effects of atherogenic diet on hepatic gene expression across mouse strains.

Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA.

Physiol Genomics. 2009 Nov 6;39(3):172-82. doi: 10.1152/physiolgenomics.90350.2008. Epub 2009 Aug 11.


What are microarrays teaching us about sleep?

Mackiewicz M, Zimmerman JE, Shockley KR, Churchill GA, Pack AI.

Trends Mol Med. 2009 Feb;15(2):79-87. doi: 10.1016/j.molmed.2008.12.002. Epub 2009 Jan 21. Review.


PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells.

Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA, Lecka-Czernik B.

J Cell Biochem. 2009 Feb 1;106(2):232-46. doi: 10.1002/jcb.21994.


Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I.

Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ.

Endocrinology. 2009 Mar;150(3):1330-40. doi: 10.1210/en.2008-0936. Epub 2008 Oct 23.


PPARgamma2 Regulates a Molecular Signature of Marrow Mesenchymal Stem Cells.

Shockley KR, Rosen CJ, Churchill GA, Lecka-Czernik B.

PPAR Res. 2007;2007:81219. doi: 10.1155/2007/81219.


Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification.

Stylianou IM, Affourtit JP, Shockley KR, Wilpan RY, Abdi FA, Bhardwaj S, Rollins J, Churchill GA, Paigen B.

Genetics. 2008 Mar;178(3):1795-805. doi: 10.1534/genetics.107.081216. Epub 2008 Feb 3.


Impact of substrate glycoside linkage and elemental sulfur on bioenergetics of and hydrogen production by the hyperthermophilic archaeon Pyrococcus furiosus.

Chou CJ, Shockley KR, Conners SB, Lewis DL, Comfort DA, Adams MW, Kelly RM.

Appl Environ Microbiol. 2007 Nov;73(21):6842-53. Epub 2007 Sep 7.


Macromolecule biosynthesis: a key function of sleep.

Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, Naidoo N, Baldwin DA, Jensen ST, Churchill GA, Pack AI.

Physiol Genomics. 2007 Nov 14;31(3):441-57. Epub 2007 Aug 14.


Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo.

Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR, Reid IR, Grey A, Rosen CJ.

Endocrinology. 2007 Feb;148(2):903-11. Epub 2006 Nov 22.


Role of the beta1 subunit in the function and stability of the 20S proteasome in the hyperthermophilic archaeon Pyrococcus furiosus.

Madding LS, Michel JK, Shockley KR, Conners SB, Epting KL, Johnson MR, Kelly RM.

J Bacteriol. 2007 Jan;189(2):583-90. Epub 2006 Nov 17.


Multiple mechanisms limit the duration of wakefulness in Drosophila brain.

Zimmerman JE, Rizzo W, Shockley KR, Raizen DM, Naidoo N, Mackiewicz M, Churchill GA, Pack AI.

Physiol Genomics. 2006 Nov 27;27(3):337-50. Epub 2006 Sep 5.


Inheritance patterns of transcript levels in F1 hybrid mice.

Cui X, Affourtit J, Shockley KR, Woo Y, Churchill GA.

Genetics. 2006 Oct;174(2):627-37. Epub 2006 Aug 3.


Gene expression analysis of mouse chromosome substitution strains.

Shockley KR, Churchill GA.

Mamm Genome. 2006 Jun;17(6):598-614. Epub 2006 Jun 12.


Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus.

Lee HS, Shockley KR, Schut GJ, Conners SB, Montero CI, Johnson MR, Chou CJ, Bridger SL, Wigner N, Brehm SD, Jenney FE Jr, Comfort DA, Kelly RM, Adams MW.

J Bacteriol. 2006 Mar;188(6):2115-25.


The Thermotoga maritima phenotype is impacted by syntrophic interaction with Methanococcus jannaschii in hyperthermophilic coculture.

Johnson MR, Conners SB, Montero CI, Chou CJ, Shockley KR, Kelly RM.

Appl Environ Microbiol. 2006 Jan;72(1):811-8.


An expression-driven approach to the prediction of carbohydrate transport and utilization regulons in the hyperthermophilic bacterium Thermotoga maritima.

Conners SB, Montero CI, Comfort DA, Shockley KR, Johnson MR, Chhabra SR, Kelly RM.

J Bacteriol. 2005 Nov;187(21):7267-82.


Genome-wide transcriptional variation within and between steady states for continuous growth of the hyperthermophile Thermotoga Maritima.

Shockley KR, Scott KL, Pysz MA, Conners SB, Johnson MR, Montero CI, Wolfinger RD, Kelly RM.

Appl Environ Microbiol. 2005 Sep;71(9):5572-6.

Supplemental Content

Loading ...
Support Center