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A Pilot Study To Evaluate The Effect Of A Novel Calcium And Vitamin D-Containing Oral Bolus On Serum Calcium Levels In Holstein Dairy Cows Following Parturition.

Shock DA, Roche SM, Genore R, Olson ME.

Vet Med (Auckl). 2019 Nov 13;10:151-158. doi: 10.2147/VMRR.S219740. eCollection 2019.


DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context.

Howard MJ, Cavanaugh NA, Batra VK, Shock DD, Beard WA, Wilson SH.

J Biol Chem. 2020 Jan 10;295(2):529-538. doi: 10.1074/jbc.RA119.010594. Epub 2019 Dec 4.


Cost-benefit of implementing a participatory extension model for improving on-farm adoption of Johne's disease control recommendations.

Roche SM, Von Massow M, Renaud D, Shock DA, Jones-Bitton A, Kelton DF.

J Dairy Sci. 2020 Jan;103(1):451-472. doi: 10.3168/jds.2019-16708. Epub 2019 Oct 16.


A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows.

Shock D, Roche S, Olson M.

Vet Sci. 2019 Sep 5;6(3). pii: E73. doi: 10.3390/vetsci6030073.


Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β.

Howard MJ, Foley KG, Shock DD, Batra VK, Wilson SH.

J Biol Chem. 2019 May 3;294(18):7194-7201. doi: 10.1074/jbc.RA118.006809. Epub 2019 Mar 18.


A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition.

Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH.

Nucleic Acids Res. 2019 Apr 8;47(6):3197-3207. doi: 10.1093/nar/gkz002.


Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial.

Shock DA, Renaud DL, Roche SM, Poliquin R, Thomson R, Olson ME.

PLoS One. 2018 Dec 12;13(12):e0209236. doi: 10.1371/journal.pone.0209236. eCollection 2018. Erratum in: PLoS One. 2018 Dec 31;13(12):e0210326.


Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.

Jamsen JA, Beard WA, Pedersen LC, Shock DD, Moon AF, Krahn JM, Bebenek K, Kunkel TA, Wilson SH.

Nat Commun. 2017 Aug 15;8(1):253. doi: 10.1038/s41467-017-00271-7.


Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction.

Shock DD, Freudenthal BD, Beard WA, Wilson SH.

Nat Chem Biol. 2017 Oct;13(10):1074-1080. doi: 10.1038/nchembio.2450. Epub 2017 Jul 31.


Adoption and consistency of application of premilking preparation in Ontario dairy herds.

Belage E, Dufour S, Shock DA, Jones-Bitton A, Kelton DF.

J Dairy Sci. 2017 May;100(5):3902-3911. doi: 10.3168/jds.2016-11698. Epub 2017 Mar 2.


Studying the relationship between on-farm environmental conditions and local meteorological station data during the summer.

Shock DA, LeBlanc SJ, Leslie KE, Hand K, Godkin MA, Coe JB, Kelton DF.

J Dairy Sci. 2016 Mar;99(3):2169-2179. doi: 10.3168/jds.2015-9795. Epub 2016 Jan 6.


Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.

Perera L, Freudenthal BD, Beard WA, Shock DD, Pedersen LG, Wilson SH.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5228-36. doi: 10.1073/pnas.1511207112. Epub 2015 Sep 8.


Exploring the characteristics and dynamics of Ontario dairy herds experiencing increases in bulk milk somatic cell count during the summer.

Shock DA, LeBlanc SJ, Leslie KE, Hand K, Godkin MA, Coe JB, Kelton DF.

J Dairy Sci. 2015 Jun;98(6):3741-53. doi: 10.3168/jds.2014-8675. Epub 2015 Apr 8.


Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.

Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH.

Nature. 2015 Jan 29;517(7536):635-9. doi: 10.1038/nature13886. Epub 2014 Nov 17.


Substrate-induced DNA polymerase β activation.

Beard WA, Shock DD, Batra VK, Prasad R, Wilson SH.

J Biol Chem. 2014 Nov 7;289(45):31411-22. doi: 10.1074/jbc.M114.607432. Epub 2014 Sep 26.


Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.

Kirby TW, Derose EF, Beard WA, Shock DD, Wilson SH, London RE.

Biochemistry. 2014 Apr 15;53(14):2413-22. doi: 10.1021/bi5001855. Epub 2014 Apr 2.


Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity.

Sassa A, Beard WA, Shock DD, Wilson SH.

J Vis Exp. 2013 Aug 19;(78):e50695. doi: 10.3791/50695.


Observing a DNA polymerase choose right from wrong.

Freudenthal BD, Beard WA, Shock DD, Wilson SH.

Cell. 2013 Jul 3;154(1):157-68. doi: 10.1016/j.cell.2013.05.048.


Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.

Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP.

J Biol Chem. 2013 Aug 9;288(32):23573-85. doi: 10.1074/jbc.M113.476150. Epub 2013 Jun 24.


Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction.

Batra VK, Perera L, Lin P, Shock DD, Beard WA, Pedersen LC, Pedersen LG, Wilson SH.

J Am Chem Soc. 2013 May 29;135(21):8078-88. doi: 10.1021/ja403842j. Epub 2013 May 16.


Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.

Oertell K, Wu Y, Zakharova VM, Kashemirov BA, Shock DD, Beard WA, Wilson SH, McKenna CE, Goodman MF.

Biochemistry. 2012 Oct 30;51(43):8491-501. doi: 10.1021/bi3010335. Epub 2012 Oct 19.


Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH.

Chembiochem. 2012 Mar 5;13(4):528-30. doi: 10.1002/cbic.201100738. Epub 2012 Feb 7.


Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion.

Batra VK, Shock DD, Beard WA, McKenna CE, Wilson SH.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):113-8. doi: 10.1073/pnas.1112235108. Epub 2011 Dec 16.


Metal-induced DNA translocation leads to DNA polymerase conformational activation.

Kirby TW, DeRose EF, Cavanaugh NA, Beard WA, Shock DD, Mueller GA, Wilson SH, London RE.

Nucleic Acids Res. 2012 Apr;40(7):2974-83. doi: 10.1093/nar/gkr1218. Epub 2011 Dec 14.


A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways.

Prasad R, Beard WA, Batra VK, Liu Y, Shock DD, Wilson SH.

Mol Biol (Mosk). 2011 Jul-Aug;45(4):586-600. Review.


Anomalies in evaporative light scattering detection.

Shock D, Dennis GR, Guiochon G, Dasgupta PK, Shalliker RA.

Anal Chim Acta. 2011 Oct 10;703(2):245-9. doi: 10.1016/j.aca.2011.06.060. Epub 2011 Jul 14.


Substrate channeling in mammalian base excision repair pathways: passing the baton.

Prasad R, Shock DD, Beard WA, Wilson SH.

J Biol Chem. 2010 Dec 24;285(52):40479-88. doi: 10.1074/jbc.M110.155267. Epub 2010 Oct 14.


Base excision repair and design of small molecule inhibitors of human DNA polymerase β.

Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA, Prasad R, Hou EW, Liu Y, Asagoshi K, Horton JK, Stefanick DF, Kedar PS, Carrozza MJ, Masaoka A, Heacock ML.

Cell Mol Life Sci. 2010 Nov;67(21):3633-47. doi: 10.1007/s00018-010-0489-1. Epub 2010 Sep 16. Review.


The assessment of pi-pi selective stationary phases for two-dimensional HPLC analysis of foods: application to the analysis of coffee.

Mnatsakanyan M, Stevenson PG, Shock D, Conlan XA, Goodie TA, Spencer KN, Barnett NW, Francis PS, Shalliker RA.

Talanta. 2010 Sep 15;82(4):1349-57. doi: 10.1016/j.talanta.2010.06.065. Epub 2010 Jul 24.


Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.

Surya Prakash GK, Zibinsky M, Upton TG, Kashemirov BA, McKenna CE, Oertell K, Goodman MF, Batra VK, Pedersen LC, Beard WA, Shock DD, Wilson SH, Olah GA.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15693-8. doi: 10.1073/pnas.1007430107. Epub 2010 Aug 19.


Application of power functions to chromatographic data for the enhancement of signal to noise ratios and separation resolution.

Shalliker RA, Stevenson PG, Shock D, Mnatsakanyan M, Dasgupta PK, Guiochon G.

J Chromatogr A. 2010 Sep 3;1217(36):5693-9. doi: 10.1016/j.chroma.2010.07.007. Epub 2010 Aug 2.


High performance liquid chromatography with two simultaneous on-line antioxidant assays: Evaluation and comparison of espresso coffees.

Mnatsakanyan M, Goodie TA, Conlan XA, Francis PS, McDermott GP, Barnett NW, Shock D, Gritti F, Guiochon G, Shalliker RA.

Talanta. 2010 May 15;81(3):837-42. doi: 10.1016/j.talanta.2010.01.024. Epub 2010 Jan 22.


Performance of columns packed with the new shell particles, Kinetex-C18.

Gritti F, Leonardis I, Shock D, Stevenson P, Shalliker A, Guiochon G.

J Chromatogr A. 2010 Mar 5;1217(10):1589-603. doi: 10.1016/j.chroma.2009.12.079. Epub 2010 Jan 7.


DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".

Beard WA, Shock DD, Batra VK, Pedersen LC, Wilson SH.

J Biol Chem. 2009 Nov 13;284(46):31680-9. doi: 10.1074/jbc.M109.029843. Epub 2009 Sep 15.


Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function.

Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, Pedersen LC, Beard WA, Wilson SH.

Org Lett. 2009 May 7;11(9):1883-6. doi: 10.1021/ol701755k.


Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

Liang F, Jain N, Hutchens T, Shock DD, Beard WA, Wilson SH, Chiarelli MP, Cho BP.

J Med Chem. 2008 Oct 23;51(20):6460-70. doi: 10.1021/jm800692a. Epub 2008 Sep 24.


Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH.

Mol Cell. 2008 May 9;30(3):315-24. doi: 10.1016/j.molcel.2008.02.025.


Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.

Liu Y, Prasad R, Beard WA, Kedar PS, Hou EW, Shock DD, Wilson SH.

J Biol Chem. 2007 May 4;282(18):13532-41. Epub 2007 Mar 12.


Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.

Batra VK, Shock DD, Prasad R, Beard WA, Hou EW, Pedersen LC, Sayer JM, Yagi H, Kumar S, Jerina DM, Wilson SH.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17231-6. Epub 2006 Nov 1.


Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

Batra VK, Beard WA, Shock DD, Krahn JM, Pedersen LC, Wilson SH.

Structure. 2006 Apr;14(4):757-66.


Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH.

Structure. 2005 Aug;13(8):1225-33.


DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts.

Braithwaite EK, Prasad R, Shock DD, Hou EW, Beard WA, Wilson SH.

J Biol Chem. 2005 May 6;280(18):18469-75. Epub 2005 Mar 3.


DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.

Liu Y, Beard WA, Shock DD, Prasad R, Hou EW, Wilson SH.

J Biol Chem. 2005 Feb 4;280(5):3665-74. Epub 2004 Nov 22.


Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

Beard WA, Shock DD, Wilson SH.

J Biol Chem. 2004 Jul 23;279(30):31921-9. Epub 2004 May 15.


Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

Prasad R, Bebenek K, Hou E, Shock DD, Beard WA, Woodgate R, Kunkel TA, Wilson SH.

J Biol Chem. 2003 Aug 8;278(32):29649-54. Epub 2003 May 29.


Rapid segmental and subdomain motions of DNA polymerase beta.

Kim SJ, Beard WA, Harvey J, Shock DD, Knutson JR, Wilson SH.

J Biol Chem. 2003 Feb 14;278(7):5072-81. Epub 2002 Nov 27.


Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.

Beard WA, Shock DD, Vande Berg BJ, Wilson SH.

J Biol Chem. 2002 Dec 6;277(49):47393-8. Epub 2002 Oct 4.


Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.

Barry WT, Boudignon-Proudhon C, Shock DD, McFadden A, Weiss JM, Sondek J, Parise LV.

J Biol Chem. 2002 Aug 9;277(32):28877-83. Epub 2002 May 21.


Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

Beard WA, Shock DD, Yang XP, DeLauder SF, Wilson SH.

J Biol Chem. 2002 Mar 8;277(10):8235-42. Epub 2001 Dec 26.

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