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Items: 7


Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins.

Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.

EMBO Rep. 2019 Feb 7. pii: e46451. doi: 10.15252/embr.201846451. [Epub ahead of print]


Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome.

Shmueli MD, Levy-Kanfo L, Haj E, Schoenfeld AR, Gazit E, Segal D.

Oncogene. 2019 Feb;38(7):1038-1049. doi: 10.1038/s41388-018-0491-x. Epub 2018 Sep 7.


Interplay between protein glycosylation pathways in Alzheimer's disease.

Frenkel-Pinter M, Shmueli MD, Raz C, Yanku M, Zilberzwige S, Gazit E, Segal D.

Sci Adv. 2017 Sep 15;3(9):e1601576. doi: 10.1126/sciadv.1601576. eCollection 2017 Sep.


The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.

Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D.

Biochemistry. 2015 Jun 23;54(24):3729-38. doi: 10.1021/bi501092p. Epub 2015 Jun 11.


Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome.

Shmueli MD, Schnaider L, Herzog G, Gazit E, Segal D.

PLoS One. 2014 Oct 13;9(10):e109864. doi: 10.1371/journal.pone.0109864. eCollection 2014.


Structural insights into the folding defects of oncogenic pVHL lead to correction of its function in vitro.

Shmueli MD, Schnaider L, Rosenblum D, Herzog G, Gazit E, Segal D.

PLoS One. 2013 Jun 20;8(6):e66333. doi: 10.1371/journal.pone.0066333. Print 2013.


Evaluating Drosophila p53 as a model system for studying cancer mutations.

Herzog G, Joerger AC, Shmueli MD, Fersht AR, Gazit E, Segal D.

J Biol Chem. 2012 Dec 28;287(53):44330-7. doi: 10.1074/jbc.M112.417980. Epub 2012 Nov 7.

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