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In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD.

Blood Adv. 2019 Jul 23;3(14):2082-2092. doi: 10.1182/bloodadvances.2019000227.


PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.

Juchem KW, Sacirbegovic F, Zhang C, Sharpe AH, Russell K, McNiff JM, Demetris AJ, Shlomchik MJ, Shlomchik WD.

J Immunol. 2018 Jan 15;200(2):834-846. doi: 10.4049/jimmunol.1701076. Epub 2017 Dec 6.


Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS, Lakkis FG.

Sci Immunol. 2017 Jun 23;2(12). pii: eaam6202. doi: 10.1126/sciimmunol.aam6202.


Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity.

Matte-Martone C, Liu J, Zhou M, Chikina M, Green DR, Harty JT, Shlomchik WD.

J Clin Invest. 2017 Jun 30;127(7):2765-2776. doi: 10.1172/JCI85736. Epub 2017 Jun 12.


Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease.

Bruce DW, Stefanski HE, Vincent BG, Dant TA, Reisdorf S, Bommiasamy H, Serody DA, Wilson JE, McKinnon KP, Shlomchik WD, Armistead PM, Ting JPY, Woosley JT, Blazar BR, Zaiss DMW, McKenzie ANJ, Coghill JM, Serody JS.

J Clin Invest. 2017 May 1;127(5):1813-1825. doi: 10.1172/JCI91816. Epub 2017 Apr 4.


Graft-infiltrating host dendritic cells play a key role in organ transplant rejection.

Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE.

Nat Commun. 2016 Aug 24;7:12623. doi: 10.1038/ncomms12623.


Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH.

Nat Immunol. 2016 Apr;17(4):414-21. doi: 10.1038/ni.3396. Epub 2016 Feb 22.


Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts.

Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD.

J Clin Invest. 2015 Jul 1;125(7):2677-89. doi: 10.1172/JCI81229. Epub 2015 Jun 8.


CD45 ligation expands Tregs by promoting interactions with DCs.

Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM.

J Clin Invest. 2014 Oct;124(10):4603-13. doi: 10.1172/JCI74087. Epub 2014 Sep 9.


Non-self recognition by monocytes initiates allograft rejection.

Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG.

J Clin Invest. 2014 Aug;124(8):3579-89. doi: 10.1172/JCI74370. Epub 2014 Jul 1.


Cognate antigen directs CD8+ T cell migration to vascularized transplants.

Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG.

J Clin Invest. 2013 Jun;123(6):2663-71. doi: 10.1172/JCI66722. Epub 2013 May 15.


Allograft outcomes in outbred mice.

Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG.

Am J Transplant. 2013 Mar;13(3):580-8. doi: 10.1111/ajt.12056. Epub 2013 Jan 11.


Biology of graft-versus-host responses: recent insights.

MacDonald KP, Shlomchik WD, Reddy P.

Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S10-4. doi: 10.1016/j.bbmt.2012.11.005. Review. No abstract available.


Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction.

Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD.

J Immunol. 2012 Apr 15;188(8):3804-11. doi: 10.4049/jimmunol.1102795. Epub 2012 Mar 14.


Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.

Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG.

Transpl Immunol. 2012 Mar;26(2-3):113-8. doi: 10.1016/j.trim.2011.12.006. Epub 2011 Dec 24.


Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation.

Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD.

Blood. 2011 Dec 8;118(24):6426-37. doi: 10.1182/blood-2011-06-358747. Epub 2011 Sep 30.


Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.

Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD.

Blood. 2011 Nov 24;118(22):5965-76. doi: 10.1182/blood-2011-07-367011. Epub 2011 Sep 13.


Multiphoton intravital microscopy of the transplanted mouse kidney.

Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG.

Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x. Epub 2011 Aug 11.


A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.

Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, Farber DL, Caton AJ, Shlomchik WD, Shlomchik MJ.

Blood. 2011 Dec 1;118(23):6209-19. doi: 10.1182/blood-2011-01-330035. Epub 2011 Jul 18.


Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⁺ effector memory T cells.

Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Jain D, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ.

Eur J Immunol. 2011 Sep;41(9):2782-92. doi: 10.1002/eji.201141678. Epub 2011 Aug 18.


Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.

Wang Y, Camirand G, Lin Y, Froicu M, Deng S, Shlomchik WD, Lakkis FG, Rothstein DM.

J Immunol. 2011 Mar 1;186(5):2809-18. doi: 10.4049/jimmunol.0903805. Epub 2011 Jan 26.


Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.

Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD.

J Immunol. 2011 Jan 1;186(1):230-41. doi: 10.4049/jimmunol.1002965. Epub 2010 Nov 22.


Langerhans cells are not required for graft-versus-host disease.

Li H, Kaplan DH, Matte-Martone C, Tan HS, Venkatesan S, Johnson K, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD.

Blood. 2011 Jan 13;117(2):697-707. doi: 10.1182/blood-2010-07-299073. Epub 2010 Oct 13.


A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental graft-versus-host disease.

Tawara I, Shlomchik WD, Jones A, Zou W, Nieves E, Liu C, Toubai T, Duran-Struuck R, Sun Y, Clouthier SG, Evers R, Lowler KP, Levy RB, Reddy P.

J Immunol. 2010 Oct 1;185(7):3866-72. doi: 10.4049/jimmunol.1001625. Epub 2010 Sep 1.


NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.

Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG.

J Immunol. 2010 Jun 15;184(12):6649-57. doi: 10.4049/jimmunol.0903729. Epub 2010 May 14.


Recipient B cells are not required for graft-versus-host disease induction.

Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD.

Biol Blood Marrow Transplant. 2010 Sep;16(9):1222-30. doi: 10.1016/j.bbmt.2010.03.015. Epub 2010 Mar 23.


NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction.

Miller JS, Warren EH, van den Brink MR, Ritz J, Shlomchik WD, Murphy WJ, Barrett AJ, Kolb HJ, Giralt S, Bishop MR, Blazar BR, Falkenburg JH.

Biol Blood Marrow Transplant. 2010 May;16(5):565-86. doi: 10.1016/j.bbmt.2010.02.005. Epub 2010 Feb 10.


Type I interferons are not critical for skin allograft rejection or the generation of donor-specific CD8+ memory T cells.

Oberbarnscheidt MH, Obhrai JS, Williams AL, Rothstein DM, Shlomchik WD, Chalasani G, Lakkis FG.

Am J Transplant. 2010 Jan;10(1):162-7. doi: 10.1111/j.1600-6143.2009.02871.x. Epub 2009 Nov 24.


An innate response to allogeneic nonself mediated by monocytes.

Zecher D, van Rooijen N, Rothstein DM, Shlomchik WD, Lakkis FG.

J Immunol. 2009 Dec 15;183(12):7810-6. doi: 10.4049/jimmunol.0902194.


Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.

Zheng H, Matte-Martone C, Jain D, McNiff J, Shlomchik WD.

J Immunol. 2009 May 15;182(10):5938-48. doi: 10.4049/jimmunol.0802212.


MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries.

Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G.

J Exp Med. 2008 Dec 22;205(13):3159-71. doi: 10.1084/jem.20081298. Epub 2008 Dec 8.


Characterization of a novel gain of function glucocorticoid receptor knock-in mouse.

Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D.

J Biol Chem. 2009 Mar 6;284(10):6249-59. doi: 10.1074/jbc.M807997200. Epub 2008 Nov 18.


Langerhans cells are not required for efficient skin graft rejection.

Obhrai JS, Oberbarnscheidt M, Zhang N, Mueller DL, Shlomchik WD, Lakkis FG, Shlomchik MJ, Kaplan DH.

J Invest Dermatol. 2008 Aug;128(8):1950-5. doi: 10.1038/jid.2008.52. Epub 2008 Mar 13.


Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells.

Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ.

Blood. 2008 May 15;111(10):5242-51. doi: 10.1182/blood-2007-09-107953. Epub 2008 Feb 19.


CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL.

Matte-Martone C, Liu J, Jain D, McNiff J, Shlomchik WD.

Blood. 2008 Apr 1;111(7):3884-92. doi: 10.1182/blood-2007-11-125294. Epub 2008 Jan 25.


Memory T cells in GVHD and GVL.

Anderson BE, Zheng H, Taylor PA, Matte-Martone C, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik MJ, Shlomchik WD.

Biol Blood Marrow Transplant. 2008 Jan;14(1 Suppl 1):19-20. Review. No abstract available. Erratum in: Biol Blood Marrow Transplant. 2008 Nov;14(11):1317-8.


Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease.

Zheng H, Matte-Martone C, Li H, Anderson BE, Venketesan S, Sheng Tan H, Jain D, McNiff J, Shlomchik WD.

Blood. 2008 Feb 15;111(4):2476-84. Epub 2007 Nov 28.


Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.

Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ.

J Exp Med. 2007 Oct 29;204(11):2545-52. Epub 2007 Oct 15.


Graft-versus-host disease.

Shlomchik WD.

Nat Rev Immunol. 2007 May;7(5):340-52. Review.


Transplantation's greatest challenges: advances in chronic graft-versus-host disease.

Shlomchik WD, Lee SJ, Couriel D, Pavletic SZ.

Biol Blood Marrow Transplant. 2007 Jan;13(1 Suppl 1):2-10. Review.


Recipient gammadelta T cells in graft-versus-host disease.

Anderson BE, Shlomchik WD, Shlomchik MJ.

Blood. 2006 May 1;107(9):3808-9; author reply 3809. No abstract available.


Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.

Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ.

Immunity. 2005 Dec;23(6):611-20.


Target antigens determine graft-versus-host disease phenotype.

Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD.

J Immunol. 2004 Nov 1;173(9):5467-75.


Donor APCs are required for maximal GVHD but not for GVL.

Matte CC, Liu J, Cormier J, Anderson BE, Athanasiadis I, Jain D, McNiff J, Shlomchik WD.

Nat Med. 2004 Sep;10(9):987-92. Epub 2004 Aug 1.


Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease.

Anderson BE, McNiff JM, Matte C, Athanasiadis I, Shlomchik WD, Shlomchik MJ.

Blood. 2004 Sep 1;104(5):1565-73. Epub 2004 May 18.


Graft-versus-leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing.

Matte CC, Cormier J, Anderson BE, Athanasiadis I, Liu J, Emerson SG, Pear W, Shlomchik WD.

Blood. 2004 Jun 1;103(11):4353-61. Epub 2004 Feb 24.


Antigen presentation in graft-vs-host disease.

Shlomchik WD.

Exp Hematol. 2003 Dec;31(12):1187-97. Review. No abstract available.


Memory CD4+ T cells do not induce graft-versus-host disease.

Anderson BE, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik MJ, Shlomchik WD.

J Clin Invest. 2003 Jul;112(1):101-8.

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