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Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation.

Ardell JL, Foreman RD, Armour JA, Shivkumar K.

JCI Insight. 2019 Oct 31. pii: 131648. doi: 10.1172/jci.insight.131648. [Epub ahead of print]


Renal denervation as adjunctive therapy to cardiac sympathetic denervation for ablation refractory ventricular tachycardia.

Bradfield JS, Hayase J, Liu K, Moriarty J, Kee ST, Do D, Ajijola OA, Vaseghi M, Gima J, Sorg J, Cote S, Pavez G, Buch E, Khakpour H, Krokhaleva Y, Macias C, Fujimura O, Boyle NG, Shivkumar K.

Heart Rhythm. 2019 Sep 17. pii: S1547-5271(19)30837-9. doi: 10.1016/j.hrthm.2019.09.016. [Epub ahead of print]


Structural Interventions and Potential Unforeseen Limits on Access to Ventricular Tachycardia Substrates.

Diamantakos E, Harvey R, Shivkumar K, Bradfield JS.

JACC Clin Electrophysiol. 2019 Aug;5(8):996-997. doi: 10.1016/j.jacep.2019.04.010. Epub 2019 Aug 19. No abstract available.


Neuromodulation for Ventricular Tachycardia and Atrial Fibrillation: A Clinical Scenario-Based Review.

Zhu C, Hanna P, Rajendran PS, Shivkumar K.

JACC Clin Electrophysiol. 2019 Aug;5(8):881-896. doi: 10.1016/j.jacep.2019.06.009. Epub 2019 Aug 19. Review.


Increased baseline ECG R-R dispersion predicts improvement in systolic function after atrial fibrillation ablation.

Koene RJ, Buch E, Seo YJ, Li JM, Mbai M, Chandrashekhar Y, Shivkumar K, Tholakanahalli VN.

Open Heart. 2019 Jun 25;6(1):e000958. doi: 10.1136/openhrt-2018-000958. eCollection 2019.


Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents.

Challis RC, Kumar SR, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V.

Nat Protoc. 2019 Aug;14(8):2597. doi: 10.1038/s41596-019-0155-5.


Cardiac sympathetic denervation for refractory ventricular arrhythmias in patients with structural heart disease: A systematic review.

Shah R, Assis F, Alugubelli N, Okada DR, Cardoso R, Shivkumar K, Tandri H.

Heart Rhythm. 2019 Oct;16(10):1499-1505. doi: 10.1016/j.hrthm.2019.06.018. Epub 2019 Jun 25.


Cardiac perforation complicating cardiac electrophysiology procedures: value of angiography and use of a closure device to avoid cardiac surgery.

Shenthar J, Singh B, Banavalikar B, Chakali SS, Delhaas T, Shivkumar K, Bradfield JS.

J Interv Card Electrophysiol. 2019 Jun 28. doi: 10.1007/s10840-019-00577-0. [Epub ahead of print]


Reply to the Editor- Bipolar ablation of refractory VT circuits: Current opportunities and limitations.

Al-Hadithi ABAK, Khakpour H, Cruz D, Boyle NG, Shivkumar K, Bradfield JS.

HeartRhythm Case Rep. 2019 Feb 8;5(5):288-289. doi: 10.1016/j.hrcr.2019.02.001. eCollection 2019 May. No abstract available.


Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation.

Scherschel K, Hedenus K, Jungen C, Lemoine MD, Rübsamen N, Veldkamp MW, Klatt N, Lindner D, Westermann D, Casini S, Kuklik P, Eickholt C, Klöcker N, Shivkumar K, Christ T, Zeller T, Willems S, Meyer C.

Sci Transl Med. 2019 May 22;11(493). pii: eaav7770. doi: 10.1126/scitranslmed.aav7770.


Monomorphic Ventricular Arrhythmias in Athletes.

Hsu JJ, Nsair A, Aboulhosn JA, Horwich TB, Dave RH, Shannon KM, Boyle NG, Shivkumar K, Bradfield JS.

Arrhythm Electrophysiol Rev. 2019 May;8(2):83-89. doi: 10.15420/aer.2019.19.3. Review.


Anesthetizing the Fibrillating Heart.

Hanna P, Zhu C, Rajendran PS, Shivkumar K.

J Am Heart Assoc. 2019 May 21;8(10):e012713. doi: 10.1161/JAHA.119.012713.


Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies.

Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, Shivkumar K.

Nat Commun. 2019 Apr 26;10(1):1944. doi: 10.1038/s41467-019-09770-1.


Mastering the art of epicardial access in cardiac electrophysiology.

Romero J, Shivkumar K, Di Biase L, Avendano R, Anderson RD, Natale A, Kumar S.

Heart Rhythm. 2019 Nov;16(11):1738-1749. doi: 10.1016/j.hrthm.2019.04.038. Epub 2019 Apr 20.


Catheter Ablation of Ventricular Arrhythmias.

Shivkumar K.

N Engl J Med. 2019 Apr 18;380(16):1555-1564. doi: 10.1056/NEJMra1615244. Review. No abstract available.


Neuroinflammation as a mechanism for cardiovascular diseases.

Rajendran PS, Hanna P, Zhu C, Shivkumar K.

Int J Cardiol. 2019 Aug 1;288:128-129. doi: 10.1016/j.ijcard.2019.04.003. Epub 2019 Apr 4. No abstract available.


Premature ventricular contraction diurnal profiles predict distinct clinical characteristics and beta-blocker responses.

Hamon D, Swid MA, Rajendran PS, Liu A, Boyle NG, Shivkumar K, Bradfield JS.

J Cardiovasc Electrophysiol. 2019 Jun;30(6):836-843. doi: 10.1111/jce.13944. Epub 2019 Apr 16.


Autonomic Nervous System Dysfunction: JACC Focus Seminar.

Goldberger JJ, Arora R, Buckley U, Shivkumar K.

J Am Coll Cardiol. 2019 Mar 19;73(10):1189-1206. doi: 10.1016/j.jacc.2018.12.064. Review.


Limitations of 12-lead electrocardiogram wide complex tachycardia algorithms in a patient with left atrial flutter and large myocardial infarction.

Macias C, Khakpour H, Buch E, Shivkumar K, Bradfield JS.

HeartRhythm Case Rep. 2018 Apr 12;5(2):70-73. doi: 10.1016/j.hrcr.2018.04.001. eCollection 2019 Feb. No abstract available.


Feasibility of percutaneous epicardial mapping and ablation for refractory atrial fibrillation: Insights into substrate and lesion transmurality.

Jiang R, Buch E, Gima J, Upadhyay GA, Nayak HM, Beaser AD, Aziz Z, Shivkumar K, Tung R.

Heart Rhythm. 2019 Aug;16(8):1151-1159. doi: 10.1016/j.hrthm.2019.02.018. Epub 2019 Feb 16.


Catheter ablation in the vicinity of the proximal conduction system: Your eyes cannot see what your mind does not know.

Bradfield JS, Fujimura O, Boyle NG, Shivkumar K.

Heart Rhythm. 2019 Mar;16(3):378-379. doi: 10.1016/j.hrthm.2019.01.006. Epub 2019 Jan 8. No abstract available.


Systemic AAV vectors for widespread and targeted gene delivery in rodents.

Challis RC, Ravindra Kumar S, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V.

Nat Protoc. 2019 Feb;14(2):379-414. doi: 10.1038/s41596-018-0097-3. Erratum in: Nat Protoc. 2019 Aug;14(8):2597.


Incessant intraseptal ventricular tachycardia ablated utilizing extracorporeal membrane oxygenation and bipolar ablation.

Al-Hadithi ABAK, Khakpour H, Cruz D, Boyle NG, Shivkumar K, Bradfield JS.

HeartRhythm Case Rep. 2018 Oct 2;4(12):557-560. doi: 10.1016/j.hrcr.2018.01.014. eCollection 2018 Dec. No abstract available.


Predictive Score for Identifying Survival and Recurrence Risk Profiles in Patients Undergoing Ventricular Tachycardia Ablation.

Vergara P, Tzou WS, Tung R, Brombin C, Nonis A, Vaseghi M, Frankel DS, Di Biase L, Tedrow U, Mathuria N, Nakahara S, Tholakanahalli V, Bunch TJ, Weiss JP, Dickfeld T, Lakireddy D, Burkhardt JD, Santangeli P, Callans D, Natale A, Marchlinski F, Stevenson WG, Shivkumar K, Sauer WH, Della Bella P.

Circ Arrhythm Electrophysiol. 2018 Dec;11(12):e006730. doi: 10.1161/CIRCEP.118.006730.


Journal of Cardiovascular Electrophysiology: Redefining Our Mission.

Ellenbogen KA, Tung R, Shivkumar K, Miller JM.

J Cardiovasc Electrophysiol. 2019 Jan;30(1):5-6. doi: 10.1111/jce.13801. Epub 2018 Dec 16. No abstract available.


Contemporary Management of Electrical Storm.

Geraghty L, Santangeli P, Tedrow UB, Shivkumar K, Kumar S.

Heart Lung Circ. 2019 Jan;28(1):123-133. doi: 10.1016/j.hlc.2018.10.005. Epub 2018 Oct 15. Review.


Targeting the Cardiac Ganglionated Plexi for Atrial Fibrillation: Modulate or Destroy?

Hanna P, Shivkumar K.

JACC Clin Electrophysiol. 2018 Oct;4(10):1359-1361. doi: 10.1016/j.jacep.2018.09.001. No abstract available.


Catheter Ablation of Ventricular Arrhythmia for Ebstein's Anomaly in Unoperated and Post-Surgical Patients.

Moore JP, Shannon KM, Gallotti RG, McLeod CJ, Chiriac A, Walsh EP, Sreeram N, Patel AR, De Groot NM, von Alvensleben J, Balaji S, Frankel DS, Miyake CY, Perry JC, Shivkumar K.

JACC Clin Electrophysiol. 2018 Oct;4(10):1300-1307. doi: 10.1016/j.jacep.2018.05.009. Epub 2018 Jun 27.


Ageing, the autonomic nervous system and arrhythmia: From brain to heart.

Chadda KR, Ajijola OA, Vaseghi M, Shivkumar K, Huang CL, Jeevaratnam K.

Ageing Res Rev. 2018 Dec;48:40-50. doi: 10.1016/j.arr.2018.09.005. Epub 2018 Oct 6. Review.


Persistent left superior vena cava as an arrhythmogenic source in atrial fibrillation: results from a multicenter experience.

Turagam MK, Atoui M, Atkins D, Di Biase L, Shivkumar K, Jared Bunch T, Mohanty S, Gianni C, Natale A, Lakkireddy D.

J Interv Card Electrophysiol. 2019 Mar;54(2):93-100. doi: 10.1007/s10840-018-0444-x. Epub 2018 Sep 27.


Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI.

Kung GL, Vaseghi M, Gahm JK, Shevtsov J, Garfinkel A, Shivkumar K, Ennis DB.

Front Physiol. 2018 Aug 22;9:826. doi: 10.3389/fphys.2018.00826. eCollection 2018.


Outcomes of Catheter Ablation of Ventricular Tachycardia Based on Etiology in Nonischemic Heart Disease: An International Ventricular Tachycardia Ablation Center Collaborative Study.

Vaseghi M, Hu TY, Tung R, Vergara P, Frankel DS, Di Biase L, Tedrow UB, Gornbein JA, Yu R, Mathuria N, Nakahara S, Tzou WS, Sauer WH, Burkhardt JD, Tholakanahalli VN, Dickfeld TM, Weiss JP, Bunch TJ, Reddy M, Callans DJ, Lakkireddy DR, Natale A, Marchlinski FE, Stevenson WG, Della Bella P, Shivkumar K.

JACC Clin Electrophysiol. 2018 Sep;4(9):1141-1150. doi: 10.1016/j.jacep.2018.05.007. Epub 2018 Jul 25.


Progression of myocardial ischemia leads to unique changes in immediate-early gene expression in the spinal cord dorsal horn.

Saddic LA, Howard-Quijano K, Kipke J, Kubo Y, Dale EA, Hoover D, Shivkumar K, Eghbali M, Mahajan A.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1592-H1601. doi: 10.1152/ajpheart.00337.2018. Epub 2018 Sep 14.


Calming the Nervous Heart: Autonomic Therapies in Heart Failure.

Hanna P, Shivkumar K, Ardell JL.

Card Fail Rev. 2018 Aug;4(2):92-98. doi: 10.15420/cfr.2018.20.2. Review.


Percutaneous Hemodynamic Assist Devices: Unloading the Left Atrium to Prevent Atrial Remodeling.

Shivkumar K, Hanna P.

J Am Coll Cardiol. 2018 Aug 14;72(7):751-753. doi: 10.1016/j.jacc.2018.06.015. No abstract available.


Intramyocardial radiofrequency ablation of ventricular arrhythmias using intracoronary wire mapping and a coronary reentry system: Description of a novel technique.

Romero J, Diaz JC, Hayase J, Dave RH, Bradfield JS, Shivkumar K.

HeartRhythm Case Rep. 2018 Jun 23;4(7):285-292. doi: 10.1016/j.hrcr.2018.03.005. eCollection 2018 Jul. No abstract available.


Neural ablation to treat ventricular arrhythmias.

Hanna P, Rajendran PS, Shivkumar K.

Europace. 2018 Dec 1;20(12):1880-1881. doi: 10.1093/europace/euy134. No abstract available.


Right ventricular lead proarrhythmia: A novel intervention for an under-recognized phenomenon.

Hayase J, Khakpour H, Shivkumar K, Bradfield JS.

HeartRhythm Case Rep. 2017 Dec 12;4(2):50-53. doi: 10.1016/j.hrcr.2017.10.009. eCollection 2018 Feb. No abstract available.


RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity.

Bardsley EN, Davis H, Ajijola OA, Buckler KJ, Ardell JL, Shivkumar K, Paterson DJ.

Sci Rep. 2018 Jun 5;8(1):8633. doi: 10.1038/s41598-018-26651-7.


Hemodynamic Support in Ventricular Tachycardia Ablation: An International VT Ablation Center Collaborative Group Study.

Turagam MK, Vuddanda V, Atkins D, Santangeli P, Frankel DS, Tung R, Vaseghi M, Sauer WH, Tzou W, Mathuria N, Nakahara S, Dickfeld TM, Bunch TJ, Weiss P, Di Biase L, Tholakanahalli V, Vakil K, Tedrow UB, Stevenson WG, Della Bella P, Shivkumar K, Marchlinski FE, Callans DJ, Natale A, Reddy M, Lakkireddy D.

JACC Clin Electrophysiol. 2017 Dec 26;3(13):1534-1543. doi: 10.1016/j.jacep.2017.07.005. Epub 2017 Nov 15.


Vagal Neuromodulation for Atrial Arrhythmias.

Shivkumar K, Ardell JL.

JACC Clin Electrophysiol. 2017 Sep;3(9):939-941. doi: 10.1016/j.jacep.2017.06.018. Epub 2017 Sep 18. No abstract available.


Post-Extrasystolic Potentiation as a Predictor of Recovery of Left Ventricular Dysfunction After Radiofrequency Catheter Ablation.

Krishnan B, Sankar A, Anand I, Adabag S, Li JM, McFalls EO, Benditt DG, Shivkumar K, Tholakanahalli VN.

JACC Clin Electrophysiol. 2017 Nov;3(11):1283-1291. doi: 10.1016/j.jacep.2017.05.017. Epub 2017 Nov 6.


Value of a Posterior Electrocardiographic Lead for Localization of Ventricular Outflow Tract Arrhythmias: The V4/V8 Ratio.

Zhang F, Hamon D, Fang Z, Xu Y, Yang B, Ju W, Bradfield J, Shivkumar K, Chen M, Tung R.

JACC Clin Electrophysiol. 2017 Jul;3(7):678-686. doi: 10.1016/j.jacep.2016.12.018. Epub 2017 Mar 1.


Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.

Liu K, Li D, Hao G, McCaffary D, Neely O, Woodward L, Ioannides D, Lu CJ, Brescia M, Zaccolo M, Tandri H, Ajijola OA, Ardell JL, Shivkumar K, Paterson DJ.

JCI Insight. 2018 May 3;3(9). pii: 98694. doi: 10.1172/jci.insight.98694.


Endocardial ablation of ventricular ectopic beats arising from the basal inferoseptal process of the left ventricle.

Li A, Zuberi Z, Bradfield JS, Zarif JK, Ward DE, Anderson RH, Shivkumar K, Saba MM.

Heart Rhythm. 2018 Sep;15(9):1356-1362. doi: 10.1016/j.hrthm.2018.04.029. Epub 2018 Apr 28.


Ventricular arrhythmia burden after transcatheter versus surgical pulmonary valve replacement.

Wadia SK, Lluri G, Aboulhosn JA, Shivkumar K, Reemtsen BL, Laks H, Biniwale RM, Levi DS, Salem M, Moore JP.

Heart. 2018 Nov;104(21):1791-1796. doi: 10.1136/heartjnl-2017-312769. Epub 2018 Apr 10.


Autonomic Regulation and Ventricular Arrhythmias.

Meng L, Shivkumar K, Ajijola O.

Curr Treat Options Cardiovasc Med. 2018 Apr 7;20(5):38. doi: 10.1007/s11936-018-0633-z. Review.


Mechanisms and management of refractory ventricular arrhythmias in the age of autonomic modulation.

Bradfield JS, Ajijola OA, Vaseghi M, Shivkumar K.

Heart Rhythm. 2018 Aug;15(8):1252-1260. doi: 10.1016/j.hrthm.2018.02.015. Epub 2018 Feb 14. Review.


Morphological Spectra of Adult Human Stellate Ganglia: Implications for Thoracic Sympathetic Denervation.

Kwon OJ, Pendekanti S, Fox JN, Yanagawa J, Fishbein MC, Shivkumar K, Lambert HW, Ajijola OA.

Anat Rec (Hoboken). 2018 Feb 16;301(7):1244-1250. doi: 10.1002/ar.23797. [Epub ahead of print]


Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress.

Yoshie K, Rajendran PS, Massoud L, Kwon O, Tadimeti V, Salavatian S, Ardell JL, Shivkumar K, Ajijola OA.

Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H954-H966. doi: 10.1152/ajpheart.00593.2017. Epub 2018 Jan 16.

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