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Items: 1 to 50 of 158

1.

Limited gut cell repertoire for multiple hormones.

Shivdasani RA.

Nat Cell Biol. 2018 Aug;20(8):865-867. doi: 10.1038/s41556-018-0153-9. No abstract available.

PMID:
30038256
2.

RORα-expressing T regulatory cells restrain allergic skin inflammation.

Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS.

Sci Immunol. 2018 Mar 2;3(21). pii: eaao6923. doi: 10.1126/sciimmunol.aao6923.

PMID:
29500225
3.

Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.

Saxena M, Roman AKS, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA.

Genes Dev. 2017 Dec 1;31(23-24):2391-2404. doi: 10.1101/gad.308536.117. Epub 2018 Jan 10.

4.

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.

Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA.

Cell Stem Cell. 2017 Jul 6;21(1):65-77.e5. doi: 10.1016/j.stem.2017.05.001. Epub 2017 Jun 22.

5.

A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.

Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3. No abstract available.

6.

Challenges and emerging directions in single-cell analysis.

Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I.

Genome Biol. 2017 May 8;18(1):84. doi: 10.1186/s13059-017-1218-y. Review.

7.

Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients.

Schumacher SE, Shim BY, Corso G, Ryu MH, Kang YK, Roviello F, Saksena G, Peng S, Shivdasani RA, Bass AJ, Beroukhim R.

PLoS One. 2017 Apr 20;12(4):e0176045. doi: 10.1371/journal.pone.0176045. eCollection 2017.

8.

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine.

Jadhav U, Shivdasani RA.

Cell Mol Gastroenterol Hepatol. 2016 Sep 26;2(6):714-715. doi: 10.1016/j.jcmgh.2016.09.006. eCollection 2016 Nov. No abstract available.

9.

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CW.

Nat Genet. 2017 Feb;49(2):296-302. doi: 10.1038/ng.3744. Epub 2016 Dec 12.

10.

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.

Cejas P, Cavazza A, Yandava CN, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA.

Cancer Res. 2017 Feb 1;77(3):766-779. doi: 10.1158/0008-5472.CAN-16-1346. Epub 2016 Nov 29.

11.

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.

Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA.

Cell Rep. 2016 Aug 23;16(8):2053-2060. doi: 10.1016/j.celrep.2016.07.056. Epub 2016 Aug 11.

12.

Sox2 Suppresses Gastric Tumorigenesis in Mice.

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K.

Cell Rep. 2016 Aug 16;16(7):1929-41. doi: 10.1016/j.celrep.2016.07.034. Epub 2016 Aug 4.

13.

NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.

Zang C, Luyten A, Chen J, Liu XS, Shivdasani RA.

Sci Rep. 2016 Jul 26;6:30255. doi: 10.1038/srep30255.

14.

Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells.

Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y.

Methods Mol Biol. 2016;1422:23-31. doi: 10.1007/978-1-4939-3603-8_3.

PMID:
27246019
15.

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA.

Cell. 2016 Jun 2;165(6):1389-1400. doi: 10.1016/j.cell.2016.04.031. Epub 2016 May 19.

16.

Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles.

Cejas P, Li L, O'Neill NK, Duarte M, Rao P, Bowden M, Zhou CW, Mendiola M, Burgos E, Feliu J, Moreno-Rubio J, Guadalajara H, Moreno V, García-Olmo D, Bellmunt J, Mullane S, Hirsch M, Sweeney CJ, Richardson A, Liu XS, Brown M, Shivdasani RA, Long HW.

Nat Med. 2016 Jun;22(6):685-91. doi: 10.1038/nm.4085. Epub 2016 Apr 25.

PMID:
27111282
17.

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q.

Cell Stem Cell. 2016 Mar 3;18(3):410-21. doi: 10.1016/j.stem.2016.01.003. Epub 2016 Feb 18.

18.

Stomach development, stem cells and disease.

Kim TH, Shivdasani RA.

Development. 2016 Feb 15;143(4):554-65. doi: 10.1242/dev.124891. Review.

19.

Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.

Hanyuda A, Kim SA, Martinez-Fernandez A, Qian ZR, Yamauchi M, Nishihara R, Morikawa T, Liao X, Inamura K, Mima K, Cao Y, Zhang X, Wu K, Chan AT, Giovannucci EL, Meyerhardt JA, Fuchs CS, Shivdasani RA, Ogino S.

Ann Surg Oncol. 2016 Mar;23(3):908-17. doi: 10.1245/s10434-015-4967-4. Epub 2015 Nov 17.

20.

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas.

Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):598-609.e6.

21.

Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.

San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA.

Stem Cell Reports. 2015 Nov 10;5(5):673-681. doi: 10.1016/j.stemcr.2015.09.006. Epub 2015 Oct 17.

22.

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.

Pomerantz MM, Li F, Takeda DY, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, Loda M, Long HW, Freedman ML.

Nat Genet. 2015 Nov;47(11):1346-51. doi: 10.1038/ng.3419. Epub 2015 Oct 12.

23.

Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.

Jayewickreme CD, Shivdasani RA.

Dev Biol. 2015 Sep 1;405(1):21-32. doi: 10.1016/j.ydbio.2015.05.024. Epub 2015 Jun 6.

24.

The use of murine-derived fundic organoids in studies of gastric physiology.

Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y.

J Physiol. 2015 Apr 15;593(8):1809-27. doi: 10.1113/jphysiol.2014.283028. Epub 2015 Feb 19.

25.

Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.

San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP.

J Biol Chem. 2015 Jan 16;290(3):1850-60. doi: 10.1074/jbc.M114.620211. Epub 2014 Dec 8.

26.

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.

Luyten A, Zang C, Liu XS, Shivdasani RA.

Genes Dev. 2014 Aug 15;28(16):1827-39. doi: 10.1101/gad.240101.114.

27.

Dissecting engineered cell types and enhancing cell fate conversion via CellNet.

Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ.

Cell. 2014 Aug 14;158(4):889-902. doi: 10.1016/j.cell.2014.07.021.

28.

Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.

Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y.

Gastroenterology. 2014 Sep;147(3):655-666.e9. doi: 10.1053/j.gastro.2014.05.006. Epub 2014 May 20.

29.

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

San Roman AK, Jayewickreme CD, Murtaugh LC, Shivdasani RA.

Stem Cell Reports. 2014 Jan 30;2(2):127-34. doi: 10.1016/j.stemcr.2013.12.012. eCollection 2014 Feb 11.

30.

Radiation redux: reserve intestinal stem cells miss the call to duty.

Shivdasani RA.

Cell Stem Cell. 2014 Feb 6;14(2):135-6. doi: 10.1016/j.stem.2014.01.015.

31.

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.

Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA.

Nature. 2014 Feb 27;506(7489):511-5. doi: 10.1038/nature12903. Epub 2014 Jan 12.

32.

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA.

Oncogene. 2014 Dec 4;33(49):5637-48. doi: 10.1038/onc.2013.517. Epub 2013 Dec 9.

33.

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.

Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, Meyerson M.

Nat Genet. 2013 Dec;45(12):1483-6. doi: 10.1038/ng.2821. Epub 2013 Nov 3.

34.

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia.

Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8105-10. doi: 10.1073/pnas.1221216110. Epub 2013 Apr 25.

35.

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.

Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA.

Mol Cell Biol. 2013 May;33(9):1735-45. doi: 10.1128/MCB.01463-12. Epub 2013 Feb 19.

36.

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.

Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J.

J Biol Chem. 2013 Mar 29;288(13):9017-27. doi: 10.1074/jbc.M112.444240. Epub 2013 Feb 7.

37.

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.

Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA.

Mol Cell Biol. 2013 Jan;33(2):281-92. doi: 10.1128/MCB.01185-12. Epub 2012 Nov 5. Erratum in: Mol Cell Biol. 2015 Jan;35(2):496.

38.

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling.

Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR.

Sci Transl Med. 2012 Aug 22;4(148):148ra117. doi: 10.1126/scitranslmed.3003808.

39.

Stem cell niches: famished Paneth cells, gluttonous stem cells.

Kim TH, Shivdasani RA.

Curr Biol. 2012 Jul 24;22(14):R579-80. doi: 10.1016/j.cub.2012.06.017.

40.

Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis.

Dulak AM, Schumacher SE, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos AH, Saksena G, Baca SC, Baselga J, Tabernero J, Barretina J, Enzinger PC, Corso G, Roviello F, Lin L, Bandla S, Luketich JD, Pennathur A, Meyerson M, Ogino S, Shivdasani RA, Beer DG, Godfrey TE, Beroukhim R, Bass AJ.

Cancer Res. 2012 Sep 1;72(17):4383-93. Epub 2012 Jul 2.

41.

GEFs on the RhoAd to a colossal nucleus.

Shivdasani RA.

Dev Cell. 2012 Mar 13;22(3):471-2. doi: 10.1016/j.devcel.2012.02.010.

42.

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.

Kim TH, Escudero S, Shivdasani RA.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3932-7. doi: 10.1073/pnas.1113890109. Epub 2012 Feb 21.

43.

Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling.

Horst D, Chen J, Morikawa T, Ogino S, Kirchner T, Shivdasani RA.

Cancer Res. 2012 Mar 15;72(6):1547-56. doi: 10.1158/0008-5472.CAN-11-3222. Epub 2012 Feb 8.

44.

The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons.

Ho Sui SJ, Begley K, Reilly D, Chapman B, McGovern R, Rocca-Sera P, Maguire E, Altschuler GM, Hansen TA, Sompallae R, Krivtsov A, Shivdasani RA, Armstrong SA, Culhane AC, Correll M, Sansone SA, Hofmann O, Hide W.

Nucleic Acids Res. 2012 Jan;40(Database issue):D984-91. doi: 10.1093/nar/gkr1051. Epub 2011 Nov 24.

45.

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.

Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M.

Genome Res. 2012 Feb;22(2):292-8. doi: 10.1101/gr.126573.111. Epub 2011 Oct 18.

46.

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab.

Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, Fujisaka Y, Philips J, Shimizu T, Maenishi O, Cho Y, Sun J, Destro A, Taira K, Takeda K, Okabe T, Swanson J, Itoh H, Takada M, Lifshits E, Okuno K, Engelman JA, Shivdasani RA, Nishio K, Fukuoka M, Varella-Garcia M, Nakagawa K, Jänne PA.

Sci Transl Med. 2011 Sep 7;3(99):99ra86. doi: 10.1126/scitranslmed.3002442.

47.

Boundaries, junctions and transitions in the gastrointestinal tract.

San Roman AK, Shivdasani RA.

Exp Cell Res. 2011 Nov 15;317(19):2711-8. doi: 10.1016/j.yexcr.2011.07.011. Epub 2011 Jul 23. Review.

48.

Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation.

Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA.

PLoS One. 2011;6(7):e22493. doi: 10.1371/journal.pone.0022493. Epub 2011 Jul 22.

49.

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA.

Development. 2011 Aug;138(15):3225-33. doi: 10.1242/dev.066233.

50.

Targeting PI3K signaling as a therapeutic approach for colorectal cancer.

Zhang J, Roberts TM, Shivdasani RA.

Gastroenterology. 2011 Jul;141(1):50-61. doi: 10.1053/j.gastro.2011.05.010. Review.

PMID:
21723986

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