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Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.

Manning JR, Thapa D, Zhang M, Stoner MW, Traba J, Corey C, Shiva S, Sack MN, Scott I.

Biochem J. 2019 May 28. pii: BCJ20190302. doi: 10.1042/BCJ20190302. [Epub ahead of print]


Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.

Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BA.

PLoS One. 2019 May 28;14(5):e0203101. doi: 10.1371/journal.pone.0203101. eCollection 2019.


Perception of tobacco use in young adults in urban India: a qualitative exploration with relevant health policy analysis.

Ghose S, Sardar A, Shiva S, Mullan BE, Datta SS.

Ecancermedicalscience. 2019 Mar 28;13:915. doi: 10.3332/ecancer.2019.915. eCollection 2019.


Platelet bioenergetics correlate with muscle energetics and are altered in older adults.

Braganza AC, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S.

JCI Insight. 2019 May 23;5. pii: 128248. doi: 10.1172/jci.insight.128248.


Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, Lai YC, Shiva S, Scott I.

Physiol Rep. 2019 Apr;7(8):e14054. doi: 10.14814/phy2.14054.


Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Patil P, Falabella M, Saeed A, Lee D, Kaufman B, Shiva S, Croix CS, Van Houten B, Niedernhofer LJ, Robbins PD, Lee J, Gwendolyn S, Vo NV.

Mech Ageing Dev. 2019 Jun;180:97-106. doi: 10.1016/j.mad.2019.04.006. Epub 2019 Apr 17.


The Neuronal Ceroid Lipofuscinoses-Linked Loss of Function CLN5 and CLN8 Variants Disrupt Normal Lysosomal Function.

Parvin S, Rezazadeh M, Hosseinzadeh H, Moradi M, Shiva S, Gharesouran J.

Neuromolecular Med. 2019 Jun;21(2):160-169. doi: 10.1007/s12017-019-08529-7. Epub 2019 Mar 27.


Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.

Chacko BK, Smith MR, Johnson MS, Benavides G, Culp ML, Pilli J, Shiva S, Uppal K, Go YM, Jones DP, Darley-Usmar VM.

Redox Biol. 2019 Apr;22:101165. doi: 10.1016/j.redox.2019.101165. Epub 2019 Mar 10.


Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation.

Braganza A, Quesnelle K, Bickta J, Reyes C, Wang Y, Jessup M, St Croix C, Arlotti J, Singh SV, Shiva S.

J Biol Chem. 2019 May 3;294(18):7269-7282. doi: 10.1074/jbc.RA118.006673. Epub 2019 Mar 14.


Platelets: Lone Rangers of Inflammatory Signaling in the Lung.

Nguyen Q, Shiva S.

Am J Respir Cell Mol Biol. 2019 Mar 8. doi: 10.1165/rcmb.2019-0057ED. [Epub ahead of print] No abstract available.


Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.

de Jesus DS, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, Kaufman BA, Gladwin MT, Pagano PJ.

Redox Biol. 2019 Apr;22:101138. doi: 10.1016/j.redox.2019.101138. Epub 2019 Feb 8.


Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.

Manning JR, Thapa D, Zhang M, Stoner MW, Traba J, McTiernan CF, Corey C, Shiva S, Sack MN, Scott I.

J Mol Cell Cardiol. 2019 Apr;129:69-78. doi: 10.1016/j.yjmcc.2019.02.009. Epub 2019 Feb 15.


Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis.

Khoo NKH, Fazzari M, Chartoumpekis DV, Li L, Guimaraes DA, Arteel GE, Shiva S, Freeman BA.

Redox Biol. 2019 Apr;22:101132. doi: 10.1016/j.redox.2019.101132. Epub 2019 Feb 1.


BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J 3rd, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY.

Circulation. 2019 May 7;139(19):2238-2255. doi: 10.1161/CIRCULATIONAHA.118.035889.


Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.

Winnica D, Corey C, Mullett S, Reynolds M, Hill G, Wendell S, Que L, Holguin F, Shiva S.

Antioxid Redox Signal. 2019 Mar 6. doi: 10.1089/ars.2018.7627. [Epub ahead of print]


Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium.

Kullmann FA, McDonnell BM, Wolf-Johnston AS, Kanai AJ, Shiva S, Chelimsky T, Rodriguez L, Birder LA.

Neurourol Urodyn. 2019 Feb;38(2):572-581. doi: 10.1002/nau.23876. Epub 2018 Dec 21.


Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero J, Shiva S, Gladwin MT.

Physiol Rev. 2019 Jan 1;99(1):311-379. doi: 10.1152/physrev.00036.2017. Review.


Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis.

Cárdenes N, Álvarez D, Sellarés J, Peng Y, Corey C, Wecht S, Nouraie SM, Shanker S, Sembrat J, Bueno M, Shiva S, Mora AL, Rojas M.

Stem Cell Res Ther. 2018 Sep 26;9(1):257. doi: 10.1186/s13287-018-0970-6.


Moving mitochondria - Breathing new signaling into asthmatic airways.

Nguyen Q, Shiva S.

Redox Biol. 2018 Sep;18:244-245. doi: 10.1016/j.redox.2018.07.013. Epub 2018 Jul 21. No abstract available.


Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Bilan VP, Schneider F, Novelli EM, Kelley EE, Shiva S, Gladwin MT, Jackson EK, Tofovic SP.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018791557. doi: 10.1177/2045894018791557. Epub 2018 Jul 13.


Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets.

Wang B, Shi Y, Tejero J, Powell SM, Thomas LM, Gladwin MT, Shiva S, Zhang Y, Richter-Addo GB.

Biochemistry. 2018 Aug 14;57(32):4788-4802. doi: 10.1021/acs.biochem.8b00542. Epub 2018 Jul 27.


Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.

Thapa D, Stoner MW, Zhang M, Xie B, Manning JR, Guimaraes D, Shiva S, Jurczak MJ, Scott I.

Redox Biol. 2018 Sep;18:25-32. doi: 10.1016/j.redox.2018.06.003. Epub 2018 Jun 9.


The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF.

JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172/jci.insight.97470. eCollection 2018 Apr 5.


Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change.

Ioja S, Singamsetty S, Corey C, Guo L, Shah F, Jurczak MJ, McVerry BJ, Shiva S, O'Donnell CP.

Oxid Med Cell Longev. 2018 Feb 4;2018:9649608. doi: 10.1155/2018/9649608. eCollection 2018.


An efficient modified method for plant leaf lipid extraction results in improved recovery of phosphatidic acid.

Shiva S, Enninful R, Roth MR, Tamura P, Jagadish K, Welti R.

Plant Methods. 2018 Feb 13;14:14. doi: 10.1186/s13007-018-0282-y. eCollection 2018.


Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

Shimizu Y, Polavarapu R, Eskla KL, Nicholson CK, Koczor CA, Wang R, Lewis W, Shiva S, Lefer DJ, Calvert JW.

J Mol Cell Cardiol. 2018 Mar;116:29-40. doi: 10.1016/j.yjmcc.2018.01.011. Epub 2018 Feb 3.


Bone Mineral Density and Bone Metabolism in Patients with Duchenne Muscular Dystrophy.

Barzegar M, Niknam E, Habibi P, Shiva S, Tahmasebi S.

Iran J Child Neurol. 2018 Winter;12(1):77-83.


Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.

Thomas DD, Corey C, Hickok J, Wang Y, Shiva S.

Redox Biol. 2018 May;15:277-283. doi: 10.1016/j.redox.2017.12.007. Epub 2017 Dec 23.


Comparative Transcriptome and Lipidome Analyses Reveal Molecular Chilling Responses in Chilling-Tolerant Sorghums.

Marla SR, Shiva S, Welti R, Liu S, Burke JJ, Morris GP.

Plant Genome. 2017 Nov;10(3). doi: 10.3835/plantgenome2017.03.0025.


IPF lung fibroblasts have a senescent phenotype.

Álvarez D, Cárdenes N, Sellarés J, Bueno M, Corey C, Hanumanthu VS, Peng Y, D'Cunha H, Sembrat J, Nouraie M, Shanker S, Caufield C, Shiva S, Armanios M, Mora AL, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1164-L1173. doi: 10.1152/ajplung.00220.2017. Epub 2017 Aug 31.


Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease.

Milanese C, Tapias V, Gabriels S, Cerri S, Levandis G, Blandini F, Tresini M, Shiva S, Greenamyre JT, Gladwin MT, Mastroberardino PG.

Antioxid Redox Signal. 2018 Jan 1;28(1):44-61. doi: 10.1089/ars.2017.6992. Epub 2017 Sep 21.


Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT.

Hypertension. 2017 Sep;70(3):634-644. doi: 10.1161/HYPERTENSIONAHA.117.09016.


Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, O'Doherty RM, Shiva S, Scott I.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H265-H274. doi: 10.1152/ajpheart.00752.2016. Epub 2017 May 19.


Reply: Carbon Monoxide Exposure in Workplaces, Including Coffee Processing Facilities.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1081-1082. doi: 10.1164/rccm.201704-0773LE. No abstract available.


Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction.

Tohme S, Yazdani HO, Liu Y, Loughran P, van der Windt DJ, Huang H, Simmons RL, Shiva S, Tai S, Tsung A.

Hepatology. 2017 Jul;66(1):182-197. doi: 10.1002/hep.29184. Epub 2017 May 22.


Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough?

Dezfulian C, Taft M, Corey C, Hill G, Krehel N, Rittenberger JC, Guyette FX, Shiva S.

Redox Biol. 2017 Aug;12:491-498. doi: 10.1016/j.redox.2017.03.010. Epub 2017 Mar 18.


Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity.

Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S.

JCI Insight. 2017 Mar 9;2(5):e91415. doi: 10.1172/jci.insight.91415.


Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):694-695. doi: 10.1164/rccm.201612-2463LE. No abstract available.


Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT.

Sci Transl Med. 2016 Dec 7;8(368):368ra173.


An In-vitro Comparative Study of Shear Bond Strength of Composite Resin to Bleached Enamel using three Herbal Antioxidants.

Mukka PK, Komineni NK, Pola S, Soujanya E, Karne AR, Nenavath B, Shiva S, Vuppunuthula P.

J Clin Diagn Res. 2016 Oct;10(10):ZC89-ZC92. Epub 2016 Oct 1.


The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.

Ramani K, Garg AV, Jawale CV, Conti HR, Whibley N, Jackson EK, Shiva SS, Horne W, Kolls JK, Gaffen SL, Biswas PS.

PLoS Pathog. 2016 Nov 4;12(11):e1005952. doi: 10.1371/journal.ppat.1005952. eCollection 2016 Nov.


Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):596-606. doi: 10.1164/rccm.201606-1275CI. Review. Erratum in: Am J Respir Crit Care Med. 2017 Aug 1;196 (3):398-399.


Caveolin-1 controls mitochondrial function through regulation of m-AAA mitochondrial protease.

Volonte D, Liu Z, Shiva S, Galbiati F.

Aging (Albany NY). 2016 Oct 4;8(10):2355-2369. doi: 10.18632/aging.101051.


AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC.

J Proteome Res. 2016 Oct 7;15(10):3883-3895. Epub 2016 Sep 27.


Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.

Kumar A, Corey C, Scott I, Shiva S, D'Cunha J.

PLoS One. 2016 Aug 8;11(8):e0160783. doi: 10.1371/journal.pone.0160783. eCollection 2016.


Regional Disruptions in Endothelial Nitric Oxide Pathway Associated With Bicuspid Aortic Valve.

Kotlarczyk MP, Billaud M, Green BR, Hill JC, Shiva S, Kelley EE, Phillippi JA, Gleason TG.

Ann Thorac Surg. 2016 Oct;102(4):1274-81. doi: 10.1016/j.athoracsur.2016.04.001. Epub 2016 Jun 7.


Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.

Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A.

Cell Rep. 2016 May 24;15(8):1700-14. doi: 10.1016/j.celrep.2016.04.060. Epub 2016 May 12.


Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.

Sehrawat A, Kim SH, Hahm ER, Arlotti JA, Eiseman J, Shiva SS, Rigatti LH, Singh SV.

Mol Carcinog. 2017 Feb;56(2):337-348. doi: 10.1002/mc.22497. Epub 2016 May 5.


Electrophysiologic pattern and prevalence of subclinical peripheral neuropathy in children and adolescents with type I diabetes mellitus in Iran.

Toopchizadeh V, Shiva S, Khiabani NY, Ghergherechi R.

Saudi Med J. 2016 Mar;37(3):299-303. doi: 10.15537/smj.2016.3.13625.


LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.

Zou C, Synan MJ, Li J, Xiong S, Manni ML, Liu Y, Chen BB, Zhao Y, Shiva S, Tyurina YY, Jiang J, Lee JS, Das S, Ray A, Ray P, Kagan VE, Mallampalli RK.

J Cell Sci. 2016 Jan 1;129(1):51-64. doi: 10.1242/jcs.176701. Epub 2015 Nov 24.

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