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Items: 1 to 50 of 80

1.

Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study.

Niu X, Amendola LM, Hart R, Bennette CS, Heagerty P, Horike-Pyne M, Trinidad SB, Rosenthal EA, Comstock B, Nefcy C, Hisama FM, Bennett RL, Grady WM, Gallego CJ, Tarczy-Hornoch P, Fullerton SM, Burke W, Regier DA, Dorschner MO, Shirts BH, Robertson PD, Nickerson DA, Patrick DL, Jarvik GP, Veenstra DL.

Contemp Clin Trials. 2019 Sep;84:105820. doi: 10.1016/j.cct.2019.105820. Epub 2019 Aug 7.

PMID:
31400517
2.

Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests.

Amendola LM, Hart MR, Bennett RL, Horike-Pyne M, Dorschner M, Shirts B, Jarvik GP.

J Genet Couns. 2019 Jul 17. doi: 10.1002/jgc4.1155. [Epub ahead of print]

PMID:
31317629
3.

Exploring the effect of ascertainment bias on genetic studies that use clinical pedigrees.

Ranola JMO, Tsai GJ, Shirts BH.

Eur J Hum Genet. 2019 Jul 11. doi: 10.1038/s41431-019-0467-5. [Epub ahead of print]

PMID:
31296927
4.

Comparison of CDH1 Penetrance Estimates in Clinically Ascertained Families vs Families Ascertained for Multiple Gastric Cancers.

Roberts ME, Ranola JMO, Marshall ML, Susswein LR, Graceffo S, Bohnert K, Tsai G, Klein RT, Hruska KS, Shirts BH.

JAMA Oncol. 2019 Jun 27. doi: 10.1001/jamaoncol.2019.1208. [Epub ahead of print]

PMID:
31246251
5.

Patient goals, motivations, and attitudes in a patient-driven variant reclassification study.

Tsai GJ, Garrett LT, Makhnoon S, Bowen DJ, Burke W, Shirts BH.

J Genet Couns. 2019 Jun;28(3):558-569. doi: 10.1002/jgc4.1052. Epub 2018 Dec 31.

PMID:
31163102
6.

Incorporating user feedback in the design of a genetics analysis tool: A two-part approach.

Swaminathan A, Shirts BH, Chen AT.

J Biomed Inform. 2019 Jul;95:103204. doi: 10.1016/j.jbi.2019.103204. Epub 2019 May 7.

PMID:
31075532
7.

Technical, Biological, and Systems Barriers for Molecular Clinical Decision Support.

Krumm N, Shirts BH.

Clin Lab Med. 2019 Jun;39(2):281-294. doi: 10.1016/j.cll.2019.01.007. Epub 2019 Mar 28. Review.

PMID:
31036281
8.

Patients' perspectives of variants of uncertain significance and strategies for uncertainty management.

Makhnoon S, Shirts BH, Bowen DJ.

J Genet Couns. 2019 Apr;28(2):313-325. doi: 10.1002/jgc4.1075. Epub 2019 Jan 12.

PMID:
30636062
9.

Outcomes of 92 patient-driven family studies for reclassification of variants of uncertain significance.

Tsai GJ, Rañola JMO, Smith C, Garrett LT, Bergquist T, Casadei S, Bowen DJ, Shirts BH.

Genet Med. 2019 Jun;21(6):1435-1442. doi: 10.1038/s41436-018-0335-7. Epub 2018 Oct 30.

PMID:
30374176
10.

Scaling resolution of variant classification differences in ClinVar between 41 clinical laboratories through an outlier approach.

Harrison SM, Dolinksy JS, Chen W, Collins CD, Das S, Deignan JL, Garber KB, Garcia J, Jarinova O, Knight Johnson AE, Koskenvuo JW, Lee H, Mao R, Mar-Heyming R, McFaddin AS, Moyer K, Nagan N, Rentas S, Santani AB, Seppälä EH, Shirts BH, Tidwell T, Topper S, Vincent LM, Vinette K, Rehm HL; ClinGen Sequence Variant Inter-Laboratory Discrepancy Resolution Working Group.

Hum Mutat. 2018 Nov;39(11):1641-1649. doi: 10.1002/humu.23643.

PMID:
30311378
11.

Rare loss of function variants in candidate genes and risk of colorectal cancer.

Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, Nassir R, Vickers KT, Li C, Grady WM, Peters U, Jarvik GP; NHLBI GO Exome Sequencing Project.

Hum Genet. 2018 Oct;137(10):795-806. doi: 10.1007/s00439-018-1938-4. Epub 2018 Sep 28.

PMID:
30267214
12.

Experiences of patients seeking to participate in variant of uncertain significance reclassification research.

Makhnoon S, Garrett LT, Burke W, Bowen DJ, Shirts BH.

J Community Genet. 2019 Apr;10(2):189-196. doi: 10.1007/s12687-018-0375-3. Epub 2018 Jul 19.

13.

Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio.

Ranola JMO, Pearlman R, Hampel H, Shirts BH.

Fam Cancer. 2019 Jan;18(1):67-73. doi: 10.1007/s10689-018-0096-0.

PMID:
30019097
14.

Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes.

Shirts BH, Konnick EQ, Upham S, Walsh T, Ranola JMO, Jacobson AL, King MC, Pearlman R, Hampel H, Pritchard CC.

Am J Hum Genet. 2018 Jul 5;103(1):19-29. doi: 10.1016/j.ajhg.2018.05.001. Epub 2018 Jun 7.

15.

Efficient Detection of Copy Number Mutations in PMS2 Exons with a Close Homolog.

Herman DS, Smith C, Liu C, Vaughn CP, Palaniappan S, Pritchard CC, Shirts BH.

J Mol Diagn. 2018 Jul;20(4):512-521. doi: 10.1016/j.jmoldx.2018.03.010. Epub 2018 May 22.

16.

Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.

Hampel H, Pearlman R, Beightol M, Zhao W, Jones D, Frankel WL, Goodfellow PJ, Yilmaz A, Miller K, Bacher J, Jacobson A, Paskett E, Shields PG, Goldberg RM, de la Chapelle A, Shirts BH, Pritchard CC; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2018 Jun 1;4(6):806-813. doi: 10.1001/jamaoncol.2018.0104. Erratum in: JAMA Oncol. 2018 Jun 1;4(6):891.

17.

Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski P, Leiserson MDM, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U.

Cancer Discov. 2018 Jun;8(6):730-749. doi: 10.1158/2159-8290.CD-17-1327. Epub 2018 Mar 6.

18.

Hereditary cancer gene panel test reports: wide heterogeneity suggests need for standardization.

Makhnoon S, Shirts BH, Bowen DJ, Fullerton SM.

Genet Med. 2018 Nov;20(11):1438-1445. doi: 10.1038/gim.2018.23. Epub 2018 Mar 1.

PMID:
29493582
19.

Knowledge for Precision Medicine: Mechanistic Reasoning and Methodological Pluralism.

Tonelli MR, Shirts BH.

JAMA. 2017 Nov 7;318(17):1649-1650. doi: 10.1001/jama.2017.11914. No abstract available.

PMID:
29052713
20.

A comparison of cosegregation analysis methods for the clinical setting.

Rañola JMO, Liu Q, Rosenthal EA, Shirts BH.

Fam Cancer. 2018 Apr;17(2):295-302. doi: 10.1007/s10689-017-0017-7.

21.

Power of pedigree likelihood analysis in extended pedigrees to classify rare variants of uncertain significance in cancer risk genes.

Rosenthal EA, Ranola JMO, Shirts BH.

Fam Cancer. 2017 Oct;16(4):611-620. doi: 10.1007/s10689-017-9989-6.

22.

Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance.

Lieberman S, Walsh T, Schechter M, Adar T, Goldin E, Beeri R, Sharon N, Baris H, Ben Avi L, Half E, Lerer I, Shirts BH, Pritchard CC, Tomlinson I, King MC, Levy-Lahad E, Peretz T, Goldberg Y.

Gastroenterology. 2017 Jun;152(8):1876-1880.e1. doi: 10.1053/j.gastro.2017.02.014. Epub 2017 Feb 24.

PMID:
28242209
23.

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.

Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, Bacher J, Bigley C, Nelsen L, Goodfellow PJ, Goldberg RM, Paskett E, Shields PG, Freudenheim JL, Stanich PP, Lattimer I, Arnold M, Liyanarachchi S, Kalady M, Heald B, Greenwood C, Paquette I, Prues M, Draper DJ, Lindeman C, Kuebler JP, Reynolds K, Brell JM, Shaper AA, Mahesh S, Buie N, Weeman K, Shine K, Haut M, Edwards J, Bastola S, Wickham K, Khanduja KS, Zacks R, Pritchard CC, Shirts BH, Jacobson A, Allen B, de la Chapelle A, Hampel H; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2017 Apr 1;3(4):464-471. doi: 10.1001/jamaoncol.2016.5194.

24.

A survey of current practices for genomic sequencing test interpretation and reporting processes in US laboratories.

O'Daniel JM, McLaughlin HM, Amendola LM, Bale SJ, Berg JS, Bick D, Bowling KM, Chao EC, Chung WK, Conlin LK, Cooper GM, Das S, Deignan JL, Dorschner MO, Evans JP, Ghazani AA, Goddard KA, Gornick M, Farwell Hagman KD, Hambuch T, Hegde M, Hindorff LA, Holm IA, Jarvik GP, Knight Johnson A, Mighion L, Morra M, Plon SE, Punj S, Richards CS, Santani A, Shirts BH, Spinner NB, Tang S, Weck KE, Wolf SM, Yang Y, Rehm HL.

Genet Med. 2017 May;19(5):575-582. doi: 10.1038/gim.2016.152. Epub 2016 Nov 3.

25.

Family-Specific Variants and the Limits of Human Genetics.

Shirts BH, Pritchard CC, Walsh T.

Trends Mol Med. 2016 Nov;22(11):925-934. doi: 10.1016/j.molmed.2016.09.007. Epub 2016 Oct 11. Review.

26.

Practical considerations for implementing genomic information resources. Experiences from eMERGE and CSER.

Rasmussen LV, Overby CL, Connolly J, Chute CG, Denny JC, Freimuth R, Hartzler AL, Holm IA, Manzi S, Pathak J, Peissig PL, Smith M, Williams MS, Shirts BH, Stoffel EM, Tarczy-Hornoch P, Rohrer Vitek CR, Wolf WA, Starren J.

Appl Clin Inform. 2016 Sep 21;7(3):870-82. doi: 10.4338/ACI-2016-04-RA-0060.

27.

Modeling the costs of clinical decision support for genomic precision medicine.

Mathias PC, Tarczy-Hornoch P, Shirts BH.

AMIA Jt Summits Transl Sci Proc. 2016 Jul 20;2016:60-4. eCollection 2016.

28.

Family Studies for Classification of Variants of Uncertain Classification: Current Laboratory Clinical Practice and a New Web-Based Educational Tool.

Garrett LT, Hickman N, Jacobson A, Bennett RL, Amendola LM, Rosenthal EA, Shirts BH.

J Genet Couns. 2016 Dec;25(6):1146-1156. Epub 2016 Jul 16.

29.

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.

Green RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium.

Am J Hum Genet. 2016 Jul 7;99(1):246. doi: 10.1016/j.ajhg.2016.06.002. No abstract available.

30.

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.

Green RC, Goddard KAB, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium.

Am J Hum Genet. 2016 Jun 2;98(6):1051-1066. doi: 10.1016/j.ajhg.2016.04.011. Epub 2016 May 12. Erratum in: Am J Hum Genet. 2016 Jul 7;99(1):246.

31.

CADD score has limited clinical validity for the identification of pathogenic variants in noncoding regions in a hereditary cancer panel.

Mather CA, Mooney SD, Salipante SJ, Scroggins S, Wu D, Pritchard CC, Shirts BH.

Genet Med. 2016 Dec;18(12):1269-1275. doi: 10.1038/gim.2016.44. Epub 2016 May 5.

32.

Applying Ancestry and Sex Computation as a Quality Control Tool in Targeted Next-Generation Sequencing.

Mathias PC, Turner EH, Scroggins SM, Salipante SJ, Hoffman NG, Pritchard CC, Shirts BH.

Am J Clin Pathol. 2016 Mar;145(3):308-15. doi: 10.1093/ajcp/aqv098. Epub 2016 Feb 20.

PMID:
27124912
33.

Improving performance of multigene panels for genomic analysis of cancer predisposition.

Shirts BH, Casadei S, Jacobson AL, Lee MK, Gulsuner S, Bennett RL, Miller M, Hall SA, Hampel H, Hisama FM, Naylor LV, Goetsch C, Leppig K, Tait JF, Scroggins SM, Turner EH, Livingston R, Salipante SJ, King MC, Walsh T, Pritchard CC.

Genet Med. 2016 Oct;18(10):974-81. doi: 10.1038/gim.2015.212. Epub 2016 Feb 4.

PMID:
26845104
34.

The genomic CDS sandbox: An assessment among domain experts.

Aziz A, Kawamoto K, Eilbeck K, Williams MS, Freimuth RR, Hoffman MA, Rasmussen LV, Overby CL, Shirts BH, Hoffman JM, Welch BM.

J Biomed Inform. 2016 Apr;60:84-94. doi: 10.1016/j.jbi.2015.12.019. Epub 2016 Jan 15.

35.

Physician perspectives of CYP2C19 and clopidogrel drug-gene interaction active clinical decision support alerts.

Nishimura AA, Shirts BH, Salama J, Smith JW, Devine B, Tarczy-Hornoch P.

Int J Med Inform. 2016 Feb;86:117-25. doi: 10.1016/j.ijmedinf.2015.11.004. Epub 2015 Nov 11.

36.

Next Generation Sequencing in the Clinic: a Patterns of Care Study in a Retrospective Cohort of Subjects Referred to a Genetic Medicine Clinic for Suspected Lynch Syndrome.

Gallego CJ, Perez ML, Burt A, Amendola LM, Shirts BH, Pritchard CC, Hisama FM, Bennett RL, Veenstra DL, Jarvik GP.

J Genet Couns. 2016 Jun;25(3):515-9. doi: 10.1007/s10897-015-9902-0. Epub 2015 Dec 5.

PMID:
26637299
37.

Pragmatic and Ethical Challenges of Incorporating the Genome into the Electronic Medical Record.

Nishimura AA, Tarczy-Hornoch P, Shirts BH.

Curr Genet Med Rep. 2014 Dec 1;2(4):201-211.

38.

CSER and eMERGE: current and potential state of the display of genetic information in the electronic health record.

Shirts BH, Salama JS, Aronson SJ, Chung WK, Gray SW, Hindorff LA, Jarvik GP, Plon SE, Stoffel EM, Tarczy-Hornoch PZ, Van Allen EM, Weck KE, Chute CG, Freimuth RR, Grundmeier RW, Hartzler AL, Li R, Peissig PL, Peterson JF, Rasmussen LV, Starren JB, Williams MS, Overby CL.

J Am Med Inform Assoc. 2015 Nov;22(6):1231-42. doi: 10.1093/jamia/ocv065. Epub 2015 Jul 3.

39.

Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis Syndromes: A Cost-Effectiveness Analysis.

Gallego CJ, Shirts BH, Bennette CS, Guzauskas G, Amendola LM, Horike-Pyne M, Hisama FM, Pritchard CC, Grady WM, Burke W, Jarvik GP, Veenstra DL.

J Clin Oncol. 2015 Jun 20;33(18):2084-91. doi: 10.1200/JCO.2014.59.3665. Epub 2015 May 4.

40.

A bayesian approach to laboratory utilization management.

Hauser RG, Jackson BR, Shirts BH.

J Pathol Inform. 2015 Feb 24;6:10. doi: 10.4103/2153-3539.151921. eCollection 2015.

41.

Clinical laboratory analytics: Challenges and promise for an emerging discipline.

Shirts BH, Jackson BR, Baird GS, Baron JM, Clements B, Grisson R, Hauser RG, Taylor JR, Terrazas E, Brimhall B.

J Pathol Inform. 2015 Feb 24;6:9. doi: 10.4103/2153-3539.151919. eCollection 2015.

42.

Development of clinical decision support alerts for pharmacogenomic incidental findings from exome sequencing.

Nishimura AA, Shirts BH, Dorschner MO, Amendola LM, Smith JW, Jarvik GP, Tarczy-Hornoch P.

Genet Med. 2015 Nov;17(11):939-42. doi: 10.1038/gim.2015.5. Epub 2015 Mar 5.

43.

Actionable exomic incidental findings in 6503 participants: challenges of variant classification.

Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, Jarvik ER, Itsara A, Turner EH, Herman DS, Schleit J, Burt A, Jamal SM, Abrudan JL, Johnson AD, Conlin LK, Dulik MC, Santani A, Metterville DR, Kelly M, Foreman AK, Lee K, Taylor KD, Guo X, Crooks K, Kiedrowski LA, Raffel LJ, Gordon O, Machini K, Desnick RJ, Biesecker LG, Lubitz SA, Mulchandani S, Cooper GM, Joffe S, Richards CS, Yang Y, Rotter JI, Rich SS, O'Donnell CJ, Berg JS, Spinner NB, Evans JP, Fullerton SM, Leppig KA, Bennett RL, Bird T, Sybert VP, Grady WM, Tabor HK, Kim JH, Bamshad MJ, Wilfond B, Motulsky AG, Scott CR, Pritchard CC, Walsh TD, Burke W, Raskind WH, Byers P, Hisama FM, Rehm H, Nickerson DA, Jarvik GP.

Genome Res. 2015 Mar;25(3):305-15. doi: 10.1101/gr.183483.114. Epub 2015 Jan 30.

44.

Do we now know what inappropriate laboratory utilization is? An expanded systematic review of laboratory clinical audits.

Hauser RG, Shirts BH.

Am J Clin Pathol. 2014 Jun;141(6):774-83. doi: 10.1309/AJCPX1HIEM4KLGNU. Review.

PMID:
24838320
45.

Deep sequencing with intronic capture enables identification of an APC exon 10 inversion in a patient with polyposis.

Shirts BH, Salipante SJ, Casadei S, Ryan S, Martin J, Jacobson A, Vlaskin T, Koehler K, Livingston RJ, King MC, Walsh T, Pritchard CC.

Genet Med. 2014 Oct;16(10):783-6. doi: 10.1038/gim.2014.30. Epub 2014 Mar 27.

46.

The 2013 symposium on pathology data integration and clinical decision support and the current state of field.

Baron JM, Dighe AS, Arnaout R, Balis UJ, Black-Schaffer WS, Carter AB, Henricks WH, Higgins JM, Jackson BR, Kim J, Klepeis VE, Le LP, Louis DN, Mandelker D, Mermel CH, Michaelson JS, Nagarajan R, Platt ME, Quinn AM, Rao L, Shirts BH, Gilbertson JR.

J Pathol Inform. 2014 Jan 31;5(1):2. doi: 10.4103/2153-3539.126145. eCollection 2014.

47.

Refining the structure and content of clinical genomic reports.

Dorschner MO, Amendola LM, Shirts BH, Kiedrowski L, Salama J, Gordon AS, Fullerton SM, Tarczy-Hornoch P, Byers PH, Jarvik GP.

Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):85-92. doi: 10.1002/ajmg.c.31395. Epub 2014 Mar 10.

48.

Laboratory informatics based evaluation of methylene tetrahydrofolate reductase C677T genetic test overutilization.

Cohen DA, Shirts BH, Jackson BR, Parker LS.

J Pathol Inform. 2013 Nov 29;4:33. doi: 10.4103/2153-3539.122389. eCollection 2013.

49.

A Template for Authoring and Adapting Genomic Medicine Content in the eMERGE Infobutton Project.

Overby CL, Rasmussen LV, Hartzler A, Connolly JJ, Peterson JF, Hedberg RE, Freimuth RR, Shirts BH, Denny JC, Larson EB, Chute CG, Jarvik GP, Ralston JD, Shuldiner AR, Starren J, Kullo IJ, Tarczy-Hornoch P, Williams MS.

AMIA Annu Symp Proc. 2014 Nov 14;2014:944-53. eCollection 2014.

50.

Large numbers of individuals are required to classify and define risk for rare variants in known cancer risk genes.

Shirts BH, Jacobson A, Jarvik GP, Browning BL.

Genet Med. 2014 Jul;16(7):529-34. doi: 10.1038/gim.2013.187. Epub 2013 Dec 19.

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