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Items: 1 to 50 of 339

1.

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.

Shimizu K, Yamasaki S, Sakurai M, Yumoto N, Ikeda M, Mishima-Tsumagari C, Kukimoto-Niino M, Watanabe T, Kawamura M, Shirouzu M, Fujii SI.

Front Immunol. 2019 Jun 26;10:1450. doi: 10.3389/fimmu.2019.01450. eCollection 2019.

2.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.

Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O.

Nat Struct Mol Biol. 2019 Jun;26(6):510-517. doi: 10.1038/s41594-019-0237-7. Epub 2019 Jun 3.

PMID:
31160781
3.

HCV IRES Captures an Actively Translating 80S Ribosome.

Yokoyama T, Machida K, Iwasaki W, Shigeta T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Harada Y, Shigematsu H, Shirouzu M, Tadakuma H, Imataka H, Ito T.

Mol Cell. 2019 Jun 20;74(6):1205-1214.e8. doi: 10.1016/j.molcel.2019.04.022. Epub 2019 May 9.

PMID:
31080011
4.

Structural basis for eIF2B inhibition in integrated stress response.

Kashiwagi K, Yokoyama T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Shirouzu M, Ito T.

Science. 2019 May 3;364(6439):495-499. doi: 10.1126/science.aaw4104.

PMID:
31048492
5.

Biophysical characterization of heme binding to the intrinsically disordered region of Bach1.

Segawa K, Watanabe-Matsui M, Tsuda K, Matsui T, Shirouzu M, Igarashi K, Murayama K.

Eur Biophys J. 2019 May;48(4):361-369. doi: 10.1007/s00249-019-01364-5. Epub 2019 Apr 1.

PMID:
30937482
6.

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.

Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.

J Med Chem. 2019 Apr 11;62(7):3407-3427. doi: 10.1021/acs.jmedchem.8b01888. Epub 2019 Apr 1.

PMID:
30883102
7.

Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.

Kukimoto-Niino M, Tsuda K, Ihara K, Mishima-Tsumagari C, Honda K, Ohsawa N, Shirouzu M.

Structure. 2019 May 7;27(5):741-748.e3. doi: 10.1016/j.str.2019.02.001. Epub 2019 Mar 7.

PMID:
30853411
8.

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

Sekimata K, Sato T, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Honma T, Tanaka A, Shirouzu M, Yokoyama S, Miyazono K, Hashizume Y, Koyama H.

Chem Pharm Bull (Tokyo). 2019;67(3):224-235. doi: 10.1248/cpb.c18-00598.

9.

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.

Ehara H, Kujirai T, Fujino Y, Shirouzu M, Kurumizaka H, Sekine SI.

Science. 2019 Feb 15;363(6428):744-747. doi: 10.1126/science.aav8912. Epub 2019 Feb 7.

PMID:
30733384
10.

Metastable asymmetrical structure of a shaftless V1 motor.

Maruyama S, Suzuki K, Imamura M, Sasaki H, Matsunami H, Mizutani K, Saito Y, Imai FL, Ishizuka-Katsura Y, Kimura-Someya T, Shirouzu M, Uchihashi T, Ando T, Yamato I, Murata T.

Sci Adv. 2019 Jan 30;5(1):eaau8149. doi: 10.1126/sciadv.aau8149. eCollection 2019 Jan.

11.

Cell-Free Protein Synthesis Using S30 Extracts from Escherichia coli RFzero Strains for Efficient Incorporation of Non-Natural Amino Acids into Proteins.

Adachi J, Katsura K, Seki E, Takemoto C, Shirouzu M, Terada T, Mukai T, Sakamoto K, Yokoyama S.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E492. doi: 10.3390/ijms20030492.

12.

Development of a simple new flow cytometric antibody-dependent cellular cytotoxicity (ADCC) assay with excellent sensitivity.

Tanaka M, Ishige A, Yaguchi M, Matsumoto T, Shirouzu M, Yokoyama S, Ishikawa F, Kitabayashi I, Takemori T, Harada M.

J Immunol Methods. 2019 Jan;464:74-86. doi: 10.1016/j.jim.2018.10.014. Epub 2018 Oct 31.

PMID:
30389576
13.

Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.

Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N.

J Cell Biol. 2018 Dec 3;217(12):4164-4183. doi: 10.1083/jcb.201711178. Epub 2018 Oct 8.

14.

Structural basis of the nucleosome transition during RNA polymerase II passage.

Kujirai T, Ehara H, Fujino Y, Shirouzu M, Sekine SI, Kurumizaka H.

Science. 2018 Nov 2;362(6414):595-598. doi: 10.1126/science.aau9904. Epub 2018 Oct 4.

PMID:
30287617
15.

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs.

Shigematsu H, Imasaki T, Doki C, Sumi T, Aoki M, Uchikubo-Kamo T, Sakamoto A, Tokuraku K, Shirouzu M, Nitta R.

J Cell Biol. 2018 Dec 3;217(12):4155-4163. doi: 10.1083/jcb.201711182. Epub 2018 Oct 1.

16.

Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.

Ohbayashi N, Murayama K, Kato-Murayama M, Kukimoto-Niino M, Uejima T, Matsuda T, Ohsawa N, Yokoyoma S, Nojima H, Shirouzu M.

ChemistryOpen. 2018 Sep 10;7(9):721-727. doi: 10.1002/open.201800177. eCollection 2018 Sep.

17.

Cryo-EM structures of the human volume-regulated anion channel LRRC8.

Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O.

Nat Struct Mol Biol. 2018 Sep;25(9):797-804. doi: 10.1038/s41594-018-0109-6. Epub 2018 Aug 20.

PMID:
30127360
18.

Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.

Takaya D, Inaka K, Omura A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A.

Bioorg Med Chem. 2018 Sep 1;26(16):4726-4734. doi: 10.1016/j.bmc.2018.08.014. Epub 2018 Aug 11.

PMID:
30121213
19.

Ecto-F0/F1 ATPase as a novel candidate of prothymosin α receptor.

Ueda H, Matsunaga H, Matsushita Y, Maeda S, Iwamoto R, Yokoyama S, Shirouzu M.

Expert Opin Biol Ther. 2018 Jul;18(sup1):89-94. doi: 10.1080/14712598.2018.1454427.

PMID:
30063859
20.

Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.

Inouye S, Tomabechi Y, Hosoya T, Sekine SI, Shirouzu M.

J Biochem. 2018 Sep 1;164(3):247-255. doi: 10.1093/jb/mvy049.

PMID:
29796619
21.

Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.

Katsura K, Tomabechi Y, Matsuda T, Yonemochi M, Mikuni J, Ohsawa N, Terada T, Yokoyama S, Kukimoto-Niino M, Takemoto C, Shirouzu M.

Protein Expr Purif. 2018 Oct;150:92-99. doi: 10.1016/j.pep.2018.05.005. Epub 2018 May 21.

PMID:
29793032
22.

Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II.

Tamogami J, Kikukawa T, Ohkawa K, Ohsawa N, Nara T, Demura M, Miyauchi S, Kimura-Someya T, Shirouzu M, Yokoyama S, Shimono K, Kamo N.

J Photochem Photobiol B. 2018 Jun;183:35-45. doi: 10.1016/j.jphotobiol.2018.04.012. Epub 2018 Apr 11.

PMID:
29684719
23.

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.

Yamagata A, Miyazaki Y, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M, Fukai S.

Nat Commun. 2018 Apr 18;9(1):1546. doi: 10.1038/s41467-018-03947-w.

24.

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity.

Nishio K, Belle R, Katoh T, Kawamura A, Sengoku T, Hanada K, Ohsawa N, Shirouzu M, Yokoyama S, Suga H.

Chembiochem. 2018 May 4;19(9):979-985. doi: 10.1002/cbic.201800047. Epub 2018 Apr 17.

PMID:
29665240
25.

Structural Insights into the Altering Function of CRMP2 by Phosphorylation.

Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, Nitta R.

Cell Struct Funct. 2018;43(1):15-23. doi: 10.1247/csf.17025.

26.

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction.

Matsuda T, Ito T, Takemoto C, Katsura K, Ikeda M, Wakiyama M, Kukimoto-Niino M, Yokoyama S, Kurosawa Y, Shirouzu M.

PLoS One. 2018 Feb 20;13(2):e0193158. doi: 10.1371/journal.pone.0193158. eCollection 2018.

27.

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.

Koda Y, Kikuzato K, Mikuni J, Tanaka A, Yuki H, Honma T, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Shirai F, Koyama H.

Bioorg Med Chem Lett. 2017 Nov 15;27(22):4994-4998. doi: 10.1016/j.bmcl.2017.10.012. Epub 2017 Oct 7.

PMID:
29037944
28.

A reproducible and scalable procedure for preparing bacterial extracts for cell-free protein synthesis.

Katsura K, Matsuda T, Tomabechi Y, Yonemochi M, Hanada K, Ohsawa N, Sakamoto K, Takemoto C, Shirouzu M.

J Biochem. 2017 Nov 1;162(5):357-369. doi: 10.1093/jb/mvx039.

PMID:
28992119
29.

Structural basis for CRMP2-induced axonal microtubule formation.

Niwa S, Nakamura F, Tomabechi Y, Aoki M, Shigematsu H, Matsumoto T, Yamagata A, Fukai S, Hirokawa N, Goshima Y, Shirouzu M, Nitta R.

Sci Rep. 2017 Sep 6;7(1):10681. doi: 10.1038/s41598-017-11031-4.

30.

Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts.

Tokunaga Y, Shirouzu M, Sugahara R, Yoshiura Y, Kiryu I, Ototake M, Nagasawa T, Somamoto T, Nakao M.

Sci Rep. 2017 Aug 8;7(1):7536. doi: 10.1038/s41598-017-08000-2.

31.

Structure of the complete elongation complex of RNA polymerase II with basal factors.

Ehara H, Yokoyama T, Shigematsu H, Yokoyama S, Shirouzu M, Sekine SI.

Science. 2017 Sep 1;357(6354):921-924. doi: 10.1126/science.aan8552. Epub 2017 Aug 3.

PMID:
28775211
32.

Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.

Shoji S, Hanada K, Ohsawa N, Shirouzu M.

Biochem J. 2017 Sep 7;474(18):3207-3226. doi: 10.1042/BCJ20161104.

33.

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T.

Bioorg Med Chem. 2017 Aug 15;25(16):4259-4264. doi: 10.1016/j.bmc.2017.05.053. Epub 2017 Jun 16.

PMID:
28662963
34.

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.

Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S.

J Biol Chem. 2017 Aug 11;292(32):13428-13440. doi: 10.1074/jbc.M117.786509. Epub 2017 Jun 27.

35.

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1.

Hosaka T, Okazaki M, Kimura-Someya T, Ishizuka-Katsura Y, Ito K, Yokoyama S, Dodo K, Sodeoka M, Shirouzu M.

Protein Sci. 2017 Sep;26(9):1749-1758. doi: 10.1002/pro.3211. Epub 2017 Jun 21.

36.

Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a light-driven proton pump from a marine alga.

Tamogami J, Kikukawa T, Nara T, Demura M, Kimura-Someya T, Shirouzu M, Yokoyama S, Miyauchi S, Shimono K, Kamo N.

Biophys Physicobiol. 2017 Mar 1;14:49-55. doi: 10.2142/biophysico.14.0_49. eCollection 2017.

37.

Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G.

Iwakura N, Yokoyama T, Quaglia F, Mitsuoka K, Mio K, Shigematsu H, Shirouzu M, Kaji A, Kaji H.

PLoS One. 2017 May 24;12(5):e0177972. doi: 10.1371/journal.pone.0177972. eCollection 2017.

38.

Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.

Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S.

Mol Microbiol. 2017 May;104(4):677-689. doi: 10.1111/mmi.13658. Epub 2017 Mar 20.

39.

Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.

Kuwasako K, Nameki N, Tsuda K, Takahashi M, Sato A, Tochio N, Inoue M, Terada T, Kigawa T, Kobayashi N, Shirouzu M, Ito T, Sakamoto T, Wakamatsu K, Güntert P, Takahashi S, Yokoyama S, Muto Y.

Protein Sci. 2017 Feb;26(2):280-291. doi: 10.1002/pro.3080. Epub 2016 Nov 27.

40.

Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor.

Suzuki K, Mizutani K, Maruyama S, Shimono K, Imai FL, Muneyuki E, Kakinuma Y, Ishizuka-Katsura Y, Shirouzu M, Yokoyama S, Yamato I, Murata T.

Nat Commun. 2016 Oct 27;7:13235. doi: 10.1038/ncomms13235.

41.

SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity.

Muramatsu T, Takemoto C, Kim YT, Wang H, Nishii W, Terada T, Shirouzu M, Yokoyama S.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12997-13002. Epub 2016 Oct 31.

42.

Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region.

Suenaga T, Watanabe-Matsui M, Uejima T, Shima H, Matsui T, Ikeda-Saito M, Shirouzu M, Igarashi K, Murayama K.

J Biochem. 2016 Nov;160(5):291-298. Epub 2016 May 20.

PMID:
27206783
43.

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.

Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Podyma-Inoue KA, Rajapakshe AR, Watabe T, Shirouzu M, Hara-Yokoyama M.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):489-495. doi: 10.1016/j.bbrc.2016.09.093. Epub 2016 Sep 20.

PMID:
27663661
44.

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

Shinoda T, Shinya N, Ito K, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Yokoyama S, Shirouzu M.

Sci Rep. 2016 Sep 20;6:33632. doi: 10.1038/srep33632.

45.

Structural basis of cucumisin protease activity regulation by its propeptide.

Sotokawauchi A, Kato-Murayama M, Murayama K, Hosaka T, Maeda I, Onjo M, Ohsawa N, Kato DI, Arima K, Shirouzu M.

J Biochem. 2017 Jan;161(1):45-53. doi: 10.1093/jb/mvw053. Epub 2016 Sep 10.

PMID:
27616715
46.

TNIK inhibition abrogates colorectal cancer stemness.

Masuda M, Uno Y, Ohbayashi N, Ohata H, Mimata A, Kukimoto-Niino M, Moriyama H, Kashimoto S, Inoue T, Goto N, Okamoto K, Shirouzu M, Sawa M, Yamada T.

Nat Commun. 2016 Aug 26;7:12586. doi: 10.1038/ncomms12586.

47.

Cell-free methods to produce structurally intact mammalian membrane proteins.

Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S.

Sci Rep. 2016 Jul 28;6:30442. doi: 10.1038/srep30442.

48.

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility.

Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R.

Structure. 2016 Aug 2;24(8):1322-1334. doi: 10.1016/j.str.2016.05.021. Epub 2016 Jul 21.

49.

Structural Mechanism for Light-driven Transport by a New Type of Chloride Ion Pump, Nonlabens marinus Rhodopsin-3.

Hosaka T, Yoshizawa S, Nakajima Y, Ohsawa N, Hato M, DeLong EF, Kogure K, Yokoyama S, Kimura-Someya T, Iwasaki W, Shirouzu M.

J Biol Chem. 2016 Aug 19;291(34):17488-17495. doi: 10.1074/jbc.M116.728220. Epub 2016 Jun 30.

50.

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.

Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA.

Science. 2016 Jun 24;352(6293):1542-7. doi: 10.1126/science.aaf5023.

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