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Items: 1 to 50 of 328

1.

Development of a simple new flow cytometric antibody-dependent cellular cytotoxicity (ADCC) assay with excellent sensitivity.

Tanaka M, Ishige A, Yaguchi M, Matsumoto T, Shirouzu M, Yokoyama S, Ishikawa F, Kitabayashi I, Takemori T, Harada M.

J Immunol Methods. 2018 Oct 31. pii: S0022-1759(18)30276-X. doi: 10.1016/j.jim.2018.10.014. [Epub ahead of print]

PMID:
30389576
2.

Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.

Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N.

J Cell Biol. 2018 Dec 3;217(12):4164-4183. doi: 10.1083/jcb.201711178. Epub 2018 Oct 8.

PMID:
30297389
3.

Structural basis of the nucleosome transition during RNA polymerase II passage.

Kujirai T, Ehara H, Fujino Y, Shirouzu M, Sekine SI, Kurumizaka H.

Science. 2018 Nov 2;362(6414):595-598. doi: 10.1126/science.aau9904. Epub 2018 Oct 4.

PMID:
30287617
4.

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs.

Shigematsu H, Imasaki T, Doki C, Sumi T, Aoki M, Uchikubo-Kamo T, Sakamoto A, Tokuraku K, Shirouzu M, Nitta R.

J Cell Biol. 2018 Dec 3;217(12):4155-4163. doi: 10.1083/jcb.201711182. Epub 2018 Oct 1.

PMID:
30275105
5.

Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.

Ohbayashi N, Murayama K, Kato-Murayama M, Kukimoto-Niino M, Uejima T, Matsuda T, Ohsawa N, Yokoyoma S, Nojima H, Shirouzu M.

ChemistryOpen. 2018 Sep 10;7(9):721-727. doi: 10.1002/open.201800177. eCollection 2018 Sep.

6.

Cryo-EM structures of the human volume-regulated anion channel LRRC8.

Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O.

Nat Struct Mol Biol. 2018 Sep;25(9):797-804. doi: 10.1038/s41594-018-0109-6. Epub 2018 Aug 20.

PMID:
30127360
7.

Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.

Takaya D, Inaka K, Omura A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A.

Bioorg Med Chem. 2018 Sep 1;26(16):4726-4734. doi: 10.1016/j.bmc.2018.08.014. Epub 2018 Aug 11.

PMID:
30121213
8.

Ecto-F0/F1 ATPase as a novel candidate of prothymosin α receptor.

Ueda H, Matsunaga H, Matsushita Y, Maeda S, Iwamoto R, Yokoyama S, Shirouzu M.

Expert Opin Biol Ther. 2018 Jul;18(sup1):89-94. doi: 10.1080/14712598.2018.1454427.

PMID:
30063859
9.

Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.

Inouye S, Tomabechi Y, Hosoya T, Sekine SI, Shirouzu M.

J Biochem. 2018 Sep 1;164(3):247-255. doi: 10.1093/jb/mvy049.

PMID:
29796619
10.

Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.

Katsura K, Tomabechi Y, Matsuda T, Yonemochi M, Mikuni J, Ohsawa N, Terada T, Yokoyama S, Kukimoto-Niino M, Takemoto C, Shirouzu M.

Protein Expr Purif. 2018 Oct;150:92-99. doi: 10.1016/j.pep.2018.05.005. Epub 2018 May 21.

PMID:
29793032
11.

Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II.

Tamogami J, Kikukawa T, Ohkawa K, Ohsawa N, Nara T, Demura M, Miyauchi S, Kimura-Someya T, Shirouzu M, Yokoyama S, Shimono K, Kamo N.

J Photochem Photobiol B. 2018 Jun;183:35-45. doi: 10.1016/j.jphotobiol.2018.04.012. Epub 2018 Apr 11.

PMID:
29684719
12.

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.

Yamagata A, Miyazaki Y, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M, Fukai S.

Nat Commun. 2018 Apr 18;9(1):1546. doi: 10.1038/s41467-018-03947-w.

13.

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity.

Nishio K, Belle R, Katoh T, Kawamura A, Sengoku T, Hanada K, Ohsawa N, Shirouzu M, Yokoyama S, Suga H.

Chembiochem. 2018 May 4;19(9):979-985. doi: 10.1002/cbic.201800047. Epub 2018 Apr 17.

PMID:
29665240
14.

Structural Insights into the Altering Function of CRMP2 by Phosphorylation.

Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, Nitta R.

Cell Struct Funct. 2018;43(1):15-23. doi: 10.1247/csf.17025.

15.

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction.

Matsuda T, Ito T, Takemoto C, Katsura K, Ikeda M, Wakiyama M, Kukimoto-Niino M, Yokoyama S, Kurosawa Y, Shirouzu M.

PLoS One. 2018 Feb 20;13(2):e0193158. doi: 10.1371/journal.pone.0193158. eCollection 2018.

16.

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.

Koda Y, Kikuzato K, Mikuni J, Tanaka A, Yuki H, Honma T, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Shirai F, Koyama H.

Bioorg Med Chem Lett. 2017 Nov 15;27(22):4994-4998. doi: 10.1016/j.bmcl.2017.10.012. Epub 2017 Oct 7.

PMID:
29037944
17.

A reproducible and scalable procedure for preparing bacterial extracts for cell-free protein synthesis.

Katsura K, Matsuda T, Tomabechi Y, Yonemochi M, Hanada K, Ohsawa N, Sakamoto K, Takemoto C, Shirouzu M.

J Biochem. 2017 Nov 1;162(5):357-369. doi: 10.1093/jb/mvx039.

PMID:
28992119
18.

Structural basis for CRMP2-induced axonal microtubule formation.

Niwa S, Nakamura F, Tomabechi Y, Aoki M, Shigematsu H, Matsumoto T, Yamagata A, Fukai S, Hirokawa N, Goshima Y, Shirouzu M, Nitta R.

Sci Rep. 2017 Sep 6;7(1):10681. doi: 10.1038/s41598-017-11031-4.

19.

Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts.

Tokunaga Y, Shirouzu M, Sugahara R, Yoshiura Y, Kiryu I, Ototake M, Nagasawa T, Somamoto T, Nakao M.

Sci Rep. 2017 Aug 8;7(1):7536. doi: 10.1038/s41598-017-08000-2.

20.

Structure of the complete elongation complex of RNA polymerase II with basal factors.

Ehara H, Yokoyama T, Shigematsu H, Yokoyama S, Shirouzu M, Sekine SI.

Science. 2017 Sep 1;357(6354):921-924. doi: 10.1126/science.aan8552. Epub 2017 Aug 3.

PMID:
28775211
21.

Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.

Shoji S, Hanada K, Ohsawa N, Shirouzu M.

Biochem J. 2017 Sep 7;474(18):3207-3226. doi: 10.1042/BCJ20161104.

22.

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T.

Bioorg Med Chem. 2017 Aug 15;25(16):4259-4264. doi: 10.1016/j.bmc.2017.05.053. Epub 2017 Jun 16.

PMID:
28662963
23.

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.

Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S.

J Biol Chem. 2017 Aug 11;292(32):13428-13440. doi: 10.1074/jbc.M117.786509. Epub 2017 Jun 27.

24.

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1.

Hosaka T, Okazaki M, Kimura-Someya T, Ishizuka-Katsura Y, Ito K, Yokoyama S, Dodo K, Sodeoka M, Shirouzu M.

Protein Sci. 2017 Sep;26(9):1749-1758. doi: 10.1002/pro.3211. Epub 2017 Jun 21.

25.

Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a light-driven proton pump from a marine alga.

Tamogami J, Kikukawa T, Nara T, Demura M, Kimura-Someya T, Shirouzu M, Yokoyama S, Miyauchi S, Shimono K, Kamo N.

Biophys Physicobiol. 2017 Mar 1;14:49-55. doi: 10.2142/biophysico.14.0_49. eCollection 2017.

26.

Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G.

Iwakura N, Yokoyama T, Quaglia F, Mitsuoka K, Mio K, Shigematsu H, Shirouzu M, Kaji A, Kaji H.

PLoS One. 2017 May 24;12(5):e0177972. doi: 10.1371/journal.pone.0177972. eCollection 2017.

27.

Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.

Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S.

Mol Microbiol. 2017 May;104(4):677-689. doi: 10.1111/mmi.13658. Epub 2017 Mar 20.

28.

Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.

Kuwasako K, Nameki N, Tsuda K, Takahashi M, Sato A, Tochio N, Inoue M, Terada T, Kigawa T, Kobayashi N, Shirouzu M, Ito T, Sakamoto T, Wakamatsu K, Güntert P, Takahashi S, Yokoyama S, Muto Y.

Protein Sci. 2017 Feb;26(2):280-291. doi: 10.1002/pro.3080. Epub 2016 Nov 27.

29.

Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor.

Suzuki K, Mizutani K, Maruyama S, Shimono K, Imai FL, Muneyuki E, Kakinuma Y, Ishizuka-Katsura Y, Shirouzu M, Yokoyama S, Yamato I, Murata T.

Nat Commun. 2016 Oct 27;7:13235. doi: 10.1038/ncomms13235.

30.

SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity.

Muramatsu T, Takemoto C, Kim YT, Wang H, Nishii W, Terada T, Shirouzu M, Yokoyama S.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12997-13002. Epub 2016 Oct 31.

31.

Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region.

Suenaga T, Watanabe-Matsui M, Uejima T, Shima H, Matsui T, Ikeda-Saito M, Shirouzu M, Igarashi K, Murayama K.

J Biochem. 2016 Nov;160(5):291-298. Epub 2016 May 20.

PMID:
27206783
32.

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.

Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Podyma-Inoue KA, Rajapakshe AR, Watabe T, Shirouzu M, Hara-Yokoyama M.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):489-495. doi: 10.1016/j.bbrc.2016.09.093. Epub 2016 Sep 20.

PMID:
27663661
33.

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

Shinoda T, Shinya N, Ito K, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Yokoyama S, Shirouzu M.

Sci Rep. 2016 Sep 20;6:33632. doi: 10.1038/srep33632.

34.

Structural basis of cucumisin protease activity regulation by its propeptide.

Sotokawauchi A, Kato-Murayama M, Murayama K, Hosaka T, Maeda I, Onjo M, Ohsawa N, Kato DI, Arima K, Shirouzu M.

J Biochem. 2017 Jan;161(1):45-53. doi: 10.1093/jb/mvw053. Epub 2016 Sep 10.

PMID:
27616715
35.

TNIK inhibition abrogates colorectal cancer stemness.

Masuda M, Uno Y, Ohbayashi N, Ohata H, Mimata A, Kukimoto-Niino M, Moriyama H, Kashimoto S, Inoue T, Goto N, Okamoto K, Shirouzu M, Sawa M, Yamada T.

Nat Commun. 2016 Aug 26;7:12586. doi: 10.1038/ncomms12586.

36.

Cell-free methods to produce structurally intact mammalian membrane proteins.

Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S.

Sci Rep. 2016 Jul 28;6:30442. doi: 10.1038/srep30442.

37.

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility.

Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R.

Structure. 2016 Aug 2;24(8):1322-1334. doi: 10.1016/j.str.2016.05.021. Epub 2016 Jul 21.

38.

Structural Mechanism for Light-driven Transport by a New Type of Chloride Ion Pump, Nonlabens marinus Rhodopsin-3.

Hosaka T, Yoshizawa S, Nakajima Y, Ohsawa N, Hato M, DeLong EF, Kogure K, Yokoyama S, Kimura-Someya T, Iwasaki W, Shirouzu M.

J Biol Chem. 2016 Aug 19;291(34):17488-17495. doi: 10.1074/jbc.M116.728220. Epub 2016 Jun 30.

39.

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.

Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA.

Science. 2016 Jun 24;352(6293):1542-7. doi: 10.1126/science.aaf5023.

40.

Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits.

Shimizu H, Miyazaki H, Ohsawa N, Shoji S, Ishizuka-Katsura Y, Tosaki A, Oyama F, Terada T, Sakamoto K, Shirouzu M, Sekine S, Nukina N, Yokoyama S.

Sci Rep. 2016 May 24;6:26618. doi: 10.1038/srep26618.

41.

Binding interactions of the peripheral stalk subunit isoforms from human V-ATPase.

Rahman S, Yamato I, Saijo S, Mizutani K, Takamuku Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Murata T.

Biosci Biotechnol Biochem. 2016 May;80(5):878-90. doi: 10.1080/09168451.2015.1135043. Epub 2016 Feb 10.

PMID:
26865189
42.

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine.

Tomabechi Y, Hosoya T, Ehara H, Sekine SI, Shirouzu M, Inouye S.

Biochem Biophys Res Commun. 2016 Jan 29;470(1):88-93. doi: 10.1016/j.bbrc.2015.12.123. Epub 2015 Dec 30.

PMID:
26746005
43.

Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation.

Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S.

Sci Rep. 2015 Nov 26;5:17204. doi: 10.1038/srep17204.

44.

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA.

Nagano S, Seki E, Lin TY, Shirouzu M, Yokoyama S, Heddle JG.

PLoS One. 2015 Nov 13;10(11):e0142313. doi: 10.1371/journal.pone.0142313. eCollection 2015.

45.

Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum.

Furuse M, Tamogami J, Hosaka T, Kikukawa T, Shinya N, Hato M, Ohsawa N, Kim SY, Jung KH, Demura M, Miyauchi S, Kamo N, Shimono K, Kimura-Someya T, Yokoyama S, Shirouzu M.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2203-16. doi: 10.1107/S1399004715015722. Epub 2015 Oct 27.

PMID:
26527138
46.

Content of intrinsic disorder influences the outcome of cell-free protein synthesis.

Tokmakov AA, Kurotani A, Ikeda M, Terazawa Y, Shirouzu M, Stefanov V, Sakurai T, Yokoyama S.

Sci Rep. 2015 Sep 11;5:14079. doi: 10.1038/srep14079.

47.

A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.

Yoshida H, Park SY, Oda T, Akiyoshi T, Sato M, Shirouzu M, Tsuda K, Kuwasako K, Unzai S, Muto Y, Urano T, Obayashi E.

Genes Dev. 2015 Aug 1;29(15):1649-60. doi: 10.1101/gad.267104.115. Epub 2015 Jul 27.

48.

Protein stabilization utilizing a redefined codon.

Ohtake K, Yamaguchi A, Mukai T, Kashimura H, Hirano N, Haruki M, Kohashi S, Yamagishi K, Murayama K, Tomabechi Y, Itagaki T, Akasaka R, Kawazoe M, Takemoto C, Shirouzu M, Yokoyama S, Sakamoto K.

Sci Rep. 2015 May 18;5:9762. doi: 10.1038/srep09762.

49.

Crystal structures of the human adiponectin receptors.

Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S.

Nature. 2015 Apr 16;520(7547):312-316. doi: 10.1038/nature14301. Epub 2015 Apr 8.

50.

Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.

Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S.

J Struct Funct Genomics. 2015 Jun;16(2):55-65. doi: 10.1007/s10969-015-9196-3. Epub 2015 Mar 24.

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