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Items: 1 to 50 of 132

1.

Efficacy and Safety of Trastuzumab in Combination with S-1 and Cisplatin Therapy for Japanese Patients with HER2-Positive Advanced Gastric Cancer: Retrospective Analysis.

Okita A, Imai H, Takahashi M, Takahashi H, Umegaki S, Kawamura Y, Hiraide S, Ouchi K, Sato Y, Okada Y, Komine K, Saijo K, Takahashi S, Takahashi M, Shirota H, Ohori H, Gamoh M, Ishioka C.

Tohoku J Exp Med. 2018 Jun;245(2):123-129. doi: 10.1620/tjem.245.123.

2.

Femtosecond Raman-Induced Kerr Effect Study of Temperature-Dependent Intermolecular Dynamics in Molten Bis(trifluoromethylsulfonyl)amide Salts: Effects of Cation Species.

Kakinuma S, Shirota H.

J Phys Chem B. 2018 Jun 7;122(22):6033-6047. doi: 10.1021/acs.jpcb.8b03302. Epub 2018 May 25.

PMID:
29745663
3.

Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors.

Ouchi K, Takahashi S, Chikamatsu S, Ito S, Takahashi Y, Kawai S, Okita A, Kasahara Y, Okada Y, Imai H, Komine K, Saijo K, Takahashi M, Shirota H, Takahashi M, Gamoh M, Ishioka C.

Int J Clin Oncol. 2018 Aug;23(4):790-798. doi: 10.1007/s10147-018-1261-z. Epub 2018 Mar 7.

4.

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.

Nie Y, He J, Shirota H, Trivett AL, Yang, Klinman DM, Oppenheim JJ, Chen X.

Sci Signal. 2018 Jan 2;11(511). pii: eaan0790. doi: 10.1126/scisignal.aan0790.

PMID:
29295954
5.

Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models.

Ito K, Hamamichi S, Abe T, Akagi T, Shirota H, Kawano S, Asano M, Asano O, Yokoi A, Matsui J, Umeda IO, Fujii H.

Cancer Sci. 2017 Nov;108(11):2273-2280. doi: 10.1111/cas.13392. Epub 2017 Sep 22.

6.

IL-4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model.

Ito SE, Shirota H, Kasahara Y, Saijo K, Ishioka C.

Cancer Immunol Immunother. 2017 Nov;66(11):1485-1496. doi: 10.1007/s00262-017-2043-6. Epub 2017 Jul 21.

PMID:
28733709
7.

The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: A retrospective, single institutional study.

Takahashi M, Takahashi M, Komine K, Yamada H, Kasahara Y, Chikamatsu S, Okita A, Ito S, Ouchi K, Okada Y, Imai H, Saijo K, Shirota H, Takahashi S, Mori T, Shimodaira H, Ishioka C.

PLoS One. 2017 Jun 22;12(6):e0179694. doi: 10.1371/journal.pone.0179694. eCollection 2017.

8.

Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis.

Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.

PLoS One. 2017 May 10;12(5):e0176972. doi: 10.1371/journal.pone.0176972. eCollection 2017.

9.

Femtosecond Raman-Induced Kerr Effect Study of Temperature-Dependent Intermolecular Dynamics in Imidazolium-Based Ionic Liquids: Effects of Anion Species and Cation Alkyl Groups.

Kakinuma S, Ishida T, Shirota H.

J Phys Chem B. 2017 Jan 12;121(1):250-264. doi: 10.1021/acs.jpcb.6b11009. Epub 2017 Jan 3.

PMID:
27991793
10.

IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity.

Shirota H, Klinman DM, Ito SE, Ito H, Kubo M, Ishioka C.

Cancer Immunol Res. 2017 Jan;5(1):61-71. doi: 10.1158/2326-6066.CIR-16-0113. Epub 2016 Dec 5.

11.

Efficacy and Safety Assessment of Paclitaxel in Patients with Docetaxel-Resistant Esophageal Squamous Cell Carcinoma.

Imai H, Komine K, Takahashi S, Saijo K, Okada Y, Kobayashi A, Okita A, Chikamatsu S, Kasahara Y, Takahashi M, Oishi T, Shirota H, Takahashi M, Shimodaira H, Ishioka C.

Chemotherapy. 2016;61(5):262-8. doi: 10.1159/000444122. Epub 2016 Apr 5.

PMID:
27043795
12.

Attainment of a Long-term Favorable Outcome by Sunitinib Treatment for Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Associated with von Hippel-Lindau Disease.

Kobayashi A, Takahashi M, Imai H, Akiyama S, Sugiyama S, Komine K, Saijo K, Takahashi M, Takahashi S, Shirota H, Sato N, Fujishima F, Shuin T, Shimodaira H, Ishioka C.

Intern Med. 2016;55(6):629-34. doi: 10.2169/internalmedicine.55.5796. Epub 2016 Mar 15.

14.

Efficacy and Safety of Carboplatin and Etoposide Combination Chemotherapy for Extrapulmonary Neuroendocrine Carcinoma: A Retrospective Case Series.

Imai H, Shirota H, Okita A, Komine K, Saijo K, Takahashi M, Takahashi S, Takahashi M, Shimodaira H, Ishioka C.

Chemotherapy. 2016;61(3):111-6. doi: 10.1159/000441551. Epub 2015 Dec 5.

PMID:
26636658
15.

CpG Oligonucleotides as Cancer Vaccine Adjuvants.

Shirota H, Tross D, Klinman DM.

Vaccines (Basel). 2015 May 8;3(2):390-407. doi: 10.3390/vaccines3020390. Review.

16.
17.

Glass transition dynamics and conductivity scaling in ionic deep eutectic solvents: The case of (acetamide + lithium nitrate/sodium thiocyanate) melts.

Tripathy SN, Wojnarowska Z, Knapik J, Shirota H, Biswas R, Paluch M.

J Chem Phys. 2015 May 14;142(18):184504. doi: 10.1063/1.4919946.

PMID:
25978897
18.

[Rhabdomyolysis].

Shirota H, Ohishi T.

Nihon Rinsho. 2015 Feb;73 Suppl 2:499-502. Japanese. No abstract available.

PMID:
25831811
19.

Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.

Wang J, Shirota Y, Bayik D, Shirota H, Tross D, Gulley JL, Wood LV, Berzofsky JA, Klinman DM.

J Immunol. 2015 May 1;194(9):4215-21. doi: 10.4049/jimmunol.1402004. Epub 2015 Mar 30.

20.

Dynamic Kerr effect study on six-membered-ring molecular liquids: benzene, 1,3-cyclohexadiene, 1,4-cyclohexadiene, cyclohexene, and cyclohexane.

Kakinuma S, Shirota H.

J Phys Chem B. 2015 Apr 2;119(13):4713-24. doi: 10.1021/acs.jpcb.5b00460. Epub 2015 Mar 18.

PMID:
25741755
21.

Effects of Aromaticity in Cations and Their Functional Groups on the Low-Frequency Spectra and Physical Properties of Ionic Liquids.

Shirota H, Matsuzaki H, Ramati S, Wishart JF.

J Phys Chem B. 2015 Jul 23;119(29):9173-87. doi: 10.1021/jp509412z. Epub 2014 Dec 1.

PMID:
25389916
22.
23.

Simulated distribution and ecotoxicity-based assessment of chemically-dispersed oil in Tokyo Bay.

Koyama J, Imakado C, Uno S, Kuroda T, Hara S, Majima T, Shirota H, Añasco NC.

Mar Pollut Bull. 2014 Aug 30;85(2):487-93. doi: 10.1016/j.marpolbul.2014.04.001. Epub 2014 Apr 20.

PMID:
24759511
24.

TLR-9 agonist immunostimulatory sequence adjuvants linked to cancer antigens.

Shirota H, Klinman DM.

Methods Mol Biol. 2014;1139:337-44. doi: 10.1007/978-1-4939-0345-0_27.

PMID:
24619691
25.

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.

Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.

J Autoimmun. 2014 Sep;53:33-45. doi: 10.1016/j.jaut.2014.02.003. Epub 2014 Feb 28.

26.

[A case of rectal gastrointestinal stromal tumor in an elderly patient who was successfully treated with imatinib mesylate with no significant adverse events].

Gomi K, Mihara M, Abe M, Ikeda Y, Shimada K, Maruyama K, Kajikawa S, Shirota H.

Gan To Kagaku Ryoho. 2014 Jan;41(1):103-6. Japanese.

PMID:
24423962
27.

Recent progress concerning CpG DNA and its use as a vaccine adjuvant.

Shirota H, Klinman DM.

Expert Rev Vaccines. 2014 Feb;13(2):299-312. doi: 10.1586/14760584.2014.863715. Epub 2013 Nov 26. Review.

PMID:
24308579
28.

Solvent dependence of 7-azaindole dimerization.

Shirota H, Fukuda T, Kato T.

J Phys Chem B. 2013 Dec 19;117(50):16196-205. doi: 10.1021/jp408040s. Epub 2013 Dec 10.

PMID:
24191715
29.

Use of CpG oligonucleotides for cancer immunotherapy and their effect on immunity in the tumor microenvironment.

Shirota H, Klinman DM.

Immunotherapy. 2013 Aug;5(8):787-9. doi: 10.2217/imt.13.70. No abstract available.

PMID:
23902544
30.

β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.

Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.

J Immunol. 2013 Jul 15;191(2):865-74. doi: 10.4049/jimmunol.1201648. Epub 2013 Jun 17.

31.

Intermolecular/interionic vibrations of 1-methyl-3-n-octylimidazolium tetrafluoroborate ionic liquid and benzene mixtures.

Shirota H.

J Phys Chem B. 2013 Jul 3;117(26):7985-95. doi: 10.1021/jp402456g. Epub 2013 Jun 21.

PMID:
23742750
32.

Differences in Ion Interactions for Isoelectronic Ionic Liquid Homologs.

Lee HY, Shirota H, Castner EW Jr.

J Phys Chem Lett. 2013 May 2;4(9):1477-83. doi: 10.1021/jz400465x. Epub 2013 Apr 16.

PMID:
26282302
33.

Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2.

Kobayashi N, Hong C, Klinman DM, Shirota H.

J Immunol. 2013 Feb 15;190(4):1882-9. doi: 10.4049/jimmunol.1201063. Epub 2013 Jan 7.

34.

Dicationic versus monocationic ionic liquids: distinctive ionic dynamics and dynamical heterogeneity.

Ishida T, Shirota H.

J Phys Chem B. 2013 Jan 31;117(4):1136-50. doi: 10.1021/jp3110425. Epub 2013 Jan 15.

PMID:
23272700
35.

How does the ionic liquid organizational landscape change when nonpolar cationic alkyl groups are replaced by polar isoelectronic diethers?

Kashyap HK, Santos CS, Daly RP, Hettige JJ, Murthy NS, Shirota H, Castner EW Jr, Margulis CJ.

J Phys Chem B. 2013 Jan 31;117(4):1130-5. doi: 10.1021/jp311032p. Epub 2013 Jan 22.

PMID:
23259707
36.

Intermolecular/interionic vibrations of 1-methyl-3-n-octylimidazolium tetrafluoroborate ionic liquid and H2O mixtures.

Shirota H, Biswas R.

J Phys Chem B. 2012 Nov 26;116(46):13765-73. doi: 10.1021/jp307436t. Epub 2012 Nov 13.

PMID:
23148797
37.

Effect of CpG ODN on monocytic myeloid derived suppressor cells.

Shirota H, Klinman DM.

Oncoimmunology. 2012 Aug 1;1(5):780-782.

38.

Comparing intermediate range order for alkyl- vs. ether-substituted cations in ionic liquids.

Triolo A, Russina O, Caminiti R, Shirota H, Lee HY, Santos CS, Murthy NS, Castner EW Jr.

Chem Commun (Camb). 2012 May 21;48(41):4959-61. doi: 10.1039/c2cc31550e. Epub 2012 Apr 12.

PMID:
22499284
39.

Comparison of low-frequency spectra between aromatic and nonaromatic cation based ionic liquids using femtosecond Raman-induced Kerr effect spectroscopy.

Shirota H.

Chemphyschem. 2012 May 14;13(7):1638-48. doi: 10.1002/cphc.201100731. Epub 2012 Jan 17.

PMID:
22253145
40.

Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells.

Shirota Y, Shirota H, Klinman DM.

J Immunol. 2012 Feb 15;188(4):1592-9. doi: 10.4049/jimmunol.1101304. Epub 2012 Jan 9.

41.

Intermolecular vibrations and diffusive orientational dynamics of Cs condensed ring aromatic molecular liquids.

Shirota H.

J Phys Chem A. 2011 Dec 22;115(50):14262-75. doi: 10.1021/jp208389n. Epub 2011 Nov 23.

PMID:
22060730
42.

Low-frequency modes of the benzoic acid dimer in chloroform observed by the optical Kerr effect.

Yamaguchi S, Mazur K, Heisler IA, Shirota H, Tominaga K, Meech SR.

J Chem Phys. 2011 Oct 7;135(13):134504. doi: 10.1063/1.3635778.

PMID:
21992321
43.

Glass transition dynamics of room-temperature ionic liquid 1-methyl-3-trimethylsilylmethylimidazolium tetrafluoroborate.

Jarosz G, Mierzwa M, Zioło J, Paluch M, Shirota H, Ngai KL.

J Phys Chem B. 2011 Nov 10;115(44):12709-16. doi: 10.1021/jp207291k. Epub 2011 Oct 17.

PMID:
21950493
44.

Microscopic aspects in dicationic ionic liquids through the low-frequency spectra by femtosecond Raman-induced Kerr effect spectroscopy.

Shirota H, Ishida T.

J Phys Chem B. 2011 Sep 22;115(37):10860-70. doi: 10.1021/jp206266e. Epub 2011 Aug 30.

PMID:
21834594
45.

Intermolecular vibrational spectra of C3v CXY3 Molecular Liquids, CHCl3, CHBr3, CFBr3, and CBrCl3.

Shirota H, Kato T.

J Phys Chem A. 2011 Aug 18;115(32):8797-807. doi: 10.1021/jp203255u. Epub 2011 Jul 25.

PMID:
21749053
46.

Intermolecular vibrational modes and orientational dynamics of cooperative hydrogen-bonding dimer of 7-azaindole in solution.

Kato T, Shirota H.

J Chem Phys. 2011 Apr 28;134(16):164504. doi: 10.1063/1.3583642.

PMID:
21528970
47.

Ultrafast dynamics in 1-butyl-3-methylimidazolium-based ionic liquids: a femtosecond Raman-induced Kerr effect spectroscopic study.

Fukazawa H, Ishida T, Shirota H.

J Phys Chem B. 2011 Apr 28;115(16):4621-31. doi: 10.1021/jp200370f. Epub 2011 Apr 4.

PMID:
21506609
48.

CpG-conjugated apoptotic tumor cells elicit potent tumor-specific immunity.

Shirota H, Klinman DM.

Cancer Immunol Immunother. 2011 May;60(5):659-69. doi: 10.1007/s00262-011-0973-y. Epub 2011 Feb 4.

PMID:
21318638
49.

A novel role for IL-22R1 as a driver of inflammation.

Savan R, McFarland AP, Reynolds DA, Feigenbaum L, Ramakrishnan K, Karwan M, Shirota H, Klinman DM, Dunleavy K, Pittaluga S, Anderson SK, Donnelly RP, Wilson WH, Young HA.

Blood. 2011 Jan 13;117(2):575-84. doi: 10.1182/blood-2010-05-285908. Epub 2010 Oct 22.

50.

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