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Items: 11

1.

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.

Chambers RJ, Abrams K, Castleberry TA, Cheng JB, Fisher DA, Kamath AV, Marfat A, Nettleton DO, Pillar JD, Salter ED, Sheils AL, Shirley JT, Turner CR, Umland JP, Lam KT.

Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. Epub 2005 Nov 2.

PMID:
16263279
2.

Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.

Chambers RJ, Marfat A, Antognoli GW, Cheng JB, Damon DB, Kuperman AV, Liston TC, Mebus C, Pillar JS, Shirley JT, Watson JW.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2773-8.

PMID:
10509933
3.

Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

Chambers RJ, Antognoli GW, Cheng JB, Kuperman AV, Liston TC, Marfat A, Owens BS, Pillar JS, Shirley JT, Watson JW.

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3577-82.

PMID:
9934474
4.

N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.

Brown MF, Marfat A, Antognoli G, Chambers RJ, Cheng JB, Damon DB, Liston TE, McGlynn MA, O'Sullivan SP, Owens BS, Pillar JS, Shirley JT, Watson JW.

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2451-6.

PMID:
9873560
5.

Development of new chromanol antagonists of leukotriene D4.

Chambers RJ, Antognoli GW, Cheng JB, Marfat A, Pillar JS, Shirley JT, Watson JW.

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1791-6.

PMID:
9873435
6.

Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.

Kleinman EF, Campbell E, Giordano LA, Cohan VL, Jenkinson TH, Cheng JB, Shirley JT, Pettipher ER, Salter ED, Hibbs TA, DiCapua FM, Bordner J.

J Med Chem. 1998 Jan 29;41(3):266-70. No abstract available.

PMID:
9464356
7.

Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.

Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW.

J Med Chem. 1996 Jan 5;39(1):120-5.

PMID:
8568798
8.
10.

Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs.

Cheng JB, Pillar JS, Conklyn MJ, Breslow R, Shirley JT, Showell HJ.

J Pharmacol Exp Ther. 1990 Nov;255(2):664-71.

PMID:
2243346

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