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Items: 19


Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF.

J Clin Pharmacol. 2019 Nov 19. doi: 10.1002/jcph.1549. [Epub ahead of print]


Corrigendum to: The Use of Metabolomics to Identify Biological Signatures of Manganese Exposure.

Baker MG, Simpson CD, Lin YS, Shireman LM, Seixas N.

Ann Work Expo Health. 2019 Jul 1. pii: wxz034. doi: 10.1093/annweh/wxz034. [Epub ahead of print] No abstract available.


The reproducibility of urinary ions in manganese exposed workers.

Baker MG, Lin YS, Simpson CD, Shireman LM, Searles Nielsen S, Racette BA, Seixas N.

J Trace Elem Med Biol. 2019 Jan;51:204-211. doi: 10.1016/j.jtemb.2018.11.001. Epub 2018 Nov 3.


Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.

Perazzolo S, Shireman LM, Koehn J, McConnachie LA, Kraft JC, Shen DD, Ho RJY.

J Pharm Sci. 2018 Dec;107(12):3153-3162. doi: 10.1016/j.xphs.2018.07.032. Epub 2018 Aug 16.


Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine.

Wagner DJ, Shireman LM, Ahn S, Shen DD, Wang J.

Drug Metab Dispos. 2018 Sep;46(9):1277-1284. doi: 10.1124/dmd.118.082131. Epub 2018 Jun 18.


An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.

Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, O'Brien KD.

PLoS One. 2017 Dec 6;12(12):e0186459. doi: 10.1371/journal.pone.0186459. eCollection 2017.


Prediction of Intravenous Busulfan Clearance by Endogenous Plasma Biomarkers Using Global Pharmacometabolomics.

Lin YS, Kerr SJ, Randolph T, Shireman LM, Senn T, McCune JS.

Metabolomics. 2016 Oct;12(10). pii: 161. doi: 10.1007/s11306-016-1106-6. Epub 2016 Sep 15.


The Use of Metabolomics to Identify Biological Signatures of Manganese Exposure.

Baker MG, Simpson CD, Lin YS, Shireman LM, Seixas N.

Ann Work Expo Health. 2017 May 1;61(4):406-415. doi: 10.1093/annweh/wxw032.


P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine.

Liao MZ, Gao C, Shireman LM, Phillips B, Risler LJ, Neradugomma NK, Choudhari P, Prasad B, Shen DD, Mao Q.

Pharmacol Res. 2017 May;119:61-71. doi: 10.1016/j.phrs.2017.01.018. Epub 2017 Jan 19.


Pharmacodynamics of Ceftaroline plus Ampicillin against Enterococcus faecalis in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations.

Werth BJ, Shireman LM.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02235-16. doi: 10.1128/AAC.02235-16. Print 2017 Apr.


Pharmacometabonomic Prediction of Busulfan Clearance in Hematopoetic Cell Transplant Recipients.

Navarro SL, Randolph TW, Shireman LM, Raftery D, McCune JS.

J Proteome Res. 2016 Aug 5;15(8):2802-11. doi: 10.1021/acs.jproteome.6b00370. Epub 2016 Jul 20.


Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.

Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, Lin YS.

Drug Metab Dispos. 2016 Mar;44(3):343-51. doi: 10.1124/dmd.115.067900. Epub 2015 Dec 17. Review.


Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.

Tay-Sontheimer J, Shireman LM, Beyer RP, Senn T, Witten D, Pearce RE, Gaedigk A, Gana Fomban CL, Lutz JD, Isoherranen N, Thummel KE, Fiehn O, Leeder JS, Lin YS.

Pharmacogenomics. 2014 Dec;15(16):1947-62. doi: 10.2217/pgs.14.155. Erratum in: Pharmacogenomics. 2015 Jan;16(2):174. Pharmacogenomics. 2015 Jul;16(8):913.


Cloning, expression and analysis of the olfactory glutathione S-transferases in coho salmon.

Espinoza HM, Shireman LM, McClain V, Atkins W, Gallagher EP.

Biochem Pharmacol. 2013 Mar 15;85(6):839-48. doi: 10.1016/j.bcp.2012.11.018. Epub 2012 Dec 19.


Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal.

Shireman LM, Kripps KA, Balogh LM, Conner KP, Whittington D, Atkins WM.

Arch Biochem Biophys. 2010 Dec 15;504(2):182-9. doi: 10.1016/ Epub 2010 Sep 15.


Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.

Balogh LM, Le Trong I, Kripps KA, Shireman LM, Stenkamp RE, Zhang W, Mannervik B, Atkins WM.

Biochemistry. 2010 Feb 23;49(7):1541-8. doi: 10.1021/bi902038u.


The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases.

Balogh LM, Roberts AG, Shireman LM, Greene RJ, Atkins WM.

J Biol Chem. 2008 Jun 13;283(24):16702-10. doi: 10.1074/jbc.M801725200. Epub 2008 Apr 17.


Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases.

Hou L, Honaker MT, Shireman LM, Balogh LM, Roberts AG, Ng KC, Nath A, Atkins WM.

J Biol Chem. 2007 Aug 10;282(32):23264-74. Epub 2007 Jun 8.


NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity.

Roberts AG, DĂ­az MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP.

Biochemistry. 2006 Feb 14;45(6):1673-84.


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