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Items: 1 to 50 of 103

1.

Effect of Osmolality on the Pharmacokinetic Interaction Between Apple Juice and Atenolol in Rats.

Funai Y, Shirasaka Y, Ishihara M, Takemura M, Ichijo K, Kishimoto H, Inoue K.

Drug Metab Dispos. 2019 Jan 8. pii: dmd.118.084483. doi: 10.1124/dmd.118.084483. [Epub ahead of print]

PMID:
30622163
2.

Comprehensive Study on Enteric Viruses and Indicators in Surface Water in Kyoto, Japan, During 2014-2015 Season.

Hata A, Hanamoto S, Ihara M, Shirasaka Y, Yamashita N, Tanaka H.

Food Environ Virol. 2018 Dec;10(4):353-364. doi: 10.1007/s12560-018-9355-3. Epub 2018 Aug 27.

PMID:
30151619
3.

Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of d-luciferin.

Furuya T, Takehara I, Shimura A, Kishimoto H, Yasujima T, Ohta K, Shirasaka Y, Yuasa H, Inoue K.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2152-2157. doi: 10.1016/j.bbrc.2017.12.102. Epub 2017 Dec 20.

PMID:
29273507
4.

Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine.

Ichijo K, Oda R, Ishihara M, Okada R, Moteki Y, Funai Y, Horiuchi T, Kishimoto H, Shirasaka Y, Inoue K.

J Pharm Sci. 2017 Sep;106(9):2889-2894. doi: 10.1016/j.xphs.2017.04.030. Epub 2017 Apr 24.

PMID:
28450238
5.

Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions.

Jing J, Nelson C, Paik J, Shirasaka Y, Amory JK, Isoherranen N.

J Pharmacol Exp Ther. 2017 May;361(2):246-258. doi: 10.1124/jpet.117.240523. Epub 2017 Mar 8.

6.

Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse.

Shirasaka Y, Lee N, Duan H, Ho H, Pak J, Wang J.

J Chem Neuroanat. 2017 Oct;83-84:99-106. doi: 10.1016/j.jchemneu.2016.09.006. Epub 2016 Sep 15.

7.

Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice.

Shirasaka Y, Lee N, Zha W, Wagner D, Wang J.

Drug Metab Pharmacokinet. 2016 Oct;31(5):385-388. doi: 10.1016/j.dmpk.2016.04.005. Epub 2016 Apr 30.

8.

Facile preparation of N-doped TiO2 at ambient temperature and pressure under UV light with 4-nitrophenol as the nitrogen source and its photocatalytic activities.

Horikoshi S, Shirasaka Y, Uchida H, Horikoshi N, Serpone N.

Photochem Photobiol Sci. 2016 Aug 4;15(8):1061-70. doi: 10.1039/c6pp00167j. Epub 2016 Jul 22.

PMID:
27444263
9.

Quantitative Distribution of Infectious F-Specific RNA Phage Genotypes in Surface Waters.

Hata A, Hanamoto S, Shirasaka Y, Yamashita N, Tanaka H.

Appl Environ Microbiol. 2016 Jun 30;82(14):4244-4252. doi: 10.1128/AEM.00621-16. Print 2016 Jul 15.

10.

Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial.

Ohtsuka Y, Yoshinaga H, Shirasaka Y, Takayama R, Takano H, Iyoda K.

Epilepsy Res. 2016 Mar;121:1-7. doi: 10.1016/j.eplepsyres.2016.01.002. Epub 2016 Jan 12.

11.

Absorption-Enhancing Effect of Nitric Oxide on the Absorption of Hydrophobic Drugs in Rat Duodenum.

Kishimoto H, Miyazaki K, Takizawa Y, Shirasaka Y, Inoue K.

J Pharm Sci. 2016 Feb;105(2):729-733. doi: 10.1002/jps.24677. Epub 2016 Jan 11.

PMID:
26458075
12.

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.

Yin J, Duan H, Shirasaka Y, Prasad B, Wang J.

Drug Metab Dispos. 2015 Dec;43(12):1872-81. doi: 10.1124/dmd.115.066175. Epub 2015 Sep 15.

13.

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE.

Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1.

14.

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.

Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG.

Drug Metab Dispos. 2015 Aug;43(8):1226-35. doi: 10.1124/dmd.115.064428. Epub 2015 May 28.

15.

Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan.

Ohtsuka Y, Yoshinaga H, Shirasaka Y, Takayama R, Takano H, Iyoda K.

Epilepsy Res. 2014 Nov;108(9):1627-36. doi: 10.1016/j.eplepsyres.2014.08.019. Epub 2014 Sep 2.

16.

Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.

Shirasaka Y, Mori T, Murata Y, Nakanishi T, Tamai I.

Pharm Res. 2014 Aug;31(8):2035-43. doi: 10.1007/s11095-014-1305-7. Epub 2014 Feb 19.

PMID:
24549825
17.

MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.

Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, Itoh Y.

Cell Physiol Biochem. 2013;32(4):942-50. doi: 10.1159/000354497. Epub 2013 Oct 1.

18.

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I.

J Pharm Sci. 2013 Sep;102(9):3418-26. doi: 10.1002/jps.23653. Epub 2013 Jun 21.

PMID:
23794501
19.

Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.

Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD.

Drug Metab Dispos. 2013 Aug;41(8):1566-74. doi: 10.1124/dmd.112.049940. Epub 2013 May 30.

20.

A human Dravet syndrome model from patient induced pluripotent stem cells.

Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.

Mol Brain. 2013 May 2;6:19. doi: 10.1186/1756-6606-6-19.

21.

Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.

Shirasaka Y, Sager JE, Lutz JD, Davis C, Isoherranen N.

Drug Metab Dispos. 2013 Jul;41(7):1414-24. doi: 10.1124/dmd.113.051722. Epub 2013 Apr 25.

22.

A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS.

Shirasaka Y, Shichiri M, Kasai T, Ohno Y, Nakanishi T, Hayashi K, Nishiura A, Tamai I.

J Endocrinol. 2013 Apr 29;217(3):265-74. doi: 10.1530/JOE-12-0339. Print 2013 Jun.

PMID:
23528477
23.

Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.

Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, Tamai I.

Drug Metab Dispos. 2013 Mar;41(3):615-21. doi: 10.1124/dmd.112.049635. Epub 2012 Dec 21.

24.

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I.

J Pharm Sci. 2013 Jan;102(1):280-8. doi: 10.1002/jps.23357. Epub 2012 Nov 6.

PMID:
23132664
25.

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.

Arakawa H, Shirasaka Y, Haga M, Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2012 Sep;33(6):332-41. doi: 10.1002/bdd.1809. Epub 2012 Aug 30.

PMID:
22899169
26.

Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake.

Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Muraoka M, Nakatsuji Y, Kida T, Akashi M.

Mol Pharm. 2012 Apr 2;9(4):922-9. doi: 10.1021/mp300017e. Epub 2012 Mar 1.

PMID:
22352425
27.

Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.

Shirasaka Y, Mori T, Shichiri M, Nakanishi T, Tamai I.

Drug Metab Pharmacokinet. 2012;27(3):360-4. Epub 2011 Dec 27.

28.

Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.

Nakanishi T, Fukushi A, Sato M, Yoshifuji M, Gose T, Shirasaka Y, Ohe K, Kobayashi M, Kawai K, Tamai I.

Mol Pharm. 2011 Dec 5;8(6):2142-50. doi: 10.1021/mp200096r. Epub 2011 Oct 28.

PMID:
21999946
29.

Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.

Nakanishi T, Fukuyama Y, Fujita M, Shirasaka Y, Tamai I.

Drug Metab Pharmacokinet. 2011;26(6):632-6. Epub 2011 Oct 12.

30.

Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.

Shirasaka Y, Suzuki K, Nakanishi T, Tamai I.

J Pharm Sci. 2011 Sep;100(9):3843-53. doi: 10.1002/jps.22586. Epub 2011 Apr 24.

PMID:
21520088
31.

Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability.

Sugano K, Shirasaka Y, Yamashita S.

Int J Pharm. 2011 Oct 14;418(2):161-7. doi: 10.1016/j.ijpharm.2011.03.059. Epub 2011 Apr 8.

PMID:
21497189
32.

Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.

Nakanishi T, Shibue Y, Fukuyama Y, Yoshida K, Fukuda H, Shirasaka Y, Tamai I.

Drug Metab Dispos. 2011 Jun;39(6):984-91. doi: 10.1124/dmd.111.038059. Epub 2011 Mar 17.

33.

The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.

Imanaga J, Kotegawa T, Imai H, Tsutsumi K, Yoshizato T, Ohyama T, Shirasaka Y, Tamai I, Tateishi T, Ohashi K.

Pharmacogenet Genomics. 2011 Feb;21(2):84-93.

PMID:
21280267
34.

Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.

Shirasaka Y, Suzuki K, Shichiri M, Nakanishi T, Tamai I.

Drug Metab Pharmacokinet. 2011;26(2):171-9. Epub 2010 Dec 27.

35.

Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.

Sato M, Wakayama T, Mamada H, Shirasaka Y, Nakanishi T, Tamai I.

Biochim Biophys Acta. 2011 Jun;1808(6):1441-7. doi: 10.1016/j.bbamem.2010.11.002. Epub 2010 Nov 11.

36.

Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.

Nakanishi T, Haruta T, Shirasaka Y, Tamai I.

Drug Metab Dispos. 2011 Jan;39(1):117-22. doi: 10.1124/dmd.110.035402. Epub 2010 Oct 20.

37.

Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport.

Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I.

Mol Pharm. 2010 Oct 4;7(5):1747-56. doi: 10.1021/mp100130b. Epub 2010 Sep 3.

PMID:
20735088
38.

Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.

Shirasaka Y, Suzuki K, Nakanishi T, Tamai I.

Pharm Res. 2010 Oct;27(10):2141-9. doi: 10.1007/s11095-010-0216-5. Epub 2010 Aug 5.

PMID:
20686826
39.

Quantitation of talinolol in rat plasma by LC-MS-MS.

Li Y, Shirasaka Y, Langguth P, Tamai I.

J Chromatogr Sci. 2010 May-Jun;48(5):367-70.

PMID:
20515530
40.

Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.

Nakamura T, Fujiwara R, Ishiguro N, Oyabu M, Nakanishi T, Shirasaka Y, Maeda T, Tamai I.

Biol Pharm Bull. 2010;33(4):691-6.

41.

Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.

Sakuma S, Teraoka Y, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Ikumi Y, Kida T, Akashi M.

Eur J Pharm Biopharm. 2010 Aug;75(3):366-74. doi: 10.1016/j.ejpb.2010.04.003. Epub 2010 Apr 24.

PMID:
20399853
42.

Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.

Sato M, Mamada H, Anzai N, Shirasaka Y, Nakanishi T, Tamai I.

Biol Pharm Bull. 2010;33(3):498-503.

43.

Model analysis of the concentration-dependent permeability of P-gp substrates.

Tachibana T, Kitamura S, Kato M, Mitsui T, Shirasaka Y, Yamashita S, Sugiyama Y.

Pharm Res. 2010 Mar;27(3):442-6. doi: 10.1007/s11095-009-0026-9. Epub 2010 Feb 5.

PMID:
20135207
44.
45.

Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis.

Muto A, Oguni H, Takahashi Y, Shirasaka Y, Sawaishi Y, Yano T, Hoshida T, Osaka H, Nakasu S, Akasaka N, Sugai K, Miyamoto A, Takahashi S, Suzuki M, Ohmori I, Nabatame S, Osawa M.

Brain Dev. 2010 Jun;32(6):445-53. doi: 10.1016/j.braindev.2009.10.004. Epub 2009 Nov 25.

PMID:
19942389
46.

Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.

Shirasaka Y, Kuraoka E, Spahn-Langguth H, Nakanishi T, Langguth P, Tamai I.

J Pharmacol Exp Ther. 2010 Jan;332(1):181-9. doi: 10.1124/jpet.109.159756. Epub 2009 Sep 24.

47.

Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats.

Fujita M, Nakanishi T, Shibue Y, Kobayashi D, Moseley RH, Shirasaka Y, Tamai I.

Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G681-6. doi: 10.1152/ajpgi.00238.2009. Epub 2009 Aug 13.

48.

Oseltamivir (tamiflu) is a substrate of peptide transporter 1.

Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.

Drug Metab Dispos. 2009 Aug;37(8):1676-81. doi: 10.1124/dmd.109.026922. Epub 2009 May 13.

49.

Organic anion transporter OAT1 is involved in renal handling of citrulline.

Nakakariya M, Shima Y, Shirasaka Y, Mitsuoka K, Nakanishi T, Tamai I.

Am J Physiol Renal Physiol. 2009 Jul;297(1):F71-9. doi: 10.1152/ajprenal.90662.2008. Epub 2009 Apr 29.

50.

Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells.

Mitsuoka K, Shirasaka Y, Fukushi A, Sato M, Nakamura T, Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2009 Apr;30(3):126-37. doi: 10.1002/bdd.653.

PMID:
19322909

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