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Items: 1 to 50 of 66

1.

Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.

Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K.

Sci Rep. 2019 Mar 5;9(1):3491. doi: 10.1038/s41598-019-39424-7.

2.
3.

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.

Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K.

Leukemia. 2012 Jun;26(6):1238-46. doi: 10.1038/leu.2011.379. Epub 2012 Jan 6.

PMID:
22289924
4.

Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.

Shiraga T, Yajima K, Suzuki K, Suzuki K, Hashimoto T, Iwatsubo T, Miyashita A, Usui T.

Drug Metab Dispos. 2012 Feb;40(2):276-82. doi: 10.1124/dmd.111.042614. Epub 2011 Oct 26.

PMID:
22031623
5.

Electrochemical generation of silver acetylides from terminal alkynes with a Ag anode and integration into sequential Pd-catalysed coupling with arylboronic acids.

Mitsudo K, Shiraga T, Mizukawa J, Suga S, Tanaka H.

Chem Commun (Camb). 2010 Dec 28;46(48):9256-8. doi: 10.1039/c0cc02633f. Epub 2010 Oct 28.

6.

Pharmacokinetics and tissue distribution of tacrolimus (FK506) after a single or repeated ocular instillation in rabbits.

Fujita E, Teramura Y, Shiraga T, Yoshioka S, Iwatsubo T, Kawamura A, Kamimura H.

J Ocul Pharmacol Ther. 2008 Jun;24(3):309-19. doi: 10.1089/jop.2007.0083.

PMID:
18476801
7.

Effect of cyclosporine and tacrolimus on cytochrome p450 activities in human liver microsomes.

Niwa T, Yamamoto S, Saito M, Shiraga T, Takagi A.

Yakugaku Zasshi. 2007 Jan;127(1):209-16.

8.

[Effect of genetic polymorphism of cytochrome P450 3A and transporter gene on pharmacokinetics of tacrolimus, a calcineurin inhibitor].

Niwa T, Shiraga T, Omura M, Kondo T, Kuroda M, Takagi A.

Nihon Yakurigaku Zasshi. 2006 Dec;128(6):395-404. Review. Japanese. No abstract available.

PMID:
17167213
9.

[Drug-drug interaction of antifungal drugs].

Niwa T, Shiraga T, Takagi A.

Yakugaku Zasshi. 2005 Oct;125(10):795-805. Review. Japanese.

10.

Effect of antifungal drugs on cytochrome P450 (CYP) 1A2, CYP2D6, and CYP2E1 activities in human liver microsomes.

Niwa T, Inoue-Yamamoto S, Shiraga T, Takagi A.

Biol Pharm Bull. 2005 Sep;28(9):1813-6.

11.
12.

Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs.

Niwa T, Shiraga T, Ishii I, Kagayama A, Takagi A.

Biol Pharm Bull. 2005 Sep;28(9):1711-6.

13.

Interindividual variability in 5-Fluorouracil metabolism and procainamide N-acetylation in human liver cytosol.

Niwa T, Shiraga T, Ohno Y, Kagayama A.

Biol Pharm Bull. 2005 Jun;28(6):1071-4.

14.

MZF-1 and DbpA interact with DNase I hypersensitive sites that correlate with expression of the human MUC1 mucin gene.

Shiraga T, Winpenny JP, Carter EJ, McCarthy VA, Hollingsworth MA, Harris A.

Exp Cell Res. 2005 Aug 1;308(1):41-52.

PMID:
15893750
15.

Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population.

Iwasaki M, Yoshimura Y, Asahi S, Saito K, Sakai S, Morita S, Takenaka O, Inoda T, Kashiyama E, Aoyama A, Nakabayashi T, Omori S, Kuwabara T, Izumi T, Nakamura K, Takanaka K, Nakayama Y, Takeuchi M, Nakamura H, Kametani S, Terauchi Y, Hashizume T, Nagayama S, Kume T, Achira M, Kawai H, Kawashiro T, Nakamura A, Nakai Y, Kagayama A, Shiraga T, Niwa T, Yoshimura T, Morita J, Ohsawa F, Tani M, Osawa N, Ida K, Noguchi K.

Drug Metab Pharmacokinet. 2004 Dec;19(6):444-52.

16.

No inhibition of cytochrome P450 activities in human liver microsomes by sulpiride, an antipsychotic drug.

Niwa T, Inoue S, Shiraga T, Takagi A.

Biol Pharm Bull. 2005 Jan;28(1):188-91.

17.
18.

New SRM data dependent exclusion (MS)n measurement for structural determination of drug metabolites using LC/ESI/Ion trap MS.

Tozuka Z, Kaneko H, Shiraga T, Beppu M, Niwa T, Kawamura A, Kagayama A.

Drug Metab Pharmacokinet. 2003;18(6):390-403.

19.

Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations.

Yasui H, Deo K, Ogura Y, Yoshida H, Shiraga T, Kagayama A, Sakurai H.

Drug Metab Pharmacokinet. 2002;17(5):416-26.

20.

Strategy for structure elucidation of drug metabolites derived from protonated molecules and (MS)n fragmentation of zotepine, tiaramide and their metabolites.

Tozuka Z, Kaneko H, Shiraga T, Mitani Y, Kawamura A, Kagayama A, Aoba A.

Drug Metab Pharmacokinet. 2002;17(4):316-39.

21.
22.

Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia.

Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T, Kubuki Y, Okayama A, Hamada K, Okabe H, Murakami Y, Tsubouchi H, Morishita K.

Blood. 2005 Feb 1;105(3):1204-13. Epub 2004 Oct 7.

23.
24.

Effect of cefixime and cefdinir, oral cephalosporins, on cytochrome P450 activities in human hepatic microsomes.

Niwa T, Shiraga T, Hashimoto T, Kagayama A.

Biol Pharm Bull. 2004 Jan;27(1):97-9.

25.

Strategy for structural elucidation of drugs and drug metabolites using (MS)n fragmentation in an electrospray ion trap.

Tozuka Z, Kaneko H, Shiraga T, Mitani Y, Beppu M, Terashita S, Kawamura A, Kagayama A.

J Mass Spectrom. 2003 Aug;38(8):793-808. Review.

PMID:
12938100
26.

In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes.

Niwa T, Shiraga T, Yamasaki S, Ishibashi K, Ohno Y, Kagayama A.

Xenobiotica. 2003 Jul;33(7):717-29.

PMID:
12893521
27.

Identification of two novel elements involved in human MUCI gene expression in vivo.

Shiraga T, Smith D, Nuthall HN, Hollingsworth MA, Harris A.

Mol Med. 2002 Jan;8(1):33-41.

28.

Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.

Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A.

Drug Metab Dispos. 2000 Sep;28(9):1128-34.

PMID:
10950860
29.

Sulfotransferase catalyzing sulfation of heterocyclic amines.

Yamazoe Y, Nagata K, Yoshinari K, Fujita K, Shiraga T, Iwasaki K.

Cancer Lett. 1999 Sep 1;143(2):103-7.

PMID:
10503886
30.

N-sulphoconjugation of amines by human cytosolic hydroxysteroid sulphotransferase.

Shiraga T, Hata T, Yamazoe Y, Ohno Y, Iwasaki K.

Xenobiotica. 1999 Apr;29(4):341-7.

PMID:
10375005
31.

The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects.

Möller A, Iwasaki K, Kawamura A, Teramura Y, Shiraga T, Hata T, Schäfer A, Undre NA.

Drug Metab Dispos. 1999 Jun;27(6):633-6.

PMID:
10348790
32.

Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.

Shiraga T, Kaneko H, Iwasaki K, Tozuka Z, Suzuki A, Hata T.

Xenobiotica. 1999 Mar;29(3):217-29.

PMID:
10219963
33.

Purification and characterization of two amine N-sulfotransferases, AST-RB1 (ST3A1) and AST-RB2 (ST2A8), from liver cytosols of male rabbits.

Shiraga T, Iwasaki K, Hata T, Yoshinari K, Nagata K, Yamazoe Y, Ohno Y.

Arch Biochem Biophys. 1999 Feb 15;362(2):265-74.

PMID:
9989935
34.

Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepT1.

Shiraga T, Miyamoto K, Tanaka H, Yamamoto H, Taketani Y, Morita K, Tamai I, Tsuji A, Takeda E.

Gastroenterology. 1999 Feb;116(2):354-62.

PMID:
9922316
35.

Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals.

Yoshinari K, Nagata K, Ogino M, Fujita K, Shiraga T, Iwasaki K, Hata T, Yamazoe Y.

J Biochem. 1998 Mar;123(3):479-86.

36.

Molecular cloning, expression, and enzymatic characterization of rabbit hydroxysteroid sulfotransferase AST-RB2.

Yoshinari K, Nagata K, Shiraga T, Iwasaki K, Hata T, Ogino M, Ueda R, Fujita K, Shimada M, Yamazoe Y.

J Biochem. 1998 Apr;123(4):740-6.

37.

Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury.

Tanaka H, Miyamoto KI, Morita K, Haga H, Segawa H, Shiraga T, Fujioka A, Kouda T, Taketani Y, Hisano S, Fukui Y, Kitagawa K, Takeda E.

Gastroenterology. 1998 Apr;114(4):714-23.

PMID:
9516392
38.

The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.

Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, Tsuji A.

J Pharm Pharmacol. 1997 Aug;49(8):796-801.

PMID:
9379359
39.

Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.

Miyamoto K, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A, Takeda E.

Biochim Biophys Acta. 1996 Feb 7;1305(1-2):34-8.

PMID:
8605246
40.

Interactions of FK506 (tacrolimus) with clinically important drugs.

Matsuda H, Iwasaki K, Shiraga T, Tozuka Z, Hata T, Guengerich FP.

Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):57-64.

PMID:
8824931
41.

Species- and gender-related differences in amine, alcohol and phenol sulphoconjugations.

Shiraga T, Iwasaki K, Takeshita K, Matsuda H, Niwa T, Tozuka Z, Hata T, Guengerich FP.

Xenobiotica. 1995 Nov;25(10):1063-71.

PMID:
8578762
42.

Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey.

Niwa T, Kaneko H, Naritomi Y, Togawa A, Shiraga T, Iwasaki K, Tozuka Z, Hata T.

Xenobiotica. 1995 Nov;25(10):1041-9.

PMID:
8578760
43.

Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.

Iwasaki K, Shiraga T, Matsuda H, Nagase K, Tokuma Y, Hata T, Fujii Y, Sakuma S, Fujitsu T, Fujikawa A, et al.

Drug Metab Dispos. 1995 Jan;23(1):28-34.

PMID:
7536652
44.

Isolation and characterization of an alicyclic amine N-sulfotransferase from female rat liver.

Naritomi Y, Niwa T, Shiraga T, Iwasaki K, Noda K.

Biol Pharm Bull. 1994 Aug;17(8):1008-11.

PMID:
7820098
45.

Effect of repeated injection of somatomedin C on drug metabolizing enzyme activities in rats.

Niwa T, Naritomi Y, Kawano M, Ueda-Shimohira Y, Takeshita K, Shiraga T, Iwasaki K, Noda K.

Res Commun Chem Pathol Pharmacol. 1994 Mar;83(3):341-8.

PMID:
8008983
46.

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes.

Shiraga T, Matsuda H, Nagase K, Iwasaki K, Noda K, Yamazaki H, Shimada T, Funae Y.

Biochem Pharmacol. 1994 Feb 11;47(4):727-35.

PMID:
7510480
47.

Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs.

Shiraga T, Iwasaki K, Nozaki K, Tamura T, Yamazoe Y, Kato R, Takanaka A.

Biol Pharm Bull. 1994 Jan;17(1):22-8.

PMID:
8185738
48.

Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes.

Iwasaki K, Matsuda H, Nagase K, Shiraga T, Tokuma Y, Uchida K.

Res Commun Chem Pathol Pharmacol. 1993 Nov;82(2):209-16.

PMID:
7508138
49.

Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone.

Iwasaki K, Shiraga T, Nagase K, Tozuka Z, Noda K, Sakuma S, Fujitsu T, Shimatani K, Sato A, Fujioka M.

Drug Metab Dispos. 1993 Nov-Dec;21(6):971-7.

PMID:
7507815
50.

Perinatal development of amine, alcohol and phenol sulfoconjugations in the rat.

Iwasaki K, Shiraga T, Takeshita K, Katashima M, Nagase K, Tada K, Noda K, Noguchi H.

Res Commun Chem Pathol Pharmacol. 1993 Aug;81(2):183-90.

PMID:
8210697

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