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Aurora A kinase inhibition destabilizes PAX3-FOXO1 and MYCN and synergizes with Navitoclax to induce Rhabdomyosarcoma cell death.

Ommer J, Selfe JL, Wachtel M, O'Brien EM, Laubscher D, Roemmele M, Kasper S, Delattre O, Surdez D, Petts G, Kelsey A, Shipley J, Schäfer BW.

Cancer Res. 2019 Dec 30. pii: canres.1479.2019. doi: 10.1158/0008-5472.CAN-19-1479. [Epub ahead of print]


A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas.

Gatz SA, Aladowicz E, Casanova M, Chisholm JC, Kearns PR, Fulda S, Geoerger B, Schäfer BW, Shipley JM.

Front Oncol. 2019 Nov 22;9:1271. doi: 10.3389/fonc.2019.01271. eCollection 2019. Review.


Epigenetic Targets in Synovial Sarcoma: A Mini-Review.

Hale R, Sandakly S, Shipley J, Walters Z.

Front Oncol. 2019 Oct 18;9:1078. doi: 10.3389/fonc.2019.01078. eCollection 2019. Review.


A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.

George SL, Izquierdo E, Campbell J, Koutroumanidou E, Proszek P, Jamal S, Hughes D, Yuan L, Marshall LV, Carceller F, Chisholm JC, Vaidya S, Mandeville H, Angelini P, Wasti A, Bexelius T, Thway K, Gatz SA, Clarke M, Al-Lazikani B, Barone G, Anderson J, Tweddle DA, Gonzalez D, Walker BA, Barton J, Depani S, Eze J, Ahmed SW, Moreno L, Pearson A, Shipley J, Jones C, Hargrave D, Jacques TS, Hubank M, Chesler L.

Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19.


Does measuring the bone mineral density of patients identified as having an osteopaenic X-ray appearance affect bone health treatment decisions? A real-world retrospective analysis.

Williams T, Wadeley A, Hardcastle S, Webb J, Shipley J, Ahmed T.

Clin Med (Lond). 2019 Jun;19(Suppl 3):16-17. doi: 10.7861/clinmedicine.19-3-s16. No abstract available.


Insights into pediatric rhabdomyosarcoma research: Challenges and goals.

Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM.

Pediatr Blood Cancer. 2019 Oct;66(10):e27869. doi: 10.1002/pbc.27869. Epub 2019 Jun 21. Review.


Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.

Romo-Morales A, Aladowicz E, Blagg J, Gatz SA, Shipley JM.

Pediatr Blood Cancer. 2019 Sep;66(9):e27888. doi: 10.1002/pbc.27888. Epub 2019 Jun 17.


IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches.

Selfe J, Shipley JM.

Andrology. 2019 Jul;7(4):536-544. doi: 10.1111/andr.12658. Epub 2019 Jun 9. Review.


VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.

Figeac N, Mohamed AD, Sun C, Schönfelder M, Matallanas D, Garcia-Munoz A, Missiaglia E, Collie-Duguid E, De Mello V, Pobbati AV, Pruller J, Jaka O, Harridge SDR, Hong W, Shipley J, Vargesson N, Zammit PS, Wackerhage H.

J Cell Sci. 2019 Jul 5;132(13). pii: jcs225946. doi: 10.1242/jcs.225946.


"We need more things for us": Being low income and underoccupied in older age.

Heatwole Shank KS, Kenley B, Brown S, Shipley J, Baum M, Beers C.

Can J Occup Ther. 2020 Feb;87(1):21-29. doi: 10.1177/0008417419838360. Epub 2019 Apr 25.


Response: "Enhancing WIKISTIM.Org Using Machine Learning Approaches".

Shipley J, North RB.

Neuromodulation. 2019 Apr;22(3):368-369. doi: 10.1111/ner.12948. Epub 2019 Mar 25. No abstract available.



Skapek SX, Ferrari A, Gupta AA, Lupo PJ, Butler E, Shipley J, Barr FG, Hawkins DS.

Nat Rev Dis Primers. 2019 Jan 7;5(1):1. doi: 10.1038/s41572-018-0051-2. Review.


How can stroke care be improved for younger service users? A qualitative study on the unmet needs of younger adults in inpatient and outpatient stroke care in Australia.

Shipley J, Luker J, Thijs V, Bernhardt J.

Disabil Rehabil. 2019 Jan 7:1-8. doi: 10.1080/09638288.2018.1534278. [Epub ahead of print]


The personal and social experiences of community-dwelling younger adults after stroke in Australia: a qualitative interview study.

Shipley J, Luker J, Thijs V, Bernhardt J.

BMJ Open. 2018 Dec 16;8(12):e023525. doi: 10.1136/bmjopen-2018-023525.

15. An On-Line Database of Published Neurostimulation Studies.

North RB, Shipley J.

Neuromodulation. 2018 Dec;21(8):828-836. doi: 10.1111/ner.12882. Epub 2018 Nov 29.


Resource Ephemerality Drives Social Foraging in Bats.

Egert-Berg K, Hurme ER, Greif S, Goldstein A, Harten L, Herrera M LG, Flores-Martínez JJ, Valdés AT, Johnston DS, Eitan O, Borissov I, Shipley JR, Medellin RA, Wilkinson GS, Goerlitz HR, Yovel Y.

Curr Biol. 2018 Nov 19;28(22):3667-3673.e5. doi: 10.1016/j.cub.2018.09.064. Epub 2018 Nov 1.


Feeding ecology of fishes associated with artificial reefs in the northwest Gulf of Mexico.

Dance KM, Rooker JR, Shipley JB, Dance MA, Wells RJD.

PLoS One. 2018 Oct 2;13(10):e0203873. doi: 10.1371/journal.pone.0203873. eCollection 2018.


Aquatic insects rich in omega-3 fatty acids drive breeding success in a widespread bird.

Twining CW, Shipley JR, Winkler DW.

Ecol Lett. 2018 Dec;21(12):1812-1820. doi: 10.1111/ele.13156. Epub 2018 Sep 24.


Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ.

Sci Rep. 2018 Aug 21;8(1):12771. doi: 10.1038/s41598-018-30922-8.


Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ.

Sci Rep. 2018 Jul 13;8(1):10614. doi: 10.1038/s41598-018-29043-z. Erratum in: Sci Rep. 2018 Aug 21;8(1):12771.


Fusion status in patients with lymph node-positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).

Gallego S, Zanetti I, Orbach D, Ranchère D, Shipley J, Zin A, Bergeron C, de Salvo GL, Chisholm J, Ferrari A, Jenney M, Mandeville HC, Rogers T, Merks JHM, Mudry P, Glosli H, Milano GM, Ferman S, Bisogno G; European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).

Cancer. 2018 Aug 1;124(15):3201-3209. doi: 10.1002/cncr.31553. Epub 2018 May 24.


The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.

O'Brien EM, Selfe JL, Martins AS, Walters ZS, Shipley JM.

BMC Cancer. 2018 Feb 21;18(1):217. doi: 10.1186/s12885-018-4129-8.


A Multicenter Study of the Validity and Reliability of Responses to Hand Cold Challenge as Measured by Laser Speckle Contrast Imaging and Thermography: Outcome Measures for Systemic Sclerosis-Related Raynaud's Phenomenon.

Wilkinson JD, Leggett SA, Marjanovic EJ, Moore TL, Allen J, Anderson ME, Britton J, Buch MH, Del Galdo F, Denton CP, Dinsdale G, Griffiths B, Hall F, Howell K, MacDonald A, McHugh NJ, Manning JB, Pauling JD, Roberts C, Shipley JA, Herrick AL, Murray AK.

Arthritis Rheumatol. 2018 Jun;70(6):903-911. doi: 10.1002/art.40457. Epub 2018 Apr 23.


Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours.

Izquierdo E, Yuan L, George S, Hubank M, Jones C, Proszek P, Shipley J, Gatz SA, Stinson C, Moore AS, Clifford SC, Hicks D, Lindsey JC, Hill RM, Jacques TS, Chalker J, Thway K, O'Connor S, Marshall L, Moreno L, Pearson A, Chesler L, Walker BA, De Castro DG.

Oncotarget. 2017 Dec 6;8(67):112036-112050. doi: 10.18632/oncotarget.23000. eCollection 2017 Dec 19.


Examination of Clock and Adcyap1 gene variation in a neotropical migratory passerine.

Contina A, Bridge ES, Ross JD, Shipley JR, Kelly JF.

PLoS One. 2018 Jan 11;13(1):e0190859. doi: 10.1371/journal.pone.0190859. eCollection 2018.


IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance.

Selfe J, Goddard NC, McIntyre A, Taylor KR, Renshaw J, Popov SD, Thway K, Summersgill B, Huddart RA, Gilbert DC, Shipley JM.

J Pathol. 2018 Feb;244(2):242-253. doi: 10.1002/path.5008. Epub 2018 Jan 10.


Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8+ lymphocytes in primary sarcomas is subtype dependent.

van Erp AEM, Versleijen-Jonkers YMH, Hillebrandt-Roeffen MHS, van Houdt L, Gorris MAJ, van Dam LS, Mentzel T, Weidema ME, Savci-Heijink CD, Desar IME, Merks HHM, van Noesel MM, Shipley J, van der Graaf WTA, Flucke UE, Meyer-Wentrup FAG.

Oncotarget. 2017 Jul 7;8(41):71371-71384. doi: 10.18632/oncotarget.19071. eCollection 2017 Sep 19.


ATR Is a Therapeutic Target in Synovial Sarcoma.

Jones SE, Fleuren EDG, Frankum J, Konde A, Williamson CT, Krastev DB, Pemberton HN, Campbell J, Gulati A, Elliott R, Menon M, Selfe JL, Brough R, Pettitt SJ, Niedzwiedz W, van der Graaf WTA, Shipley J, Ashworth A, Lord CJ.

Cancer Res. 2017 Dec 15;77(24):7014-7026. doi: 10.1158/0008-5472.CAN-17-2056. Epub 2017 Oct 16.


Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.

Litchfield K, Levy M, Orlando G, Loveday C, Law PJ, Migliorini G, Holroyd A, Broderick P, Karlsson R, Haugen TB, Kristiansen W, Nsengimana J, Fenwick K, Assiotis I, Kote-Jarai Z, Dunning AM, Muir K, Peto J, Eeles R, Easton DF, Dudakia D, Orr N, Pashayan N; UK Testicular Cancer Collaboration; PRACTICAL Consortium, Bishop DT, Reid A, Huddart RA, Shipley J, Grotmol T, Wiklund F, Houlston RS, Turnbull C.

Nat Genet. 2017 Jul;49(7):1133-1140. doi: 10.1038/ng.3896. Epub 2017 Jun 12.


Fusion gene addiction: can tumours be forced to give up the habit?

Selfe JL, Shipley J.

J Pathol. 2017 Jul;242(3):263-266. doi: 10.1002/path.4902. Epub 2017 May 29.


Impact of fusion gene status versus histology on risk-stratification for rhabdomyosarcoma: Retrospective analyses of patients on UK trials.

Selfe J, Olmos D, Al-Saadi R, Thway K, Chisholm J, Kelsey A, Shipley J.

Pediatr Blood Cancer. 2017 Jul;64(7). doi: 10.1002/pbc.26386. Epub 2016 Dec 30.


MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas.

Missiaglia E, Shepherd CJ, Aladowicz E, Olmos D, Selfe J, Pierron G, Delattre O, Walters Z, Shipley J.

Cancer Lett. 2017 Jan 28;385:251-260. doi: 10.1016/j.canlet.2016.10.011. Epub 2016 Oct 29.


Asymmetric energetic costs in reciprocal-cross hybrids between carnivorous mice (Onychomys).

Shipley JR, Campbell P, Searle JB, Pasch B.

J Exp Biol. 2016 Dec 1;219(Pt 23):3803-3809. Epub 2016 Sep 29.


Omega-3 long-chain polyunsaturated fatty acids support aerial insectivore performance more than food quantity.

Twining CW, Brenna JT, Lawrence P, Shipley JR, Tollefson TN, Winkler DW.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10920-5. doi: 10.1073/pnas.1603998113. Epub 2016 Sep 16. Erratum in: Proc Natl Acad Sci U S A. 2016 Nov 7;:.


Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells.

Thway K, Robertson D, Jones RL, Selfe J, Shipley J, Fisher C, Isacke CM.

Br J Cancer. 2016 Aug 9;115(4):473-9. doi: 10.1038/bjc.2016.214. Epub 2016 Jul 19.


A First-in-Patient, Multicenter, Double-Blind, 2-Arm, Placebo-Controlled, Randomized Safety and Tolerability Study of a Novel Oral Drug Candidate, CTP-499, in Chronic Kidney Disease.

Sabounjian L, Graham P, Wu L, Braman V, Cheng C, Liu J, Shipley J, Neutel J, Dao M.

Clin Pharmacol Drug Dev. 2016 Jul;5(4):314-25. doi: 10.1002/cpdd.241. Epub 2016 Feb 11.


The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.

Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C.

Nat Rev Urol. 2016 Jul;13(7):409-19. doi: 10.1038/nrurol.2016.107. Epub 2016 Jun 14. Review.


Polygenic susceptibility to testicular cancer: implications for personalised health care.

Litchfield K, Mitchell JS, Shipley J, Huddart R, Rajpert-De Meyts E, Skakkebæk NE, Houlston RS, Turnbull C.

Br J Cancer. 2016 Jun 14;114(12):e22. doi: 10.1038/bjc.2016.136. Epub 2016 May 26. No abstract available.


The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.

Mohamed A, Sun C, De Mello V, Selfe J, Missiaglia E, Shipley J, Murray GI, Zammit PS, Wackerhage H.

J Pathol. 2016 Sep;240(1):3-14. doi: 10.1002/path.4745.


Symptoms of Raynaud's phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology.

Scolnik M, Vasta B, Hart DJ, Shipley JA, McHugh NJ, Pauling JD.

Rheumatol Int. 2016 Oct;36(10):1371-7. doi: 10.1007/s00296-016-3483-6. Epub 2016 May 2.


Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines.

Noor DAM, Jeyapalan JN, Alhazmi S, Carr M, Squibb B, Wallace C, Tan C, Cusack M, Hughes J, Reader T, Shipley J, Sheer D, Scotting PJ.

NPJ Genom Med. 2016 Jan 13;1:15009. doi: 10.1038/npjgenmed.2015.9. eCollection 2016.


8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J.

J Med Chem. 2016 Feb 25;59(4):1388-409. doi: 10.1021/acs.jmedchem.5b01635. Epub 2016 Jan 7.


Identification of four new susceptibility loci for testicular germ cell tumour.

Litchfield K, Holroyd A, Lloyd A, Broderick P, Nsengimana J, Eeles R, Easton DF, Dudakia D, Bishop DT, Reid A, Huddart RA, Grotmol T, Wiklund F, Shipley J, Houlston RS, Turnbull C.

Nat Commun. 2015 Oct 27;6:8690. doi: 10.1038/ncomms9690.


Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group.

Hingorani P, Missiaglia E, Shipley J, Anderson JR, Triche TJ, Delorenzi M, Gastier-Foster J, Wing M, Hawkins DS, Skapek SX.

Clin Cancer Res. 2015 Oct 15;21(20):4733-9. doi: 10.1158/1078-0432.CCR-14-3326.


Polygenic susceptibility to testicular cancer: implications for personalised health care.

Litchfield K, Mitchell JS, Shipley J, Huddart R, Rajpert-De Meyts E, Skakkebæk NE, Houlston RS, Turnbull C.

Br J Cancer. 2015 Nov 17;113(10):1512-8. doi: 10.1038/bjc.2015.334. Epub 2015 Oct 13. Erratum in: Br J Cancer. 2016 Jun 14;114(12):e22.


Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma.

Gilbert DC, Al-Saadi R, Thway K, Chandler I, Berney D, Gabe R, Stenning SP, Sweet J, Huddart R, Shipley JM.

Clin Cancer Res. 2016 Mar 1;22(5):1265-73. doi: 10.1158/1078-0432.CCR-15-1186. Epub 2015 Oct 9.


Less Can Be More for Gene Dose and Drug Sensitivity.

Gatz SA, Shipley JM.

Clin Cancer Res. 2015 Nov 1;21(21):4750-2. doi: 10.1158/1078-0432.CCR-15-1153. Epub 2015 Jul 21.


Use of Laser Speckle Contrast Imaging to Assess Digital Microvascular Function in Primary Raynaud Phenomenon and Systemic Sclerosis: A Comparison Using the Raynaud Condition Score Diary.

Pauling JD, Shipley JA, Hart DJ, McGrogan A, McHugh NJ.

J Rheumatol. 2015 Jul;42(7):1163-8. doi: 10.3899/jrheum.141437. Epub 2015 Jun 1.


Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.

Litchfield K, Summersgill B, Yost S, Sultana R, Labreche K, Dudakia D, Renwick A, Seal S, Al-Saadi R, Broderick P, Turner NC, Houlston RS, Huddart R, Shipley J, Turnbull C.

Nat Commun. 2015 Jan 22;6:5973. doi: 10.1038/ncomms6973.


Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.

Litchfield K, Shipley J, Turnbull C.

Andrology. 2015 Jan;3(1):34-46. doi: 10.1111/andr.304. Epub 2015 Jan 19. Review.

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