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Items: 13

1.

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.

Shen H, Holenarsipur VK, Mariappan TT, Drexler DM, Cantone JL, Rajanna P, Singh Gautam S, Zhang Y, Gan J, Shipkova PA, Marathe P, Humphreys WG.

J Pharmacol Exp Ther. 2019 Jan;368(1):136-145. doi: 10.1124/jpet.118.252643. Epub 2018 Oct 25.

PMID:
30361237
2.

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Shen H, Nelson DM, Oliveira RV, Zhang Y, Mcnaney CA, Gu X, Chen W, Su C, Reily MD, Shipkova PA, Gan J, Lai Y, Marathe P, Humphreys WG.

Drug Metab Dispos. 2018 Feb;46(2):178-188. doi: 10.1124/dmd.117.077586. Epub 2017 Nov 21.

PMID:
29162614
3.

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

Zheng JJ, Shields EE, Snow KJ, Nelson DM, Olah TV, Reily MD, Robertson DG, Shipkova PA, Stryker SA, Xin B, Drexler DM.

Anal Biochem. 2016 Jun 15;503:71-8. doi: 10.1016/j.ab.2016.03.011. Epub 2016 Mar 28.

PMID:
27033006
4.

11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.

García RA, Search DJ, Lupisella JA, Ostrowski J, Guan B, Chen J, Yang WP, Truong A, He A, Zhang R, Yan M, Hellings SE, Gargalovic PS, Ryan CS, Watson LM, Langish RA, Shipkova PA, Carson NL, Taylor JR, Yang R, Psaltis GC, Harrity TW, Robl JA, Gordon DA.

PLoS One. 2013;8(2):e53192. doi: 10.1371/journal.pone.0053192. Epub 2013 Feb 1.

5.

Metabolomic and transcriptomic changes induced by overnight (16 h) fasting in male and female Sprague-Dawley rats.

Robertson DG, Ruepp SU, Stryker SA, Hnatyshyn SY, Shipkova PA, Aranibar N, Mcnaney CA, Fiehn O, Reily MD.

Chem Res Toxicol. 2011 Apr 18;24(4):481-7. doi: 10.1021/tx200074f. Epub 2011 Mar 25.

PMID:
21381695
6.

Advances in mass spectrometry applied to pharmaceutical metabolomics.

Drexler DM, Reily MD, Shipkova PA.

Anal Bioanal Chem. 2011 Mar;399(8):2645-53. doi: 10.1007/s00216-010-4370-8. Epub 2010 Nov 25. Review.

PMID:
21107980
7.

A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS(3).

Onorato JM, Langish RA, Shipkova PA, Sanders M, Wang J, Kwagh J, Dutta S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 1;873(2):144-50. doi: 10.1016/j.jchromb.2008.08.006. Epub 2008 Aug 15.

PMID:
18760978
8.

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

Drexler DM, Belcastro JV, Dickinson KE, Edinger KJ, Hnatyshyn SY, Josephs JL, Langish RA, McNaney CA, Santone KS, Shipkova PA, Tymiak AA, Zvyaga TA, Sanders M.

Assay Drug Dev Technol. 2007 Apr;5(2):247-64.

PMID:
17477833
9.

Utility of the hybrid LTQ-FTMS for drug metabolism applications.

Sanders M, Shipkova PA, Zhang H, Warrack BM.

Curr Drug Metab. 2006 Jun;7(5):547-55. Review.

PMID:
16787162
10.

A general liquid chromatography/mass spectroscopy-based assay for detection and quantitation of methyltransferase activity.

Salyan ME, Pedicord DL, Bergeron L, Mintier GA, Hunihan L, Kuit K, Balanda LA, Robertson BJ, Feder JN, Westphal R, Shipkova PA, Blat Y.

Anal Biochem. 2006 Feb 1;349(1):112-7. Epub 2005 Nov 17.

PMID:
16325755
11.

High-resolution LC/MS for analysis of minor components in complex mixtures: negative ion ESI for identification of impurities and degradation products of a novel oligosaccharide antibiotic.

Shipkova PA, Heimark L, Bartner PL, Chen G, Pramanik BN, Ganguly AK, Cody RB, Kusai A.

J Mass Spectrom. 2000 Nov;35(11):1252-8.

PMID:
11114082
12.

Structural characterization of the oligosaccharide antibiotics everninomicins by negative ion FAB and ESI/MS.

Pramanik BN, Shipkova PA, Bartner PL, Heimark L, Liu YH, Das PR, Saksena AK, Sarre OZ, Girijavallabhan VM, Ganguly AK.

J Antibiot (Tokyo). 2000 Jun;53(6):640-3. No abstract available.

13.

Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry.

Fridriksson EK, Shipkova PA, Sheets ED, Holowka D, Baird B, McLafferty FW.

Biochemistry. 1999 Jun 22;38(25):8056-63.

PMID:
10387050

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