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Items: 28

1.

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS.

J Clin Invest. 2003 Jul;112(1):83-90.

2.

Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.

Shinyama H, Masuzaki H, Fang H, Flier JS.

Endocrinology. 2003 Apr;144(4):1301-14.

PMID:
12639913
3.

A transgenic model of visceral obesity and the metabolic syndrome.

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS.

Science. 2001 Dec 7;294(5549):2166-70.

4.

Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist.

Ebisu H, Nishikawa M, Tanaka M, Okazoe T, Morizawa Y, Shinyama H, Nakamura N.

J Cardiovasc Pharmacol. 1999 Oct;34(4):526-32.

PMID:
10511127
5.

Calcium channel blocking and vasodilating actions of the novel dihydropyridine derivative AE0047.

Nishikawa M, Gohda M, Shinyama H, Matzno S, Yamanaga K, Kido H, Nakamura N.

Clin Exp Pharmacol Physiol. 1998 May;25(5):347-54.

PMID:
9612662
6.

Therapeutic effects of AE0047, a novel calcium antagonist, on progression of brain damage after stroke in stroke-prone spontaneously hypertensive rats.

Shinyama H, Nagai H, Kawamura T, Narita Y, Nakamura N, Kagitani Y.

Gen Pharmacol. 1998 Mar;30(3):379-86.

PMID:
9510090
7.

Possible mechanism for the anti-atherosclerotic action of the calcium channel blocker AE0047 in cholesterol-fed rabbits.

Hayashi K, Imada T, Yamauchi T, Kido H, Shinyama H, Matzno S, Nakamura N, Kagitani Y.

Clin Exp Pharmacol Physiol. 1998 Jan;25(1):17-25.

PMID:
9493553
8.

Effects of long-term treatment with the calcium antagonist AE0047 on cerebrovascular autoregulation and hypertrophy in spontaneously hypertensive rats.

Shinyama H, Nagai H, Kawamura T, Narita Y, Nakamura N, Kagitani Y.

J Cardiovasc Pharmacol. 1997 Nov;30(5):616-22.

PMID:
9388044
9.

Preventative and therapeutic effects of AE0047 on renal injury in stroke-prone spontaneously hypertensive rats.

Hayashi K, Koyama M, Kido H, Egi Y, Kubo Y, Shinyama H, Iwamoto M, Nakamura N, Kagitani Y.

Clin Exp Pharmacol Physiol. 1997 Nov;24(11):831-40.

PMID:
9363365
10.

Effects of AE0047 on cerebral ischaemia and oedema after middle cerebral artery occlusion in cats.

Shinyama H, Hayashi K, Kawamura T, Nakamura N, Kagitani Y.

Clin Exp Pharmacol Physiol. 1997 Nov;24(11):824-30.

PMID:
9363364
11.

Effects of the calcium antagonist AE0047 on the development of neurological deficit and infarction after middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats.

Shinyama H, Kawamura T, Iwamoto M, Egi Y, Tanaka H, Kawabata Y, Nakamura N, Kagitani Y.

J Pharm Pharmacol. 1997 Sep;49(9):919-24.

PMID:
9306262
12.

AE0047-mediated calcium channel blocking in vascular smooth muscles.

Yamanaga K, Shinyama H, Akira T, Iwamoto M, Uchida T, Nakamura N, Kagitani Y.

Gen Pharmacol. 1997 Sep;29(3):337-43.

PMID:
9378237
13.

[Antihypertensive effects of long-term treatment with AE0047, a novel long-lasting calcium antagonist, in hypertensive models of rats and dogs].

Kido H, Nishikawa M, Hayashi K, Kubo Y, Ebisu H, Egi Y, Shinyama H, Nakamura N.

Nihon Yakurigaku Zasshi. 1997 Jun;109(6):291-301. Japanese.

PMID:
9253776
14.

Antithrombin III prevents blood pressure elevation and proteinuria induced by high salt intake in pregnant stroke-prone spontaneously hypertensive rats.

Shinyama H, Yamanaga K, Akira T, Uchida T, Yaguchi M, Watanabe M, Kagitani Y.

Biol Pharm Bull. 1996 Jun;19(6):819-23.

PMID:
8799479
16.

Protective effects of AE0047, a novel calcium antagonist, on incidence of stroke and hemodynamic disturbances in stroke-prone spontaneously hypertensive rats.

Shinyama H, Nagai H, Kawamura T, Narita Y, Uchida T, Watanabe M, Kagitani Y.

J Pharmacol Exp Ther. 1995 Feb;272(2):911-9.

PMID:
7853209
17.

Effects of AE0047 on renal haemodynamics and function in anaesthetized dogs.

Hayashi K, Uchida T, Kido H, Shinyama H, Watanabe M.

Clin Exp Pharmacol Physiol. 1993 Feb;20(2):103-11.

PMID:
8443973
18.

Phosphoramidon inhibits the conversion of intracisternally administered big endothelin-1 to endothelin-1.

Shinyama H, Uchida T, Kido H, Hayashi K, Watanabe M, Matsumura Y, Ikegawa R, Takaoka M, Morimoto S.

Biochem Biophys Res Commun. 1991 Jul 15;178(1):24-30.

PMID:
2069564
19.

Phosphoramidon prevents cerebral vasospasm following subarachnoid hemorrhage in dogs: the relationship to endothelin-1 levels in the cerebrospinal fluid.

Matsumura Y, Ikegawa R, Suzuki Y, Takaoka M, Uchida T, Kido H, Shinyama H, Hayashi K, Watanabe M, Morimoto S.

Life Sci. 1991;49(11):841-8.

PMID:
1875792
20.

Diuretic effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) in anesthetized rats.

Morimoto S, Matsumura Y, Ohyama T, Shinyama H, Ichihara T, Takahashi Y, Hisaki K.

Jpn J Pharmacol. 1990 Mar;52(3):431-9.

21.

Effects of Bay K 8644 on renal function and renin secretion in anesthetized rats.

Ichihara T, Matsumura Y, Shinyama H, Ohyama T, Morimoto S.

Life Sci. 1989;44(25):1945-53.

PMID:
2472542
22.

Stimulatory effects of neuronally released norepinephrine on renin release in vitro.

Matsumura Y, Kawazoe S, Ichihara T, Shinyama H, Kageyama M, Morimoto S.

Am J Physiol. 1988 Oct;255(4 Pt 2):F614-20.

PMID:
3052110
23.

Calmodulin-independent stimulation of renin release by exposure of rat kidney cortical slices to calcium.

Matsumura Y, Koyama Y, Shinyama H, Uriu T, Ichihara T, Morimoto S.

Clin Exp Pharmacol Physiol. 1988 Aug;15(8):585-90.

PMID:
2856063
24.

Stimulatory effects of neuronally released norepinephrine on renin release from rat kidney cortical slices.

Matsumura Y, Kawazoe S, Ichihara T, Shinyama H, Kageyama M, Morimoto S.

Clin Exp Hypertens A. 1988;10(6):1305-7.

PMID:
3066533
25.

Inhibitory effects of calcium channel agonists on renin release from rat kidney cortical slices.

Matsumura Y, Uriu T, Shinyama H, Sasaki Y, Morimoto S.

J Pharmacol Exp Ther. 1987 Jun;241(3):1000-5.

PMID:
2439680
26.

Renin release in anesthetized rats is enhanced by the calmodulin antagonist W-7.

Shinyama H, Matsumura Y, Sasaki Y, Ichihara T, Morimoto S.

Life Sci. 1987 Apr 27;40(17):1687-94.

PMID:
3550349
27.

The different effects of exogenous and neuronally released norepinephrine on renin release in rat kidney cortical slices.

Sasaki Y, Matsumura Y, Shinyama H, Kageyama M, Morimoto S.

Eur J Pharmacol. 1986 Jun 24;125(3):457-60.

PMID:
3525199
28.

The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices.

Matsumura Y, Sasaki Y, Shinyama H, Morimoto S.

Eur J Pharmacol. 1985 Nov 19;117(3):369-72.

PMID:
2416580

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