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Items: 25

1.

Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts.

Takahashi M, Miki S, Fujimoto K, Fukuoka K, Matsushita Y, Maida Y, Yasukawa M, Hayashi M, Shinkyo R, Kikuchi K, Mukasa A, Nishikawa R, Tamura K, Narita Y, Hamada A, Masutomi K, Ichimura K.

Cancer Sci. 2019 Jul;110(7):2247-2257. doi: 10.1111/cas.14067. Epub 2019 Jun 10.

2.

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.

Ando H, Yoshinaga T, Yamamoto W, Asakura K, Uda T, Taniguchi T, Ojima A, Shinkyo R, Kikuchi K, Osada T, Hayashi S, Kasai C, Miyamoto N, Tashibu H, Yamazaki D, Sugiyama A, Kanda Y, Sawada K, Sekino Y.

J Pharmacol Toxicol Methods. 2017 Mar - Apr;84:111-127. doi: 10.1016/j.vascn.2016.12.003. Epub 2016 Dec 10.

3.

Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.

Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP.

J Biol Chem. 2011 Sep 23;286(38):33021-8. doi: 10.1074/jbc.M111.282434. Epub 2011 Aug 3.

4.

Inhibition of human cytochrome P450 3A4 by cholesterol.

Shinkyo R, Guengerich FP.

J Biol Chem. 2011 May 27;286(21):18426-33. doi: 10.1074/jbc.M111.240457. Epub 2011 Apr 6.

5.

Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.

Xiao Y, Shinkyo R, Guengerich FP.

Drug Metab Dispos. 2011 Jun;39(6):944-6. doi: 10.1124/dmd.111.039321. Epub 2011 Mar 23.

6.

Insight into functional diversity of cytochrome P450 in the white-rot basidiomycete Phanerochaete chrysosporium: involvement of versatile monooxygenase.

Hirosue S, Tazaki M, Hiratsuka N, Yanai S, Kabumoto H, Shinkyo R, Arisawa A, Sakaki T, Tsunekawa H, Johdo O, Ichinose H, Wariishi H.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):118-23. doi: 10.1016/j.bbrc.2011.02.121. Epub 2011 Mar 21.

PMID:
21362401
7.

Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction.

Shinkyo R, Guengerich FP.

J Biol Chem. 2011 Feb 11;286(6):4632-43. doi: 10.1074/jbc.M110.193409. Epub 2010 Dec 8.

8.

Metabolism of mono- and dichloro-dibenzo-p-dioxins by Phanerochaete chrysosporium cytochromes P450.

Kasai N, Ikushiro S, Shinkyo R, Yasuda K, Hirosue S, Arisawa A, Ichinose H, Wariishi H, Sakaki T.

Appl Microbiol Biotechnol. 2010 Mar;86(2):773-80.

PMID:
20201136
9.

Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1.

Hayashi K, Sugimoto H, Shinkyo R, Yamada M, Ikeda S, Ikushiro S, Kamakura M, Shiro Y, Sakaki T.

Biochemistry. 2008 Nov 18;47(46):11964-72. doi: 10.1021/bi801222d. Epub 2008 Oct 21.

PMID:
18937506
10.

Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3.

Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T.

Biochemistry. 2008 Apr 1;47(13):4017-27. doi: 10.1021/bi7023767. Epub 2008 Mar 4.

PMID:
18314962
11.

cDNA cloning and characterization of feline CYP1A1 and CYP1A2.

Tanaka N, Miyasho T, Shinkyo R, Sakaki T, Yokota H.

Life Sci. 2006 Nov 25;79(26):2463-73. Epub 2006 Oct 5.

PMID:
17097115
12.

Enzymatic properties of human CYP2W1 expressed in Escherichia coli.

Yoshioka H, Kasai N, Ikushiro S, Shinkyo R, Kamakura M, Ohta M, Inouye K, Sakaki T.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):169-74. Epub 2006 Apr 27.

PMID:
16677611
13.

Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant.

Shinkyo R, Kamakura M, Ikushiro S, Inouye K, Sakaki T.

Appl Microbiol Biotechnol. 2006 Sep;72(3):584-90. Epub 2006 Feb 18.

PMID:
16489453
14.

Cytochrome P450 2E polymorphism in feline liver.

Tanaka N, Shinkyo R, Sakaki T, Kasamastu M, Imaoka S, Funae Y, Yokota H.

Biochim Biophys Acta. 2005 Nov 15;1726(2):194-205. Epub 2005 Aug 18.

PMID:
16168565
15.

Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus.

Orihara K, Yamazaki T, Shinkyo R, Sakaki T, Inouye K, Tsukamoto A, Sugiura J, Shishido K.

Appl Microbiol Biotechnol. 2005 Nov;69(1):22-8. Epub 2005 Oct 20.

PMID:
15812643
16.

Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant.

Sulistyaningdyah WT, Ogawa J, Li QS, Shinkyo R, Sakaki T, Inouye K, Schmid RD, Shimizu S.

Biotechnol Lett. 2004 Dec;26(24):1857-60.

PMID:
15672228
17.

Metabolism of 26,26,26,27,27,27-F6-1 alpha,23S,25-trihydroxyvitamin D3 by human UDP-glucuronosyltransferase 1A3.

Kasai N, Sakaki T, Shinkyo R, Ikushiro S, Iyanagi T, Ohta M, Inouye K.

Drug Metab Dispos. 2005 Jan;33(1):102-7. Epub 2004 Oct 26.

PMID:
15507540
18.

Metabolism of vitamin D by human microsomal CYP2R1.

Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K.

Biochem Biophys Res Commun. 2004 Nov 5;324(1):451-7.

PMID:
15465040
19.

Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDP-glucuronosyltransferase in human liver microsomes.

Kasai N, Sakaki T, Shinkyo R, Ikushiro S, Iyanagi T, Kamao M, Okano T, Ohta M, Inouye K.

Drug Metab Dispos. 2004 Aug;32(8):870-5.

PMID:
15258113
20.

Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.

Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K.

Biochem Biophys Res Commun. 2004 Jul 16;320(1):156-64.

PMID:
15207715
21.

Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis.

Shinkyo R, Sakaki T, Takita T, Ohta M, Inouye K.

Biochem Biophys Res Commun. 2003 Aug 29;308(3):511-7.

PMID:
12914780
22.

Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.

Ikezawa N, Tanaka M, Nagayoshi M, Shinkyo R, Sakaki T, Inouye K, Sato F.

J Biol Chem. 2003 Oct 3;278(40):38557-65. Epub 2003 May 5.

23.

Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins.

Shinkyo R, Sakaki T, Ohta M, Inouye K.

Arch Biochem Biophys. 2003 Jan 1;409(1):180-7.

PMID:
12464257
24.

Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems.

Inouye K, Shinkyo R, Takita T, Ohta M, Sakaki T.

J Agric Food Chem. 2002 Sep 11;50(19):5496-502.

PMID:
12207498
25.

Biodegradation of polychlorinated dibenzo-p-dioxins by recombinant yeast expressing rat CYP1A subfamily.

Sakaki T, Shinkyo R, Takita T, Ohta M, Inouye K.

Arch Biochem Biophys. 2002 May 1;401(1):91-8.

PMID:
12054491

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