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Items: 1 to 50 of 54

1.

Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes.

McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T.

Front Immunol. 2017 Sep 13;8:1094. doi: 10.3389/fimmu.2017.01094. eCollection 2017.

2.

Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly.

Sugahara H, Okai S, Odamaki T, Wong CB, Kato K, Mitsuyama E, Xiao JZ, Shinkura R.

Front Microbiol. 2017 Sep 12;8:1757. doi: 10.3389/fmicb.2017.01757. eCollection 2017.

3.

Intestinal IgA as a modulator of the gut microbiota.

Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S, Kato T, Miyauchi E, Ohno H, Shinkura R.

Gut Microbes. 2017 Sep 3;8(5):486-492. doi: 10.1080/19490976.2017.1310357. Epub 2017 Apr 6. Review.

4.

High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.

Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.

Nat Microbiol. 2016 Jul 4;1(9):16103. doi: 10.1038/nmicrobiol.2016.103.

PMID:
27562257
5.

A novel germline mutation in a patient with nevoid basal cell carcinoma syndrome showing cystic lesion in the lung.

Miyata R, Kurosawa M, Sato M, Kono T, Takubo Y, Okai S, Yamada K, Shinkura R, Date H, Matsuda F.

Hum Genome Var. 2015 Jun 11;2:15014. doi: 10.1038/hgv.2015.14. eCollection 2015.

6.

Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses.

Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto N; Human Disease Genomics Working Group; Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium, Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M, Mimori T, Yamada R, Matsuda F.

PLoS One. 2011;6(6):e20457. doi: 10.1371/journal.pone.0020457. Epub 2011 Jun 3.

7.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7920-5. doi: 10.1073/pnas.1104423108. Epub 2011 Apr 25.

8.

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.

Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.

Nat Immunol. 2011 Mar;12(3):264-70. doi: 10.1038/ni.1991. Epub 2011 Jan 23.

PMID:
21258321
9.

AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.

Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.

Leukemia. 2010 May;24(5):1018-24. doi: 10.1038/leu.2010.40. Epub 2010 Apr 1.

PMID:
20357822
10.

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22375-80. doi: 10.1073/pnas.0911879106. Epub 2009 Dec 11.

11.

B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.

Tran TH, Nakata M, Suzuki K, Begum NA, Shinkura R, Fagarasan S, Honjo T, Nagaoka H.

Nat Immunol. 2010 Feb;11(2):148-54. doi: 10.1038/ni.1829. Epub 2009 Dec 6.

12.

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.

Int Immunol. 2009 Aug;21(8):947-55. doi: 10.1093/intimm/dxp061. Epub 2009 Jun 25.

PMID:
19556307
13.

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

Doi T, Kato L, Ito S, Shinkura R, Wei M, Nagaoka H, Wang J, Honjo T.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2758-63. doi: 10.1073/pnas.0813253106. Epub 2009 Feb 6.

14.

Molecular mechanism for generation of antibody memory.

Shivarov V, Shinkura R, Doi T, Begum NA, Nagaoka H, Okazaki IM, Ito S, Nonaka T, Kinoshita K, Honjo T.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):569-75. doi: 10.1098/rstb.2008.0183. Review.

15.

Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.

Shivarov V, Shinkura R, Honjo T.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15866-71. doi: 10.1073/pnas.0806641105. Epub 2008 Oct 2.

16.

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.

Wang J, Shinkura R, Muramatsu M, Nagaoka H, Kinoshita K, Honjo T.

J Biol Chem. 2008 Jan 4;283(1):660. No abstract available.

17.

Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.

Muramatsu M, Nagaoka H, Shinkura R, Begum NA, Honjo T.

Adv Immunol. 2007;94:1-36. Review.

PMID:
17560270
18.

Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.

Yabe D, Fukuda H, Aoki M, Yamada S, Takebayashi S, Shinkura R, Yamamoto N, Honjo T.

Genesis. 2007 May;45(5):300-6.

PMID:
17457934
19.

Regulation of AID function in vivo.

Shinkura R, Okazaki IM, Muto T, Begum NA, Honjo T.

Adv Exp Med Biol. 2007;596:71-81. Review. No abstract available.

PMID:
17338177
20.

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

Tsuji M, Shinkura R, Kuroda K, Yabe D, Honjo T.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1610-5. Epub 2007 Jan 22.

21.

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.

Begum NA, Izumi N, Nishikori M, Nagaoka H, Shinkura R, Honjo T.

J Biol Chem. 2007 Jan 5;282(1):731-42. Epub 2006 Nov 6.

22.

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.

Wang J, Shinkura R, Muramatsu M, Nagaoka H, Kinoshita K, Honjo T.

J Biol Chem. 2006 Jul 14;281(28):19115-23. Epub 2006 May 10. Retraction in: Wang J, Shinkura R, Muramatsu M, Nagaoka H, Kinoshita K, Honjo T. J Biol Chem. 2008 Jan 4;283(1):660.

23.

Molecular basis for the involvement of thymidine phosphorylase in cancer invasion.

Gotanda T, Haraguchi M, Tachiwada T, Shinkura R, Koriyama C, Akiba S, Kawahara M, Nishiyama K, Sumizawa T, Furukawa T, Mimata H, Nomura Y, Akiyama S, Nakagawa M.

Int J Mol Med. 2006 Jun;17(6):1085-91.

PMID:
16685420
24.

AID to overcome the limitations of genomic information by introducing somatic DNA alterations.

Honjo T, Muramatsu M, Nagaoka H, Kinoshita K, Shinkura R.

Proc Jpn Acad Ser B Phys Biol Sci. 2006 May;82(3):104-20. Review.

25.

AID to overcome the limitations of genomic information.

Honjo T, Nagaoka H, Shinkura R, Muramatsu M.

Nat Immunol. 2005 Jul;6(7):655-61. Review.

PMID:
15970938
26.

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T.

Science. 2004 Aug 20;305(5687):1160-3.

27.

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.

Begum NA, Kinoshita K, Muramatsu M, Nagaoka H, Shinkura R, Honjo T.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13003-7. Epub 2004 Aug 18.

28.

Separate domains of AID are required for somatic hypermutation and class-switch recombination.

Shinkura R, Ito S, Begum NA, Nagaoka H, Muramatsu M, Kinoshita K, Sakakibara Y, Hijikata H, Honjo T.

Nat Immunol. 2004 Jul;5(7):707-12. Epub 2004 Jun 13.

PMID:
15195091
29.

Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.

Tian M, Jones DA, Smith M, Shinkura R, Alt FW.

Mol Cell Biol. 2004 Mar;24(6):2237-42.

30.

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.

Ito S, Nagaoka H, Shinkura R, Begum N, Muramatsu M, Nakata M, Honjo T.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1975-80. Epub 2004 Feb 9.

31.
32.

Occupational recovery after open-door type laminoplasty for patients with ossification of the posterior longitudinal ligament.

Kamizono J, Matsunaga S, Hayashi K, Shinkura R, Koriyama C, Sakou T, Komiya S.

Spine (Phila Pa 1976). 2003 Aug 15;28(16):1889-92.

PMID:
12923480
33.

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.

Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.

EMBO J. 2003 Jul 15;22(14):3602-12.

34.

The influence of transcriptional orientation on endogenous switch region function.

Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW.

Nat Immunol. 2003 May;4(5):435-41.

PMID:
12679811
35.

Pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament.

Matsunaga S, Kukita M, Hayashi K, Shinkura R, Koriyama C, Sakou T, Komiya S.

J Neurosurg. 2002 Mar;96(2 Suppl):168-72.

PMID:
12450279
36.

A simple method for evaluating abnormal lengthening of the QT interval during the face immersion test.

Kamimura J, Yoshinaga M, Kono Y, Yanagi S, Nishi J, Nomura Y, Fukushige T, Kusubae R, Shinkura R, Miyata K.

Pediatr Cardiol. 2002 Mar-Apr;23(2):122-6. Epub 2002 Feb 19.

PMID:
11889520
37.

Quantitative evaluation of skin condition in an epidemiological survey of females living in northern versus southern Japan.

Hillebrand GG, Miyamoto K, Schnell B, Ichihashi M, Shinkura R, Akiba S.

J Dermatol Sci. 2001 Aug;27 Suppl 1:S42-52.

PMID:
11514124
38.

Human leukocyte antigens related to Epstein-Barr virus-associated gastric carcinoma in Japanese patients.

Koriyama C, Shinkura R, Hamasaki Y, Fujiyoshi T, Eizuru Y, Tokunaga M.

Eur J Cancer Prev. 2001 Feb;10(1):69-75.

PMID:
11263593
39.

Thioredoxin inhibits tumor necrosis factor- or interleukin-1-induced NF-kappaB activation at a level upstream of NF-kappaB-inducing kinase.

Takeuchi J, Hirota K, Itoh T, Shinkura R, Kitada K, Yodoi J, Namba T, Fukuda K.

Antioxid Redox Signal. 2000 Spring;2(1):83-92.

PMID:
11232604
40.

Mechanism of B1 cell differentiation and migration in GALT.

Fagarasan S, Shinkura R, Kamata T, Nogaki F, Ikuta K, Honjo T.

Curr Top Microbiol Immunol. 2000;252:221-9. No abstract available.

PMID:
11125479
42.

Influence of chronic UV exposure and lifestyle on facial skin photo-aging--results from a pilot study.

Akiba S, Shinkura R, Miyamoto K, Hillebrand G, Yamaguchi N, Ichihashi M.

J Epidemiol. 1999 Dec;9(6 Suppl):S136-42.

PMID:
10709362
43.

Epstein-Barr virus-specific antibodies in Epstein-Barr virus-positive and -negative gastric carcinoma cases in Japan.

Shinkura R, Yamamoto N, Koriyama C, Shinmura Y, Eizuru Y, Tokunaga M.

J Med Virol. 2000 Apr;60(4):411-6.

PMID:
10686024
44.

Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40.

Garceau N, Kosaka Y, Masters S, Hambor J, Shinkura R, Honjo T, Noelle RJ.

J Exp Med. 2000 Jan 17;191(2):381-6.

45.
46.

Epstein-Barr virus-associated gastric carcinoma in Mexico: analysis of 135 consecutive gastrectomies in two hospitals.

Herrera-Goepfert R, Reyes E, Hernández-Avila M, Mohar A, Shinkura R, Fujiyama C, Akiba S, Eizuru Y, Harada Y, Tokunaga M.

Mod Pathol. 1999 Sep;12(9):873-8.

PMID:
10496595
47.

IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches.

Yoshida H, Honda K, Shinkura R, Adachi S, Nishikawa S, Maki K, Ikuta K, Nishikawa SI.

Int Immunol. 1999 May;11(5):643-55.

PMID:
10330270
48.

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase.

Shinkura R, Kitada K, Matsuda F, Tashiro K, Ikuta K, Suzuki M, Kogishi K, Serikawa T, Honjo T.

Nat Genet. 1999 May;22(1):74-7.

PMID:
10319865
49.

Asthma-like disease in the children living in the neighborhood of Mt. Sakurajima.

Uda H, Akiba S, Hatano H, Shinkura R.

J Epidemiol. 1999 Feb;9(1):27-31.

50.

Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjögren's syndrome.

Tsubata R, Tsubata T, Hiai H, Shinkura R, Matsumura R, Sumida T, Miyawaki S, Ishida H, Kumagai S, Nakao K, Honjo T.

Eur J Immunol. 1996 Nov;26(11):2742-8.

PMID:
8921964

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