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Items: 1 to 50 of 269

1.

Multicenter survey of sutureless 27-gauge vitrectomy for primary rhegmatogenous retinal detachment: a consecutive series of 410 cases.

Shinkai Y, Oshima Y, Yoneda K, Kogo J, Imai H, Watanabe A, Matsui Y, Suzuki K, Sotozono C; 27G Vitrectomy Study Group.

Graefes Arch Clin Exp Ophthalmol. 2019 Sep 2. doi: 10.1007/s00417-019-04448-2. [Epub ahead of print]

PMID:
31478083
2.

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.

Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M.

Sci Signal. 2019 Jun 25;12(587). pii: eaaw1920. doi: 10.1126/scisignal.aaw1920.

PMID:
31239323
3.

Prostate Stem Cell Antigen Gene Polymorphism Is Associated with H. pylori-related Promoter DNA Methylation in Nonneoplastic Gastric Epithelium.

Tahara T, Tahara S, Horiguchi N, Kato T, Shinkai Y, Okubo M, Terada T, Yoshida D, Funasaka K, Nagasaka M, Nakagawa Y, Kurahashi H, Shibata T, Tsukamoto T, Ohmiya N.

Cancer Prev Res (Phila). 2019 Sep;12(9):579-584. doi: 10.1158/1940-6207.CAPR-19-0035. Epub 2019 Jun 18.

PMID:
31213476
4.

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.

Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y.

Environ Health Perspect. 2019 Jun;127(6):67002. doi: 10.1289/EHP4949. Epub 2019 Jun 5.

5.
6.

Pain characteristics and incidence of functional disability among community-dwelling older adults.

Makino K, Lee S, Bae S, Jung S, Shinkai Y, Chiba I, Shimada H.

PLoS One. 2019 Apr 15;14(4):e0215467. doi: 10.1371/journal.pone.0215467. eCollection 2019.

7.

Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress.

Shinkai Y, Kumagai Y.

Toxicol Sci. 2019 Jul 1;170(1):3-9. doi: 10.1093/toxsci/kfz091.

PMID:
30985901
8.

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.

Au Yeung WK, Brind'Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H.

Cell Rep. 2019 Apr 2;27(1):282-293.e4. doi: 10.1016/j.celrep.2019.03.002.

9.

Histone H1 quantity determines the efficiency of chromatin condensation in both apoptotic and live cells.

Kijima M, Yamagishi H, Hara Y, Kasai M, Takami Y, Takemura H, Miyanari Y, Shinkai Y, Mizuta R.

Biochem Biophys Res Commun. 2019 Apr 30;512(2):202-207. doi: 10.1016/j.bbrc.2019.03.030. Epub 2019 Mar 14.

PMID:
30879765
10.

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825.

Shinkai Y, Koyasu S, Nakayama KI, Murphy KM, Loh DY, Reinherz EL, Alt FW.

J Immunol. 2019 Mar 1;202(5):1317-1320. No abstract available.

PMID:
30782850
11.

G9a-dependent histone methylation can be induced in G1 phase of cell cycle.

Fukuda M, Sakaue-Sawano A, Shimura C, Tachibana M, Miyawaki A, Shinkai Y.

Sci Rep. 2019 Jan 30;9(1):956. doi: 10.1038/s41598-018-37507-5.

12.

The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Mar 18;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340. Epub 2019 Feb 7.

PMID:
30681327
13.

The effect of a multicomponent intervention to promote community activity on cognitive function in older adults with mild cognitive impairment: A randomized controlled trial.

Bae S, Lee S, Lee S, Jung S, Makino K, Harada K, Harada K, Shinkai Y, Chiba I, Shimada H.

Complement Ther Med. 2019 Feb;42:164-169. doi: 10.1016/j.ctim.2018.11.011. Epub 2018 Nov 13.

PMID:
30670238
14.

Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.

Kori S, Ferry L, Matano S, Jimenji T, Kodera N, Tsusaka T, Matsumura R, Oda T, Sato M, Dohmae N, Ando T, Shinkai Y, Defossez PA, Arita K.

Structure. 2019 Mar 5;27(3):485-496.e7. doi: 10.1016/j.str.2018.11.012. Epub 2019 Jan 10.

PMID:
30639225
15.

Retraction Notice to: Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a.

Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK.

Cell Stem Cell. 2019 Jan 3;24(1):193. doi: 10.1016/j.stem.2018.12.008. Epub 2018 Dec 27. No abstract available.

PMID:
30595496
16.

Intestinal F-box protein regulates quick avoidance behavior of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa.

Saito R, Shinkai Y, Doi M.

Genes Cells. 2019 Mar;24(3):192-201. doi: 10.1111/gtc.12666. Epub 2019 Jan 28.

17.

Daily Physical Activity and Functional Disability Incidence in Community-Dwelling Older Adults with Chronic Pain: A Prospective Cohort Study.

Makino K, Lee S, Lee S, Bae S, Jung S, Shinkai Y, Shimada H.

Pain Med. 2018 Dec 18. doi: 10.1093/pm/pny263. [Epub ahead of print]

PMID:
30561732
18.

FOXA2 gene mutation in a patient with congenital complex pituitary hormone deficiency.

Boda H, Miyata M, Inagaki H, Shinkai Y, Kato T, Yoshikawa T, Kurahashi H.

Eur J Med Genet. 2018 Nov 8. pii: S1769-7212(18)30408-7. doi: 10.1016/j.ejmg.2018.11.004. [Epub ahead of print]

PMID:
30414530
19.

Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553-563.

Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T.

J Immunol. 2018 Nov 1;201(9):2530-2540. No abstract available.

PMID:
30348658
20.

Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.

Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y.

Epigenetics Chromatin. 2018 Oct 4;11(1):56. doi: 10.1186/s13072-018-0231-z.

21.

The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells.

Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J.

Sci Rep. 2018 Sep 24;8(1):14237. doi: 10.1038/s41598-018-32200-z.

22.

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.

Sohtome Y, Shimazu T, Barjau J, Fujishiro S, Akakabe M, Terayama N, Dodo K, Ito A, Yoshida M, Shinkai Y, Sodeoka M.

Chem Commun (Camb). 2018 Aug 14;54(66):9202-9205. doi: 10.1039/c8cc03907k.

PMID:
30063235
23.

DNA methylation accumulation in gastric mucosa adjacent to cancer after Helicobacter pylori eradication.

Tahara S, Tahara T, Horiguchi N, Kato T, Shinkai Y, Yamashita H, Yamada H, Kawamura T, Terada T, Okubo M, Nagasaka M, Nakagawa Y, Shibata T, Yamada S, Urano M, Tsukamoto T, Kurahashi H, Kuroda M, Ohmiya N.

Int J Cancer. 2019 Jan 1;144(1):80-88. doi: 10.1002/ijc.31667. Epub 2018 Nov 12.

PMID:
29978464
24.
25.
26.

A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.

Fukuda K, Okuda A, Yusa K, Shinkai Y.

Genome Res. 2018 Jun;28(6):846-858. doi: 10.1101/gr.227280.117. Epub 2018 May 4.

27.

A Simple Method for Visualization of Locus-Specific H4K20me1 Modifications in Living Caenorhabditis elegans Single Cells.

Shinkai Y, Kuramochi M, Doi M.

G3 (Bethesda). 2018 Jul 2;8(7):2249-2255. doi: 10.1534/g3.118.200333.

28.

Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage-Associated Genes in Proliferating CD8 T Cells.

Verbaro DJ, Sakurai N, Kim B, Shinkai Y, Egawa T.

J Immunol. 2018 Jun 15;200(12):3891-3896. doi: 10.4049/jimmunol.1701700. Epub 2018 May 2.

29.

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing.

Kato M, Takemoto K, Shinkai Y.

Nat Commun. 2018 Apr 27;9(1):1683. doi: 10.1038/s41467-018-04132-9.

30.

Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis.

Kawaguchi H, Matsumoto I, Osada A, Kurata I, Ebe H, Tanaka Y, Inoue A, Umeda N, Kondo Y, Tsuboi H, Shinkai Y, Kumagai Y, Ishigami A, Sumida T.

Arthritis Res Ther. 2018 Apr 10;20(1):66. doi: 10.1186/s13075-018-1562-7.

31.

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.

Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi H, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M.

Stem Cell Reports. 2018 Apr 10;10(4):1340-1354. doi: 10.1016/j.stemcr.2018.02.002. Epub 2018 Mar 8.

32.

Biochemical validation of EHMT1 missense mutations in Kleefstra syndrome.

Yamada A, Shimura C, Shinkai Y.

J Hum Genet. 2018 May;63(5):555-562. doi: 10.1038/s10038-018-0413-3. Epub 2018 Feb 19.

PMID:
29459631
33.

Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.

Shimazu T, Furuse T, Balan S, Yamada I, Okuno S, Iwanari H, Suzuki T, Hamakubo T, Dohmae N, Yoshikawa T, Wakana S, Shinkai Y.

Sci Rep. 2018 Jan 19;8(1):1179. doi: 10.1038/s41598-018-19615-4.

34.

[Clinical Study of Testicular Fasciotomy for Testicular Torsion].

Nagasawa S, Kanematsu A, Shinkai Y, Shimatani K, Hashimoto T, Togo Y, Suzuki T, Go S, Nojima M, Yamamoto S.

Hinyokika Kiyo. 2017 Nov;63(11):455-459. doi: 10.14989/ActaUrolJap_63_11_455. Japanese.

35.

Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet.

Umezawa M, Nakamura M, El-Ghoneimy AA, Onoda A, Shaheen HM, Hori H, Shinkai Y, El-Sayed YS, El-Far AH, Takeda K.

Food Chem Toxicol. 2018 Jan;111:284-294. doi: 10.1016/j.fct.2017.11.027. Epub 2017 Nov 21.

PMID:
29175182
36.

The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity.

Akiyama M, Shinkai Y, Unoki T, Shim I, Ishii I, Kumagai Y.

Chem Res Toxicol. 2017 Dec 18;30(12):2209-2217. doi: 10.1021/acs.chemrestox.7b00278. Epub 2017 Nov 20.

PMID:
29116755
37.

Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.

Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.

Cell Rep. 2017 Sep 19;20(12):2756-2765. doi: 10.1016/j.celrep.2017.08.088.

38.

Correction: Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly.

Shirai A, Kawaguchi T, Shimojo H, Muramatsu D, Ishida-Yonetani M, Nishimura Y, Kimura H, Nakayama JI, Shinkai Y.

Elife. 2017 Sep 6;6. pii: e31641. doi: 10.7554/eLife.31641. No abstract available.

39.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

40.

Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly.

Shirai A, Kawaguchi T, Shimojo H, Muramatsu D, Ishida-Yonetani M, Nishimura Y, Kimura H, Nakayama JI, Shinkai Y.

Elife. 2017 Aug 1;6. pii: e25317. doi: 10.7554/eLife.25317. Erratum in: Elife. 2017 Sep 06;6:.

41.

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.

Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.

Oncogene. 2017 Nov 9;36(45):6262-6271. doi: 10.1038/onc.2017.222. Epub 2017 Jul 10.

PMID:
28692045
42.

Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.

Abiko Y, Shinkai Y, Unoki T, Hirose R, Uehara T, Kumagai Y.

Sci Rep. 2017 Jul 6;7(1):4814. doi: 10.1038/s41598-017-04590-z.

43.

Essential roles of G9a in cell proliferation and differentiation during tooth development.

Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.

Exp Cell Res. 2017 Aug 15;357(2):202-210. doi: 10.1016/j.yexcr.2017.05.016. Epub 2017 May 17.

PMID:
28527696
44.

Silencing of BCR/ABL Chimeric Gene in Human Chronic Myelogenous Leukemia Cell Line K562 by siRNA-Nuclear Export Signal Peptide Conjugates.

Shinkai Y, Kashihara S, Minematsu G, Fujii H, Naemura M, Kotake Y, Morita Y, Ohnuki K, Fokina AA, Stetsenko DA, Filichev VV, Fujii M.

Nucleic Acid Ther. 2017 Jun;27(3):168-175. doi: 10.1089/nat.2016.0647. Epub 2017 Mar 29.

PMID:
28355131
45.

Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice.

Li YJ, Shimizu T, Shinkai Y, Hirata Y, Inagaki H, Takeda K, Azuma A, Yamamoto M, Kawada T.

Int J Mol Sci. 2017 Mar 17;18(3). pii: E649. doi: 10.3390/ijms18030649.

46.

Cadmium-Mediated Activation of the HSP90/HSF1 Pathway Regulated by Reactive Persulfides/Polysulfides.

Shinkai Y, Masuda A, Akiyama M, Xian M, Kumagai Y.

Toxicol Sci. 2017 Apr 1;156(2):412-421. doi: 10.1093/toxsci/kfw268.

47.

1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.

Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.

Free Radic Biol Med. 2017 Mar;104:118-128. doi: 10.1016/j.freeradbiomed.2016.12.047. Epub 2016 Dec 31.

PMID:
28049024
48.

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production.

Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.

J Biol Chem. 2017 Jan 6;292(1):205-216. doi: 10.1074/jbc.M116.744755. Epub 2016 Nov 21.

49.

Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.

Muramatsu D, Kimura H, Kotoshiba K, Tachibana M, Shinkai Y.

Cell Struct Funct. 2016 Dec 3;41(2):145-152. Epub 2016 Oct 12.

50.

Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells.

Hara T, Yoshida E, Shinkai Y, Yamamoto C, Fujiwara Y, Kumagai Y, Kaji T.

J Cell Biochem. 2017 May;118(5):1087-1096. doi: 10.1002/jcb.25721. Epub 2017 Jan 10.

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