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Items: 38

1.

Synthesis of Aryl C-Glycosides via Iron-Catalyzed Cross Coupling of Halosugars: Stereoselective Anomeric Arylation of Glycosyl Radicals.

Adak L, Kawamura S, Toma G, Takenaka T, Isozaki K, Takaya H, Orita A, Li HC, Shing TKM, Nakamura M.

J Am Chem Soc. 2017 Aug 9;139(31):10693-10701. doi: 10.1021/jacs.7b03867. Epub 2017 Aug 1.

PMID:
28762276
2.

Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition.

Ng WL, Li HC, Lau KM, Chan AKN, Lau CB, Shing TKM.

Sci Rep. 2017 Jul 17;7(1):5581. doi: 10.1038/s41598-017-05895-9.

3.

Palladium-Catalyzed Arylation of Carbasugars Enables the Discovery of Potent and Selective SGLT2 Inhibitors.

Ng WL, Lau KM, Lau CB, Shing TK.

Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13818-13821. doi: 10.1002/anie.201608758. Epub 2016 Oct 4.

PMID:
27699962
4.

Intramolecular direct aldol reactions of sugar 2,7-diketones: syntheses of hydroxylated cycloalka(e)nones.

Shing TK, Cheng HM.

Org Biomol Chem. 2015 Apr 28;13(16):4795-802. doi: 10.1039/c5ob00253b.

PMID:
25811918
5.

Syntheses of arabinose-derived pyrrolidine catalysts and their applications in intramolecular Diels-Alder reactions.

Shing TK, Wu KW, Wu HT, Xiao Q.

Org Biomol Chem. 2015 Feb 14;13(6):1754-62. doi: 10.1039/c4ob02219j.

PMID:
25503272
6.

Conformationally locked bicyclo[4.3.0]nonane carbanucleosides: synthesis and bio-evaluation.

Shing TK, Wong AW, Li H, Liu ZF, Chan PK.

Org Biomol Chem. 2014 Dec 14;12(46):9439-45. doi: 10.1039/c4ob01763c. Epub 2014 Oct 17.

PMID:
25325214
7.

Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors.

Shing TK, Ng WL, Chan JY, Lau CB.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8401-5. doi: 10.1002/anie.201302543. Epub 2013 Jun 19. No abstract available.

PMID:
23784919
8.

Synthesis of chiral hydroxylated enones as potential anti-tumor agents.

Shing TK, Wu HT, Kwok HF, Lau CB.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7562-5. doi: 10.1016/j.bmcl.2012.10.026. Epub 2012 Oct 13.

PMID:
23102892
9.

Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells.

Wang CH, Wu HT, Cheng HM, Yen TJ, Lu IH, Chang HC, Jao SC, Shing TK, Li WS.

J Med Chem. 2011 Dec 22;54(24):8574-81. doi: 10.1021/jm201131n. Epub 2011 Nov 23.

PMID:
22085405
10.
11.

An alternative synthesis of 1,1'-bis-valienamine from D-glucose.

Shing TK, Cheng HM.

J Org Chem. 2010 May 21;75(10):3522-5. doi: 10.1021/jo100474p.

PMID:
20392097
12.

Facile syntheses of (+)-gabosines A, D, and E.

Shing TK, Cheng HM.

Org Biomol Chem. 2009 Dec 21;7(24):5098-102. doi: 10.1039/b911810a. Epub 2009 Oct 16.

PMID:
20024104
13.

Carbocyclization of carbohydrates: diastereoselective synthesis of (+)-gabosine F, (-)-gabosine O, and (+)-4-epi-gabosine O.

Shing TK, So KH, Kwok WS.

Org Lett. 2009 Nov 5;11(21):5070-3. doi: 10.1021/ol902071e.

PMID:
19803475
14.

Stereo- and regioselectivity in an intramolecular nitrone-alkene cycloaddition of hept-6-enoses with a trans-acetonide blocking group.

Shing TK, Wong WF, Ikeno T, Yamada T.

Chemistry. 2009 Mar 2;15(11):2693-707. doi: 10.1002/chem.200800867.

PMID:
19180592
15.

Presence of donor-derived DNA and cells in the urine of sex-mismatched hematopoietic stem cell transplant recipients: implication for the transrenal hypothesis.

Hung EC, Shing TK, Chim SS, Yeung PC, Chan RW, Chik KW, Lee V, Tsui NB, Li CK, Wong CS, Chiu RW, Lo YM.

Clin Chem. 2009 Apr;55(4):715-22. doi: 10.1373/clinchem.2008.113530. Epub 2008 Oct 30.

16.

Intramolecular direct aldol reactions of sugar diketones: syntheses of valiolamine and validoxylamine G.

Shing TK, Cheng HM.

Org Lett. 2008 Sep 18;10(18):4137-9. doi: 10.1021/ol801889n. Epub 2008 Aug 26.

PMID:
18729372
17.

Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent.

Shing TK, Cheng HM, Wong WF, Kwong CS, Li J, Lau CB, Leung PS, Cheng CH.

Org Lett. 2008 Jul 17;10(14):3145-8. doi: 10.1021/ol8010503. Epub 2008 Jun 17.

PMID:
18557625
18.

Detection and characterization of placental microRNAs in maternal plasma.

Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW, Lo YM.

Clin Chem. 2008 Mar;54(3):482-90. doi: 10.1373/clinchem.2007.097972. Epub 2008 Jan 24.

19.

Short syntheses of gabosine I and gabosine G from delta-D-gluconolactone.

Shing TK, Cheng HM.

J Org Chem. 2007 Aug 17;72(17):6610-3. Epub 2007 Jul 19.

PMID:
17637067
20.

Intramolecular nitrile oxide-alkene cycloaddition of sugar derivatives with unmasked hydroxyl group(s).

Shing TK, Wong WF, Cheng HM, Kwok WS, So KH.

Org Lett. 2007 Mar 1;9(5):753-6. Epub 2007 Jan 31.

PMID:
17263540
22.

Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells.

Nissom PM, Sanny A, Kok YJ, Hiang YT, Chuah SH, Shing TK, Lee YY, Wong KT, Hu WS, Sim MY, Philp R.

Mol Biotechnol. 2006 Oct;34(2):125-40.

PMID:
17172658
24.

Mild manganese(III) acetate catalyzed allylic oxidation: application to simple and complex alkenes.

Shing TK, Yeung YY, Su PL.

Org Lett. 2006 Jul 6;8(14):3149-51.

PMID:
16805574
26.

Total synthesis of (-)-samaderine Y from (S)-(+)-carvone.

Shing TK, Yeung YY.

Angew Chem Int Ed Engl. 2005 Dec 9;44(48):7981-4. No abstract available.

PMID:
16283683
27.

Arabinose-derived ketones as catalysts for asymmetric epoxidation of alkenes.

Shing TK, Leung GY, Luk T.

J Org Chem. 2005 Sep 2;70(18):7279-89.

PMID:
16122249
28.

Facile, efficient, and enantiospecific syntheses of 1,1'-N-linked pseudodisaccharides as a new class of glycosidase inhibitors.

Shing TK, Kwong CS, Cheung AW, Kok SH, Yu Z, Li J, Cheng CH.

J Am Chem Soc. 2004 Dec 15;126(49):15990-2.

PMID:
15584732
29.

Studies towards simalikalactone D and quassimarin: construction of an advanced pentacyclic intermediate.

Shing TK, Zhu XY, Yeung YY.

Chemistry. 2003 Nov 21;9(22):5489-500.

PMID:
14639632
30.

Facile and Enantiospecific Syntheses of Goniotriol Analogues.

Shing TK, Tai VW.

J Org Chem. 1999 Mar 19;64(6):2140-2144. No abstract available.

PMID:
11674316
31.

Enantiospecific Syntheses of Valienamine and 2-epi-Valienamine(1).

Shing TK, Li TY, Kok SH.

J Org Chem. 1999 Mar 19;64(6):1941-1946.

PMID:
11674286
32.

Acyclic Stereodifferentiation: Selective Construction of Tetrahydropyran/Oxepane via Intramolecular Nitrone-Alkene Cycloaddition of Acyclic 3-O-Allylmonosaccharides.

Shing TK, Zhong YL, Mak TC, Wang Rj RJ, Xue F.

J Org Chem. 1998 Feb 6;63(3):414-415. No abstract available.

PMID:
11672019
33.

A new synthesis of valienamine.

Kok SH, Lee CC, Shing TK.

J Org Chem. 2001 Oct 19;66(21):7184-90. No abstract available.

PMID:
11597249
34.

Total synthesis of (+)-quassin.

Shing TK, Jiang Q.

J Org Chem. 2000 Oct 20;65(21):7059-69.

PMID:
11031029
35.

Efficient and Facile Glycol Cleavage Oxidation Using Improved Silica Gel-Supported Sodium Metaperiodate.

Zhong YL, Shing TK.

J Org Chem. 1997 Apr 18;62(8):2622-2624. No abstract available.

PMID:
11671605
36.

Kinetic studies on cyclophellitol analogues--mechanism-based inactivators.

Tai VW, Fung PH, Wong YS, Shing TK.

Biochem Biophys Res Commun. 1995 Aug 4;213(1):175-80.

PMID:
7639733
37.

Antitumor effect of chemically synthesized (+)-goniopypyrone.

Shing TK, Look M, Choy YM.

Chemotherapy. 1993 Mar-Apr;39(2):132-4.

PMID:
8458246
38.

Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone.

Aghil O, Bibby MC, Carrington SJ, Double J, Douglas KT, Phillips RM, Shing TK.

Anticancer Drug Des. 1992 Feb;7(1):67-82.

PMID:
1543528

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