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Items: 1 to 50 of 300

1.

Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.

Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.

ACS Chem Biol. 2019 Aug 16;14(8):1819-1828. doi: 10.1021/acschembio.9b00410. Epub 2019 Jul 31.

PMID:
31365229
2.

An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.

Kobayashi M, Tomita T, Shin-Ya K, Nishiyama M, Kuzuyama T.

Angew Chem Int Ed Engl. 2019 Jul 26. doi: 10.1002/anie.201906864. [Epub ahead of print]

PMID:
31350791
3.

A Case of Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder.

Sakaguchi R, Fujikawa K, Okamoto M, Matsuo E, Matsumoto K, Uchida T, Shin-Ya K, Nakashima M, Mizokami A, Kawakami A.

Intern Med. 2019 Jul 10. doi: 10.2169/internalmedicine.2995-19. [Epub ahead of print]

4.

Comprehensive Derivatization of Thioviridamides by Heterologous Expression.

Kudo K, Koiwai H, Kagaya N, Nishiyama M, Kuzuyama T, Shin-Ya K, Ikeda H.

ACS Chem Biol. 2019 Jun 21;14(6):1135-1140. doi: 10.1021/acschembio.9b00330. Epub 2019 Jun 11.

PMID:
31184470
5.

The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.

Romo AJ, Shiraishi T, Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-Ya K, Nishiyama M, Kuzuyama T, Liu HW.

J Am Chem Soc. 2019 May 31. doi: 10.1021/jacs.9b03021. [Epub ahead of print]

PMID:
31150226
6.

Statins affect human glioblastoma and other cancers through TGF-β inhibition.

Xiao A, Brenneman B, Floyd D, Comeau L, Spurio K, Olmez I, Lee J, Nakano I, Godlewski J, Bronisz A, Kagaya N, Shin-Ya K, Purow B.

Oncotarget. 2019 Mar 1;10(18):1716-1728. doi: 10.18632/oncotarget.26733. eCollection 2019 Mar 1.

7.

Solid-liquid Interface Screening SystemーApplication to the Screening of Antibiotic and Cytotoxic Substance-producing Fungi.

Oda S, Nomura S, Nakagawa M, Shin-Ya K, Kagaya N, Kawahara T.

Biocontrol Sci. 2019;24(1):47-56. doi: 10.4265/bio.24.47.

8.

Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.

Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.

J Biochem. 2019 Jul 1;166(1):41-50. doi: 10.1093/jb/mvz007.

PMID:
30690451
9.

Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb.

Hashimoto T, Hashimoto J, Kozone I, Amagai K, Kawahara T, Takahashi S, Ikeda H, Shin-Ya K.

Org Lett. 2018 Dec 21;20(24):7996-7999. doi: 10.1021/acs.orglett.8b03570. Epub 2018 Dec 13.

PMID:
30543302
10.

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer.

Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T.

Bioorg Med Chem. 2018 Dec 15;26(23-24):6023-6034. doi: 10.1016/j.bmc.2018.11.001. Epub 2018 Nov 7.

PMID:
30455074
11.

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution.

Awakawa T, Fujioka T, Zhang L, Hoshino S, Hu Z, Hashimoto J, Kozone I, Ikeda H, Shin-Ya K, Liu W, Abe I.

Nat Commun. 2018 Aug 30;9(1):3534. doi: 10.1038/s41467-018-05877-z.

12.

Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster.

Thong WL, Shin-Ya K, Nishiyama M, Kuzuyama T.

ACS Chem Biol. 2018 Sep 21;13(9):2615-2622. doi: 10.1021/acschembio.8b00553. Epub 2018 Aug 17.

PMID:
30080389
13.

Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria.

Matsuda K, Tomita T, Shin-Ya K, Wakimoto T, Kuzuyama T, Nishiyama M.

J Am Chem Soc. 2018 Jul 25;140(29):9083-9086. doi: 10.1021/jacs.8b05354. Epub 2018 Jul 17.

PMID:
30001119
14.

Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms.

Kim JH, Komatsu M, Shin-Ya K, Omura S, Ikeda H.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6828-6833. doi: 10.1073/pnas.1800715115. Epub 2018 Jun 14.

15.

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.

Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, Branzei D, Neuman KC, Brosh RM Jr.

Nucleic Acids Res. 2018 Jul 6;46(12):6238-6256. doi: 10.1093/nar/gky403.

16.

Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.

Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

J Am Chem Soc. 2018 May 30;140(21):6631-6639. doi: 10.1021/jacs.8b02769. Epub 2018 May 21.

PMID:
29716187
17.

Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster.

Kawahara T, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Koiwai H, Komatsu M, Fujie M, Sato N, Ikeda H, Shin-Ya K.

J Nat Prod. 2018 Feb 23;81(2):264-269. doi: 10.1021/acs.jnatprod.7b00607. Epub 2018 Jan 30.

PMID:
29381067
18.

JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA00071.

Kawahara T, Fujiwara T, Kagaya N, Shin-Ya K.

J Antibiot (Tokyo). 2018 Mar;71(3):390-392. doi: 10.1038/s41429-017-0010-2. Epub 2018 Jan 18.

PMID:
29348521
19.

Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation.

Du D, Katsuyama Y, Shin-Ya K, Ohnishi Y.

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1954-1957. doi: 10.1002/anie.201709636. Epub 2018 Jan 17.

PMID:
29265713
20.

Functional analysis of methyltransferases participating in streptothricin-related antibiotic biosynthesis.

Niikura H, Maruyama C, Ogasawara Y, Shin-Ya K, Dairi T, Hamano Y.

J Biosci Bioeng. 2018 Feb;125(2):148-154. doi: 10.1016/j.jbiosc.2017.09.004. Epub 2017 Oct 10.

PMID:
29029816
21.

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-Ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.

J Biol Chem. 2017 Dec 8;292(49):20076-20085. doi: 10.1074/jbc.M117.815936. Epub 2017 Oct 12.

22.

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.

Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.

Sci Rep. 2017 Jun 15;7(1):3605. doi: 10.1038/s41598-017-03785-8.

23.

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.

Amagai K, Ikeda H, Hashimoto J, Kozone I, Izumikawa M, Kudo F, Eguchi T, Nakamura T, Osada H, Takahashi S, Shin-Ya K.

Sci Rep. 2017 Jun 13;7(1):3382. doi: 10.1038/s41598-017-03308-5.

24.

N-Phenylacetylation and Nonribosomal Peptide Synthetases with Substrate Promiscuity for Biosynthesis of Heptapeptide Variants, JBIR-78 and JBIR-95.

Takeda K, Kemmoku K, Satoh Y, Ogasawara Y, Shin-Ya K, Dairi T.

ACS Chem Biol. 2017 Jul 21;12(7):1813-1819. doi: 10.1021/acschembio.7b00314. Epub 2017 May 19.

PMID:
28505407
25.

Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer.

Kudo K, Ozaki T, Shin-Ya K, Nishiyama M, Kuzuyama T.

J Am Chem Soc. 2017 May 24;139(20):6799-6802. doi: 10.1021/jacs.7b02071. Epub 2017 May 12.

PMID:
28497964
26.

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.

Zhang L, Hashimoto T, Qin B, Hashimoto J, Kozone I, Kawahara T, Okada M, Awakawa T, Ito T, Asakawa Y, Ueki M, Takahashi S, Osada H, Wakimoto T, Ikeda H, Shin-Ya K, Abe I.

Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1740-1745. doi: 10.1002/anie.201611371. Epub 2017 Jan 11.

PMID:
28133950
27.

Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit.

Matsuda K, Hasebe F, Shiwa Y, Kanesaki Y, Tomita T, Yoshikawa H, Shin-Ya K, Kuzuyama T, Nishiyama M.

ACS Chem Biol. 2017 Jan 20;12(1):124-131. doi: 10.1021/acschembio.6b00818. Epub 2016 Nov 30.

PMID:
28103675
28.

Complete genome sequence and expression profile of the commercial lytic enzyme producer Lysobacter enzymogenes M497-1.

Takami H, Toyoda A, Uchiyama I, Itoh T, Takaki Y, Arai W, Nishi S, Kawai M, Shin-Ya K, Ikeda H.

DNA Res. 2017 Apr 1;24(2):169-177. doi: 10.1093/dnares/dsw055.

29.

Synthesis of Spiromamakone A Benzo Analogues via Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene.

Tsukamoto H, Hanada S, Kumasaka K, Kagaya N, Izumikawa M, Shin-Ya K, Doi T.

Org Lett. 2016 Oct 7;18(19):4848-4851. Epub 2016 Sep 20.

PMID:
27648608
30.

Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740.

Kawahara T, Itoh M, Izumikawa M, Sakata N, Tsuchida T, Shin-Ya K.

J Antibiot (Tokyo). 2017 Feb;70(2):226-229. doi: 10.1038/ja.2016.116. Epub 2016 Sep 14. No abstract available.

PMID:
27624401
31.

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Du D, Katsuyama Y, Onaka H, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem. 2016 Aug 3;17(15):1464-71. doi: 10.1002/cbic.201600167. Epub 2016 Jun 17.

PMID:
27311327
32.

Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi.

Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, Machida M, Kawahara T, Shin-Ya K, Gomi K, Oikawa H.

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):8072-5. doi: 10.1002/anie.201602611. Epub 2016 May 11.

33.

Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.

Katsuyama Y, Sone K, Satou R, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem. 2016 Jun 2;17(11):1021-8. doi: 10.1002/cbic.201600095. Epub 2016 May 9.

PMID:
27158812
34.

Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis.

Healy AR, Izumikawa M, Slawin AM, Shin-Ya K, Westwood NJ.

Angew Chem Weinheim Bergstr Ger. 2015 Mar 23;127(13):4118-4122. Epub 2015 Feb 4.

35.

tRNA-Dependent Aminoacylation of an Amino Sugar Intermediate in the Biosynthesis of a Streptothricin-Related Antibiotic.

Maruyama C, Niikura H, Izumikawa M, Hashimoto J, Shin-Ya K, Komatsu M, Ikeda H, Kuroda M, Sekizuka T, Ishikawa J, Hamano Y.

Appl Environ Microbiol. 2016 May 31;82(12):3640-8. doi: 10.1128/AEM.00725-16. Print 2016 Jun 15.

36.

Methylbenzene-Containing Polyketides from a Streptomyces that Spontaneously Acquired Rifampicin Resistance: Structural Elucidation and Biosynthesis.

Thong WL, Shin-ya K, Nishiyama M, Kuzuyama T.

J Nat Prod. 2016 Apr 22;79(4):857-64. doi: 10.1021/acs.jnatprod.5b00922. Epub 2016 Feb 24.

PMID:
26905826
37.

G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.

Hasegawa D, Okabe S, Okamoto K, Nakano I, Shin-ya K, Seimiya H.

Biochem Biophys Res Commun. 2016 Feb 26;471(1):75-81. doi: 10.1016/j.bbrc.2016.01.176. Epub 2016 Feb 1.

38.

Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.

Miyanaga A, Hayakawa Y, Numakura M, Hashimoto J, Teruya K, Hirano T, Shin-Ya K, Kudo F, Eguchi T.

Biosci Biotechnol Biochem. 2016 May;80(5):935-41. doi: 10.1080/09168451.2015.1132155. Epub 2016 Jan 28.

PMID:
26818633
39.

JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77.

Motohashi K, Izumikawa M, Kagaya N, Takagi M, Shin-Ya K.

J Antibiot (Tokyo). 2016 Sep;69(9):707-8. doi: 10.1038/ja.2015.135. Epub 2016 Jan 6. No abstract available.

PMID:
26732254
40.

Class of cyclic ribosomal peptide synthetic genes in filamentous fungi.

Nagano N, Umemura M, Izumikawa M, Kawano J, Ishii T, Kikuchi M, Tomii K, Kumagai T, Yoshimi A, Machida M, Abe K, Shin-Ya K, Asai K.

Fungal Genet Biol. 2016 Jan;86:58-70. doi: 10.1016/j.fgb.2015.12.010. Epub 2015 Dec 15.

41.

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E71-80. doi: 10.1073/pnas.1517188113. Epub 2015 Dec 22.

42.

Curromycin A as a GRP78 downregulator and a new cyclic dipeptide from Streptomyces sp.

Hayakawa Y, Akimoto M, Ishikawa A, Izawa M, Shin-ya K.

J Antibiot (Tokyo). 2016 Mar;69(3):187-8. doi: 10.1038/ja.2015.115. Epub 2015 Nov 25. No abstract available.

PMID:
26601685
43.
44.

Characterization of the biosynthetic gene cluster for maklamicin, a spirotetronate-class antibiotic of the endophytic Micromonospora sp. NBRC 110955.

Daduang R, Kitani S, Hashimoto J, Thamchaipenet A, Igarashi Y, Shin-ya K, Ikeda H, Nihira T.

Microbiol Res. 2015 Nov;180:30-9. doi: 10.1016/j.micres.2015.07.003. Epub 2015 Jul 22.

45.

Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142.

Kawahara T, Kagaya N, Masuda Y, Doi T, Izumikawa M, Ohta K, Hirao A, Shin-ya K.

Org Lett. 2015 Nov 6;17(21):5476-9. doi: 10.1021/acs.orglett.5b02842. Epub 2015 Oct 23.

PMID:
26493489
46.

Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Ohno S, Katsuyama Y, Tajima Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem. 2015 Nov 2;16(16):2385-91. doi: 10.1002/cbic.201500317. Epub 2015 Sep 25.

PMID:
26403163
47.

MBJ-0110, a novel cyclopeptide isolated from the fungus Penicillium sp. f25267.

Kawahara T, Itoh M, Kozone I, Izumikawa M, Sakata N, Tsuchida T, Shin-Ya K.

J Antibiot (Tokyo). 2016 Jan;69(1):66-8. doi: 10.1038/ja.2015.78. Epub 2015 Jul 8. No abstract available.

PMID:
26152283
48.

Asymmetric Total Synthesis of ent-Pyripyropene A.

Fuse S, Ikebe A, Oosumi K, Karasawa T, Matsumura K, Izumikawa M, Johmoto K, Uekusa H, Shin-ya K, Doi T, Takahashi T.

Chemistry. 2015 Jun 22;21(26):9454-60. doi: 10.1002/chem.201500703. Epub 2015 May 26.

PMID:
26014374
49.

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Lu S, Nishimura S, Hirai G, Ito M, Kawahara T, Izumikawa M, Sodeoka M, Shin-ya K, Tsuchida T, Kakeya H.

Chem Commun (Camb). 2015 May 11;51(38):8074-7. doi: 10.1039/c5cc01953b. Epub 2015 Apr 14.

PMID:
25869768
50.

New acylated anthocyanins from purple yam and their antioxidant activity.

Moriya C, Hosoya T, Agawa S, Sugiyama Y, Kozone I, Shin-Ya K, Terahara N, Kumazawa S.

Biosci Biotechnol Biochem. 2015;79(9):1484-92. doi: 10.1080/09168451.2015.1027652. Epub 2015 Apr 7.

PMID:
25848974

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