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Acetylcholine receptors: Key players in cancer development.

Chen J, Cheuk IWY, Shin VY, Kwong A.

Surg Oncol. 2019 Sep 4;31:46-53. doi: 10.1016/j.suronc.2019.09.003. [Epub ahead of print] Review.


Methylated Septin 9 and Carcinoembryonic Antigen for Serological Diagnosis and Monitoring of Patients with Colorectal Cancer After Surgery.

Ma ZY, Law WL, Ng EKO, Chan CSY, Lau KS, Cheng YY, Shin VY, Kwong A, Leung WK.

Sci Rep. 2019 Jul 17;9(1):10326. doi: 10.1038/s41598-019-46876-4.


Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer.

Zhu L, Zhu Y, Han S, Chen M, Song P, Dai D, Xu W, Jiang T, Feng L, Shin VY, Wang X, Jin H.

Cell Death Dis. 2019 May 16;10(6):383. doi: 10.1038/s41419-019-1585-2.


SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.

Yousafzai NA, Zhou Q, Xu W, Shi Q, Xu J, Feng L, Chen H, Shin VY, Jin H, Wang X.

Cell Death Dis. 2019 May 1;10(5):363. doi: 10.1038/s41419-019-1592-3.


Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness.

Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H, Kwong A.

Cell Death Dis. 2019 Mar 20;10(4):270. doi: 10.1038/s41419-019-1513-5.


Screening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations.

Kwong A, Shin VY, Ma ES, Chan CT, Ford JM, Kurian AW, Tai E.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):4-6. No abstract available.


Breast and ovarian cancer penetrance of BRCA1/2 mutations among Hong Kong women.

Zhang L, Shin VY, Chai X, Zhang A, Chan TL, Ma ES, Rebbeck TR, Chen J, Kwong A.

Oncotarget. 2018 Feb 2;9(38):25025-25033. doi: 10.18632/oncotarget.24382. eCollection 2018 May 18.


MiR-92 suppresses proliferation and induces apoptosis by targeting EP4/Notch1 axis in gastric cancer.

Shin VY, Siu MT, Liu X, Ng EKO, Kwong A, Chu KM.

Oncotarget. 2018 May 11;9(36):24209-24220. doi: 10.18632/oncotarget.24819. eCollection 2018 May 11.


Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.

Li J, Song P, Jiang T, Dai D, Wang H, Sun J, Zhu L, Xu W, Feng L, Shin VY, Morrison H, Wang X, Jin H.

Mol Ther. 2018 Jul 5;26(7):1828-1839. doi: 10.1016/j.ymthe.2018.04.014. Epub 2018 Apr 14.


Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels.

Kwong A, Ho JCW, Shin VY, Kurian AW, Tai E, Esserman LJ, Weitzel JN, Lin PH, Field M, Domchek SM, Lo J, Ngan HYS, Ma ESK, Chan TL, Ford JM.

Oncotarget. 2017 Dec 20;9(8):7832-7843. doi: 10.18632/oncotarget.23471. eCollection 2018 Jan 30.


Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis.

Cheuk IW, Shin VY, Kwong A.

J Breast Cancer. 2017 Mar;20(1):12-19. doi: 10.4048/jbc.2017.20.1.12. Epub 2017 Mar 24. Review.


miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer.

Chen J, Shin VY, Siu MT, Ho JC, Cheuk I, Kwong A.

BMC Cancer. 2016 Nov 14;16(1):887.


Overexpression of GOLPH3 is associated with poor survival in Non-small-cell lung cancer.

Tang W, Han M, Ruan B, Jin W, Lou J, Yuan X, Chen D, Chen Y, Shin VY, Jin H, Wang X.

Am J Transl Res. 2016 Apr 15;8(4):1756-62. eCollection 2016.


Detection of Germline Mutation in Hereditary Breast and/or Ovarian Cancers by Next-Generation Sequencing on a Four-Gene Panel.

Kwong A, Shin VY, Au CH, Law FB, Ho DN, Ip BK, Wong AT, Lau SS, To RM, Choy G, Ford JM, Ma ES, Chan TL.

J Mol Diagn. 2016 Jul;18(4):580-94. doi: 10.1016/j.jmoldx.2016.03.005. Epub 2016 May 5.


Germline RECQL mutations in high risk Chinese breast cancer patients.

Kwong A, Shin VY, Cheuk IWY, Chen J, Au CH, Ho DN, Chan TL, Ma ESK, Akbari MR, Narod SA.

Breast Cancer Res Treat. 2016 Jun;157(2):211-215. doi: 10.1007/s10549-016-3784-1. Epub 2016 Apr 28.


Response to: Comment on 'Circulating cell-free miRNAs as biomarker for triple-negative breast cancer'.

Shin VY, Kwong A.

Br J Cancer. 2016 May 10;114(10):e6. doi: 10.1038/bjc.2016.2. Epub 2016 Apr 21. No abstract available.


A new paradigm of genetic testing for hereditary breast/ovarian cancers.

Kwong A, Chen JW, Shin VY.

Hong Kong Med J. 2016 Apr;22(2):171-7. doi: 10.12809/hkmj154634. Epub 2016 Mar 14. Review.


Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis.

Cheuk IW, Shin VY, Siu MT, Tsang JY, Ho JC, Chen J, Tse GM, Wang X, Kwong A.

Am J Cancer Res. 2015 Oct 15;5(11):3389-99. eCollection 2015.


A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer.

Shin VY, Ng EK, Chan VW, Kwong A, Chu KM.

Mol Cancer. 2015 Nov 25;14:202. doi: 10.1186/s12943-015-0473-3.


The importance of analysis of long-range rearrangement of BRCA1 and BRCA2 in genetic diagnosis of familial breast cancer.

Kwong A, Chen J, Shin VY, Ho JC, Law FB, Au CH, Chan TL, Ma ES, Ford JM.

Cancer Genet. 2015 Sep;208(9):448-54. doi: 10.1016/j.cancergen.2015.05.031. Epub 2015 Jun 9.


Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.

Kwong A, Shin VY, Ho JC, Kang E, Nakamura S, Teo SH, Lee AS, Sng JH, Ginsburg OM, Kurian AW, Weitzel JN, Siu MT, Law FB, Chan TL, Narod SA, Ford JM, Ma ES, Kim SW.

J Med Genet. 2016 Jan;53(1):15-23. doi: 10.1136/jmedgenet-2015-103132. Epub 2015 Jul 17. Review.


Histone deacetylase 3 inhibits new tumor suppressor gene DTWD1 in gastric cancer.

Ma Y, Yue Y, Pan M, Sun J, Chu J, Lin X, Xu W, Feng L, Chen Y, Chen D, Shin VY, Wang X, Jin H.

Am J Cancer Res. 2015 Jan 15;5(2):663-73. eCollection 2015.


Circulating cell-free miRNAs as biomarker for triple-negative breast cancer.

Shin VY, Siu JM, Cheuk I, Ng EK, Kwong A.

Br J Cancer. 2015 May 26;112(11):1751-9. doi: 10.1038/bjc.2015.143. Epub 2015 Apr 23.


MicroRNAs are differentially deregulated in mammary malignant phyllodes tumour.

Tsang JY, Ni YB, Ng EK, Shin VY, Mak KF, Go EM, Tawasil J, Chan SK, Ko CW, Kwong A, Tse GM.

Histopathology. 2015 Sep;67(3):294-305. doi: 10.1111/his.12648. Epub 2015 Mar 2.


Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.

Shen J, Xiao Z, Wu WK, Wang MH, To KF, Chen Y, Yang W, Li MS, Shin VY, Tong JH, Kang W, Zhang L, Li M, Wang L, Lu L, Chan RL, Wong SH, Yu J, Chan MT, Chan FK, Sung JJ, Cheng AS, Cho CH.

Cancer Res. 2015 Feb 15;75(4):754-65. doi: 10.1158/0008-5472.CAN-14-1301. Epub 2014 Dec 12.


Elevation of methylated DNA in KILLIN/PTEN in the plasma of patients with thyroid and/or breast cancer.

Ng EK, Shin VY, Leung CP, Chan VW, Law FB, Siu MT, Lang BH, Ma ES, Kwong A.

Onco Targets Ther. 2014 Nov 11;7:2085-92. doi: 10.2147/OTT.S53597. eCollection 2014.


MiRNA as potential biomarkers and therapeutic targets for gastric cancer.

Shin VY, Chu KM.

World J Gastroenterol. 2014 Aug 14;20(30):10432-9. doi: 10.3748/wjg.v20.i30.10432. Review.


Animal models of gastrointestinal inflammation and cancer.

Lu L, Chan RL, Luo XM, Wu WK, Shin VY, Cho CH.

Life Sci. 2014 Jul 11;108(1):1-6. doi: 10.1016/j.lfs.2014.04.036. Epub 2014 May 11. Review.


MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.

Ng EK, Li R, Shin VY, Siu JM, Ma ES, Kwong A.

Tumour Biol. 2014 Mar;35(3):2591-8. doi: 10.1007/s13277-013-1341-7. Epub 2013 Nov 13.


Circulating microRNAs as specific biomarkers for breast cancer detection.

Ng EK, Li R, Shin VY, Jin HC, Leung CP, Ma ES, Pang R, Chua D, Chu KM, Law WL, Law SY, Poon RT, Kwong A.

PLoS One. 2013;8(1):e53141. doi: 10.1371/journal.pone.0053141. Epub 2013 Jan 3.


Nicotine and gastrointestinal disorders: its role in ulceration and cancer development.

Chu KM, Cho CH, Shin VY.

Curr Pharm Des. 2013;19(1):5-10. Review.


Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients.

Ng EK, Leung CP, Shin VY, Wong CL, Ma ES, Jin HC, Chu KM, Kwong A.

PLoS One. 2011;6(7):e22233. doi: 10.1371/journal.pone.0022233. Epub 2011 Jul 18.


Effects of adrenaline in human colon adenocarcinoma HT-29 cells.

Wong HP, Ho JW, Koo MW, Yu L, Wu WK, Lam EK, Tai EK, Ko JK, Shin VY, Chu KM, Cho CH.

Life Sci. 2011 Jun 20;88(25-26):1108-12. doi: 10.1016/j.lfs.2011.04.007. Epub 2011 Apr 30.


A microRNA contribution to aberrant Ras activation in gastric cancer.

Lam EK, Wang X, Shin VY, Zhang S, Morrison H, Sun J, Ng EK, Yu J, Jin H.

Am J Transl Res. 2011 Feb;3(2):209-18. Epub 2011 Feb 6.


4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro.

Shin VY, Jin HC, Ng EK, Cho CH, Leung WK, Sung JJ, Chu KM.

Cancer Sci. 2011 May;102(5):926-33. doi: 10.1111/j.1349-7006.2011.01885.x. Epub 2011 Mar 14.


NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.

Shin VY, Jin H, Ng EK, Cheng AS, Chong WW, Wong CY, Leung WK, Sung JJ, Chu KM.

Carcinogenesis. 2011 Feb;32(2):240-5. doi: 10.1093/carcin/bgq240. Epub 2010 Nov 15.


Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.

Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH.

Cancer Lett. 2010 Jun 28;292(2):237-45. doi: 10.1016/j.canlet.2009.12.011. Epub 2010 Jan 12.


Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.

Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC.

Oncogene. 2010 Jan 21;29(3):442-50. doi: 10.1038/onc.2009.332. Epub 2009 Nov 2.


Effects of cigarette smoking and restraint stress on human colon tumor growth in mice.

Wong HP, Li ZJ, Shin VY, Tai EK, Wu WK, Yu L, Cho CH.

Digestion. 2009;80(4):209-14. doi: 10.1159/000231898. Epub 2009 Sep 17.


Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening.

Ng EK, Chong WW, Jin H, Lam EK, Shin VY, Yu J, Poon TC, Ng SS, Sung JJ.

Gut. 2009 Oct;58(10):1375-81. doi: 10.1136/gut.2008.167817. Epub 2009 Feb 6.


Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways.

Shin VY, Jin HC, Ng EK, Yu J, Leung WK, Cho CH, Sung JJ.

Toxicol Appl Pharmacol. 2008 Dec 1;233(2):254-61. doi: 10.1016/j.taap.2008.08.012. Epub 2008 Sep 6.


Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice.

Liu ES, Ye YN, Shin VY, Wu WK, Wong BC, Cho CH.

Cancer Invest. 2007 Dec;25(8):750-7.


Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats.

Lam EK, Yu L, Wong HP, Wu WK, Shin VY, Tai EK, So WH, Woo PC, Cho CH.

Eur J Pharmacol. 2007 Jun 22;565(1-3):171-9. Epub 2007 Mar 7.


Shift of homeostasis from parenchymal regeneration to fibroblast proliferation induced by lipopolysaccharide-activated macrophages in gastric mucosal healing in vitro.

Wu WK, Law PT, Wong HP, Lam EK, Tai EK, Shin VY, Cho CH.

Wound Repair Regen. 2007 Mar-Apr;15(2):221-6. Erratum in: Wound Repair Regen. 2007 May-Jun;15(3):431. Wu, William Ka Kei [corrected to Wu, William K K]; Law, Priscilla Tak Yin [corrected to Law, Priscilla T Y]; Wong, Helen Pui Shan [corrected to Wong, Helen P S]; Lam, Emily Kai Yee [corrected to Lam, Emily K Y]; Tai, Emily Kin Ki [corrected to Tai, Emily K.


Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells.

Shin VY, Wu WK, Chu KM, Koo MW, Wong HP, Lam EK, Tai EK, Cho CH.

Toxicol Sci. 2007 Mar;96(1):21-9. Epub 2006 Sep 26.


The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats.

Yang YH, Wu WK, Tai EK, Wong HP, Lam EK, So WH, Shin VY, Cho CH.

J Pharmacol Exp Ther. 2006 Aug;318(2):547-54. Epub 2006 May 2.


Heparin increases human gastric carcinoma cell growth.

Wu WK, Shin VY, Ye YN, Wong HP, Huang FY, Hui MK, Lam EK, Cho CH.

Anticancer Res. 2006 Jan-Feb;26(1A):439-43.


Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells.

Wu WK, Li GR, Wong HP, Hui MK, Tai EK, Lam EK, Shin VY, Ye YN, Li P, Yang YH, Luo JC, Cho CH.

J Cell Physiol. 2006 May;207(2):437-44.


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