Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 10

1.

The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.

Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M.

EMBO Mol Med. 2018 Mar;10(3). pii: e8047. doi: 10.15252/emmm.201708047.

2.

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.

Azevedo CM, Watterson KR, Wargent ET, Hansen SV, Hudson BD, Kępczyńska MA, Dunlop J, Shimpukade B, Christiansen E, Milligan G, Stocker CJ, Ulven T.

J Med Chem. 2016 Oct 13;59(19):8868-8878. Epub 2016 Sep 22.

PMID:
27570890
3.

Complex Pharmacology of Free Fatty Acid Receptors.

Milligan G, Shimpukade B, Ulven T, Hudson BD.

Chem Rev. 2017 Jan 11;117(1):67-110. doi: 10.1021/acs.chemrev.6b00056. Epub 2016 Jun 14. Review.

4.

Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice.

Gozal D, Qiao Z, Almendros I, Zheng J, Khalyfa A, Shimpukade B, Ulven T.

Int J Obes (Lond). 2016 Jul;40(7):1143-9. doi: 10.1038/ijo.2016.37. Epub 2016 Mar 16.

PMID:
26980479
5.

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T.

J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15.

PMID:
26928019
6.

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

Hudson BD, Shimpukade B, Milligan G, Ulven T.

J Biol Chem. 2014 Jul 18;289(29):20345-58. doi: 10.1074/jbc.M114.561449. Epub 2014 May 24.

7.

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4.

Butcher AJ, Hudson BD, Shimpukade B, Alvarez-Curto E, Prihandoko R, Ulven T, Milligan G, Tobin AB.

J Biol Chem. 2014 Jun 27;289(26):18451-65. doi: 10.1074/jbc.M114.568816. Epub 2014 May 9.

8.

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26.

9.

Discovery of a potent and selective GPR120 agonist.

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T.

J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2.

PMID:
22519963
10.

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.

Henderson AJ, Guzzo PR, Ghosh A, Kaur J, Koo JM, Nacro K, Panduga S, Pathak R, Shimpukade B, Tan V, Xiang K, Wierschke JD, Isherwood ML.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1494-8. doi: 10.1016/j.bmcl.2012.01.022. Epub 2012 Jan 14.

PMID:
22290076

Supplemental Content

Loading ...
Support Center