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Evaluation of the total distribution volume of 18F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling.

Romanov V, Isohashi K, Alobthani G, Beshr R, Horitsugi G, Kanai Y, Naka S, Watabe T, Shimosegawa E, Hatazawa J.

Ann Nucl Med. 2019 Dec 5. doi: 10.1007/s12149-019-01427-9. [Epub ahead of print]


Theranostics targeting fibroblast activation protein in the tumor stroma: 64Cu and 225Ac labelled FAPI-04 in pancreatic cancer xenograft mouse models.

Watabe T, Liu Y, Kaneda-Nakashima K, Shirakami Y, Lindner T, Ooe K, Toyoshima A, Nagata K, Shimosegawa E, Haberkorn U, Kratochwil C, Shinohara A, Giesel F, Hatazawa J.

J Nucl Med. 2019 Oct 4. pii: jnumed.119.233122. doi: 10.2967/jnumed.119.233122. [Epub ahead of print]


Validation of magnetic resonance imaging-based automatic high-grade glioma segmentation accuracy via 11C-methionine positron emission tomography.

Ozaki T, Kinoshita M, Arita H, Kagawa N, Fujimoto Y, Kanemura Y, Sakai M, Watanabe Y, Nakanishi K, Shimosegawa E, Hatazawa J, Kishima H.

Oncol Lett. 2019 Oct;18(4):4074-4081. doi: 10.3892/ol.2019.10734. Epub 2019 Aug 8.


Preserved Cerebral Oxygen Metabolism in Astrocytic Dysfunction: A Combination Study of 15O-Gas PET with 14C-Acetate Autoradiography.

Macaisa CM, Watabe T, Liu Y, Romanov V, Kanai Y, Horitsugi G, Kato H, Shimosegawa E, Hatazawa J.

Brain Sci. 2019 May 3;9(5). pii: E101. doi: 10.3390/brainsci9050101.


Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus.

Azuma S, Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Matsumoto T, Yoshiyama K, Kishima H, Shimosegawa E, Tanaka T, Ikeda M.

Psychogeriatrics. 2019 Nov;19(6):527-538. doi: 10.1111/psyg.12435. Epub 2019 Mar 27.


Impact of 18F-PSMA-1007 Uptake in Prostate Cancer Using Different Peptide Concentrations: Preclinical PET/CT Study on Mice.

Soeda F, Watabe T, Naka S, Liu Y, Horitsugi G, Neels OC, Kopka K, Tatsumi M, Shimosegawa E, Giesel FL, Hatazawa J.

J Nucl Med. 2019 Nov;60(11):1594-1599. doi: 10.2967/jnumed.118.223479. Epub 2019 Mar 22.


Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2.

Aoki M, Watabe T, Nagamori S, Naka S, Ikeda H, Kongpracha P, Horitsugi G, Kanai Y, Shimosegawa E, Kanai Y, Hatazawa J.

Ann Nucl Med. 2019 Jun;33(6):394-403. doi: 10.1007/s12149-019-01346-9. Epub 2019 Feb 28.


Enhancement of 211At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer.

Watabe T, Kaneda-Nakashima K, Liu Y, Shirakami Y, Ooe K, Toyoshima A, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa J.

J Nucl Med. 2019 Sep;60(9):1301-1307. doi: 10.2967/jnumed.118.222638. Epub 2019 Feb 22.


Simplified Dynamic Phantom for Pediatric Renography: A Description of Instrument and its Performance.

Kamiya T, Watabe T, Fujino K, Victor R, Kawamura Y, Isohashi K, Matsunaga K, Tatsumi M, Kato H, Shimosegawa E, Hatazawa J.

Asia Ocean J Nucl Med Biol. 2019 Winter;7(1):38-48. doi: 10.22038/AOJNMB.2018.11803.


Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: A case-control study.

Kanemoto H, Kazui H, Suehiro T, Kishima H, Suzuki Y, Sato S, Azuma S, Matsumoto T, Yoshiyama K, Shimosegawa E, Tanaka T, Ikeda M.

Int J Geriatr Psychiatry. 2019 Mar;34(3):453-462. doi: 10.1002/gps.5038. Epub 2018 Dec 21.


11C-methionine-18F-FDG dual-PET-tracer-based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy.

Hirata T, Kinoshita M, Tamari K, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa K.

J Neurosurg. 2019 Sep 21;131(3):676-686. doi: 10.3171/2018.4.JNS1859.


Preliminary feasibility study on differential diagnosis between radiation-induced cerebral necrosis and recurrent brain tumor by means of [18F]fluoro-borono-phenylalanine PET/CT.

Beshr R, Isohashi K, Watabe T, Naka S, Horitsugi G, Romanov V, Kato H, Miyatake SI, Shimosegawa E, Hatazawa J.

Ann Nucl Med. 2018 Dec;32(10):702-708. doi: 10.1007/s12149-018-1296-2. Epub 2018 Sep 7.


Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies.

Kanai Y, Miyake Y, Shimosegawa E, Hatazawa J.

Asia Ocean J Nucl Med Biol. 2018 Spring;6(2):149-154. doi: 10.22038/aojnmb.2018.10846.


Evaluation of the default-mode network by quantitative 15O-PET: comparative study between cerebral blood flow and oxygen consumption.

Aoe J, Watabe T, Shimosegawa E, Kato H, Kanai Y, Naka S, Matsunaga K, Isohashi K, Tatsumi M, Hatazawa J.

Ann Nucl Med. 2018 Aug;32(7):485-491. doi: 10.1007/s12149-018-1272-x. Epub 2018 Jun 22.


Detection of neuroinflammation before selective neuronal loss appearance after mild focal ischemia using [18F]DPA-714 imaging.

Miyajima N, Ito M, Rokugawa T, Iimori H, Momosaki S, Omachi S, Shimosegawa E, Hatazawa J, Abe K.

EJNMMI Res. 2018 Jun 8;8(1):43. doi: 10.1186/s13550-018-0400-x.


Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats.

Ikeda H, Hayashi Y, Takahashi N, Watabe T, Kanai Y, Shinohara A, Kato H, Watabe H, Shimosegawa E, Hatazawa J.

Appl Radiat Isot. 2018 Sep;139:251-255. doi: 10.1016/j.apradiso.2018.05.021. Epub 2018 May 23.


Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET.

Rokugawa T, Konishi H, Ito M, Iimori H, Nagai R, Shimosegawa E, Hatazawa J, Abe K.

EJNMMI Res. 2018 May 31;8(1):40. doi: 10.1186/s13550-018-0394-4.


Influence of region-of-interest designs on quantitative measurement of multimodal imaging of MR non-enhancing gliomas.

Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Watanabe Y, Shimosegawa E, Hatazawa J, Hashimoto N, Fujimoto Y, Kishima H.

Oncol Lett. 2018 May;15(5):7934-7940. doi: 10.3892/ol.2018.8319. Epub 2018 Mar 22.


Value of 18F-FDG PET/CT in discrimination between indolent and aggressive non-Hodgkin's lymphoma: A study of 328 patients.

Alobthani G, Romanov V, Isohashi K, Matsunaga K, Watabe T, Kato H, Tatsumi M, Shimosegawa E, Hatazawa J.

Hell J Nucl Med. 2018 Jan-Apr;21(1):7-14. doi: 10.1967/s002449910701. Epub 2018 Mar 20.


Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.

Kato H, Isohashi K, Shimosegawa E, Hatazawa J.

PLoS One. 2018 Jan 11;13(1):e0190720. doi: 10.1371/journal.pone.0190720. eCollection 2018.


Quantitative pulmonary blood flow measurement using 15O-H2O PET with and without tissue fraction correction: a comparison study.

Matsunaga K, Yanagawa M, Otsuka T, Hirata H, Kijima T, Kumanogoh A, Tomiyama N, Shimosegawa E, Hatazawa J.

EJNMMI Res. 2017 Dec 22;7(1):102. doi: 10.1186/s13550-017-0350-8.


Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms.

Horitsugi G, Watabe T, Kanai Y, Ikeda H, Kato H, Naka S, Ishibashi M, Matsunaga K, Isohashi K, Shimosegawa E, Hatazawa J.

EJNMMI Res. 2017 Oct 27;7(1):91. doi: 10.1186/s13550-017-0335-7.


Assessment of Mediastinal Tumors Using SUVmax and Volumetric Parameters on FDG-PET/CT.

Morita T, Tatsumi M, Ishibashi M, Isohashi K, Kato H, Honda O, Shimosegawa E, Tomiyama N, Hatazawa J.

Asia Ocean J Nucl Med Biol. 2017 Winter;5(1):22-29. doi: 10.22038/aojnmb.2016.7996.


Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A 11C-donepezil PET Study.

Mochida I, Shimosegawa E, Kanai Y, Naka S, Matsunaga K, Isohashi K, Horitsugi G, Watabe T, Kato H, Hatazawa J.

Asia Ocean J Nucl Med Biol. 2017 Winter;5(1):3-9. doi: 10.22038/aojnmb.2016.7513.


First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera.

Kishimoto A, Kataoka J, Taya T, Tagawa L, Mochizuki S, Ohsuka S, Nagao Y, Kurita K, Yamaguchi M, Kawachi N, Matsunaga K, Ikeda H, Shimosegawa E, Hatazawa J.

Sci Rep. 2017 May 18;7(1):2110. doi: 10.1038/s41598-017-02377-w.


Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET.

Watabe T, Hanaoka K, Naka S, Kanai Y, Ikeda H, Aoki M, Shimosegawa E, Kirihata M, Hatazawa J.

Ann Nucl Med. 2017 Jul;31(6):481-485. doi: 10.1007/s12149-017-1172-5. Epub 2017 Apr 24.


Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET.

Watabe T, Kanai Y, Ikeda H, Horitsugi G, Matsunaga K, Kato H, Isohashi K, Abe K, Shimosegawa E, Hatazawa J.

EJNMMI Res. 2017 Dec;7(1):16. doi: 10.1186/s13550-017-0263-6. Epub 2017 Feb 16.


Neural Basis of Apathy in Patients with Amnestic Mild Cognitive Impairment.

Kazui H, Takahashi R, Yamamoto Y, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Shimosegawa E, Ishii K, Tanaka T.

J Alzheimers Dis. 2017;55(4):1403-1416. doi: 10.3233/JAD-160223.


Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.

Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T.

J Neurosurg. 2016 Nov;125(5):1136-1142. Epub 2016 Feb 26.


Comparison of the image-derived radioactivity and blood-sample radioactivity for estimating the clinical indicators of the efficacy of boron neutron capture therapy (BNCT): 4-borono-2-18F-fluoro-phenylalanine (FBPA) PET study.

Isohashi K, Shimosegawa E, Naka S, Kanai Y, Horitsugi G, Mochida I, Matsunaga K, Watabe T, Kato H, Tatsumi M, Hatazawa J.

EJNMMI Res. 2016 Dec;6(1):75. Epub 2016 Oct 18.


Assessment of 10B concentration in boron neutron capture therapy: potential of image-guided therapy using 18FBPA PET.

Shimosegawa E, Isohashi K, Naka S, Horitsugi G, Hatazawa J.

Ann Nucl Med. 2016 Dec;30(10):749-755. Epub 2016 Sep 1.


18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET.

Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, Kanai Y, Hagiwara K, Aoki M, Shimosegawa E, Kanai Y, Hatazawa J.

Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):321-331. doi: 10.1007/s00259-016-3487-1. Epub 2016 Aug 22.


CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses.

Kato H, Shimosegawa E, Fujino K, Hatazawa J.

PLoS One. 2016 Jul 21;11(7):e0159505. doi: 10.1371/journal.pone.0159505. eCollection 2016.


Prognostic Value of FDG-PET, Based on the Revised Response Criteria, in Patients with Malignant Lymphoma: A Comparison with CT/MRI Evaluations, Based on the International Working Group/Cotswolds Meeting Criteria.

Isohashi K, Tatsumi M, Kato H, Fukushima K, Maeda T, Watabe T, Shimosegawa E, Kanakura Y, Hatazawa J.

Asia Ocean J Nucl Med Biol. 2015 Summer;3(2):91-8.


Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia.

Momosaki S, Ito M, Yamato H, Iimori H, Sumiyoshi H, Morimoto K, Imamoto N, Watabe T, Shimosegawa E, Hatazawa J, Abe K.

J Cereb Blood Flow Metab. 2017 Feb;37(2):605-613. doi: 10.1177/0271678X16635183. Epub 2016 Jul 20.


Genetic and Environmental Influences on Regional Brain Uptake of 18F-FDG: A PET Study on Monozygotic and Dizygotic Twins.

Watanabe S, Kato H, Shimosegawa E, Hatazawa J.

J Nucl Med. 2016 Mar;57(3):392-7. doi: 10.2967/jnumed.115.164004. Epub 2015 Nov 19.


Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas.

Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.

AJNR Am J Neuroradiol. 2016 Jan;37(1):44-50. doi: 10.3174/ajnr.A4460. Epub 2015 Sep 17.


Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.

Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S.

Metabolism. 2015 Sep;64(9):1165-74. doi: 10.1016/j.metabol.2015.05.017. Epub 2015 Jun 6.


FBPA PET in boron neutron capture therapy for cancer: prediction of (10)B concentration in the tumor and normal tissue in a rat xenograft model.

Hanaoka K, Watabe T, Naka S, Kanai Y, Ikeda H, Horitsugi G, Kato H, Isohashi K, Shimosegawa E, Hatazawa J.

EJNMMI Res. 2014 Dec 20;4(1):70. doi: 10.1186/s13550-014-0070-2. eCollection 2014 Dec.


11C-acetate PET imaging in patients with multiple sclerosis.

Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.

PLoS One. 2014 Nov 4;9(11):e111598. doi: 10.1371/journal.pone.0111598. eCollection 2014.


Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat.

Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J.

PLoS One. 2014 Sep 16;9(9):e107427. doi: 10.1371/journal.pone.0107427. eCollection 2014.


Nuclear medicine practice in Japan: a report of the seventh nationwide survey in 2012.

Kinuya S, Kuwabara Y, Inoue K, Sakamoto S, Shimosegawa E, Takeoka K, Takeda Y, Toyama H, Niio Y, Nishiyama Y, Yoshinaga K, Yoshimura M.

Ann Nucl Med. 2014 Dec;28(10):1032-8. doi: 10.1007/s12149-014-0893-y. Epub 2014 Aug 12.


Paradoxical reduction of cerebral blood flow after acetazolamide loading: a hemodynamic and metabolic study with (15)O PET.

Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Tatsumi M, Kitagawa K, Fujinaka T, Yoshimine T, Hatazawa J.

Neurosci Bull. 2014 Oct;30(5):845-56. doi: 10.1007/s12264-013-1459-z. Epub 2014 Aug 6.


CBF/CBV maps in normal volunteers studied with (15)O PET: a possible index of cerebral perfusion pressure.

Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Hatazawa J.

Neurosci Bull. 2014 Oct;30(5):857-62. doi: 10.1007/s12264-013-1458-0. Epub 2014 Aug 1.


Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions.

Yamauchi M, Imabayashi E, Matsuda H, Nakagawara J, Takahashi M, Shimosegawa E, Hatazawa J, Suzuki M, Iwanaga H, Fukuda K, Iihara K, Iida H.

Ann Nucl Med. 2014 Nov;28(9):836-50. doi: 10.1007/s12149-014-0879-9. Epub 2014 Jul 8.


Limitation of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) to detect early synchronous primary cancers in patients with untreated head and neck squamous cell cancer.

Hanamoto A, Takenaka Y, Shimosegawa E, Ymamamoto Y, Yoshii T, Nakahara S, Hatazawa J, Inohara H.

Ann Nucl Med. 2013 Dec;27(10):880-5. doi: 10.1007/s12149-013-0765-x. Epub 2013 Aug 25.


Optimization of [11C]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV.

Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, Watabe H, Hatazawa J.

EJNMMI Res. 2013 Apr 15;3(1):27. doi: 10.1186/2191-219X-3-27.


Quantitative evaluation of cerebral blood flow and oxygen metabolism in normal anesthetized rats: 15O-labeled gas inhalation PET with MRI Fusion.

Watabe T, Shimosegawa E, Watabe H, Kanai Y, Hanaoka K, Ueguchi T, Isohashi K, Kato H, Tatsumi M, Hatazawa J.

J Nucl Med. 2013 Feb;54(2):283-90. doi: 10.2967/jnumed.112.109751. Epub 2013 Jan 3.


[The potential of dual-energy virtual monochromatic imaging in reducing renal cyst pseudoenhancement: a phantom study].

Yamada S, Ueguchi T, Ukai I, Nagai Y, Yamakawa M, Shimosegawa E, Shimazu T, Hatazawa J.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2012;68(10):1379-84. Japanese.

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