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A case-control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients.

Sugisaki N, Iwakiri R, Tsuruoka N, Sakata Y, Shimoda R, Fujimoto S, Eguchi Y, Fujimoto K.

J Gastroenterol. 2018 Jun 12. doi: 10.1007/s00535-018-1483-x. [Epub ahead of print]


Higher frequency of upper gastrointestinal symptoms in healthy young Japanese females compared to males and older generations.

Kawachi K, Sakata Y, Hara M, Takeshita E, Kawakubo H, Yamaguchi D, Okamoto N, Shimoda R, Iwakiri R, Tsuruoka N, Kusano M, Fujimoto K.

Esophagus. 2018 Apr;15(2):83-87. doi: 10.1007/s10388-017-0598-0. Epub 2017 Dec 19.


The Role of an Undifferentiated Component in Submucosal Invasion and Submucosal Invasion Depth After Endoscopic Submucosal Dissection for Early Gastric Cancer.

Miyahara K, Hatta W, Nakagawa M, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Hirano M, Esaki M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Aoyagi H, Shimosegawa T.

Digestion. 2018 Jun 5;98(3):161-168. doi: 10.1159/000488529. [Epub ahead of print]


Perforation and Postoperative Bleeding Associated with Endoscopic Submucosal Dissection in Colorectal Tumors: An Analysis of 398 Lesions Treated in Saga, Japan.

Yamamoto K, Shimoda R, Ogata S, Hara M, Ito Y, Tominaga N, Nakayama A, Sakata Y, Tsuruoka N, Iwakiri R, Fujimoto K.

Intern Med. 2018 Mar 30. doi: 10.2169/internalmedicine.9186-17. [Epub ahead of print]


Immunogenicity of Quadrivalent Influenza Vaccine for Patients with Inflammatory Bowel Disease Undergoing Immunosuppressive Therapy.

Shirai S, Hara M, Sakata Y, Tsuruoka N, Yamamoto K, Shimoda R, Gomi Y, Yoshii H, Fujimoto K, Iwakiri R.

Inflamm Bowel Dis. 2018 Apr 23;24(5):1082-1091. doi: 10.1093/ibd/izx101.


Noise Exposure From High-Flow Nasal Cannula Oxygen Therapy: A Bench Study on Noise Reduction.

Kubo T, Nakajima H, Shimoda R, Seo T, Kanno Y, Kondo T, Tamai S.

Respir Care. 2018 Mar;63(3):267-273. doi: 10.4187/respcare.05668. Epub 2018 Feb 6.


Outcomes of Patients Undergoing Endoscopic Hemostasis for the Upper Gastrointestinal Bleeding Were Not Influenced by the Timing of Hospital Emergency Visits: A Situation Prevailing in Japan.

Matsuura S, Sakata Y, Tsuruoka N, Miyahara K, Hara M, Ito Y, Nakayama K, Shimamura T, Noda T, Yukimoto T, Shimoda R, Iwakiri R, Fujimoto K.

Digestion. 2018;97(3):260-266. doi: 10.1159/000485653. Epub 2018 Feb 9.


Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions.

Oka S, Tanaka S, Sano Y, Saitoh Y, Shimoda R, Tajiri H.

Dig Endosc. 2018 Mar;30(2):192-197. doi: 10.1111/den.12977. Epub 2017 Dec 12. Review.


Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers.

Tanaka Y, Sakata Y, Hara M, Kawakubo H, Tsuruoka N, Yamamoto K, Itoh Y, Hidaka H, Shimoda R, Iwakiri R, Fujimoto K.

Intern Med. 2017 Nov 15;56(22):2979-2983. doi: 10.2169/internalmedicine.8669-16. Epub 2017 Sep 25.


Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement.

Akutagawa T, Shindo T, Yamanouchi K, Hayakawa M, Ureshino H, Tsuruoka N, Sakata Y, Shimoda R, Noguchi R, Furukawa K, Morita S, Iwakiri R, Kimura S, Matsumoto M, Fujimoto K.

Intern Med. 2017 Sep 15;56(18):2431-2433. doi: 10.2169/internalmedicine.8603-16. Epub 2017 Aug 21.


High Cost of Hospitalization for Colonic Diverticular Bleeding Depended on Repeated Bleeding and Blood Transfusion: Analysis with Diagnosis Procedure Combination Data in Japan.

Ito Y, Sakata Y, Yoshida H, Nonaka S, Fujii S, Tanaka Y, Shirai S, Takeshita E, Akutagawa T, Kawakubo H, Yamamoto K, Tsuruoka N, Shimoda R, Iwakiri R, Fujimoto K.

Digestion. 2017;96(2):76-80. doi: 10.1159/000478256. Epub 2017 Jul 20.


Long-term oncological outcomes of submucosal manipulation during non-curative endoscopic submucosal dissection for submucosal invasive gastric cancer: a multicenter retrospective study in Japan.

Ito H, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hatta W, Hirano M, Esaki M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T.

Surg Endosc. 2018 Jan;32(1):196-203. doi: 10.1007/s00464-017-5659-x. Epub 2017 Jun 21.


Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study.

Nakanishi H, Doyama H, Ishikawa H, Uedo N, Gotoda T, Kato M, Nagao S, Nagami Y, Aoyagi H, Imagawa A, Kodaira J, Mitsui S, Kobayashi N, Muto M, Takatori H, Abe T, Tsujii M, Watari J, Ishiyama S, Oda I, Ono H, Kaneko K, Yokoi C, Ueo T, Uchita K, Matsumoto K, Kanesaka T, Morita Y, Katsuki S, Nishikawa J, Inamura K, Kinjo T, Yamamoto K, Yoshimura D, Araki H, Kashida H, Hosokawa A, Mori H, Yamashita H, Motohashi O, Kobayashi K, Hirayama M, Kobayashi H, Endo M, Yamano H, Murakami K, Koike T, Hirasawa K, Miyaoka Y, Hamamoto H, Hikichi T, Hanabata N, Shimoda R, Hori S, Sato T, Kodashima S, Okada H, Mannami T, Yamamoto S, Niwa Y, Yashima K, Tanabe S, Satoh H, Sasaki F, Yamazato T, Ikeda Y, Nishisaki H, Nakagawa M, Matsuda A, Tamura F, Nishiyama H, Arita K, Kawasaki K, Hoppo K, Oka M, Ishihara S, Mukasa M, Minamino H, Yao K.

Endoscopy. 2017 Oct;49(10):957-967. doi: 10.1055/s-0043-111888. Epub 2017 Jun 21.


Effectiveness of Endoscopic Hemostasis with Soft Coagulation for Non-Variceal Upper Gastrointestinal Bleeding over a 12-Year Period.

Yamaguchi D, Sakata Y, Yoshida H, Furukawa NE, Tsuruoka N, Higuchi T, Watanabe A, Shimoda R, Tsunada S, Iwakiri R, Fujimoto K.

Digestion. 2017;95(4):319-326. doi: 10.1159/000477439. Epub 2017 Jun 1.


Case of Superficial Cancer Located at the Pharyngoesophageal Junction Which Was Dissected by Endoscopic Laryngopharyngeal Surgery Combined with Endoscopic Submucosal Dissection.

Kawada K, Kawano T, Sugimoto T, Yamaguchi K, Kawamura Y, Matsui T, Okuda M, Ogo T, Kume Y, Nakajima Y, Mora A, Okada T, Hoshino A, Tokairin Y, Nakajima Y, Okada R, Kiyokawa Y, Nomura F, Asakage T, Shimoda R, Ito T.

Case Rep Otolaryngol. 2017;2017:1341059. doi: 10.1155/2017/1341059. Epub 2017 Jan 5.


The adenoma miss rate of blue-laser imaging vs. white-light imaging during colonoscopy: a randomized tandem trial.

Shimoda R, Sakata Y, Fujise T, Yamanouchi K, Tsuruoka N, Hara M, Nakayama A, Yamaguchi D, Akutagawa T, Fujimoto K, Iwakiri R.

Endoscopy. 2017 Feb;49(2):186-190. doi: 10.1055/s-0042-118450. Epub 2016 Nov 14.


High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model.

Aoki S, Sakata Y, Shimoda R, Takezawa T, Oshikata-Miyazaki A, Kimura H, Yamamoto M, Iwakiri R, Fujimoto K, Toda S.

Gastrointest Endosc. 2017 May;85(5):1076-1085. doi: 10.1016/j.gie.2016.10.012. Epub 2016 Oct 15.


Cronkhite-Canada Syndrome Complicated by Triple Primary Cancers.

Yamanouchi K, Sakata Y, Tsuruoka N, Shimoda R, Uchida M, Akutagawa T, Shirai S, Fujimoto K, Iwakiri R.

Intern Med. 2016;55(12):1569-73. doi: 10.2169/internalmedicine.55.6594. Epub 2016 Jun 15.


Increase in Endoscopic and Laparoscopic Surgery Regarding the Therapeutic Approach of Gastric Cancer Detected by Cancer Screening in Saga Prefecture, Japan.

Yamaguchi S, Sakata Y, Iwakiri R, Hara M, Akutagawa K, Shimoda R, Yamaguchi D, Hidaka H, Sakata H, Fujimoto K, Mizuguchi M, Shimoda Y, Irie H, Noshiro H.

Intern Med. 2016;55(10):1247-53. doi: 10.2169/internalmedicine.55.5339. Epub 2016 May 15.


Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan.

Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakamura K, Hirano M, Esaki M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakamura T, Shimosegawa T.

J Gastroenterol. 2017 Feb;52(2):175-184. doi: 10.1007/s00535-016-1210-4. Epub 2016 Apr 20.


Effect of additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer.

Yamanouchi K, Ogata S, Sakata Y, Tsuruoka N, Shimoda R, Nakayama A, Akutagawa T, Shirai S, Takeshita E, Yamamoto K, Fujimoto K, Iwakiri R.

Endosc Int Open. 2016 Jan;4(1):E24-9. doi: 10.1055/s-0034-1393124. Epub 2015 Nov 27.


Upper Gastrointestinal Symptoms Are More Frequent in Female than Male Young Healthy Japanese Volunteers as Evaluated by Questionnaire.

Kawakubo H, Tanaka Y, Tsuruoka N, Hara M, Yamamoto K, Hidaka H, Sakata Y, Shimoda R, Iwakiri R, Kusano M, Fujimoto K.

J Neurogastroenterol Motil. 2016 Apr 30;22(2):248-53. doi: 10.5056/jnm15140.


Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan.

Yamaguchi D, Tsuruoka N, Sakata Y, Shimoda R, Fujimoto K, Iwakiri R.

J Clin Biochem Nutr. 2015 Nov;57(3):239-43. doi: 10.3164/jcbn.15-47. Epub 2015 Oct 17.


Upper Gastrointestinal Bleeding in Japanese Patients Prescribed Antithrombotic Drugs: Differences in Trends over Time.

Yamaguchi D, Sakata Y, Tsuruoka N, Shimoda R, Higuchi T, Sakata H, Fujimoto K, Iwakiri R.

Hepatogastroenterology. 2014 Jun;61(132):1055-62.


Surgical treatment of retroperitoneal liposarcoma.

Ikeguchi M, Urushibara S, Shimoda R, Saito H, Wakatsuki T.

Yonago Acta Med. 2014 Dec;57(4):129-32. Epub 2014 Dec 26.


Repeated screening with fecal immunochemical tests reduced the incidence of colorectal cancers in Saga, Japan.

Sakata N, Sakata Y, Shimoda R, Sakata H, Iwakiri R, Fujimoto K, Mizuguchi M, Irie H, Shimoda Y, Noshiro H.

Hepatogastroenterology. 2014 Jul-Aug;61(133):1224-8.


Improving pain management in orthopedic surgical patients with opioid tolerance.

Doi K, Shimoda R, Gibbons G.

Nurs Clin North Am. 2014 Sep;49(3):415-29. doi: 10.1016/j.cnur.2014.05.015.


Enzymatic fragmentation of carbohydrate moieties of radish arabinogalactan-protein and elucidation of the structures.

Shimoda R, Okabe K, Kotake T, Matsuoka K, Koyama T, Tryfona T, Liang HC, Dupree P, Tsumuraya Y.

Biosci Biotechnol Biochem. 2014;78(5):818-31. doi: 10.1080/09168451.2014.910100. Epub 2014 May 15.


Inflammation-based prognostic scores and nutritional prognostic index in patients with locally-advanced unresectable colorectal cancer.

Ikeguchi M, Urushibara S, Shimoda R, Yamamoto M, Maeta Y, Ashida K.

World J Surg Oncol. 2014 Jul 15;12:210. doi: 10.1186/1477-7819-12-210.


Characteristics of patients with non-variceal upper gastrointestinal bleeding taking antithrombotic agents.

Yamaguchi D, Sakata Y, Tsuruoka N, Shimoda R, Higuchi T, Sakata H, Fujimoto K, Iwakiri R.

Dig Endosc. 2015 Jan;27(1):30-6. doi: 10.1111/den.12316. Epub 2014 Sep 17.


Low-dose aspirin and comorbidities are significantly related to bleeding peptic ulcers in elderly patients compared with nonelderly patients in Japan.

Higuchi T, Iwakiri R, Hara M, Shimoda R, Sakata Y, Nakayama A, Nio K, Yamaguchi S, Yamaguchi D, Watanabe A, Akutagawa T, Sakata H, Fujimoto K.

Intern Med. 2014;53(5):367-73.


Scoring of prognostic parameters in patients with unresectable advanced or recurrent colorectal cancer undergoing chemotherapy.

Ikeguchi M, Shimoda R, Yamamoto M, Maeta Y, Ashida K, Saito H.

Yonago Acta Med. 2013 Sep;56(3):69-72. Epub 2013 Sep 11.


Factors affecting short- and long-term effects of leukocyte removal therapy in active ulcerative colitis.

Nakano R, Iwakiri R, Ikeda Y, Kishi T, Tsuruoka N, Shimoda R, Sakata Y, Yamaguchi K, Fujimoto K.

J Gastroenterol Hepatol. 2013 Feb;28(2):303-8. doi: 10.1111/jgh.12049.


Risk factors for resistance to proton pump inhibitor maintenance therapy for reflux esophagitis in Japanese women over 60 years.

Watanabe A, Iwakiri R, Yamaguchi D, Higuchi T, Tsuruoka N, Miyahara K, Akutagawa K, Sakata Y, Fujise T, Oda Y, Shimoda R, Sakata H, Fujimoto K.

Digestion. 2012;86(4):323-8. doi: 10.1159/000342393. Epub 2012 Nov 1.


Perforation and postoperative bleeding of endoscopic submucosal dissection in gastric tumors: analysis of 1190 lesions in low- and high-volume centers in Saga, Japan.

Miyahara K, Iwakiri R, Shimoda R, Sakata Y, Fujise T, Shiraishi R, Yamaguchi K, Watanabe A, Yamaguchi D, Higuchi T, Tominaga N, Ogata S, Tsuruoka N, Noda T, Hidaka H, Mannen K, Endo H, Yamanouchi K, Yamazato T, Sakata H, Fujimoto K.

Digestion. 2012;86(3):273-80. doi: 10.1159/000341422. Epub 2012 Sep 14.


Two years' intensive training in endoscopic diagnosis facilitates detection of early gastric cancer.

Yamazato T, Oyama T, Yoshida T, Baba Y, Yamanouchi K, Ishii Y, Inoue F, Toda S, Mannen K, Shimoda R, Iwakiri R, Fujimoto K.

Intern Med. 2012;51(12):1461-5. Epub 2012 Jun 15.


Endoscopic reflux esophagitis and Helicobacter pylori infection in young healthy Japanese volunteers.

Takashima T, Iwakiri R, Sakata Y, Yamaguchi D, Tsuruoka N, Akutagawa K, Komatsu-Tanaka M, Higuchi T, Tanaka Y, Shimoda R, Sakata H, Kawakubo M, Oda Y, Fujimoto K.

Digestion. 2012;86(1):55-8. doi: 10.1159/000338849. Epub 2012 Jun 20.


Aneurismal type of colorectal cancer: imaging characteristics of gastrointestinal endoscopy, computed tomography and magnetic resonance imaging.

Mizuguchi M, Irie H, Nanazono T, Kamochi N, Egashira Y, Nishihara M, Shimoda R, Tsunada S, Iwakiri R, Fujimoto K, Kudo S.

Hepatogastroenterology. 2011 Mar-Apr;58(106):395-9.


Respiratory effects of balloon occluded retrograde transvenous obliteration of gastric varices: a prospective controlled study.

Arai H, Abe T, Takayama H, Toyoda M, Mori K, Ueno T, Takagi H, Shimoda R.

J Gastroenterol Hepatol. 2011 Sep;26(9):1389-94. doi: 10.1111/j.1440-1746.2011.06727.x.


NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients: evaluation by a case-control study.

Tsuruoka N, Iwakiri R, Hara M, Shirahama N, Sakata Y, Miyahara K, Eguchi Y, Shimoda R, Ogata S, Tsunada S, Sakata H, Fujimoto K.

J Gastroenterol Hepatol. 2011 Jun;26(6):1047-52. doi: 10.1111/j.1440-1746.2010.06610.x.


Low serum albumin level is risk factor for patients with percutaneous endoscopic gastrostomy.

Tominaga N, Shimoda R, Iwakiri R, Tsuruoka N, Sakata Y, Hara H, Hayashi S, Morita S, Hamasaki Y, Matsushima T, Miyazaki K, Node K, Fujimoto K.

Intern Med. 2010;49(21):2283-8. Epub 2010 Nov 1.


Degradation of carbohydrate moieties of arabinogalactan-proteins by glycoside hydrolases from Neurospora crassa.

Takata R, Tokita K, Mori S, Shimoda R, Harada N, Ichinose H, Kaneko S, Igarashi K, Samejima M, Tsumuraya Y, Kotake T.

Carbohydr Res. 2010 Nov 22;345(17):2516-22. doi: 10.1016/j.carres.2010.09.006. Epub 2010 Sep 9.


[A case of hepatocellular carcinoma complicated with Caroli's disease].

Ijima M, Shimoda R, Katakai K, Seki A, Oshimoto H, Masuda J, Morinaga N, Suzuki Y, Kakizaki S, Arai T.

Nihon Shokakibyo Gakkai Zasshi. 2010 Sep;107(9):1490-6. Review. Japanese.


Current managements and outcomes of peptic and artificial ulcer bleeding in Japan.

Fujishiro M, Abe N, Endo M, Kawahara Y, Shimoda R, Nagata S, Homma K, Morita Y, Uedo N.

Dig Endosc. 2010 Jul;22 Suppl 1:S9-14. doi: 10.1111/j.1443-1661.2010.00961.x.


Retrospective multicenter study concerning electrocautery forceps with soft coagulation for nonmalignant gastroduodenal ulcer bleeding in Japan.

Fujishiro M, Abe N, Endo M, Kawahara Y, Shimoda R, Nagata S, Homma K, Morita Y, Uedo N.

Dig Endosc. 2010 Jul;22 Suppl 1:S15-8. doi: 10.1111/j.1443-1661.2010.00962.x.


[Two cases of esophageal achalasia, in which localized botulinum toxin injections were effective to improve symptoms].

Tominaga N, Iwakiri R, Tsuruoka N, Nakayama M, Arima S, Mannen K, Sakata Y, Shimoda R, Tsunada S, Sakata H, Fujimoto K.

Nihon Shokakibyo Gakkai Zasshi. 2010 Apr;107(4):598-604. Japanese.


Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial.

Arima S, Sakata Y, Ogata S, Tominaga N, Tsuruoka N, Mannen K, Shiraishi R, Shimoda R, Tsunada S, Sakata H, Iwakiri R, Fujimoto K.

J Gastroenterol. 2010 May;45(5):501-5. doi: 10.1007/s00535-009-0186-8. Epub 2009 Dec 25.


Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions.

Mannen K, Tsunada S, Hara M, Yamaguchi K, Sakata Y, Fujise T, Noda T, Shimoda R, Sakata H, Ogata S, Iwakiri R, Fujimoto K.

J Gastroenterol. 2010;45(1):30-6. doi: 10.1007/s00535-009-0137-4. Epub 2009 Sep 17.


Endoscopic hemostasis with metallic hemoclips for iatrogenic Mallory-Weiss tear caused by endoscopic examination.

Shimoda R, Iwakiri R, Sakata H, Ogata S, Ootani H, Sakata Y, Fujise T, Yamaguchi K, Mannen K, Arima S, Shiraishi R, Noda T, Ono A, Tsunada S, Fujimoto K.

Dig Endosc. 2009 Jan;21(1):20-3. doi: 10.1111/j.1443-1661.2008.00825.x.


Low-dose aspirin is a prominent cause of bleeding ulcers in patients who underwent emergency endoscopy.

Nakayama M, Iwakiri R, Hara M, Ootani H, Shimoda R, Tsunada S, Sakata H, Fujimoto K.

J Gastroenterol. 2009;44(9):912-8. doi: 10.1007/s00535-009-0074-2. Epub 2009 May 13.


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