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Items: 1 to 50 of 227

1.

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y.

Mol Cell. 2018 Mar 1;69(5):866-878.e7. doi: 10.1016/j.molcel.2018.02.002.

PMID:
29499138
2.

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.

Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2018 Jan 25;46(2):730-747. doi: 10.1093/nar/gkx1240.

3.

Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.

Genes Dev. 2017 Sep 15;31(18):1926. doi: 10.1101/gad.307207.117. No abstract available.

4.

Monitoring the ATM-Mediated DNA Damage Response in the Cerebellum Using Organotypic Cultures.

Tal E, Shiloh Y.

Methods Mol Biol. 2017;1599:419-430. doi: 10.1007/978-1-4939-6955-5_30.

PMID:
28477136
5.

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

Shiloh Y, Lederman HM.

Ageing Res Rev. 2017 Jan;33:76-88. doi: 10.1016/j.arr.2016.05.002. Epub 2016 May 12. Review.

PMID:
27181190
6.

Genome instability: Linking ageing and brain degeneration.

Barzilai A, Schumacher B, Shiloh Y.

Mech Ageing Dev. 2017 Jan;161(Pt A):4-18. doi: 10.1016/j.mad.2016.03.011. Epub 2016 Mar 31. Review.

PMID:
27041231
7.

Systemic DNA damage responses in aging and diseases.

Ribezzo F, Shiloh Y, Schumacher B.

Semin Cancer Biol. 2016 Jun;37-38:26-35. doi: 10.1016/j.semcancer.2015.12.005. Epub 2016 Jan 7. Review.

8.

The COP9 signalosome is vital for timely repair of DNA double-strand breaks.

Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández-Ávila MJ, Cruz-García A, Star A, Shochot L, Thomas Y, Garrett LJ, Chamovitz DA, Bodine DM, Kurz T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2015 May 19;43(9):4517-30. doi: 10.1093/nar/gkv270. Epub 2015 Apr 8.

9.

ATM: expanding roles as a chief guardian of genome stability.

Shiloh Y.

Exp Cell Res. 2014 Nov 15;329(1):154-61. doi: 10.1016/j.yexcr.2014.09.002. Epub 2014 Sep 8. Review. No abstract available.

PMID:
25218947
10.

Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.

Rashi-Elkeles S, Warnatz HJ, Elkon R, Kupershtein A, Chobod Y, Paz A, Amstislavskiy V, Sultan M, Safer H, Nietfeld W, Lehrach H, Shamir R, Yaspo ML, Shiloh Y.

Sci Signal. 2014 May 13;7(325):rs3. doi: 10.1126/scisignal.2005032.

PMID:
24825921
11.

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.

Shiloh Y, Ziv Y.

Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210. Review.

PMID:
23847781
12.

DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population.

Rasmussen LJ, Shiloh Y, Bergersen LH, Sander M, Bohr VA, Tønjum T.

Mech Ageing Dev. 2013 Oct;134(10):427-33. doi: 10.1016/j.mad.2013.05.001. Epub 2013 May 10. Review. No abstract available.

13.

Studying the cerebellar DNA damage response in the tissue culture dish.

Tzur-Gilat A, Ziv Y, Mittelman L, Barzilai A, Shiloh Y.

Mech Ageing Dev. 2013 Oct;134(10):496-505. doi: 10.1016/j.mad.2013.04.001. Epub 2013 Apr 9.

PMID:
23583690
14.

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.

Shiloh Y, Ziv Y.

Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210. doi: 10.1038/nrm3546. Epub 2013 Mar 13. Review.

PMID:
23486281
15.

The ATM protein: the importance of being active.

Shiloh Y, Ziv Y.

J Cell Biol. 2012 Aug 6;198(3):273-5. doi: 10.1083/jcb.201207063.

16.

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.

Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y.

Cell Cycle. 2011 Dec 15;10(24):4300-10. doi: 10.4161/cc.10.24.18642. Epub 2011 Dec 15.

17.

Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.

Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, Barzilai A.

J Mol Neurosci. 2012 Mar;46(3):554-68. doi: 10.1007/s12031-011-9643-y. Epub 2011 Sep 16.

PMID:
21922345
18.

Matrin 3 binds and stabilizes mRNA.

Salton M, Elkon R, Borodina T, Davydov A, Yaspo ML, Halperin E, Shiloh Y.

PLoS One. 2011;6(8):e23882. doi: 10.1371/journal.pone.0023882. Epub 2011 Aug 17.

19.

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.

Shiloh Y, Shema E, Moyal L, Oren M.

FEBS Lett. 2011 Sep 16;585(18):2795-802. doi: 10.1016/j.febslet.2011.07.034. Epub 2011 Aug 4. Review.

20.

Transcriptional modulation induced by ionizing radiation: p53 remains a central player.

Rashi-Elkeles S, Elkon R, Shavit S, Lerenthal Y, Linhart C, Kupershtein A, Amariglio N, Rechavi G, Shamir R, Shiloh Y.

Mol Oncol. 2011 Aug;5(4):336-48. doi: 10.1016/j.molonc.2011.06.004. Epub 2011 Jul 7. Review.

21.

A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.

Raz-Prag D, Galron R, Segev-Amzaleg N, Solomon AS, Shiloh Y, Barzilai A, Frenkel D.

Am J Pathol. 2011 Sep;179(3):1533-41. doi: 10.1016/j.ajpath.2011.05.026. Epub 2011 Jul 19.

22.

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.

Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y.

EMBO Rep. 2011 Jul 1;12(7):713-9. doi: 10.1038/embor.2011.96.

23.

Beyond ATM: the protein kinase landscape of the DNA damage response.

Bensimon A, Aebersold R, Shiloh Y.

FEBS Lett. 2011 Jun 6;585(11):1625-39. doi: 10.1016/j.febslet.2011.05.013. Epub 2011 May 8. Review.

24.

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.

Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y.

Mol Cell. 2011 Mar 4;41(5):529-42. doi: 10.1016/j.molcel.2011.02.015.

25.

Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.

Dar I, Yosha G, Elfassy R, Galron R, Wang ZQ, Shiloh Y, Barzilai A.

J Biol Chem. 2011 Apr 29;286(17):15361-76. doi: 10.1074/jbc.M110.204172. Epub 2011 Feb 7.

26.

Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.

Galron R, Gruber R, Lifshitz V, Lu H, Kirshner M, Ziv N, Wang ZQ, Shiloh Y, Barzilai A, Frenkel D.

J Mol Neurosci. 2011 Oct;45(2):202-11. doi: 10.1007/s12031-011-9494-6. Epub 2011 Jan 29.

PMID:
21279473
27.

KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin.

Kepkay R, Attwood KM, Ziv Y, Shiloh Y, Dellaire G.

Cell Cycle. 2011 Jan 15;10(2):308-22. Epub 2011 Jan 15.

PMID:
21228624
28.

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.

Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang SY, Chen DJ, Aebersold R, Shiloh Y.

Sci Signal. 2010 Dec 7;3(151):rs3. doi: 10.1126/scisignal.2001034.

29.

SPIKE: a database of highly curated human signaling pathways.

Paz A, Brownstein Z, Ber Y, Bialik S, David E, Sagir D, Ulitsky I, Elkon R, Kimchi A, Avraham KB, Shiloh Y, Shamir R.

Nucleic Acids Res. 2011 Jan;39(Database issue):D793-9. doi: 10.1093/nar/gkq1167. Epub 2010 Nov 19.

30.

3rd US-EU workshop: systems level understanding of DNA damage responses.

Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L.

Mutat Res. 2010 Oct 13;692(1-2):53-60. doi: 10.1016/j.mrfmmm.2010.07.012. Epub 2010 Aug 19.

31.

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response.

Salton M, Lerenthal Y, Wang SY, Chen DJ, Shiloh Y.

Cell Cycle. 2010 Apr 15;9(8):1568-76. Epub 2010 Apr 15.

PMID:
20421735
32.

USP10: friend and foe.

Jochemsen AG, Shiloh Y.

Cell. 2010 Feb 5;140(3):308-10. doi: 10.1016/j.cell.2010.01.034.

33.

Expander: from expression microarrays to networks and functions.

Ulitsky I, Maron-Katz A, Shavit S, Sagir D, Linhart C, Elkon R, Tanay A, Sharan R, Shiloh Y, Shamir R.

Nat Protoc. 2010 Feb;5(2):303-22. doi: 10.1038/nprot.2009.230. Epub 2010 Jan 28.

PMID:
20134430
34.

Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.

Barash H, R Gross E, Edrei Y, Ella E, Israel A, Cohen I, Corchia N, Ben-Moshe T, Pappo O, Pikarsky E, Goldenberg D, Shiloh Y, Galun E, Abramovitch R.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2207-12. doi: 10.1073/pnas.0908867107. Epub 2010 Jan 25.

36.

FBXO31: a new player in the ever-expanding DNA damage response orchestra.

Shiloh Y.

Sci Signal. 2009 Nov 10;2(96):pe73. doi: 10.1126/scisignal.296pe73.

PMID:
19903939
37.

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.

Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.

EMBO J. 2009 Dec 2;28(23):3667-80. doi: 10.1038/emboj.2009.302. Epub 2009 Oct 22.

38.

Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.

Baranes K, Raz-Prag D, Nitzan A, Galron R, Ashery-Padan R, Rotenstreich Y, Assaf Y, Shiloh Y, Wang ZQ, Barzilai A, Solomon AS.

Exp Neurol. 2009 Jul;218(1):24-32. doi: 10.1016/j.expneurol.2009.03.026. Epub 2009 Apr 1.

PMID:
19345213
39.

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.

Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M.

Nat Cell Biol. 2009 Jan;11(1):92-6. doi: 10.1038/ncb1817. Epub 2008 Dec 14.

40.

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.

Kirshner M, Rathavs M, Nizan A, Essers J, Kanaar R, Shiloh Y, Barzilai A.

DNA Repair (Amst). 2009 Feb 1;8(2):253-61. doi: 10.1016/j.dnarep.2008.11.005. Epub 2008 Dec 30.

PMID:
19061978
41.

Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS.

Winter D, Seidler J, Ziv Y, Shiloh Y, Lehmann WD.

J Proteome Res. 2009 Jan;8(1):418-24. doi: 10.1021/pr800304n.

PMID:
19053530
42.

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.

Genes Dev. 2008 Oct 1;22(19):2664-76. doi: 10.1101/gad.1703008. Erratum in: Genes Dev. 2017 Sep 15;31(18):1926.

43.

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA.

Mol Cell. 2008 Jul 25;31(2):167-77. doi: 10.1016/j.molcel.2008.05.017.

44.

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA.

Mol Biol Cell. 2008 Sep;19(9):3923-33. doi: 10.1091/mbc.E07-07-0698. Epub 2008 Jul 2.

45.

The role of the DNA damage response in neuronal development, organization and maintenance.

Barzilai A, Biton S, Shiloh Y.

DNA Repair (Amst). 2008 Jul 1;7(7):1010-27. doi: 10.1016/j.dnarep.2008.03.005. Epub 2008 May 23. Review.

PMID:
18458000
46.

The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle.

Biton S, Barzilai A, Shiloh Y.

DNA Repair (Amst). 2008 Jul 1;7(7):1028-38. doi: 10.1016/j.dnarep.2008.03.006. Epub 2008 May 5. Review.

PMID:
18456574
47.

SPIKE--a database, visualization and analysis tool of cellular signaling pathways.

Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, Assa J, Shiloh Y, Shamir R.

BMC Bioinformatics. 2008 Feb 20;9:110. doi: 10.1186/1471-2105-9-110.

48.

MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome.

Assaf Y, Galron R, Shapira I, Nitzan A, Blumenfeld-Katzir T, Solomon AS, Holdengreber V, Wang ZQ, Shiloh Y, Barzilai A.

Exp Neurol. 2008 Jan;209(1):181-91. Epub 2007 Oct 2.

PMID:
17976584
49.

Functional genomic delineation of TLR-induced transcriptional networks.

Elkon R, Linhart C, Halperin Y, Shiloh Y, Shamir R.

BMC Genomics. 2007 Oct 29;8:394.

50.

Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype.

Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, Shiloh Y.

Am J Med Genet A. 2007 Aug 15;143A(16):1827-34.

PMID:
17632790

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