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Items: 1 to 50 of 219

1.

Improved protein expression in HEK293 cells by over-expressing miR-22 and knocking-out its target gene, HIPK1.

Inwood S, Abaandou L, Betenbaugh M, Shiloach J.

N Biotechnol. 2020 Jan 25;54:28-33. doi: 10.1016/j.nbt.2019.08.004. Epub 2019 Aug 16.

PMID:
31425885
2.

Erratum to 'Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1-4-year-old Israeli children' [Vaccine 28 (2010) 2231-2235].

Passwell JH, Ashkenazi S, Banet-Levi Y, Ramon-Saraf R, Farzam N, Lerner-Geva L, Even-Nir H, Yerushalmi B, Chu C, Shiloach J, Robbins JB, Schneerson R; Israeli Shigella Study Group.

Vaccine. 2019 Aug 23;37(36):5504. doi: 10.1016/j.vaccine.2019.07.065. Epub 2019 Aug 1. No abstract available.

3.

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets.

Klanert G, Fernandez DJ, Weinguny M, Eisenhut P, Bühler E, Melcher M, Titus SA, Diendorfer AB, Gludovacz E, Jadhav V, Xiao S, Stern B, Lal M, Shiloach J, Borth N.

Sci Rep. 2019 Jun 18;9(1):8689. doi: 10.1038/s41598-019-45159-2.

4.

Expression of multidrug transporter P-glycoprotein in Pichia pastoris affects the host's methanol metabolism.

Liu WC, Zhou F, Xia D, Shiloach J.

Microb Biotechnol. 2019 May 26. doi: 10.1111/1751-7915.13420. [Epub ahead of print]

5.

Effect of amino acids on transcription and translation of key genes in E. coli K and B grown at a steady state in minimal medium.

Baez A, Kumar A, Sharma AK, Anderson ED, Shiloach J.

N Biotechnol. 2019 Mar 25;49:120-128. doi: 10.1016/j.nbt.2018.10.004. Epub 2018 Oct 29.

PMID:
30385399
6.

Effect of over expressing protective antigen on global gene transcription in Bacillus anthracis BH500.

Sharma AK, Leppla SH, Pomerantsev AP, Shiloach J.

Sci Rep. 2018 Oct 31;8(1):16108. doi: 10.1038/s41598-018-34196-y.

7.

Genome-Wide High-Throughput RNAi Screening for Identification of Genes Involved in Protein Production.

Inwood S, Betenbaugh MJ, Lal M, Shiloach J.

Methods Mol Biol. 2018;1850:209-219. doi: 10.1007/978-1-4939-8730-6_14.

PMID:
30242689
8.

Continuous production process of retroviral vector for adoptive T- cell therapy.

Inwood S, Xu H, Black MA, Betenbaugh MJ, Feldman S, Shiloach J.

Biochem Eng J. 2018 Apr 15;132:145-151. doi: 10.1016/j.bej.2018.01.010. Epub 2018 Jan 11.

9.

A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts.

St Amand MM, Bond MR, Riedy J, Comly M, Shiloach J, Hanover JA.

J Biol Chem. 2018 Aug 31;293(35):13673-13681. doi: 10.1074/jbc.RA118.004059. Epub 2018 Jun 28.

10.

Knocking out Ornithine Decarboxylase Antizyme 1 (OAZ1) Improves Recombinant Protein Expression in the HEK293 Cell Line.

Abaandou L, Shiloach J.

Med Sci (Basel). 2018 Jun 8;6(2). pii: E48. doi: 10.3390/medsci6020048.

11.

Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo.

Mulangu S, Alfonso VH, Hoff NA, Doshi RH, Mulembakani P, Kisalu NK, Okitolonda-Wemakoy E, Kebela BI, Marcus H, Shiloach J, Phue JN, Wright LL, Muyembe-Tamfum JJ, Sullivan NJ, Rimoin AW.

J Infect Dis. 2018 Jan 30;217(4):529-537. doi: 10.1093/infdis/jix619.

12.

Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells.

Inwood S, Betenbaugh MJ, Shiloach J.

Genes (Basel). 2018 Jan 9;9(1). pii: E25. doi: 10.3390/genes9010025. Review.

13.

New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.

Qiang X, Liotta AS, Shiloach J, Gutierrez JC, Wang H, Ochani M, Ochani K, Yang H, Rabin A, LeRoith D, Lesniak MA, Böhm M, Maaser C, Kannengiesser K, Donowitz M, Rabizadeh S, Czura CJ, Tracey KJ, Westlake M, Zarfeshani A, Mehdi SF, Danoff A, Ge X, Sanyal S, Schwartz GJ, Roth J.

NPJ Biofilms Microbiomes. 2017 Nov 13;3:31. doi: 10.1038/s41522-017-0039-9. eCollection 2017.

14.

Improving E. coli growth performance by manipulating small RNA expression.

Negrete A, Shiloach J.

Microb Cell Fact. 2017 Nov 14;16(1):198. doi: 10.1186/s12934-017-0810-x. Review.

15.

Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.

Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J.

Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201700342. Epub 2017 Nov 14.

16.

The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.

Azurmendi HF, Battistel MD, Zarb J, Lichaa F, Negrete Virgen A, Shiloach J, Freedberg DI.

Glycobiology. 2017 Sep 1;27(9):900-911. doi: 10.1093/glycob/cwx025.

17.

Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling.

Tschirhart T, Kim E, McKay R, Ueda H, Wu HC, Pottash AE, Zargar A, Negrete A, Shiloach J, Payne GF, Bentley WE.

Nat Commun. 2017 Jan 17;8:14030. doi: 10.1038/ncomms14030.

18.

Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy.

Yoon DJ, Chen KY, Lopes AM, Pan AA, Shiloach J, Mason AB, Kamei DT.

J Theor Biol. 2017 Mar 7;416:88-98. doi: 10.1016/j.jtbi.2017.01.008. Epub 2017 Jan 6.

19.

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.

Esser L, Zhou F, Pluchino KM, Shiloach J, Ma J, Tang WK, Gutierrez C, Zhang A, Shukla S, Madigan JP, Zhou T, Kwong PD, Ambudkar SV, Gottesman MM, Xia D.

J Biol Chem. 2017 Jan 13;292(2):446-461. doi: 10.1074/jbc.M116.755884. Epub 2016 Nov 18.

20.

Increasing dissolved-oxygen disrupts iron homeostasis in production cultures of Escherichia coli.

Baez A, Shiloach J.

Antonie Van Leeuwenhoek. 2017 Jan;110(1):115-124. doi: 10.1007/s10482-016-0781-7. Epub 2016 Oct 18.

PMID:
27757702
21.

Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells.

Xiao S, Chen YC, Buehler E, Mandal S, Mandal A, Betenbaugh M, Park MH, Martin S, Shiloach J.

Biotechnol Bioeng. 2016 Nov;113(11):2403-15. doi: 10.1002/bit.26017. Epub 2016 Sep 21.

22.

A comparison of strategies for immortalizing mouse embryonic fibroblasts.

Amand MMS, Hanover JA, Shiloach J.

J Biol Methods. 2016 May 23;3(2):e41. doi: 10.14440/jbm.2016.110. eCollection 2016.

23.

Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes.

Gallagher EJ, LeRoith D, Stasinopoulos M, Zelenko Z, Shiloach J.

J Diabetes Complications. 2016 Aug;30(6):999-1007. doi: 10.1016/j.jdiacomp.2016.04.019. Epub 2016 Apr 27.

24.

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells.

Chu C, Bottaro DP, Betenbaugh MJ, Shiloach J.

PLoS One. 2016 Feb 5;11(2):e0148075. doi: 10.1371/journal.pone.0148075. eCollection 2016.

25.

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.

Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT.

Nat Commun. 2015 Dec 1;6:10006. doi: 10.1038/ncomms10006.

26.

Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics.

Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ.

J Proteome Res. 2015 Nov 6;14(11):4687-703. doi: 10.1021/acs.jproteome.5b00588. Epub 2015 Oct 13.

27.

Constitutive expression of the sRNA GadY decreases acetate production and improves E. coli growth.

Negrete A, Shiloach J.

Microb Cell Fact. 2015 Sep 18;14:148. doi: 10.1186/s12934-015-0334-1.

28.

The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.

Kumar A, Shiloach J, Betenbaugh MJ, Gallagher EJ.

Nutr Metab (Lond). 2015 Mar 8;12:8. doi: 10.1186/s12986-015-0003-8. eCollection 2015.

29.

MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK293 cells.

Xiao S, Chen YC, Betenbaugh MJ, Martin SE, Shiloach J.

Biotechnol Bioeng. 2015 Aug;112(8):1632-43. doi: 10.1002/bit.25567. Epub 2015 Jun 16.

30.

Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1.

Xiao S, Shiloach J, Grisshammer R.

Methods Mol Biol. 2015;1272:51-64. doi: 10.1007/978-1-4939-2336-6_4.

PMID:
25563176
31.

Effect of elevated oxygen concentration on bacteria, yeasts, and cells propagated for production of biological compounds.

Baez A, Shiloach J.

Microb Cell Fact. 2014 Dec 19;13:181. doi: 10.1186/s12934-014-0181-5. Review.

32.

Coupling enrichment methods with proteomics for understanding and treating disease.

Kumar A, Baycin-Hizal D, Shiloach J, Bowen MA, Betenbaugh MJ.

Proteomics Clin Appl. 2015 Feb;9(1-2):33-47. doi: 10.1002/prca.201400097. Epub 2015 Jan 19. Review.

PMID:
25523641
33.

Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

Kumar A, Harrelson T, Lewis NE, Gallagher EJ, LeRoith D, Shiloach J, Betenbaugh MJ.

PLoS One. 2014 Jul 16;9(7):e102319. doi: 10.1371/journal.pone.0102319. eCollection 2014.

34.

Exploiting the proteomics revolution in biotechnology: from disease and antibody targets to optimizing bioprocess development.

Heffner KM, Hizal DB, Kumar A, Shiloach J, Zhu J, Bowen MA, Betenbaugh MJ.

Curr Opin Biotechnol. 2014 Dec;30:80-6. doi: 10.1016/j.copbio.2014.06.006. Epub 2014 Jul 3. Review.

PMID:
24997444
35.

Purified cell wall from the probiotic bacterium Lactobacillus gasseri activates systemic inflammation and, at higher doses, produces lethality in a rat model.

Xu X, Hicks C, Li Y, Su J, Shiloach J, Kaufman JB, Fitz Y, Eichacker PQ, Cui X.

Crit Care. 2014 Jul 2;18(4):R140. doi: 10.1186/cc13966.

36.

CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.

Wang H, Li Y, Truong LN, Shi LZ, Hwang PY, He J, Do J, Cho MJ, Li H, Negrete A, Shiloach J, Berns MW, Shen B, Chen L, Wu X.

Mol Cell. 2014 Jun 19;54(6):1012-21. doi: 10.1016/j.molcel.2014.04.012. Epub 2014 May 15.

37.

Production of recombinant protein by a novel oxygen-induced system in Escherichia coli.

Baez A, Majdalani N, Shiloach J.

Microb Cell Fact. 2014 Apr 7;13(1):50. doi: 10.1186/1475-2859-13-50.

38.

Engineering cells to improve protein expression.

Xiao S, Shiloach J, Betenbaugh MJ.

Curr Opin Struct Biol. 2014 Jun;26:32-8. doi: 10.1016/j.sbi.2014.03.005. Epub 2014 Apr 3. Review.

39.

Toward a new vaccine for pertussis.

Robbins JB, Schneerson R, Kubler-Kielb J, Keith JM, Trollfors B, Vinogradov E, Shiloach J.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3213-6. doi: 10.1073/pnas.1324149111. Epub 2014 Feb 20.

40.

Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells.

Negrete A, Pai A, Shiloach J.

J Virol Methods. 2014 Jan;195:240-6. doi: 10.1016/j.jviromet.2013.10.017. Epub 2013 Oct 21.

PMID:
24157258
41.

CHO microRNA engineering is growing up: recent successes and future challenges.

Jadhav V, Hackl M, Druz A, Shridhar S, Chung CY, Heffner KM, Kreil DP, Betenbaugh M, Shiloach J, Barron N, Grillari J, Borth N.

Biotechnol Adv. 2013 Dec;31(8):1501-13. doi: 10.1016/j.biotechadv.2013.07.007. Epub 2013 Aug 2. Review.

42.

Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model.

Qiu P, Li Y, Shiloach J, Cui X, Sun J, Trinh L, Kubler-Kielb J, Vinogradov E, Mani H, Al-Hamad M, Fitz Y, Eichacker PQ.

J Infect Dis. 2013 Sep;208(6):978-89. doi: 10.1093/infdis/jit247. Epub 2013 Jun 3.

43.

Transient and stable expression of the neurotensin receptor NTS1: a comparison of the baculovirus-insect cell and the T-REx-293 expression systems.

Xiao S, White JF, Betenbaugh MJ, Grisshammer R, Shiloach J.

PLoS One. 2013 May 16;8(5):e63679. doi: 10.1371/journal.pone.0063679. Print 2013.

44.

Escherichia coli avoids high dissolved oxygen stress by activation of SoxRS and manganese-superoxide dismutase.

Baez A, Shiloach J.

Microb Cell Fact. 2013 Mar 12;12:23. doi: 10.1186/1475-2859-12-23.

45.

Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells.

Druz A, Son YJ, Betenbaugh M, Shiloach J.

Metab Eng. 2013 Mar;16:87-94. doi: 10.1016/j.ymben.2012.12.004. Epub 2013 Jan 29.

46.

Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines.

Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J.

RNA Biol. 2013 Feb;10(2):287-300. doi: 10.4161/rna.23339. Epub 2013 Jan 25.

47.

Structure of the agonist-bound neurotensin receptor.

White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R.

Nature. 2012 Oct 25;490(7421):508-13. doi: 10.1038/nature11558. Epub 2012 Oct 10.

48.

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.

He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.

J Biol Chem. 2012 Sep 14;287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25.

49.

Evidence for helical structure in a tetramer of α2-8 sialic acid: unveiling a structural antigen.

Battistel MD, Shangold M, Trinh L, Shiloach J, Freedberg DI.

J Am Chem Soc. 2012 Jul 4;134(26):10717-20. doi: 10.1021/ja300624j. Epub 2012 Jun 22.

50.

Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation.

Druz A, Betenbaugh M, Shiloach J.

Nucleic Acids Res. 2012 Aug;40(15):7291-302. doi: 10.1093/nar/gks452. Epub 2012 May 25.

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