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Items: 25


Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys.

Chu H, Shillingford JM, Reddy JA, Westrick E, Nelson M, Wang EZ, Parker N, Felten AE, Vaughn JF, Xu LC, Lu YJ, Vlahov IR, Leamon CP.

Mol Pharm. 2019 Aug 13. doi: 10.1021/acs.molpharmaceut.9b00624. [Epub ahead of print]


Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.

Weimbs T, Shillingford JM, Torres J, Kruger SL, Bourgeois BC.

Clin Kidney J. 2018 Dec;11(Suppl 1):i27-i38. doi: 10.1093/ckj/sfy089. Epub 2018 Dec 17. Review.


Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease.

Kipp KR, Kruger SL, Schimmel MF, Parker N, Shillingford JM, Leamon CP, Weimbs T.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F395-F405. doi: 10.1152/ajprenal.00057.2018. Epub 2018 May 2.


Folate-conjugated rapamycin slows progression of polycystic kidney disease.

Shillingford JM, Leamon CP, Vlahov IR, Weimbs T.

J Am Soc Nephrol. 2012 Oct;23(10):1674-81. Epub 2012 Aug 2.


Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus.

Stayner C, Shields J, Slobbe L, Shillingford JM, Weimbs T, Eccles MR.

Nephrology (Carlton). 2012 Nov;17(8):739-47. doi: 10.1111/j.1440-1797.2012.01639.x.


Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18067-72. doi: 10.1073/pnas.1111966108. Epub 2011 Oct 24.


Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.


Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

Shillingford JM, Piontek KB, Germino GG, Weimbs T.

J Am Soc Nephrol. 2010 Mar;21(3):489-97. doi: 10.1681/ASN.2009040421. Epub 2010 Jan 14.


Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function.

Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW.

Mol Cell Biol. 2006 Aug;26(15):5809-26.


The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. Epub 2006 Mar 27.


Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.

Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV Jr.

Development. 2004 Jul;131(13):3047-55. Epub 2004 May 26.


Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.

Long W, Wagner KU, Lloyd KC, Binart N, Shillingford JM, Hennighausen L, Jones FE.

Development. 2003 Nov;130(21):5257-68. Epub 2003 Sep 3.


Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Bierie B, Nozawa M, Renou JP, Shillingford JM, Morgan F, Oka T, Taketo MM, Cardiff RD, Miyoshi K, Wagner KU, Robinson GW, Hennighausen L.

Oncogene. 2003 Jun 19;22(25):3875-87.


Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.

Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L.

J Histochem Cytochem. 2003 May;51(5):555-65.


Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis.

Shillingford JM, Miyoshi K, Flagella M, Shull GE, Hennighausen L.

Mol Endocrinol. 2002 Jun;16(6):1309-21.


Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.

Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L.

Mol Endocrinol. 2002 Mar;16(3):563-70.


Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L, Khazaie K.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):219-24. Epub 2002 Jan 2.


Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.

Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L.

J Cell Biol. 2001 Nov 12;155(4):531-42. Epub 2001 Nov 12.


Experimental mouse genetics-- answering fundamental questions about mammary gland biology.

Shillingford JM, Hennighausen L.

Trends Endocrinol Metab. 2001 Nov;12(9):402-8. Review.


Determination of the sequence of a mRNA from lactating sheep mammary gland that encodes a protein identical to the Na(+)-dependent glucose transporter (SGLT1).

Shillingford JM, Wood IS, Shennan DB, Shirazi-Beechey SP, Beechey RB.

Biochem Soc Trans. 1997 Aug;25(3):467S. No abstract available.


Phosphate transport via Na+ -Pi cotransport and anion exchange in lactating rat mammary tissue.

Shillingford JM, Calvert DT, Beechey RB, Shennan DB.

Exp Physiol. 1996 Mar;81(2):273-84.


The inhibition of Na(+)-Pi cotransport and Pi self-exchange mechanisms in lactating rat mammary tissue.

Shillingford JM, Beechey RB, Shennan DB.

Biochem Soc Trans. 1995 Nov;23(4):559S. No abstract available.


The regulation of anion transport in lactating rat mammary tissue.

Shillingford JM, Shennan DB, Beechey RB.

Biochem Soc Trans. 1995 Feb;23(1):26S. No abstract available.


Mechanisms of phosphate transport in the lactating rat mammary gland.

Shillingford JM, Shennan DB, Beechey RB.

Biochem Soc Trans. 1994 Nov;22(4):420S. No abstract available.


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