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Items: 1 to 50 of 71

1.

A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line.

Furutani T, Takeyama K, Koutoku H, Ito S, Taniguchi N, Suzuki E, Kudoh M, Shibasaki M, Shikama H, Kato S.

Biosci Biotechnol Biochem. 2005 Nov;69(11):2236-9.

2.

Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target.

Furutani T, Takeyama K, Tanabe M, Koutoku H, Ito S, Taniguchi N, Suzuki E, Kudoh M, Shibasaki M, Shikama H, Kato S.

J Pharmacol Exp Ther. 2005 Nov;315(2):545-52. Epub 2005 Aug 3. Retraction in: J Pharmacol Exp Ther. 2014 Mar;348(3):493.

PMID:
16079302
3.

Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure.

Miyauchi T, Fujimori A, Maeda S, Iemitsu M, Sakai S, Shikama H, Tanabe T, Matsuda M, Goto K, Yamaguchi I.

J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S64-7.

PMID:
15838361
4.

YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction.

Fujimori A, Miyauchi T, Sakai S, Yuyama H, Iemitsu M, Sanagi M, Sudoh K, Goto K, Shikama H, Yamaguchi I.

J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S354-7.

PMID:
15838319
5.

Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits.

Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.

Atherosclerosis. 2005 Mar;179(1):87-95. Epub 2004 Dec 25.

PMID:
15721013
6.

Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.

Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J.

Am J Pathol. 2004 Oct;165(4):1375-83.

7.

Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.

Fan J, Wang X, Wu L, Matsumoto SI, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T.

Transgenic Res. 2004 Jun;13(3):261-9.

PMID:
15359603
8.

Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis.

Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.

Lab Invest. 2004 Jun;84(6):715-26.

9.

Antithrombotic and thrombolytic efficacy of YM-254890, a G q/11 inhibitor, in a rat model of arterial thrombosis.

Kawasaki T, Taniguchi M, Moritani Y, Hayashi K, Saito T, Takasaki J, Nagai K, Inagaki O, Shikama H.

Thromb Haemost. 2003 Sep;90(3):406-13.

PMID:
12958608
10.

YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents.

Ugawa T, Kakuta H, Moritani H, Inagaki O, Shikama H.

Br J Pharmacol. 2003 May;139(1):140-6.

11.

Hypoglycemic agent YM440 suppresses hepatic glucose output via gluconeogenesis by reducing glucose-6-phosphatase activity in obese Zucker rats.

Kurosaki E, Nakano R, Momose K, Shimaya A, Suzuki T, Shibasaki M, Shikama H.

Eur J Pharmacol. 2003 May 9;468(2):151-8.

PMID:
12742522
12.

Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation.

Kurosaki E, Nakano R, Shimaya A, Yoshida S, Ida M, Suzuki T, Shibasaki M, Shikama H.

Biochem Pharmacol. 2003 Mar 1;65(5):795-805.

PMID:
12628477
13.

Effects of mild and moderate hypothermia on apoptosis in neuronal PC12 cells.

Shibano T, Morimoto Y, Kemmotsu O, Shikama H, Hisano K, Hua Y.

Br J Anaesth. 2002 Aug;89(2):301-5.

14.

Hypoglycemic agent YM440 ameliorates the impaired hepatic glycogenesis after glucose loading by increasing glycogen synthase activity in obese Zucker rats.

Kurosaki E, Momose K, Nakano R, Shimaya A, Suzuki T, Shibasaki M, Shikama H.

Jpn J Pharmacol. 2002 Jul;89(3):274-81.

15.

Inhibitory effects of the new anti-inflammatory agent, IS-741, on spontaneous colitis in HLA-B27/beta2-microglobulin transgenic rats.

Makino J, Andoh A, Hata K, Yotsuya S, Shikama H, Imamura M, Fujiyama Y, Bamba T.

J Gastroenterol Hepatol. 2002 Aug;17(8):854-60.

PMID:
12164961
16.

A novel MPL point mutation resulting in thrombopoietin-independent activation.

Abe M, Suzuki K, Inagaki O, Sassa S, Shikama H.

Leukemia. 2002 Aug;16(8):1500-6.

17.

Stabilization of androgen receptor protein is induced by agonist, not by antagonists.

Furutani T, Watanabe T, Tanimoto K, Hashimoto T, Koutoku H, Kudoh M, Shimizu Y, Kato S, Shikama H.

Biochem Biophys Res Commun. 2002 Jun 21;294(4):779-84.

PMID:
12061774
18.

Experimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model.

Ugawa T, Kakuta H, Moritani H, Shikama H.

Br J Pharmacol. 2002 Mar;135(6):1572-8.

19.

Suppressive effects of a new anti-inflammatory agent, IS-741, on dextran sulfate sodium-induced experimental colitis in rats.

Makino J, Andoh A, Hata K, Yotsuya S, Shikama H, Araki Y, Fujiyama Y, Bamba T.

Int J Mol Med. 2002 Apr;9(4):391-6.

PMID:
11891534
20.

Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits.

Ichikawa T, Unoki H, Sun H, Shimoyamada H, Marcovina S, Shikama H, Watanabe T, Fan J.

Am J Pathol. 2002 Jan;160(1):227-36.

21.
22.

Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis.

Fan J, Unoki H, Kojima N, Sun H, Shimoyamada H, Deng H, Okazaki M, Shikama H, Yamada N, Watanabe T.

J Biol Chem. 2001 Oct 26;276(43):40071-9. Epub 2001 Jul 26.

23.

[Asystole during electroconvulsive therapy in a patient with depression and myasthenia gravis].

Otsuka H, Shikama H, Saito T, Ishikawa T, Kemmotsu O.

Masui. 2000 Aug;49(8):893-5. Japanese.

PMID:
10998885
24.

YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species.

Ugawa T, Kakuta H, Moritani H, Matsuda K, Ishihara T, Yamaguchi M, Naganuma S, Iizumi Y, Shikama H.

Br J Pharmacol. 2000 Sep;131(1):63-70.

25.

The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation.

Morimoto Y, Kemmotsu O, Gando S, Shibano T, Shikama H.

Anesth Analg. 2000 Aug;91(2):347-52.

PMID:
10910846
26.

Pentobarbital inhibits apoptosis in neuronal cells.

Morimoto Y, Morimoto Y, Nishihira J, Kemmotsu O, Shibano T, Gando S, Shikama H.

Crit Care Med. 2000 Jun;28(6):1899-904.

PMID:
10890639
27.

The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice.

Shimaya A, Kurosaki E, Nakano R, Hirayama R, Shibasaki M, Shikama H.

Metabolism. 2000 Mar;49(3):411-7.

PMID:
10726922
28.

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.

Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K.

J Biol Chem. 2000 Jan 28;275(4):2877-84.

29.
30.

YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.

Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Fujikura T, Akaza H, Shikama H.

Jpn J Pharmacol. 1999 Feb;79(2):213-20.

31.

Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells.

Shikama H, Yotsuya S, Satake S, Sugi H, Kato M.

Biol Pharm Bull. 1999 Feb;22(2):127-31.

PMID:
10077429
32.

Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a).

Fan J, Araki M, Wu L, Challah M, Shimoyamada H, Lawn RM, Kakuta H, Shikama H, Watanabe T.

Biochem Biophys Res Commun. 1999 Feb 24;255(3):639-44.

PMID:
10049763
33.

A novel synthetic anti-acute pancreatitis agent, IS-741.

Yotsuya S, Shikama H, Nakano I, Sakai K, Kato M, Sugi H, Takada H, Koga Y.

Digestion. 1999;60 Suppl 1:34-9.

PMID:
10026429
34.

YM268 increases the glucose uptake, cell differentiation, and mRNA expression of glucose transporter in 3T3-L1 adipocytes.

Shimaya A, Kurosaki E, Shioduka K, Nakano R, Shibasaki M, Shikama H.

Horm Metab Res. 1998 Sep;30(9):543-8.

PMID:
9808320
35.

In vivo effects of pioglitazone on uncoupling protein-2 and -3 mRNA levels in skeletal muscle of hyperglycemic KK mice.

Shimokawa T, Kato M, Watanabe Y, Hirayama R, Kurosaki E, Shikama H, Hashimoto S.

Biochem Biophys Res Commun. 1998 Oct 9;251(1):374-8.

PMID:
9790963
36.

Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats.

Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Yoden T, Okada M, Fujikura T, Akaza H, Shikama H.

Prostate. 1998 Sep 15;37(1):10-8.

PMID:
9721064
37.

Inhibitory effects of YM175, a bisphosphonate, on the progression of experimental periodontitis in beagle dogs.

O'uchi N, Nishikawa H, Yoshino T, Kanoh H, Motoie H, Nishimori E, Shimaoka T, Abe T, Shikama H, Fujikura T, Matsue M, Matsue I.

J Periodontal Res. 1998 May;33(4):196-204.

PMID:
9689615
38.
39.

Insulin sensitizer YM268 ameliorates insulin resistance by normalizing the decreased content of GLUT4 in adipose tissue of obese Zucker rats.

Shimaya A, Noshiro O, Hirayama R, Yoneta T, Niigata K, Shikama H.

Eur J Endocrinol. 1997 Dec;137(6):693-700.

PMID:
9437239
40.

Increase of bone mass and mechanical strength in rats after treatment with a novel bisphosphonate, YM175, for two years.

Motoie H, Okazaki A, Kanoh H, Shikama H, Fujikura T.

Pharmacol Toxicol. 1997 Jul;81(1):42-7.

PMID:
9258984
41.

Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats.

Noshiro O, Hirayama R, Shimaya A, Yoneta T, Niigata K, Shikama H.

Int J Obes Relat Metab Disord. 1997 Feb;21(2):115-21.

PMID:
9043965
42.

Studies on aromatase inhibitors. I. Synthesis and biological evaluation of 4-amino-4H-1,2,4-triazole derivatives.

Okada M, Yoden T, Kawaminami E, Shimada Y, Kudoh M, Isomura Y, Shikama H, Fujikura T.

Chem Pharm Bull (Tokyo). 1996 Oct;44(10):1871-9.

PMID:
8904814
43.

Prevention of bone loss by bisphosphonate YM175 in ovariectomized dogs with dietary calcium restriction.

Motoie H, Kanoh H, Ogata S, Kawamuki K, Shikama H, Fujikura T.

Jpn J Pharmacol. 1996 Jul;71(3):239-46.

44.

Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell.

Kudoh M, Susaki Y, Ideyama Y, Nanya T, Mori M, Shikama H, Fujikura T.

J Steroid Biochem Mol Biol. 1996 May;58(2):189-94.

PMID:
8809200
45.

Slowing of peripheral motor nerve conduction was ameliorated by aminoguanidine in streptozocin-induced diabetic rats.

Miyauchi Y, Shikama H, Takasu T, Okamiya H, Umeda M, Hirasaki E, Ohhata I, Nakayama H, Nakagawa S.

Eur J Endocrinol. 1996 Apr;134(4):467-73.

PMID:
8640299
46.

Novel muteins of human tumor necrosis factor with potent antitumor activity and less lethal toxicity in mice.

Kuroda K, Miyata K, Shikama H, Kawagoe T, Nishimura K, Takeda K, Sakae N, Kato M.

Int J Cancer. 1995 Sep 27;63(1):152-7.

PMID:
7558445
47.

The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511.

Kudoh M, Susaki Y, Ideyama Y, Nanya T, Okada M, Shikama H, Fujikura T.

J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):265-71.

PMID:
7577709
48.

Novel mutein of tumor necrosis factor alpha (F4614) with reduced hypotensive effect.

Shikama H, Miyata K, Sakae N, Mitsuishi Y, Nishimura K, Kuroda K, Kato M.

J Interferon Cytokine Res. 1995 Aug;15(8):677-84.

PMID:
8528939
49.

Transport and metabolism of glutathione isopropyl ester in cerebrospinal fluid.

Shikama H, Ohta A, Iwai A, Koutoku H, Umeda M, Noguchi K, Takeda M, Ohhata I.

Res Commun Mol Pathol Pharmacol. 1995 Jun;88(3):349-57.

PMID:
8564390
50.

Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.

Miyata K, Mitsuishi Y, Shikama H, Kuroda K, Nishimura K, Sakae N, Kato M.

J Interferon Cytokine Res. 1995 Feb;15(2):161-9.

PMID:
8590320

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