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Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.

ElHady AK, Shih SP, Chen YC, Liu YC, Ahmed NS, Keeton AB, Piazza GA, Engel M, Abadi AH, Abdel-Halim M.

Bioorg Chem. 2020 Mar 10;98:103742. doi: 10.1016/j.bioorg.2020.103742. [Epub ahead of print]


Enterovirus and Encephalitis.

Chen BS, Lee HC, Lee KM, Gong YN, Shih SR.

Front Microbiol. 2020 Feb 20;11:261. doi: 10.3389/fmicb.2020.00261. eCollection 2020. Review.


Antiviral activity of llama-inspired single domain antibody against Enterovirus A71.

Huang PN, Wang HC, Hung HC, Tseng SN, Chang TY, Chou MY, Chen YJ, Wang YM, Shih SR, Hsu JT.

Antimicrob Agents Chemother. 2020 Mar 9. pii: AAC.01922-19. doi: 10.1128/AAC.01922-19. [Epub ahead of print]


Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster-randomized controlled trials.

Chen LK, Hwang AC, Lee WJ, Peng LN, Lin MH, Neil DL, Shih SF, Loh CH, Chiou ST; Taiwan Health Promotion Intervention Study for Elders research group.

J Cachexia Sarcopenia Muscle. 2020 Mar 5. doi: 10.1002/jcsm.12534. [Epub ahead of print]


Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study.

Fan KC, Wu HT, Wei JN, Chuang LM, Hsu CY, Yen IW, Lin CH, Lin MS, Shih SR, Wang SH, Chang TJ, Li HY.

J Clin Endocrinol Metab. 2020 May 1;105(5). pii: dgaa103. doi: 10.1210/clinem/dgaa103.


A mediation analysis for a nonrare dichotomous outcome with sequentially ordered multiple mediators.

Lai EY, Shih S, Huang YT, Wang S.

Stat Med. 2020 Feb 19. doi: 10.1002/sim.8485. [Epub ahead of print]


Inhaled Gases for Neuroprotection of Neonates: A Review.

Tolaymat Y, Doré S, Griffin HW, Shih S, Edwards ME, Weiss MD.

Front Pediatr. 2020 Jan 27;7:558. doi: 10.3389/fped.2019.00558. eCollection 2019. Review.


Multi-Reader Multi-Case Study for Performance Evaluation of High-Risk Thyroid Ultrasound with Computer-Aided Detection.

Wu MH, Chen KY, Shih SR, Ho MC, Tai HC, Chang KJ, Chen A, Chen CN.

Cancers (Basel). 2020 Feb 6;12(2). pii: E373. doi: 10.3390/cancers12020373.


Progression of insulin resistance: A link between risk factors and the incidence of diabetes.

Wu WC, Wei JN, Chen SC, Fan KC, Lin CH, Yang CY, Lin MS, Shih SR, Hua CH, Hsein YC, Chuang LM, Li HY.

Diabetes Res Clin Pract. 2020 Mar;161:108050. doi: 10.1016/j.diabres.2020.108050. Epub 2020 Feb 5.


Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis.

Chao WC, Tseng CH, Wu CL, Shih SJ, Yi CY, Chan MC.

Ann Intensive Care. 2020 Feb 7;10(1):17. doi: 10.1186/s13613-020-0635-3.


The RNA-dependent RNA polymerase of enterovirus A71 associates with ribosomal proteins and positively regulates protein translation.

Lee KM, Wu CC, Wu SE, Lin YH, Wang LT, Chang CR, Huang PN, Shih SR, Kuo RL.

RNA Biol. 2020 Apr;17(4):608-622. doi: 10.1080/15476286.2020.1722448. Epub 2020 Feb 6.


Detection of DNA Double-Strand Breaks and Chromosome Translocations Using Ligation-Mediated PCR and Inverse PCR.

Singh S, Shih SJ, Vaughan ATM.

Methods Mol Biol. 2020;2102:271-288. doi: 10.1007/978-1-0716-0223-2_15.


Parent IMPACT-III: Development and Validation of an Inflammatory Bowel Disease-specific Health-related Quality-of-life Measure.

Cushman GK, Stolz MG, Shih S, Blount R, Otley A, Talmadge C, Grant A, Reed B.

J Pediatr Gastroenterol Nutr. 2020 Feb;70(2):205-210. doi: 10.1097/MPG.0000000000002540.


Cep44 functions in centrosome cohesion by stabilizing rootletin.

Hossain D, Shih SY, Xiao X, White J, Tsang WY.

J Cell Sci. 2020 Feb 21;133(4). pii: jcs239616. doi: 10.1242/jcs.239616.


Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer.

Chang CW, Lee HC, Li LH, Chiang Chiau JS, Wang TE, Chuang WH, Chen MJ, Wang HY, Shih SC, Liu CY, Tsai TH, Chen YJ.

Int J Mol Sci. 2020 Jan 8;21(2). pii: E386. doi: 10.3390/ijms21020386.


Iron Overload Associated Endocrine Dysfunction Leading to Lower Bone Mineral Density in Thalassemia Major.

Yang WP, Chang HH, Li HY, Lai YC, Huang TY, Tsai KS, Lin KH, Lin DT, Jou ST, Lu MY, Yang YL, Chou SW, Shih SR.

J Clin Endocrinol Metab. 2020 Apr 1;105(4). pii: dgz309. doi: 10.1210/clinem/dgz309.


Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation.

Hung SJ, Hsu YM, Huang SW, Tsai HP, Lee LYY, Hurt AC, Barr IG, Shih SR, Wang JR.

J Biomed Sci. 2020 Jan 6;27(1):17. doi: 10.1186/s12929-019-0612-z.


Computerized Cytological Features for Papillary Thyroid Cancer Diagnosis-Preliminary Report.

Shih SR, Jan IS, Chen KY, Chuang WY, Wang CY, Hsiao YL, Chang TC, Chen A.

Cancers (Basel). 2019 Oct 25;11(11). pii: E1645. doi: 10.3390/cancers11111645.


Correlation of Morphology and In-Vitro Degradation Behavior of Spray Pyrolyzed Bioactive Glasses.

Bakare FF, Chou YJ, Huang YH, Tesfay AH, Moriga T, Shih SJ.

Materials (Basel). 2019 Nov 9;12(22). pii: E3703. doi: 10.3390/ma12223703.


Investigation and successful control of an echovirus 11 outbreak in neonatal intensive care units.

Ho SY, Chiu CH, Huang YC, Chen CJ, Lien R, Chu SM, Huang CG, Tsao KC, Shih SR, Hsu JF.

Pediatr Neonatol. 2019 Oct 4. pii: S1875-9572(19)30521-2. doi: 10.1016/j.pedneo.2019.09.012. [Epub ahead of print]


Topical Review: State of the Field of Child Self-Report of Acute Pain.

Cohen LL, Donati MR, Shih S, Sil S.

J Pediatr Psychol. 2020 Apr 1;45(3):239-246. doi: 10.1093/jpepsy/jsz078.


Pica in Pediatric Sickle Cell Disease.

Rodrigues N, Shih S, Cohen LL.

J Clin Psychol Med Settings. 2019 Oct 28. doi: 10.1007/s10880-019-09671-x. [Epub ahead of print]


Fibroblast Growth Factor Receptor Inhibitors Reduce Adipogenesis of Orbital Fibroblasts and Enhance Myofibroblastic Differentiation in Graves' Orbitopathy.

Shih SR, Liao SL, Shih CW, Wei YH, Lu TX, Chou CH, Yen EY, Chang YC, Lin CC, Chi YC, Yang WS, Tsai FC.

Ocul Immunol Inflamm. 2019 Oct 28:1-10. doi: 10.1080/09273948.2019.1672196. [Epub ahead of print] Erratum in: Ocul Immunol Inflamm. 2019 Nov 25;:1.


Neutrophil-to-lymphocyte ratio as a predictive marker of metabolic syndrome.

Liu CC, Ko HJ, Liu WS, Hung CL, Hu KC, Yu LY, Shih SC.

Medicine (Baltimore). 2019 Oct;98(43):e17537. doi: 10.1097/MD.0000000000017537.


Parent IMPACT-III: Development and Validation of an IBD-Specific Health-Related Quality of Life Measure.

Cushman GK, Stolz MG, Shih S, Blount R, Otley A, Talmadge C, Grant A, Reed B.

J Pediatr Gastroenterol Nutr. 2019 Oct 22. doi: 10.1097/MPG.0000000000002540. [Epub ahead of print]


Factors associated with post-partum smoking relapse in Taiwan: A trial of Smoker's helpline.

Lin CL, Lee TS, Hsu CC, Chen CY, Chao E, Shih SF, Hu HY.

Taiwan J Obstet Gynecol. 2019 Sep;58(5):667-672. doi: 10.1016/j.tjog.2019.07.015.


A nonstructural flood prevention measure for mitigating urban inundation impacts along with river flooding effects.

Shih SS, Kuo PH, Lai JS.

J Environ Manage. 2019 Dec 1;251:109553. doi: 10.1016/j.jenvman.2019.109553. Epub 2019 Sep 17.


EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.

Li ML, Lin JY, Chen BS, Weng KF, Shih SR, Calderon JD, Tolbert BS, Brewer G.

PLoS One. 2019 Sep 9;14(9):e0221048. doi: 10.1371/journal.pone.0221048. eCollection 2019.


Methods for detection and study of virus-derived small RNAs produced from the intramolecular base-pairing region of the picornavirus genome.

Lee KM, Gong YN, Shih SR.

Methods. 2019 Sep 5. pii: S1046-2023(19)30192-6. doi: 10.1016/j.ymeth.2019.08.011. [Epub ahead of print] Review.


Antivirals and vaccines for Enterovirus A71.

Lin JY, Kung YA, Shih SR.

J Biomed Sci. 2019 Sep 3;26(1):65. doi: 10.1186/s12929-019-0560-7. Review.


Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.

Huang CT, Hung CY, Hseih YC, Chang CS, Velu AB, He YC, Huang YL, Chen TA, Chen TC, Lin CY, Lin YC, Shih SR, Dutta A.

Phytomedicine. 2019 Nov;64:152904. doi: 10.1016/j.phymed.2019.152904. Epub 2019 Apr 4.


Fungal Diseases in Taiwan-National Insurance Data and Estimation.

Huang YS, Denning DW, Shih SM, Hsiung CA, Wu UI, Sun HY, Chen PY, Chen YC, Chang SC.

J Fungi (Basel). 2019 Aug 21;5(3). pii: E78. doi: 10.3390/jof5030078.


Immediate knowledge improvement and long-term teaching confidence after general medicine faculty training program.

Tseng FY, Lin LC, Ko BS, Chu TS, Tsai SL, Sheng WH, Yen CJ, Chang CH, Wu CH, Shih SR, Chiu WY, Pan SC, Chen WP, Chang PY.

J Formos Med Assoc. 2020 Jan;119(1 Pt 3):538-543. doi: 10.1016/j.jfma.2019.08.001. Epub 2019 Aug 16.


Serum fibroblast growth factor 23 and mineral metabolism in patients with euthyroid Graves' diseases: a case-control study.

Lin CH, Chang CK, Shih CW, Li HY, Chen KY, Yang WS, Tsai KS, Wang CY, Shih SR.

Osteoporos Int. 2019 Nov;30(11):2289-2297. doi: 10.1007/s00198-019-05116-1. Epub 2019 Aug 5.


Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability.

Lin RW, Chen GW, Sung HH, Lin RJ, Yen LC, Tseng YL, Chang YK, Lien SP, Shih SR, Liao CL.

J Biomed Sci. 2019 Jul 31;26(1):55. doi: 10.1186/s12929-019-0547-4.


Tumor-Induced Osteomalacia Treated as Ankylosing Spondylitis and Osteoporotic Compression Fracture.

Kao YH, Li YC, Yeh LR, Tsai JW, Li JY, Tu YK, Shih SR.

J Clin Rheumatol. 2019 Jul 25. doi: 10.1097/RHU.0000000000001152. [Epub ahead of print] No abstract available.


Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature.

Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA.

Am J Dermatopathol. 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. Review.


Weekend Admission to Inpatient Rehabilitation Facilities Is Associated With Transfer to Acute Care in a Nationwide Sample of Patients With Stroke.

Shih SL, Flavin M, Goldstein R, Slocum C, Ryan CM, Singhal A, Frankel J, Zafonte R, Schneider JC.

Am J Phys Med Rehabil. 2020 Jan;99(1):1-6. doi: 10.1097/PHM.0000000000001266.


Pitavastatin Exerts Potent Anti-Inflammatory and Immunomodulatory Effects via the Suppression of AP-1 Signal Transduction in Human T Cells.

Chen LW, Lin CS, Tsai MC, Shih SF, Lim ZW, Chen SJ, Tsui PF, Ho LJ, Lai JH, Liou JT.

Int J Mol Sci. 2019 Jul 19;20(14). pii: E3534. doi: 10.3390/ijms20143534.


Clarifying the Current Understanding of Syndromic Basal Cell Carcinomas.

Shih S, Dai C, Ansari A, Solomon JA.

J Invest Dermatol. 2019 Nov;139(11):2384-2385. doi: 10.1016/j.jid.2019.05.013. Epub 2019 Jul 19. No abstract available.


Frontline treatment of elderly non transplant-eligible multiple myeloma patients using CyBorD with or without thalidomide-based consolidation: a retrospective multi-centre analysis of real-world data.

Chan H, Chai K, Shih S, Lewsey R, Chen K, McDiarmid B, Jackson S, Simpson D.

Br J Haematol. 2019 Nov;187(4):470-477. doi: 10.1111/bjh.16095. Epub 2019 Jul 12.


Increasing risk of diabetes mellitus in postmenopausal women with newly diagnosed primary breast cancer.

Wang CY, Shih SR, Huang KC.

J Diabetes Investig. 2020 Mar;11(2):490-498. doi: 10.1111/jdi.13112. Epub 2019 Jul 27.


Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus.

Huang SY, Huang CH, Chen CJ, Chen TW, Lin CY, Lin YT, Kuo SM, Huang CG, Lee LA, Chen YH, Chen MF, Kuo RL, Shih SR.

Mol Ther Nucleic Acids. 2019 Sep 6;17:10-23. doi: 10.1016/j.omtn.2019.04.028. Epub 2019 May 15.


Manipulation of the degradation behavior of calcium sulfate by the addition of bioglass.

Hsu PY, Kuo HC, Tuan WH, Shih SJ, Naito M, Lai PL.

Prog Biomater. 2019 Jun;8(2):115-125. doi: 10.1007/s40204-019-0116-7. Epub 2019 May 24.


A fucosyltransferase inhibition assay using image-analysis and digital microfluidics.

Leclerc LMY, Soffer G, Kwan DH, Shih SCC.

Biomicrofluidics. 2019 May 10;13(3):034106. doi: 10.1063/1.5088517. eCollection 2019 May.


The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.

Wang KC, Liu YC, El-Shazly M, Shih SP, Du YC, Hsu YM, Lin HY, Chen YC, Wu YC, Yang SC, Lu MC.

Int J Mol Sci. 2019 Apr 19;20(8). pii: E1935. doi: 10.3390/ijms20081935.


Population dynamics at neuraminidase position 151 of influenza A (H1N1)pdm09 virus in clinical specimens.

Gong YN, Tsao KC, Chen GW, Wu CJ, Chen YH, Liu YC, Yang SL, Huang YC, Shih SR.

J Gen Virol. 2019 May;100(5):752-759. doi: 10.1099/jgv.0.001258. Epub 2019 Apr 17.


Integration of World-to-Chip Interfaces with Digital Microfluidics for Bacterial Transformation and Enzymatic Assays.

Moazami E, Perry JM, Soffer G, Husser MC, Shih SCC.

Anal Chem. 2019 Apr 16;91(8):5159-5168. doi: 10.1021/acs.analchem.8b05754. Epub 2019 Apr 4.


Control of Dopant Distribution in Yttrium-Doped Bioactive Glass for Selective Internal Radiotherapy Applications Using Spray Pyrolysis.

Hadush Tesfay A, Chou YJ, Tan CY, Fufa Bakare F, Tsou NT, Huang EW, Shih SJ.

Materials (Basel). 2019 Mar 25;12(6). pii: E986. doi: 10.3390/ma12060986.


Biologic Therapy in the Treatment of Cutaneous Sarcoidosis: A Literature Review.

Dai C, Shih S, Ansari A, Kwak Y, Sami N.

Am J Clin Dermatol. 2019 Jun;20(3):409-422. doi: 10.1007/s40257-019-00428-8. Review.


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