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Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling.

Lin SC, Lin CH, Shih NC, Liu HL, Wang WC, Lin KY, Liu ZY, Tseng YJ, Chang HK, Lin YC, Yeh YC, Minato H, Fujii T, Wu YC, Chen MY, Chou TY.

Oncogene. 2019 Sep 2. doi: 10.1038/s41388-019-0994-0. [Epub ahead of print]


ARTS, an AR Tourism System, for the Integration of 3D Scanning and Smartphone AR in Cultural Heritage Tourism and Pedagogy.

Shih NJ, Diao PH, Chen Y.

Sensors (Basel). 2019 Aug 28;19(17). pii: E3725. doi: 10.3390/s19173725.


Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats.

Marwari S, Poulsen A, Shih N, Lakshminarayanan R, Kini RM, Johannes CW, Dymock BW, Dawe GS.

Br J Pharmacol. 2019 Oct;176(20):3899-3923. doi: 10.1111/bph.14774. Epub 2019 Sep 11.


Corrigendum to "Inhibitory Effects of Momordicine I on High-Glucose-Induced Cell Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts".

Chen PY, Shih NL, Hao WR, Chen CC, Liu JC, Sung LC.

Oxid Med Cell Longev. 2019 Apr 4;2019:2514095. doi: 10.1155/2019/2514095. eCollection 2019.


Microbiome signatures in prostate cancer.

Banerjee S, Alwine JC, Wei Z, Tian T, Shih N, Sperling C, Guzzo T, Feldman MD, Robertson ES.

Carcinogenesis. 2019 Jul 6;40(6):749-764. doi: 10.1093/carcin/bgz008.


Diagnosing the RGS11 Lung Cancer Biomarker: The Integration of Competitive Immunoassay and Isothermal Nucleic Acid Exponential Amplification Reaction.

Chang YF, Huang YQ, Wu KM, Jou AF, Shih NY, Ho JA.

Anal Chem. 2019 Mar 5;91(5):3327-3335. doi: 10.1021/acs.analchem.8b04374. Epub 2019 Feb 15.


Inhibitory Effects of Momordicine I on High-Glucose-Induced Cell Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts.

Chen PY, Shih NL, Hao WR, Chen CC, Liu JC, Sung LC.

Oxid Med Cell Longev. 2018 Oct 8;2018:3939714. doi: 10.1155/2018/3939714. eCollection 2018. Erratum in: Oxid Med Cell Longev. 2019 Apr 4;2019:2514095.


MARINS: A Mobile Smartphone AR System for Pathfinding in a Dark Environment.

Diao PH, Shih NJ.

Sensors (Basel). 2018 Oct 13;18(10). pii: E3442. doi: 10.3390/s18103442.


Stable and discriminating features are predictive of cancer presence and Gleason grade in radical prostatectomy specimens: a multi-site study.

Leo P, Elliott R, Shih NNC, Gupta S, Feldman M, Madabhushi A.

Sci Rep. 2018 Oct 8;8(1):14918. doi: 10.1038/s41598-018-33026-5.


Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.

Penzias G, Singanamalli A, Elliott R, Gollamudi J, Shih N, Feldman M, Stricker PD, Delprado W, Tiwari S, Böhm M, Haynes AM, Ponsky L, Fu P, Tiwari P, Viswanath S, Madabhushi A.

PLoS One. 2018 Aug 31;13(8):e0200730. doi: 10.1371/journal.pone.0200730. eCollection 2018.


BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor.

Tsai HJ, Jiaang WT, Shih NY, Fletcher JA, Lin MJ, Yang MY, Chen CT, Hsu TJ, Wu CC, Lin HY, Chen LT.

Cancer Sci. 2018 Nov;109(11):3591-3601. doi: 10.1111/cas.13773. Epub 2018 Sep 21.


MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.

Boga SB, Deng Y, Zhu L, Nan Y, Cooper AB, Shipps GW Jr, Doll R, Shih NY, Zhu H, Sun R, Wang T, Paliwal S, Tsui HC, Gao X, Yao X, Desai J, Wang J, Alhassan AB, Kelly J, Patel M, Muppalla K, Gudipati S, Zhang LK, Buevich A, Hesk D, Carr D, Dayananth P, Black S, Mei H, Cox K, Sherborne B, Hruza AW, Xiao L, Jin W, Long B, Liu G, Taylor SA, Kirschmeier P, Windsor WT, Bishop R, Samatar AA.

ACS Med Chem Lett. 2018 Jun 14;9(7):761-767. doi: 10.1021/acsmedchemlett.8b00220. eCollection 2018 Jul 12.


Distinct Microbial Signatures Associated With Different Breast Cancer Types.

Banerjee S, Tian T, Wei Z, Shih N, Feldman MD, Peck KN, DeMichele AM, Alwine JC, Robertson ES.

Front Microbiol. 2018 May 15;9:951. doi: 10.3389/fmicb.2018.00951. eCollection 2018.


High-throughput adaptive sampling for whole-slide histopathology image analysis (HASHI) via convolutional neural networks: Application to invasive breast cancer detection.

Cruz-Roa A, Gilmore H, Basavanhally A, Feldman M, Ganesan S, Shih N, Tomaszewski J, Madabhushi A, González F.

PLoS One. 2018 May 24;13(5):e0196828. doi: 10.1371/journal.pone.0196828. eCollection 2018.


Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

Boga SB, Alhassan AB, Cooper AB, Doll R, Shih NY, Shipps G, Deng Y, Zhu H, Nan Y, Sun R, Zhu L, Desai J, Patel M, Muppalla K, Gao X, Wang J, Yao X, Kelly J, Gudipati S, Paliwal S, Tsui HC, Wang T, Sherborne B, Xiao L, Hruza A, Buevich A, Zhang LK, Hesk D, Samatar AA, Carr D, Long B, Black S, Dayananth P, Windsor W, Kirschmeier P, Bishop R.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034. doi: 10.1016/j.bmcl.2018.04.063. Epub 2018 Apr 26.


Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model.

Yu T, Wu C, Shih N, Li Q, Chan C, Pan H, Yao D, Pan Y, Liang W, Shen L, Zhao H, Li J, Chen S.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1686-1692. doi: 10.1016/j.bmcl.2018.04.051. Epub 2018 Apr 21.


High-Performance Sub-Micrometer Channel WSe2 Field-Effect Transistors Prepared Using a Flood-Dike Printing Method.

Wu F, Chen L, Zhang A, Hong YL, Shih NY, Cho SY, Drake GA, Fleetham T, Cong S, Cao X, Liu Q, Liu Y, Xu C, Ma Y, Shim M, Thompson ME, Ren W, Cheng HM, Zhou C.

ACS Nano. 2017 Dec 26;11(12):12536-12546. doi: 10.1021/acsnano.7b06654. Epub 2017 Dec 8.


In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically.

Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH.

Drug Des Devel Ther. 2017 Nov 16;11:3281-3290. doi: 10.2147/DDDT.S149214. eCollection 2017.


[Pharmacogenetic approaches to predicting the efficiency and safety of amlodipine in patients with arterial hypertension].

Sychev DA, Shih NV, Kalle EG, Ryzhikova KA, Morozova TE.

Biomed Khim. 2017 Oct;63(5):432-439. doi: 10.18097/PBMC20176305432. Russian.


A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice.

Lee NC, Hwu WL, Muramatsu SI, Falk DJ, Byrne BJ, Cheng CH, Shih NC, Chang KL, Tsai LK, Chien YH.

Mol Neurobiol. 2018 Jun;55(6):5299-5309. doi: 10.1007/s12035-017-0763-4. Epub 2017 Sep 11.


Development of a prodrug of hydantoin based TACE inhibitor.

Tong L, Kim SH, Chen L, Kosinski A, Shankar BB, Girijavallabhan V, Yang DY, Yu W, Zhou G, Shih NY, Chen S, Hu M, Lundell D, Niu X, Umland S, Kozlowski JA.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3704-3708. doi: 10.1016/j.bmcl.2017.07.007. Epub 2017 Jul 3.


Erratum to: Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.

Maxwell KN, Soucier-Ernst D, Tahirovic E, Troxel AB, Clark C, Feldman M, Colameco C, Kakrecha B, Langer M, Lieberman D, Morrissette JJD, Paul MR, Pan TC, Yee S, Shih N, Carpenter E, Chodosh LA, DeMichele A.

Breast Cancer Res Treat. 2017 Aug;164(3):639-640. doi: 10.1007/s10549-017-4339-9. No abstract available.


Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.

Banerjee S, Tian T, Wei Z, Peck KN, Shih N, Chalian AA, O'Malley BW, Weinstein GS, Feldman MD, Alwine J, Robertson ES.

Sci Rep. 2017 Jun 22;7(1):4036. doi: 10.1038/s41598-017-03466-6.


Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.

Tong L, Kim SH, Rosner K, Yu W, Shankar BB, Chen L, Li D, Dai C, Girijavallabhan V, Popovici-Muller J, Yang L, Zhou G, Kosinski A, Siddiqui MA, Shih NY, Guo Z, Orth P, Chen S, Lundell D, Niu X, Umland S, Kozlowski JA.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3037-3042. doi: 10.1016/j.bmcl.2017.05.062. Epub 2017 May 22.


Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.

Maxwell KN, Soucier-Ernst D, Tahirovic E, Troxel AB, Clark C, Feldman M, Colameco C, Kakrecha B, Langer M, Lieberman D, Morrissette JJD, Paul MR, Pan TC, Yee S, Shih N, Carpenter E, Chodosh LA, DeMichele A.

Breast Cancer Res Treat. 2017 Aug;164(3):627-638. doi: 10.1007/s10549-017-4257-x. Epub 2017 May 12. Erratum in: Breast Cancer Res Treat. 2017 Jun 26;:.


Development of bioanalytical assays for variegin, a peptide-based bivalent direct thrombin inhibitor.

Shih N, de Carvalho LP, Lee YH, Rocha MM, Pereira Barbosa AH, A de Sousa JM, de C Carvalho AC, Kini RM, Chan MY.

Bioanalysis. 2017 May;9(9):693-705. doi: 10.4155/bio-2017-0006. Epub 2017 May 10.


Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent.

Cruz-Roa A, Gilmore H, Basavanhally A, Feldman M, Ganesan S, Shih NNC, Tomaszewski J, González FA, Madabhushi A.

Sci Rep. 2017 Apr 18;7:46450. doi: 10.1038/srep46450.


The ovarian cancer oncobiome.

Banerjee S, Tian T, Wei Z, Shih N, Feldman MD, Alwine JC, Coukos G, Robertson ES.

Oncotarget. 2017 May 30;8(22):36225-36245. doi: 10.18632/oncotarget.16717.


SEQualyzer: interactive tool for quality control and exploratory analysis of high-throughput RNA structural profiling data.

Choudhary K, Ruan L, Deng F, Shih N, Aviran S.

Bioinformatics. 2017 Feb 1;33(3):441-443. doi: 10.1093/bioinformatics/btw627.


Synthesis of magnetic cytosine-imprinted chitosan nanoparticles.

Lee MH, Ahluwalia A, Chen JZ, Shih NL, Lin HY.

Nanotechnology. 2017 Feb 24;28(8):085705. doi: 10.1088/1361-6528/aa5641. Epub 2017 Jan 19.


Evaluating stability of histomorphometric features across scanner and staining variations: prostate cancer diagnosis from whole slide images.

Leo P, Lee G, Shih NN, Elliott R, Feldman MD, Madabhushi A.

J Med Imaging (Bellingham). 2016 Oct;3(4):047502. Epub 2016 Oct 24.


Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer.

Yang PW, Hsu IJ, Chang CW, Wang YC, Hsieh CY, Shih KH, Wong LF, Shih NY, Hsieh MS, Hou MT, Lee JM.

Sci Rep. 2016 Sep 14;6:33414. doi: 10.1038/srep33414.


BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia.

Chen LT, Chen CT, Jiaang WT, Chen TY, Butterfield JH, Shih NY, Hsu JT, Lin HY, Lin SF, Tsai HJ.

Mol Cancer Ther. 2016 Oct;15(10):2323-2333. Epub 2016 Aug 10.


Metrics for rapid quality control in RNA structure probing experiments.

Choudhary K, Shih NP, Deng F, Ledda M, Li B, Aviran S.

Bioinformatics. 2016 Dec 1;32(23):3575-3583. Epub 2016 Aug 6.


AutoStitcher: An Automated Program for Efficient and Robust Reconstruction of Digitized Whole Histological Sections from Tissue Fragments.

Penzias G, Janowczyk A, Singanamalli A, Rusu M, Shih N, Feldman M, Stricker PD, Delprado W, Tiwari S, Böhm M, Haynes AM, Ponsky L, Viswanath S, Madabhushi A.

Sci Rep. 2016 Jul 26;6:29906. doi: 10.1038/srep29906.


Using Electronic Case Summaries to Elicit Multi-Disciplinary Expert Knowledge about Referrals to Post-Acute Care.

Bowles KH, Ratcliffe S, Potashnik S, Topaz M, Holmes J, Shih NW, Naylor MD.

Appl Clin Inform. 2016 May 18;7(2):368-79. doi: 10.4338/ACI-2015-11-RA-0161. eCollection 2016.


Overexpression of regulator of G protein signaling 11 promotes cell migration and associates with advanced stages and aggressiveness of lung adenocarcinoma.

Yang SH, Li CF, Chu PY, Ko HH, Chen LT, Chen WW, Han CH, Lung JH, Shih NY.

Oncotarget. 2016 May 24;7(21):31122-36. doi: 10.18632/oncotarget.8860.


Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions.

Yin J, Swartz TE, Zhang J, Patapoff TW, Chen B, Marhoul J, Shih N, Kabakoff B, Rahimi K.

PDA J Pharm Sci Technol. 2016 Jul-Aug;70(4):382-91. doi: 10.5731/pdajpst.2016.006494. Epub 2016 Apr 18.


Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity.

Sharma M, Iyer JK, Shih N, Majumder M, Mattaparthi VS, Mukhopadhyay R, Doley R.

PLoS One. 2016 Apr 18;11(4):e0153770. doi: 10.1371/journal.pone.0153770. eCollection 2016.


Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC.

Yang CC, Tu HF, Wu CH, Chang HC, Chiang WF, Shih NC, Lee YS, Kao SY, Chang KW.

Oral Oncol. 2016 May;56:54-61. doi: 10.1016/j.oraloncology.2016.03.010. Epub 2016 Mar 25.


Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells.

Zhuang S, Cheng TH, Shih NL, Liu JC, Chen JJ, Hong HJ, Chan P.

Am J Chin Med. 2016;44(2):377-88. doi: 10.1142/S0192415X1650021X.


Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells.

Chao HH, Hong HJ, Cheng TH, Shih NL, Loh SH, Liu JC, Chen JJ, Sung LC.

Pharmacology. 2016;98(1-2):42-50. doi: 10.1159/000445075. Epub 2016 Apr 7.


Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J.

Nat Commun. 2016 Feb 9;7:10442. doi: 10.1038/ncomms10442.


Anti-α-enolase is a prognostic marker in postoperative lung cancer patients.

Hsiao KC, Shih NY, Chu PY, Hung YM, Liao JY, Chou SW, Yang YY, Chang GC, Liu KJ.

Oncotarget. 2015 Oct 27;6(33):35073-86. doi: 10.18632/oncotarget.5316.


Distinct microbiological signatures associated with triple negative breast cancer.

Banerjee S, Wei Z, Tan F, Peck KN, Shih N, Feldman M, Rebbeck TR, Alwine JC, Robertson ES.

Sci Rep. 2015 Oct 15;5:15162. doi: 10.1038/srep15162.


Computer-extracted Features Can Distinguish Noncancerous Confounding Disease from Prostatic Adenocarcinoma at Multiparametric MR Imaging.

Litjens GJ, Elliott R, Shih NN, Feldman MD, Kobus T, Hulsbergen-van de Kaa C, Barentsz JO, Huisman HJ, Madabhushi A.

Radiology. 2016 Jan;278(1):135-45. doi: 10.1148/radiol.2015142856. Epub 2015 Jul 17.


Quantitative identification of magnetic resonance imaging features of prostate cancer response following laser ablation and radical prostatectomy.

Litjens GJ, Huisman HJ, Elliott RM, Shih NN, Feldman MD, Viswanath S, Fütterer JJ, Bomers JG, Madabhushi A.

J Med Imaging (Bellingham). 2014 Oct;1(3):035001. doi: 10.1117/1.JMI.1.3.035001. Epub 2014 Oct 27.


Mitosis detection in breast cancer pathology images by combining handcrafted and convolutional neural network features.

Wang H, Cruz-Roa A, Basavanhally A, Gilmore H, Shih N, Feldman M, Tomaszewski J, Gonzalez F, Madabhushi A.

J Med Imaging (Bellingham). 2014 Oct;1(3):034003. doi: 10.1117/1.JMI.1.3.034003. Epub 2014 Oct 10.


Identifying in vivo DCE MRI markers associated with microvessel architecture and gleason grades of prostate cancer.

Singanamalli A, Rusu M, Sparks RE, Shih NN, Ziober A, Wang LP, Tomaszewski J, Rosen M, Feldman M, Madabhushi A.

J Magn Reson Imaging. 2016 Jan;43(1):149-58. doi: 10.1002/jmri.24975. Epub 2015 Jun 25.


Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.

Shih NP, François P, Delaune EA, Amacher SL.

Development. 2015 May 15;142(10):1785-93. doi: 10.1242/dev.119057.

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