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Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

Fu L, Chan YK, Nie L, Dai Q, Qian Z, Shih KC, Lai JSM, Huang R, Pan W.

BMC Ophthalmol. 2019 Feb 6;19(1):46. doi: 10.1186/s12886-019-1060-y.


Systematic Review on Therapeutic Strategies to Minimize Corneal Stromal Scarring After Injury.

Kwok SS, Shih KC, Bu Y, Lo AC, Chan TC, Lai JS, Jhanji V, Tong L.

Eye Contact Lens. 2019 Feb 1. doi: 10.1097/ICL.0000000000000584. [Epub ahead of print]


Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

D'Angelo SP, Hunger M, Brohl AS, Nghiem P, Bhatia S, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Schlichting M, Hennessy MH, Bharmal M.

Cancer Immunol Immunother. 2019 Feb 5. doi: 10.1007/s00262-018-02295-4. [Epub ahead of print]


Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report.

Cheung SSL, Lau GKK, Chan KH, Wong IYH, Lai JSM, Tang WK, Shih KC.

J Med Case Rep. 2018 Dec 3;12(1):357. doi: 10.1186/s13256-018-1893-7.


Adhesion of silicone oil and emulsification: an in vitro assessment using a microfluidic device and 'Eye-on-a-Chip'.

Lu Y, Chan YK, Lau LH, Chao Y, Shih KC, Lai SM, Wong D, Shum HC.

Acta Ophthalmol. 2018 Nov 28. doi: 10.1111/aos.13982. [Epub ahead of print]


Polymorphism in Benzene-1,3,5-tricarboxamide Supramolecular Assemblies in Water: A Subtle Trade-off between Structure and Dynamics.

Matsumoto NM, Lafleur RPM, Lou X, Shih KC, Wijnands SPW, Guibert C, van Rosendaal JWAM, Voets IK, Palmans ARA, Lin Y, Meijer EW.

J Am Chem Soc. 2018 Oct 17;140(41):13308-13316. doi: 10.1021/jacs.8b07697. Epub 2018 Oct 8.


What causes the anomalous aggregation in pluronic aqueous solutions?

Shih KC, Shen Z, Li Y, Kröger M, Chang SY, Liu Y, Nieh MP, Lai HM.

Soft Matter. 2018 Sep 26;14(37):7653-7663. doi: 10.1039/c8sm01096j.


Induction of significant intraocular pressure diurnal fluctuation in rats using a modified technique of microbead occlusion.

Fu L, Lai JSM, Lo ACY, Shih KC.

Int J Ophthalmol. 2018 Jul 18;11(7):1114-1119. doi: 10.18240/ijo.2018.07.07. eCollection 2018.


Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss.

de Bono JS, De Giorgi U, Rodrigues DN, Massard C, Bracarda S, Font A, Arranz Arija JA, Shih KC, Radavoi GD, Xu N, Chan WY, Ma H, Gendreau S, Riisnaes R, Patel PH, Maslyar DJ, Jinga V.

Clin Cancer Res. 2019 Feb 1;25(3):928-936. doi: 10.1158/1078-0432.CCR-18-0981. Epub 2018 Jul 23.


Reversible mechanofluorochromism of aniline-terminated phenylene ethynylenes.

Sharber SA, Shih KC, Mann A, Frausto F, Haas TE, Nieh MP, Thomas SW.

Chem Sci. 2018 May 24;9(24):5415-5426. doi: 10.1039/c8sc00980e. eCollection 2018 Jun 28.


Transcorneal Electrical Stimulation Inhibits Retinal Microglial Activation and Enhances Retinal Ganglion Cell Survival After Acute Ocular Hypertensive Injury.

Fu L, Fung FK, Lo AC, Chan YK, So KF, Wong IY, Shih KC, Lai JS.

Transl Vis Sci Technol. 2018 May 29;7(3):7. doi: 10.1167/tvst.7.3.7. eCollection 2018 May.


Erlotinib plus either pazopanib or placebo in patients with previously treated advanced non-small cell lung cancer: A randomized, placebo-controlled phase 2 trial with correlated serum proteomic signatures.

Spigel DR, Burris HA 3rd, Greco FA, Shih KC, Gian VG, Lipman AJ, Daniel DB, Waterhouse DM, Finney L, Heymach JV, Hainsworth JD.

Cancer. 2018 Jun 1;124(11):2355-2364. doi: 10.1002/cncr.31290. Epub 2018 Apr 12.


Phase II trial of preoperative pemetrexed plus carboplatin in patients with stage IB-III nonsquamous non-small cell lung cancer (NSCLC).

Hainsworth JD, Waterhouse DM, Shih KC, Boccia RV, Priego VM, McCleod MJ, Kudrik FJ, Mitchell RB, Burris HA 3rd, Greco FA, Spigel DR.

Lung Cancer. 2018 Apr;118:6-12. doi: 10.1016/j.lungcan.2018.01.009. Epub 2018 Jan 31.


Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial.

Kaufman HL, Russell JS, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Milella M, Brownell I, Lewis KD, Lorch JH, von Heydebreck A, Hennessy M, Nghiem P.

J Immunother Cancer. 2018 Jan 19;6(1):7. doi: 10.1186/s40425-017-0310-x.


Association of long-term glycaemic control on tear break-up times and dry eye symptoms in Chinese patients with type 2 diabetes.

Ma A, Mak MS, Shih KC, Tsui CK, Cheung RK, Lee SH, Leung H, Leung JN, Leung JT, Van-Boswell MZ, Wong MT, Ng AL, Lee CH, Jhanji V, Tong L.

Clin Exp Ophthalmol. 2018 Aug;46(6):608-615. doi: 10.1111/ceo.13146. Epub 2018 Feb 23.


Preoperative optimization of ocular surface disease before cataract surgery.

Chuang J, Shih KC, Chan TC, Wan KH, Jhanji V, Tong L.

J Cataract Refract Surg. 2017 Dec;43(12):1596-1607. doi: 10.1016/j.jcrs.2017.10.033. Review.


Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome.

Shih KC, Lun CN, Jhanji V, Thong BY, Tong L.

J Inflamm (Lond). 2017 Nov 21;14:26. doi: 10.1186/s12950-017-0174-3. eCollection 2017. Review.


Corrigendum to "Sulfoethylated nanofibrillated cellulose: Production and properties" [Carbohydr. Polym. 169 (2017) 515-523].

Naderi A, Koschella A, Heinze T, Shih KC, Nieh MP, Pfeifer A, Chang CC, Erlandsson J.

Carbohydr Polym. 2018 Jan 1;179:1. doi: 10.1016/j.carbpol.2017.09.021. Epub 2017 Sep 25. No abstract available.


Sorafenib and continued erlotinib or sorafenib alone in patients with advanced non-small cell lung cancer progressing on erlotinib: A randomized phase II study of the Sarah Cannon Research Institute (SCRI).

Spigel DR, Rubin MS, Gian VG, Shipley DL, Burris HA 3rd, Kosloff RA, Shih KC, Quinn R, Greco FA, Hainsworth JD.

Lung Cancer. 2017 Nov;113:79-84. doi: 10.1016/j.lungcan.2017.09.007. Epub 2017 Sep 18.


Advances in dry eye imaging: the present and beyond.

Chan TCY, Wan KH, Shih KC, Jhanji V.

Br J Ophthalmol. 2018 Mar;102(3):295-301. doi: 10.1136/bjophthalmol-2017-310759. Epub 2017 Oct 5. Review.


Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions In Situ.

Xia H, Fu H, Zhang Y, Shih KC, Ren Y, Anuganti M, Nieh MP, Cheng J, Lin Y.

J Am Chem Soc. 2017 Aug 16;139(32):11106-11116. doi: 10.1021/jacs.7b04986. Epub 2017 Aug 4.


Modulation of polypeptide conformation through donor-acceptor transformation of side-chain hydrogen bonding ligands.

Song Z, Mansbach RA, He H, Shih KC, Baumgartner R, Zheng N, Ba X, Huang Y, Mani D, Liu Y, Lin Y, Nieh MP, Ferguson AL, Yin L, Cheng J.

Nat Commun. 2017 Jul 21;8(1):92. doi: 10.1038/s41467-017-00079-5.


A cross-sectional comparative study on chronic ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series.

Chow LLW, Ng ALK, Chow SSW, Choy BNK, Shih KC, Wong IYH, Chan JCY, Lai JSM.

Int Ophthalmol. 2018 Jun;38(3):1155-1160. doi: 10.1007/s10792-017-0576-5. Epub 2017 May 25.


Sulfoethylated nanofibrillated cellulose: Production and properties.

Naderi A, Koschella A, Heinze T, Shih KC, Nieh MP, Pfeifer A, Chang CC, Erlandsson J.

Carbohydr Polym. 2017 Aug 1;169:515-523. doi: 10.1016/j.carbpol.2017.04.026. Epub 2017 Apr 14.


Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.

Chow LLW, Shih KC, Chan JCY, Lai JSM, Ng ALK.

BMC Ophthalmol. 2017 May 12;17(1):65. doi: 10.1186/s12886-017-0464-9.


A systematic review on the impact of diabetes mellitus on the ocular surface.

Shih KC, Lam KS, Tong L.

Nutr Diabetes. 2017 Mar 20;7(3):e251. doi: 10.1038/nutd.2017.4. Review.


A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population.

Lui MH, Lam JC, Kwong YL, Wong TS, Cheung PL, Lai SS, Yuen PL, Lam WY, Chan HY, Wong YF, Lai JS, Shih KC.

Int J Ophthalmol. 2017 Feb 18;10(2):293-299. doi: 10.18240/ijo.2017.02.18. eCollection 2017.


Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse model.

Chen CC, Lee TY, Kwok CF, Hsu YP, Shih KC, Lin YJ, Ho LT.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600292.


Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.

Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P.

Lancet Oncol. 2016 Oct;17(10):1374-1385. doi: 10.1016/S1470-2045(16)30364-3. Epub 2016 Sep 1.


Use of anti-vascular endothelial growth factor in the management of pterygium.

Mak RK, Chan TC, Marcet MM, Choy BN, Shum JW, Shih KC, Wong IY, Ng AL.

Acta Ophthalmol. 2017 Feb;95(1):20-27. doi: 10.1111/aos.13178. Epub 2016 Jul 30. Review.


Effect of high glucose, Porphyromonas gingivalis lipopolysaccharide and advanced glycation end-products on production of interleukin-6/-8 by gingival fibroblasts.

Chiu HC, Fu MM, Yang TS, Fu E, Chiang CY, Tu HP, Chin YT, Lin FG, Shih KC.

J Periodontal Res. 2017 Apr;52(2):268-276. doi: 10.1111/jre.12391. Epub 2016 Jul 11.


A phase II trial of bevacizumab and everolimus as treatment for patients with refractory, progressive intracranial meningioma.

Shih KC, Chowdhary S, Rosenblatt P, Weir AB 3rd, Shepard GC, Williams JT, Shastry M, Burris HA 3rd, Hainsworth JD.

J Neurooncol. 2016 Sep;129(2):281-8. doi: 10.1007/s11060-016-2172-3. Epub 2016 Jun 16.


Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.

Chen CC, Lee TY, Kwok CF, Hsu YP, Shih KC, Lin YJ, Ho LT.

Int J Mol Med. 2016 Mar;37(3):743-54. doi: 10.3892/ijmm.2016.2475. Epub 2016 Jan 29.


Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.

Chang TJ, Chiu YF, Sheu WH, Shih KC, Hwu CM, Quertermous T, Jou YS, Kuo SS, Chang YC, Chuang LM.

Sci Rep. 2015 Nov 26;5:14380. doi: 10.1038/srep14380.


Comparison of electroretinographic responses between two different age groups of adult Dark Agouti rats.

Fu L, Lo AC, Lai JS, Shih KC.

Int J Ophthalmol. 2015 Oct 18;8(5):898-903. doi: 10.3980/j.issn.2222-3959.2015.05.08. eCollection 2015.


Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults.

Shih KC, Janckila AJ, Lee WJ, Chou YC, Huang CJ, Kwok CF, Ho LT, Chao TY.

Clin Chim Acta. 2016 Jan 30;453:197-202. doi: 10.1016/j.cca.2015.11.004. Epub 2015 Nov 10.


Use of Atropine for Prevention of Childhood Myopia Progression in Clinical Practice.

Shih KC, Chan TC, Ng AL, Lai JS, Li WW, Cheng AC, Fan DS.

Eye Contact Lens. 2016 Jan;42(1):16-23. doi: 10.1097/ICL.0000000000000189. Review.


A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma.

Bendell JC, Kelley RK, Shih KC, Grabowsky JA, Bergsland E, Jones S, Martin T, Infante JR, Mischel PS, Matsutani T, Xu S, Wong L, Liu Y, Wu X, Mortensen DS, Chopra R, Hege K, Munster PN.

Cancer. 2015 Oct 1;121(19):3481-90. doi: 10.1002/cncr.29422. Epub 2015 Jul 15.


Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.

Chen CC, Lee TY, Kwok CF, Hsu YP, Shih KC, Lin YJ, Ho LT.

Biochem Biophys Res Commun. 2015 May 15;460(4):1063-8. doi: 10.1016/j.bbrc.2015.03.155. Epub 2015 Apr 3.


Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome.

Lin YJ, Juan CC, Kwok CF, Hsu YP, Shih KC, Chen CC, Ho LT.

Biochem Biophys Res Commun. 2015 May 8;460(3):497-503. doi: 10.1016/j.bbrc.2015.03.017. Epub 2015 Mar 28.


A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors.

Bendell JC, Kurkjian C, Infante JR, Bauer TM, Burris HA 3rd, Greco FA, Shih KC, Thompson DS, Lane CM, Finney LH, Jones SF.

Invest New Drugs. 2015 Apr;33(2):463-71. doi: 10.1007/s10637-015-0218-6. Epub 2015 Feb 25.


The role of electrical stimulation therapy in ophthalmic diseases.

Fu L, Lo AC, Lai JS, Shih KC.

Graefes Arch Clin Exp Ophthalmol. 2015 Feb;253(2):171-6. doi: 10.1007/s00417-014-2889-7. Epub 2014 Dec 14. Review.


The effect of exercise on lipid profiles and inflammatory markers in lean male adolescents: a prospective interventional study.

Huang CJ, Kwok CF, Chou CH, Chou YC, Ho LT, Shih KC.

J Investig Med. 2015 Jan;63(1):29-34. doi: 10.1097/JIM.0000000000000120.


The combination of the ankle brachial index and brachial ankle pulse wave velocity exhibits a superior association with outcomes in diabetic patients.

Chang LH, Lin HD, Kwok CF, Won JG, Chen HS, Chu CH, Hwu CM, Kuo CS, Jap TS, Shih KC, Lin LY.

Intern Med. 2014;53(21):2425-31. Epub 2014 Nov 1.


Development of 3D-QSAR combination approach for discovering and analysing neuraminidase inhibitors in silico.

Lin CY, Chi HC, Shih KC, Zhou J, Hsiao NW, Tang CY.

Int J Data Min Bioinform. 2014;9(3):305-20.


Fine structures of self-assembled beta-cyclodextrin/Pluronic in dilute and dense systems: a small angle X-ray scattering study.

Shih KC, Li CY, Li WH, Lai HM.

Soft Matter. 2014 Oct 14;10(38):7606-14. doi: 10.1039/c4sm01147c. Epub 2014 Aug 14.


Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes.

Iwai K, Shih KC, Lin X, Brubaker TA, Sochol RD, Lin L.

Lab Chip. 2014 Oct 7;14(19):3790-9. doi: 10.1039/c4lc00500g.


Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor.

Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC, Ho LT.

Biochem Biophys Res Commun. 2014 Aug 22;451(2):263-9. doi: 10.1016/j.bbrc.2014.07.119. Epub 2014 Aug 1.


Successful treatment with dabrafenib (GSK2118436) in a patient with ganglioglioma.

Shih KC, Shastry M, Williams JT, Jelsma PF, Abram SR, Ayyanar K, Burris HA 3rd, Infante JR.

J Clin Oncol. 2014 Oct 10;32(29):e98-e100. doi: 10.1200/JCO.2013.48.6852. Epub 2014 Feb 10. No abstract available.


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