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Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena.

Shih JW, Kung HJ.

J Biomed Sci. 2017 Aug 8;24(1):53. doi: 10.1186/s12929-017-0358-4. Review.


Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.

Shih JW, Chiang WF, Wu ATH, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ.

Nat Commun. 2017 Jun 22;8:15874. doi: 10.1038/ncomms15874.


Effects of accelerating voltage and specimen thickness on the spatial resolution of transmission electron backscatter diffraction in Cu.

Shih JW, Kuo KW, Kuo JC, Kuo TY.

Ultramicroscopy. 2017 Jun;177:43-52. doi: 10.1016/j.ultramic.2017.01.020. Epub 2017 Mar 1.


An HBV-tolerant immunocompetent model that effectively simulates chronic hepatitis B virus infection in mice.

Yuan L, Wang T, Zhang Y, Liu X, Zhang T, Li X, Liu P, Wu K, Shih JW, Yuan Q, Cheng T, Xia N.

Exp Anim. 2016 Nov 1;65(4):373-382. Epub 2016 Jun 6.


Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism.

Shih JW, Wang LY, Hung CL, Kung HJ, Hsieh CL.

Int J Mol Sci. 2015 Dec 4;16(12):28943-78. doi: 10.3390/ijms161226138. Review.


Detection and analysis of tupaia hepatocytes via mAbs against tupaia serum albumin.

Liu X, Yuan L, Yuan Q, Zhang Y, Wu K, Zhang T, Wu Y, Hou W, Wang T, Liu P, Shih JW, Cheng T, Xia N.

Exp Anim. 2016 May 20;65(2):117-23. doi: 10.1538/expanim.15-0086. Epub 2015 Nov 20.


Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen.

Zhang TY, Yuan Q, Zhao JH, Zhang YL, Yuan LZ, Lan Y, Lo YC, Sun CP, Wu CR, Zhang JF, Zhang Y, Cao JL, Guo XR, Liu X, Mo XB, Luo WX, Cheng T, Chen YX, Tao MH, Shih JW, Zhao QJ, Zhang J, Chen PJ, Yuan YA, Xia NS.

Gut. 2016 Apr;65(4):658-71. doi: 10.1136/gutjnl-2014-308964. Epub 2015 Sep 30.


Hepatitis E.

Petrik J, Lozano M, Seed CR, Faddy HM, Keller AJ, Prado Scuracchio PS, Wendel S, Andonov A, Fearon M, Delage G, Zhang J, Shih JW, Gallian P, Djoudi R, Tiberghien P, Izopet J, Dreier J, Vollmer T, Knabbe C, Aggarwal R, Goel A, Ciccaglione AR, Matsubayashi K, Satake M, Tadokoro K, Jeong SH, Zaaijer HL, Zhiburt E, Chay J, Teo D, Chua SS, Piron M, Sauleda S, Echevarría JM, Dalton H, Stramer SL.

Vox Sang. 2016 Jan;110(1):93-130. doi: 10.1111/vox.12285. Epub 2015 Jul 21. No abstract available.


Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease.

Yuan Q, Song LW, Cavallone D, Moriconi F, Cherubini B, Colombatto P, Oliveri F, Coco BA, Ricco G, Bonino F, Shih JW, Xia NS, Brunetto MR.

PLoS One. 2015 Jun 26;10(6):e0130209. doi: 10.1371/journal.pone.0130209. eCollection 2015.


Long-term efficacy of a hepatitis E vaccine.

Zhang J, Shih JW, Xia NS.

N Engl J Med. 2015 Jun 4;372(23):2265-6. doi: 10.1056/NEJMc1504302. No abstract available.


Construction and characterization of an infectious cDNA clone of Echovirus 25.

Hou W, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T, Xia N.

Virus Res. 2015 Jul 2;205:41-4. doi: 10.1016/j.virusres.2015.05.011. Epub 2015 May 22.


Long-term efficacy of a hepatitis E vaccine.

Zhang J, Zhang XF, Huang SJ, Wu T, Hu YM, Wang ZZ, Wang H, Jiang HM, Wang YJ, Yan Q, Guo M, Liu XH, Li JX, Yang CL, Tang Q, Jiang RJ, Pan HR, Li YM, Shih JW, Ng MH, Zhu FC, Xia NS.

N Engl J Med. 2015 Mar 5;372(10):914-22. doi: 10.1056/NEJMoa1406011. Erratum in: N Engl J Med. 2015 Apr 9;372(15):1478.


Hepatitis e vaccine to prevent morbidity and mortality during epidemics.

Nelson KE, Shih JW, Zhang J, Zhao Q, Xia N, Ticehurst JR, Labrique AB.

Open Forum Infect Dis. 2014 Nov 4;1(3):ofu098. doi: 10.1093/ofid/ofu098. eCollection 2014 Dec.


In vivo time-related evaluation of a therapeutic neutralization monoclonal antibody against lethal enterovirus 71 infection in a mouse model.

Li Z, Xu L, He D, Yang L, Liu C, Chen Y, Shih JW, Zhang J, Zhao Q, Cheng T, Xia N.

PLoS One. 2014 Oct 3;9(10):e109391. doi: 10.1371/journal.pone.0109391. eCollection 2014.


Human DExD/H RNA helicases: emerging roles in stress survival regulation.

Shih JW, Lee YH.

Clin Chim Acta. 2014 Sep 25;436:45-58. doi: 10.1016/j.cca.2014.05.003. Epub 2014 May 13.


Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop.

Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T, Xia N.

Theranostics. 2014 Feb 18;4(5):498-513. doi: 10.7150/thno.7457. eCollection 2014.


Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity.

Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Yao X, Liang ZL, Wu T, Li JX, Yan Q, Yang CL, Jiang HM, Huang HJ, Xian YL, Shih JW, Ng MH, Li YM, Wang JZ, Zhu FC, Xia NS.

Clin Microbiol Infect. 2014 Jun;20(6):O397-405. doi: 10.1111/1469-0691.12419. Epub 2013 Nov 18.


An assessment of hepatitis E virus (HEV) in US blood donors and recipients: no detectable HEV RNA in 1939 donors tested and no evidence for HEV transmission to 362 prospectively followed recipients.

Xu C, Wang RY, Schechterly CA, Ge S, Shih JW, Xia NS, Luban NL, Alter HJ.

Transfusion. 2013 Oct;53(10 Pt 2):2505-11. doi: 10.1111/trf.12326. Epub 2013 Jul 7.


Development of the hepatitis E vaccine: from bench to field.

Zhang J, Shih JW, Wu T, Li SW, Xia NS.

Semin Liver Dis. 2013 Feb;33(1):79-88. doi: 10.1055/s-0033-1338116. Epub 2013 Apr 5. Review.


The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells.

Zhang L, Alter HJ, Wang H, Jia S, Wang E, Marincola FM, Shih JW, Wang RY.

Virology. 2013 Mar 30;438(1):28-36. doi: 10.1016/j.virol.2013.01.015. Epub 2013 Feb 9. Erratum in: Virology. 2013 Dec;447(1-2):339.


Development of a novel baculovirus titration method using the Enzyme-linked immunosorbent spot (ELISPOT) assay.

Wang W, Cheng T, Ma K, Xia D, Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N.

J Virol Methods. 2013 Mar;188(1-2):114-20. doi: 10.1016/j.jviromet.2012.12.011. Epub 2012 Dec 26.


Antigenic determinants of hepatitis E virus and vaccine-induced immunogenicity and efficacy.

Zhao Q, Zhang J, Wu T, Li SW, Ng MH, Xia NS, Shih JW.

J Gastroenterol. 2013 Feb;48(2):159-68. doi: 10.1007/s00535-012-0701-1. Epub 2012 Nov 13. Review.


Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.

Chen Y, Li C, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen PJ, Zhang J, Xia N.

Vaccine. 2013 Jan 2;31(2):425-30. doi: 10.1016/j.vaccine.2012.10.032. Epub 2012 Oct 23.


The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method.

Gu Y, Hou W, Xu C, Li S, Shih JW, Xia N.

J Virol Methods. 2012 Jun;182(1-2):9-17. doi: 10.1016/j.jviromet.2012.02.007. Epub 2012 Mar 1.


Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.

Shih JW, Wang WT, Tsai TY, Kuo CY, Li HK, Wu Lee YH.

Biochem J. 2012 Jan 1;441(1):119-29. doi: 10.1042/BJ20110739.


Profile of acute infectious markers in sporadic hepatitis E.

Huang S, Zhang X, Jiang H, Yan Q, Ai X, Wang Y, Cai J, Jiang L, Wu T, Wang Z, Guan L, Shih JW, Ng MH, Zhu F, Zhang J, Xia N.

PLoS One. 2010 Oct 21;5(10):e13560. doi: 10.1371/journal.pone.0013560.


Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial.

Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang Q, Yao X, Yan Q, Xian YL, Wu T, Li YM, Miao J, Ng MH, Shih JW, Xia NS.

Lancet. 2010 Sep 11;376(9744):895-902. doi: 10.1016/S0140-6736(10)61030-6. Epub 2010 Aug 20.


RNA Interference inhibits hepatitis B virus of different genotypes in vitro and in vivo.

Zhang YL, Cheng T, Cai YJ, Yuan Q, Liu C, Zhang T, Xia DZ, Li RY, Yang LW, Wang YB, Yeo AE, Shih JW, Zhang J, Xia NS.

BMC Microbiol. 2010 Aug 10;10:214. doi: 10.1186/1471-2180-10-214.


A novel immunoassay for PreS1 and/or core-related antigens for detection of HBsAg variants.

Yuan Q, Ge S, Xiong J, Yan Q, Li Z, Hao X, Tian D, Niu J, Su Z, Chen C, Shih JW, Zhang J, Xia N.

J Virol Methods. 2010 Sep;168(1-2):108-13. doi: 10.1016/j.jviromet.2010.04.029. Epub 2010 May 6.


Humanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1.

Chen Y, Luo W, Wu WL, Fang Z, Xia L, Gui X, Chen Y, Chen H, Shih JW, Xia N.

Antiviral Res. 2010 Jul;87(1):81-4. doi: 10.1016/j.antiviral.2010.04.012. Epub 2010 May 5.


Induction of cross-reactive antibodies against mimotopes of H5N1 hemagglutinin.

Song H, Luo W, Chen Y, Du H, Tang J, Yin B, Chen Y, Shih JW, Zhang J.

Vet Microbiol. 2010 Sep 28;145(1-2):17-22. doi: 10.1016/j.vetmic.2010.02.032. Epub 2010 Mar 3.


Prevalence of hepatitis E virus in Chinese blood donors.

Guo QS, Yan Q, Xiong JH, Ge SX, Shih JW, Ng MH, Zhang J, Xia NS.

J Clin Microbiol. 2010 Jan;48(1):317-8. doi: 10.1128/JCM.01466-09. Epub 2009 Nov 25.


Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.

Yuan Q, Ou SH, Chen CR, Ge SX, Pei B, Chen QR, Yan Q, Lin YC, Ni HY, Huang CH, Yeo AE, Shih JW, Zhang J, Xia NS.

J Clin Microbiol. 2010 Feb;48(2):357-62. doi: 10.1128/JCM.01781-09. Epub 2009 Nov 25.


Antibody reactivity of conformational peptide mimics of a conserved H5N1 neutralization site in different fusion proteins.

Zheng Z, Luo W, Song H, Chen Y, Xiong J, Chen Y, Gu Y, Chen H, Shih JW, Zhang J, Xia N.

Arch Virol. 2010;155(1):19-26. doi: 10.1007/s00705-009-0542-2. Epub 2009 Nov 13.


Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.

Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N.

PLoS Pathog. 2009 Aug;5(8):e1000537. doi: 10.1371/journal.ppat.1000537. Epub 2009 Aug 7.


Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine.

Zhang J, Liu CB, Li RC, Li YM, Zheng YJ, Li YP, Luo D, Pan BB, Nong Y, Ge SX, Xiong JH, Shih JW, Ng MH, Xia NS.

Vaccine. 2009 Mar 13;27(12):1869-74. doi: 10.1016/j.vaccine.2008.12.061. Epub 2009 Jan 23.


Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.

Chen Y, Qin K, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JW, Peiris JS, Guan Y, Chen H, Xia N.

J Infect Dis. 2009 Jan 1;199(1):49-58. doi: 10.1086/594374.


Specific cellular immune response in hepatitis E patients.

Wu T, Zhang J, Su ZJ, Liu JJ, Wu XL, Wu XL, Lin CX, Ou SH, Yan Q, Shih JW, Xia NS.

Intervirology. 2008;51(5):322-7. doi: 10.1159/000172627. Epub 2008 Nov 19.


Induction of multispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and Montanide ISA 720 as adjuvants.

Qiu Q, Wang RY, Jiao X, Jin B, Sugauchi F, Grandinetti T, Alter HJ, Shih JW.

Vaccine. 2008 Oct 9;26(43):5527-5534. doi: 10.1016/j.vaccine.2008.07.034. Epub 2008 Sep 2.


Establishing cell-based reporter systems for the analysis of hTERT expression.

Huang YY, Shih JW, Lin JJ.

Methods Mol Biol. 2007;405:87-96. doi: 10.1007/978-1-60327-070-0_8.


Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.

Shih JW, Tsai TY, Chao CH, Wu Lee YH.

Oncogene. 2008 Jan 24;27(5):700-14. Epub 2007 Jul 30.


Construction and characterization of the chimeric antibody 8C11 to the hepatitis E virus.

Luo W, Chen Y, Li L, Xu C, Miao J, Shih JW, Zhang J, Xia N.

FEMS Immunol Med Microbiol. 2007 Oct;51(1):18-25. Epub 2007 Jul 20.


Induction of potent cellular immune response in mice by hepatitis C virus NS3 protein with double-stranded RNA.

Jin B, Wang RY, Qiu Q, Sugauchi F, Grandinetti T, Alter HJ, Shih JW.

Immunology. 2007 Sep;122(1):15-27. Epub 2007 Apr 23.


Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees.

Zhang P, Yu MY, Venable R, Alter HJ, Shih JW.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9214-9. Epub 2006 Jun 6.


Quantitative analysis of anti-hepatitis C virus antibody-secreting B cells in patients with chronic hepatitis C.

Umemura T, Wang RY, Schechterly C, Shih JW, Kiyosawa K, Alter HJ.

Hepatology. 2006 Jan;43(1):91-9.


The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells.

Lin SC, Li WC, Shih JW, Hong KF, Pan YR, Lin JJ.

Cancer Lett. 2006 May 8;236(1):80-8. Epub 2005 Jun 21.


Reversibility of experimental rabbit liver cirrhosis by portal collagenase administration.

Jin B, Alter HJ, Zhang ZC, Shih JW, Esteban JM, Sun T, Yang YS, Qiu Q, Liu XL, Yao L, Wang HD, Cheng LF.

Lab Invest. 2005 Aug;85(8):992-1002.


Mycoplasma penetrans infections and seroconversion in patients with AIDS: identification of major mycoplasmal antigens targeted by host antibody response.

Lo SC, Wang RY, Grandinetti T, Zou N, Hayes MM, Shih JW, Wear DJ.

FEMS Immunol Med Microbiol. 2005 Jun 1;44(3):277-82.

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