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Items: 1 to 50 of 73

1.

Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.

Yang M, Jia W, Wang D, Han F, Niu W, Zhang H, Shih DQ, Zhang X.

Dig Dis Sci. 2019 Jul;64(7):1844-1856. doi: 10.1007/s10620-019-05580-z. Epub 2019 Apr 4.

PMID:
30949903
2.

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS.

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.

3.

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.

Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS.

Immunity. 2018 Dec 18;49(6):1077-1089.e5. doi: 10.1016/j.immuni.2018.10.014. Epub 2018 Dec 11.

PMID:
30552020
4.

Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice.

Niu GC, Liu L, Zheng L, Zhang H, Shih DQ, Zhang X.

BMC Gastroenterol. 2018 Aug 13;18(1):127. doi: 10.1186/s12876-018-0850-7.

5.

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome.

Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ.

Mucosal Immunol. 2018 Sep;11(5):1466-1476. doi: 10.1038/s41385-018-0055-y. Epub 2018 Jul 9.

6.

Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis.

Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I.

Cell Mol Gastroenterol Hepatol. 2018 Feb 8;6(1):1-16. doi: 10.1016/j.jcmgh.2018.02.001. eCollection 2018.

7.

Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Primer for Internists.

Syal G, Kashani A, Shih DQ.

Am J Med. 2018 Sep;131(9):1017-1024. doi: 10.1016/j.amjmed.2018.03.010. Epub 2018 Mar 29. Review.

PMID:
29605414
8.

TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice.

Li H, Song J, Niu G, Zhang H, Guo J, Shih DQ, Targan SR, Zhang X.

Pathol Res Pract. 2018 Feb;214(2):217-227. doi: 10.1016/j.prp.2017.11.017. Epub 2017 Nov 26.

PMID:
29254800
9.

Serological, genetic and clinical associations with increased health-care resource utilization in inflammatory bowel disease.

Gu P, Kapur A, Li D, Haritunians T, Vasiliauskas E, Shih DQ, Targan SR, Spiegel BM, Mcgovern DP, Black JT, Melmed GY.

J Dig Dis. 2018 Jan;19(1):15-23. doi: 10.1111/1751-2980.12566.

10.

CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway.

Xu C, Ghali S, Wang J, Shih DQ, Ortiz C, Mussatto CC, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Fleshner P, Robbins L, Vu M, Hing TC, McGovern DPB, Koon HW.

Sci Rep. 2017 Nov 27;7(1):16351. doi: 10.1038/s41598-017-16753-z.

11.

The protection role of Atg16l1 in CD11c+dendritic cells in murine colitis.

Zhang H, Zheng L, Chen J, Fukata M, Ichikawa R, Shih DQ, Zhang X.

Immunobiology. 2017 Jul;222(7):831-841. doi: 10.1016/j.imbio.2017.03.002. Epub 2017 Mar 16.

12.

Insights on the use of biosimilars in the treatment of inflammatory bowel disease.

Zheng MK, Shih DQ, Chen GC.

World J Gastroenterol. 2017 Mar 21;23(11):1932-1943. doi: 10.3748/wjg.v23.i11.1932. Review.

13.

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ.

J Immunol. 2017 Mar 1;198(5):2133-2146. doi: 10.4049/jimmunol.1601293. Epub 2017 Jan 27.

14.

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.

15.

TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF) Regulates CXCR5+ T helper Cells in the Intestine.

Kanagavelu S, Flores C, Hagiwara S, Ruiz J, Hyun J, Cho EE, Sun F, Romero L, Shih DQ, Fukata M.

J Clin Cell Immunol. 2016 Oct;7(5). pii: 458. Epub 2016 Sep 30.

16.

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.

Jacob N, Targan SR, Shih DQ.

United European Gastroenterol J. 2016 Aug;4(4):531-40. doi: 10.1177/2050640616649356. Epub 2016 May 10. Review.

17.

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

Hoang-Yen Tran D, Hoang-Ngoc Tran D, Mattai SA, Sallam T, Ortiz C, Lee EC, Robbins L, Ho S, Lee JE, Fisseha E, Shieh C, Sideri A, Shih DQ, Fleshner P, McGovern DP, Vu M, Hing TC, Bakirtzi K, Cheng M, Su B, Law I, Karagiannides I, Targan SR, Gallo RL, Li Z, Koon HW.

Int J Obes (Lond). 2016 Sep;40(9):1424-34. doi: 10.1038/ijo.2016.90. Epub 2016 May 10.

18.

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.

Kaur M, Panikkath D, Yan X, Liu Z, Berel D, Li D, Vasiliauskas EA, Ippoliti A, Dubinsky M, Shih DQ, Melmed GY, Haritunians T, Fleshner P, Targan SR, McGovern DP.

Inflamm Bowel Dis. 2016 Apr;22(4):862-9. doi: 10.1097/MIB.0000000000000705.

19.

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.

Sidhu-Varma M, Shih DQ, Targan SR.

Inflamm Bowel Dis. 2016 Mar;22(3):548-59. doi: 10.1097/MIB.0000000000000653.

20.

Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine.

Ruiz J, Kanagavelu S, Flores C, Romero L, Riveron R, Shih DQ, Fukata M.

Front Cell Infect Microbiol. 2016 Jan 12;5:105. doi: 10.3389/fcimb.2015.00105. eCollection 2015.

21.

Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients.

Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C.

Cell Mol Gastroenterol Hepatol. 2015 Jul 1;1(4):420-432.

22.

Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits.

Taleban S, Li D, Targan SR, Ippoliti A, Brant SR, Cho JH, Duerr RH, Rioux JD, Silverberg MS, Vasiliauskas EA, Rotter JI, Haritunians T, Shih DQ, Dubinsky M, Melmed GY, McGovern DP.

J Crohns Colitis. 2016 Jan;10(1):43-9. doi: 10.1093/ecco-jcc/jjv178. Epub 2015 Oct 8.

23.

Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease.

Dezfoli S, Horton HA, Thepyasuwan N, Berel D, Targan SR, Vasiliauskas EA, Dubinsky M, Shih DQ, Kaur M, McGovern DP, Ippoliti A, Feldman EJ, Melmed GY.

Inflamm Bowel Dis. 2015 Aug;21(8):1754-60. doi: 10.1097/MIB.0000000000000448.

PMID:
25985242
24.

1,25-dihydroxyvitamin D3 regulates the development of chronic colitis by modulating both T helper (Th)1 and Th17 activation.

Zhang H, Wu H, Liu L, Li H, Shih DQ, Zhang X.

APMIS. 2015 Jun;123(6):490-501. doi: 10.1111/apm.12378. Epub 2015 Apr 23.

PMID:
25907285
25.

Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis.

Yoo JH, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C, Koon HW.

Cell Mol Gastroenterol Hepatol. 2015 Jan;1(1):55-74.e1.

26.

Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.

Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G591-604. doi: 10.1152/ajpgi.00269.2014. Epub 2015 Jan 15.

27.

Molecular patterns in human ulcerative colitis and correlation with response to infliximab.

Halloran B, Chang J, Shih DQ, McGovern D, Famulski K, Evaschesen C, Fedorak RN, Thiesen A, Targan S, Halloran PF.

Inflamm Bowel Dis. 2014 Dec;20(12):2353-63. doi: 10.1097/MIB.0000000000000239.

28.

Update 2014: advances to optimize 6-mercaptopurine and azathioprine to reduce toxicity and improve efficacy in the management of IBD.

Amin J, Huang B, Yoon J, Shih DQ.

Inflamm Bowel Dis. 2015 Feb;21(2):445-52. doi: 10.1097/MIB.0000000000000197. Review.

PMID:
25248004
29.

Use of animal models in elucidating disease pathogenesis in IBD.

Khanna PV, Shih DQ, Haritunians T, McGovern DP, Targan S.

Semin Immunopathol. 2014 Sep;36(5):541-51. doi: 10.1007/s00281-014-0444-6. Epub 2014 Sep 12. Review.

30.

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.

Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR.

Mucosal Immunol. 2014 Nov;7(6):1492-503. doi: 10.1038/mi.2014.37. Epub 2014 May 21.

31.

Immunopathology of inflammatory bowel disease.

Wallace KL, Zheng LB, Kanazawa Y, Shih DQ.

World J Gastroenterol. 2014 Jan 7;20(1):6-21. doi: 10.3748/wjg.v20.i1.6. Review.

32.

Mechanisms underlying effects of 1,25-Dihydroxyvitamin D3 on the Th17 cells.

Zhang H, Shih DQ, Zhang X.

Eur J Microbiol Immunol (Bp). 2013 Dec;3(4):237-40. doi: 10.1556/EuJMI.3.2013.4.1. Epub 2013 Nov 21. Review.

33.

Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2).

Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ.

Eur J Microbiol Immunol (Bp). 2013 Jun;3(2):141. doi: 10.1556/EuJMI.3.2013.2.8. Epub 2013 Jun 5. No abstract available.

34.

SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS.

Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ.

Eur J Microbiol Immunol (Bp). 2013 Mar;3(1):11-20. Erratum in: Eur J Microbiol Immunol (Bp). 2013 Jun;3(2):141.

35.

Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes.

Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C.

Antimicrob Agents Chemother. 2013 Jul;57(7):3214-23. doi: 10.1128/AAC.02633-12. Epub 2013 Apr 29.

36.

Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale.

Surti B, Spiegel B, Ippoliti A, Vasiliauskas EA, Simpson P, Shih DQ, Targan SR, McGovern DP, Melmed GY.

Dig Dis Sci. 2013 May;58(5):1313-21. doi: 10.1007/s10620-012-2500-1. Epub 2012 Dec 19.

37.

Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal.

Zheng L, Chen X, Guo J, Sun H, Liu L, Shih DQ, Zhang X.

Int J Mol Med. 2012 Dec;30(6):1424-30. doi: 10.3892/ijmm.2012.1151. Epub 2012 Oct 5.

PMID:
23041795
38.

Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism.

Shih DQ, Nguyen M, Zheng L, Ibanez P, Mei L, Kwan LY, Bradford K, Ting C, Targan SR, Vasiliauskas EA.

Aliment Pharmacol Ther. 2012 Sep;36(5):449-58. doi: 10.1111/j.1365-2036.2012.05206.x. Epub 2012 Jul 11.

39.

The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice.

Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW.

Gut. 2013 Sep;62(9):1295-305. doi: 10.1136/gutjnl-2012-302180. Epub 2012 Jul 3.

40.

Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice.

Zhao H, Zhang H, Wu H, Li H, Liu L, Guo J, Li C, Shih DQ, Zhang X.

BMC Gastroenterol. 2012 May 30;12:57.

41.

Facial ulceration in a patient with Crohn's disease.

Huang B, Melmed GY, Shih DQ.

Gastroenterology. 2012 May;142(5):1071, 1258. doi: 10.1053/j.gastro.2011.09.032. Epub 2012 Mar 19. No abstract available.

PMID:
22440954
42.

CD161 DEFINES EFFECTOR T CELLS THAT EXPRESS LIGHT AND RESPOND TO TL1A-DR3 SIGNALING.

Cohavy O, Shih DQ, Doherty TM, Ware CF, Targan SR.

Eur J Microbiol Immunol (Bp). 2011 Mar;1(1):70-79.

43.

Skin manifestations of inflammatory bowel disease.

Huang BL, Chandra S, Shih DQ.

Front Physiol. 2012 Feb 6;3:13. doi: 10.3389/fphys.2012.00013. eCollection 2012.

44.

Inflammatory Bowel Disease Associated Colorectal Neoplasia.

Vu M, Chang JY, Chen J, Shih DQ.

J Gastrointest Dig Syst. 2012 Jan 23;Suppl 8:002.

45.

Current concepts on the immunopathogenesis of inflammatory bowel disease.

Vora P, Shih DQ, McGovern DP, Targan SR.

Front Biosci (Elite Ed). 2012 Jan 1;4:1451-77. Review.

PMID:
22201968
46.

Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ.

Am J Pathol. 2012 Feb;180(2):636-49. doi: 10.1016/j.ajpath.2011.10.026. Epub 2011 Dec 2.

47.

Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease.

Bradford K, Shih DQ.

World J Gastroenterol. 2011 Oct 7;17(37):4166-73. doi: 10.3748/wjg.v17.i37.4166. Review.

48.

Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells.

Koon HW, Shih DQ, Hing TC, Chen J, Ho S, Zhao D, Targan SR, Pothoulakis C.

Am J Pathol. 2011 Nov;179(5):2315-26. doi: 10.1016/j.ajpath.2011.07.038. Epub 2011 Sep 23.

49.

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice.

Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C.

Gastroenterology. 2011 Nov;141(5):1852-63.e1-3. doi: 10.1053/j.gastro.2011.06.079. Epub 2011 Jul 14.

50.

Cytomegalovirus Reactivation in Ulcerative Colitis Patients.

Nguyen M, Bradford K, Zhang X, Shih DQ.

Ulcers. 2011 Jan 1;2011. pii: 282507.

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