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Items: 47


Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2).

Cocco E, Javier Carmona F, Razavi P, Won HH, Cai Y, Rossi V, Chan C, Cownie J, Soong J, Toska E, Shifman SG, Sarotto I, Savas P, Wick MJ, Papadopoulos KP, Moriarty A, Cutler RE Jr, Avogadri-Connors F, Lalani AS, Bryce RP, Chandarlapaty S, Hyman DM, Solit DB, Boni V, Loi S, Baselga J, Berger MF, Montemurro F, Scaltriti M.

Sci Signal. 2018 Oct 9;11(551). pii: eaat9773. doi: 10.1126/scisignal.aat9773.


ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.

Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N.

Genome Biol. 2018 Feb 15;19(1):36. doi: 10.1186/s13059-018-1403-7.


Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain.

Barbash S, Simchovitz A, Buchman AS, Bennett DA, Shifman S, Soreq H.

Transl Psychiatry. 2017 Aug 8;7(8):e1199. doi: 10.1038/tp.2017.163.


Widespread Allelic Heterogeneity in Complex Traits.

Hormozdiari F, Zhu A, Kichaev G, Ju CJ, Segrè AV, Joo JWJ, Won H, Sankararaman S, Pasaniuc B, Shifman S, Eskin E.

Am J Hum Genet. 2017 May 4;100(5):789-802. doi: 10.1016/j.ajhg.2017.04.005.


Varying Intolerance of Gene Pathways to Mutational Classes Explain Genetic Convergence across Neuropsychiatric Disorders.

Shohat S, Ben-David E, Shifman S.

Cell Rep. 2017 Feb 28;18(9):2217-2227. doi: 10.1016/j.celrep.2017.02.007.


Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data.

Kang EY, Martin LJ, Mangul S, Isvilanonda W, Zou J, Ben-David E, Han B, Lusis AJ, Shifman S, Eskin E.

Genetics. 2016 Nov;204(3):1057-1064. doi: 10.1534/genetics.115.177246. Epub 2016 Oct 7.


Transcriptional dynamics in colorectal carcinogenesis: new insights into the role of c-Myc and miR17 in benign to cancer transformation.

Ben-David E, Bester AC, Shifman S, Kerem B.

Cancer Res. 2014 Oct 1;74(19):5532-40. doi: 10.1158/0008-5472.CAN-14-0932. Epub 2014 Aug 14.


Bias towards large genes in autism.

Shohat S, Shifman S.

Nature. 2014 Aug 7;512(7512):E1-2. doi: 10.1038/nature13583. No abstract available.


Chromatin regulators, phenotypic robustness, and autism risk.

Suliman R, Ben-David E, Shifman S.

Front Genet. 2014 Apr 10;5:81. doi: 10.3389/fgene.2014.00081. eCollection 2014.


Competing targets of microRNA-608 affect anxiety and hypertension.

Hanin G, Shenhar-Tsarfaty S, Yayon N, Yau YH, Bennett ER, Sklan EH, Rao DC, Rankinen T, Bouchard C, Geifman-Shochat S, Shifman S, Greenberg DS, Soreq H.

Hum Mol Genet. 2014 Sep 1;23(17):4569-80. doi: 10.1093/hmg/ddu170. Epub 2014 Apr 9. Erratum in: Hum Mol Genet. 2014 Dec 15;23(24):6694. Hoe, Yau Yin [corrected to Yau, Yin Hoe].


Allelic expression analysis in the brain suggests a role for heterogeneous insults affecting epigenetic processes in autism spectrum disorders.

Ben-David E, Shohat S, Shifman S.

Hum Mol Genet. 2014 Aug 1;23(15):4111-24. doi: 10.1093/hmg/ddu128. Epub 2014 Mar 21.


Global coevolution of human microRNAs and their target genes.

Barbash S, Shifman S, Soreq H.

Mol Biol Evol. 2014 May;31(5):1237-47. doi: 10.1093/molbev/msu090. Epub 2014 Mar 4.


A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

Pandey V, Turm H, Bekenstein U, Shifman S, Kadener S.

Front Cell Neurosci. 2013 Sep 9;7:146. doi: 10.3389/fncel.2013.00146. eCollection 2013. Erratum in: Front Cell Neurosci. 2013;7:187. Varun, Pandey [corrected to Pandey, Varun]; Hagit, Turm [corrected to Turm, Hagit]; Uriya, Bekenstein [corrected to Bekenstein, Uriya]; Sagiv, Shifman [corrected to Shifman, Sagiv]; Sebastian, Kadener [corrected to Kadener, Sebastian].


Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism.

Ben-David E, Shifman S.

Mol Psychiatry. 2013 Oct;18(10):1054-6. doi: 10.1038/mp.2012.148. Epub 2012 Nov 13. No abstract available.


Fine-scale maps of recombination rates and hotspots in the mouse genome.

Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, Shifman S.

Genetics. 2012 Jul;191(3):757-64. doi: 10.1534/genetics.112.141036. Epub 2012 May 4.


Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice.

Huang GJ, Ben-David E, Tort Piella A, Edwards A, Flint J, Shifman S.

PLoS One. 2012;7(4):e35901. doi: 10.1371/journal.pone.0035901. Epub 2012 Apr 25.


Networks of neuronal genes affected by common and rare variants in autism spectrum disorders.

Ben-David E, Shifman S.

PLoS Genet. 2012;8(3):e1002556. doi: 10.1371/journal.pgen.1002556. Epub 2012 Mar 8.


Identification of a functional rare variant in autism using genome-wide screen for monoallelic expression.

Ben-David E, Granot-Hershkovitz E, Monderer-Rothkoff G, Lerer E, Levi S, Yaari M, Ebstein RP, Yirmiya N, Shifman S.

Hum Mol Genet. 2011 Sep 15;20(18):3632-41. doi: 10.1093/hmg/ddr283. Epub 2011 Jun 16.


The genetic variation of RELN expression in schizophrenia and bipolar disorder.

Ovadia G, Shifman S.

PLoS One. 2011;6(5):e19955. doi: 10.1371/journal.pone.0019955. Epub 2011 May 16.


Further investigation of the association between rs7341475 and rs17746501 and schizophrenia.

Ben-David E, Shifman S; International Schizophrenia Consortium.

Am J Med Genet B Neuropsychiatr Genet. 2010 Sep;153B(6):1244-7. doi: 10.1002/ajmg.b.31093.


Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening.

Narwani K, Biancotti JC, Golan-Lev T, Buehler N, Hill D, Shifman S, Benvenisty N, Lavon N.

In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):309-16. doi: 10.1007/s11626-010-9303-5. Epub 2010 Mar 12.


High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.

Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J.

Genome Res. 2009 Jun;19(6):1133-40. doi: 10.1101/gr.088120.108. Epub 2009 Apr 17.


Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.

O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Giegling I, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Adolfsson R, Osby U, Terenius L, Jönsson EG, Cichon S, Nöthen MM, Gill M, Corvin AP, Rujescu D, Gejman PV, Kirov G, Craddock N, Williams NM, Owen MJ; Molecular Genetics of Schizophrenia Collaboration.

Mol Psychiatry. 2009 Jan;14(1):30-6. doi: 10.1038/mp.2008.108. Epub 2008 Sep 23.


Identification of loci associated with schizophrenia by genome-wide association and follow-up.

O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR; Molecular Genetics of Schizophrenia Collaboration.

Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201.


Animal models of psychiatric disease.

Flint J, Shifman S.

Curr Opin Genet Dev. 2008 Jun;18(3):235-40. doi: 10.1016/j.gde.2008.07.002. Epub 2008 Aug 11. Review.


Genetic variants in major depression.

Flint J, Shifman S, Munafo M, Mott R.

Novartis Found Symp. 2008;289:23-32; discussion 33-42, 87-93. Review.


Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.

Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, Kendler KS, Li T, O'Donovan M, O'Neill FA, Owen MJ, Walsh D, Weinberger DR, Sun C, Flint J, Darvasi A.

PLoS Genet. 2008 Feb;4(2):e28. doi: 10.1371/journal.pgen.0040028.


Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.

Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J.

Biol Psychiatry. 2008 May 1;63(9):874-83. Epub 2008 Feb 20.


A whole genome association study of neuroticism using DNA pooling.

Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, van den Oord EJ, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE, Flint J.

Mol Psychiatry. 2008 Mar;13(3):302-12. Epub 2007 Jul 31.


Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance.

Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S.

Mol Psychiatry. 2007 May;12(5):421-2. No abstract available. Erratum in: Mol Psychiatry. 2007 Sep;12(9):881.


A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, Mott R, Flint J.

PLoS Biol. 2006 Nov;4(12):e395.


A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia.

Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, Weizman A, Yakir B, Navon R, Darvasi A.

Hum Genet. 2006 Sep;120(2):160-70. Epub 2006 Jun 17.


DCNP1: a novel candidate gene for major depression.

Willis-Owen SA, Shifman S, Copley RR, Flint J.

Mol Psychiatry. 2006 Feb;11(2):121-2. No abstract available.


Strategies for mapping and cloning quantitative trait genes in rodents.

Flint J, Valdar W, Shifman S, Mott R.

Nat Rev Genet. 2005 Apr;6(4):271-86. Review.


The beauty of admixture.

Darvasi A, Shifman S.

Nat Genet. 2005 Feb;37(2):118-9. No abstract available.


A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients.

Horowitz A, Shifman S, Rivlin N, Pisanté A, Darvasi A.

Schizophr Res. 2005 Mar 1;73(2-3):263-7.


Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.

Benmoyal-Segal L, Vander T, Shifman S, Bryk B, Ebstein RP, Marcus EL, Stessman J, Darvasi A, Herishanu Y, Friedman A, Soreq H.

FASEB J. 2005 Mar;19(3):452-4. Epub 2005 Jan 3.


COMT: a common susceptibility gene in bipolar disorder and schizophrenia.

Shifman S, Bronstein M, Sternfeld M, Pisanté A, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Yakir B, Zak NB, Darvasi A.

Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):61-4.


Linkage disequilibrium patterns of the human genome across populations.

Shifman S, Kuypers J, Kokoris M, Yakir B, Darvasi A.

Hum Mol Genet. 2003 Apr 1;12(7):771-6.


Quantitative technologies for allele frequency estimation of SNPs in DNA pools.

Shifman S, Pisanté-Shalom A, Yakir B, Darvasi A.

Mol Cell Probes. 2002 Dec;16(6):429-34.


A highly significant association between a COMT haplotype and schizophrenia.

Shifman S, Bronstein M, Sternfeld M, Pisanté-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A.

Am J Hum Genet. 2002 Dec;71(6):1296-302. Epub 2002 Oct 25.


Genetic dissection of common diseases.

Zak NB, Shifman S, Shalom A, Darvasi A.

Isr Med Assoc J. 2002 Jun;4(6):438-43. Review.


Power and efficiency of the TDT and case-control design for association scans.

McGinnis R, Shifman S, Darvasi A.

Behav Genet. 2002 Mar;32(2):135-44.


Population-based gene discovery in the post-genomic era.

Zak NB, Shifman S, Shalom A, Darvasi A.

Drug Discov Today. 2001 Nov 1;6(21):1111-1115.


The value of isolated populations.

Shifman S, Darvasi A.

Nat Genet. 2001 Aug;28(4):309-10. No abstract available.


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