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Items: 1 to 50 of 111

1.

Allostatic load and ageing: linking the microbiome and nutrition with age-related health.

Shiels PG, Buchanan S, Selman C, Stenvinkel P.

Biochem Soc Trans. 2019 Aug 15. pii: BST20190110. doi: 10.1042/BST20190110. [Epub ahead of print] Review.

PMID:
31416886
2.

Long-lived animals with negligible senescence: clues for ageing research.

Stenvinkel P, Shiels PG.

Biochem Soc Trans. 2019 Jul 31. pii: BST20190105. doi: 10.1042/BST20190105. [Epub ahead of print] Review.

PMID:
31366472
3.

Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2-lessons from evolution, the animal kingdom and rare progeroid syndromes.

Stenvinkel P, Meyer CJ, Block GA, Chertow GM, Shiels PG.

Nephrol Dial Transplant. 2019 Jul 13. pii: gfz120. doi: 10.1093/ndt/gfz120. [Epub ahead of print]

PMID:
31302696
4.

Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature.

Lang J, McKie J, Smith H, McLaughlin A, Gillberg C, Shiels PG, Minnis H.

Eur Child Adolesc Psychiatry. 2019 Apr 9. doi: 10.1007/s00787-019-01329-1. [Epub ahead of print] Review.

PMID:
30968208
5.

More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study.

Ellaway A, Dundas R, Robertson T, Shiels PG.

PLoS One. 2019 Mar 28;14(3):e0214380. doi: 10.1371/journal.pone.0214380. eCollection 2019.

6.

Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape.

Mafra D, Esgalhado M, Borges NA, Cardozo LFMF, Stockler-Pinto MB, Craven H, Buchanan SJ, Lindholm B, Stenvinkel P, Shiels PG.

J Nutr. 2019 Mar 1;149(3):372-380. doi: 10.1093/jn/nxy289.

PMID:
30796783
7.

Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment.

Hobson S, Arefin S, Kublickiene K, Shiels PG, Stenvinkel P.

Toxins (Basel). 2019 Feb 1;11(2). pii: E82. doi: 10.3390/toxins11020082. Review.

8.

MicroRNAs in AKI and Kidney Transplantation.

Ledeganck KJ, Gielis EM, Abramowicz D, Stenvinkel P, Shiels PG, Van Craenenbroeck AH.

Clin J Am Soc Nephrol. 2019 Mar 7;14(3):454-468. doi: 10.2215/CJN.08020718. Epub 2019 Jan 2. Review.

PMID:
30602462
9.

Has the Expansion in Extended Criteria Deceased Donors Led to a Different Type of Delayed Graft Function and Poorer Outcomes?

Stevenson RP, Shapter O, Aitken E, Stevenson K, Shiels PG, Kingsmore DB.

Transplant Proc. 2018 Dec;50(10):3160-3164. doi: 10.1016/j.transproceed.2018.07.022.

PMID:
30577182
10.

Perceived Neighbourhood Problems over Time and Associations with Adiposity.

Ellaway A, Dundas R, Olsen JR, Shiels PG.

Int J Environ Res Public Health. 2018 Aug 28;15(9). pii: E1854. doi: 10.3390/ijerph15091854.

11.

Extracellular Vesicles, Ageing, and Therapeutic Interventions.

Panagiotou N, Neytchev O, Selman C, Shiels PG.

Cells. 2018 Aug 18;7(8). pii: E110. doi: 10.3390/cells7080110. Review.

12.

A molecular signature for delayed graft function.

McGuinness D, Mohammed S, Monaghan L, Wilson PA, Kingsmore DB, Shapter O, Stevenson KS, Coley SM, Devey L, Kirkpatrick RB, Shiels PG.

Aging Cell. 2018 Oct;17(5):e12825. doi: 10.1111/acel.12825. Epub 2018 Aug 9.

13.

Role of accelerated aging in limb muscle wasting of patients with COPD.

Lakhdar R, McGuinness D, Drost EM, Shiels PG, Bastos R, MacNee W, Rabinovich RA.

Int J Chron Obstruct Pulmon Dis. 2018 Jun 25;13:1987-1998. doi: 10.2147/COPD.S155952. eCollection 2018.

14.

The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review.

Maguire D, Talwar D, Shiels PG, McMillan D.

Clin Nutr ESPEN. 2018 Jun;25:8-17. doi: 10.1016/j.clnesp.2018.02.007. Epub 2018 Mar 15.

PMID:
29779823
15.

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom.

Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T, Shiels PG, Johnson RJ.

Nat Rev Nephrol. 2018 Apr;14(4):265-284. doi: 10.1038/nrneph.2017.169. Epub 2018 Jan 15. Review.

PMID:
29332935
16.

Telomere Homeostasis: Interplay with Magnesium.

Maguire D, Neytchev O, Talwar D, McMillan D, Shiels PG.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E157. doi: 10.3390/ijms19010157. Review.

17.

Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers.

Lu L, Johnman C, McGlynn L, Mackay DF, Shiels PG, Pell JP.

Int J Epidemiol. 2017 Dec 1;46(6):1978-1984. doi: 10.1093/ije/dyx212.

PMID:
29040594
18.

Inflammation and premature aging in advanced chronic kidney disease.

Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG, Shiels PG, Stenvinkel P.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017. Epub 2017 Jul 12. Review.

19.

Current epigenetic aspects the clinical kidney researcher should embrace.

Witasp A, Van Craenenbroeck AH, Shiels PG, Ekström TJ, Stenvinkel P, Nordfors L.

Clin Sci (Lond). 2017 Jun 30;131(14):1649-1667. doi: 10.1042/CS20160596. Print 2017 Jul 15. Review.

PMID:
28667065
20.

The role of epigenetics in renal ageing.

Shiels PG, McGuinness D, Eriksson M, Kooman JP, Stenvinkel P.

Nat Rev Nephrol. 2017 Aug;13(8):471-482. doi: 10.1038/nrneph.2017.78. Epub 2017 Jun 19. Review.

PMID:
28626222
21.

Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout.

Vazirpanah N, Kienhorst LBE, Van Lochem E, Wichers C, Rossato M, Shiels PG, Dalbeth N, Stamp LK, Merriman TR, Janssen M, Radstake TRDJ, Broen JC.

Ann Rheum Dis. 2017 Jul;76(7):1313-1319. doi: 10.1136/annrheumdis-2016-210538. Epub 2017 Mar 27.

PMID:
28347991
22.

CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease.

Stenvinkel P, Luttropp K, McGuinness D, Witasp A, Qureshi AR, Wernerson A, Nordfors L, Schalling M, Ripsweden J, Wennberg L, Söderberg M, Bárány P, Olauson H, Shiels PG.

Aging (Albany NY). 2017 Feb 9;9(2):494-507. doi: 10.18632/aging.101173.

23.

Increased Telomere Attrition After Renal Transplantation-Impact of Antimetabolite Therapy.

Luttropp K, Nordfors L, McGuinness D, Wennberg L, Curley H, Quasim T, Genberg H, Sandberg J, Sönnerborg I, Schalling M, Qureshi AR, Bárány P, Shiels PG, Stenvinkel P.

Transplant Direct. 2016 Nov 16;2(12):e116. eCollection 2016 Dec.

24.

Microvesicles as Vehicles for Tissue Regeneration: Changing of the Guards.

Panagiotou N, Wayne Davies R, Selman C, Shiels PG.

Curr Pathobiol Rep. 2016;4(4):181-187. Epub 2016 Aug 27. Review.

25.

Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat.

Khojah SM, Payne AP, McGuinness D, Shiels PG.

Cells. 2016 Oct 17;5(4). pii: E38.

26.

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake.

McClelland R, Christensen K, Mohammed S, McGuinness D, Cooney J, Bakshi A, Demou E, MacDonald E, Caslake M, Stenvinkel P, Shiels PG; work was done on behalf of the pSoBiD team.

Aging (Albany NY). 2016 May;8(5):1135-49. doi: 10.18632/aging.100948.

27.

Circulating markers of ageing and allostatic load: A slow train coming.

Shiels PG, Stenvinkel P, Kooman JP, McGuinness D.

Pract Lab Med. 2016 Apr 19;7:49-54. doi: 10.1016/j.plabm.2016.04.002. eCollection 2017 Apr.

28.

Correction: Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing.

McGuinness D, Leierer J, Shapter O, Mohammed S, Gingell-Littlejohn M, Kingsmore DB, Little AM, Kerschbaum J, Schneeberger S, Maglione M, Nadalin S, Wagner S, Königsrainer A, Aitken E, Whalen H, Clancy M, McConnachie A, Koppelstaetter C, Stevenson KS, Shiels PG.

PLoS One. 2016 Mar 10;11(3):e0151506. doi: 10.1371/journal.pone.0151506. eCollection 2016. No abstract available.

29.

Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease.

Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S, Maruyama S.

Blood Purif. 2016;41(1-3):25-33. doi: 10.1159/000440971. Epub 2015 Oct 20.

PMID:
26960211
30.

Corrigendum to "Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study" [Neuroimage Clin. 2 (2013) 646-57].

Krishnadas R, McLean J, Batty GD, Burns H, Deans KA, Ford I, McConnachie A, McGinty A, McLean JS, Millar K, Sattar N, Shiels PG, Velupillai YN, Packard CJ, Cavanagh J.

Neuroimage Clin. 2015 Jun 22;9:e1. doi: 10.1016/j.nicl.2015.06.004. eCollection 2015.

31.

Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing.

McGuinness D, Leierer J, Shapter O, Mohammed S, Gingell-Littlejohn M, Kingsmore DB, Little AM, Kerschbaum J, Schneeberger S, Maglione M, Nadalin S, Wagner S, Königsrainer A, Aitken E, Whalen H, Clancy M, McConnachie A, Koppelstaetter C, Stevenson KS, Shiels PG.

PLoS One. 2016 Jan 6;11(1):e0146378. doi: 10.1371/journal.pone.0146378. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0151506.

32.

Nutrients and ageing: what can we learn about ageing interactions from animal biology?

Stenvinkel P, Kooman JP, Shiels PG.

Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):19-25. doi: 10.1097/MCO.0000000000000234. Review.

PMID:
26485336
33.

Microvesicles but Not Exosomes from Pathfinder Cells Stimulate Functional Recovery of the Pancreas in a Mouse Streptozotocin-Induced Diabetes Model.

McGuinness D, Anthony DF, Moulisova V, MacDonald AI, MacIntyre A, Thomson J, Nag A, Davies RW, Shiels PG.

Rejuvenation Res. 2016 Jun;19(3):223-32. doi: 10.1089/rej.2015.1723. Epub 2016 Feb 10.

PMID:
26414011
34.

Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1686-7. doi: 10.1093/ije/dyv169. Epub 2015 Sep 24. No abstract available.

PMID:
26403813
35.

Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1739-41. doi: 10.1093/ije/dyv170. Epub 2015 Sep 24. No abstract available.

PMID:
26403811
36.

Reproducibility of Telomere Length Assessment--An International Collaborative Study.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1749-54. doi: 10.1093/ije/dyv171. Epub 2015 Sep 24. No abstract available.

37.

Premature aging in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences.

Kooman JP, Shiels PG, Stenvinkel P.

Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):528-34. doi: 10.1097/MCO.0000000000000218. Review.

PMID:
26372510
38.

Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis.

Ochoa E, Martin JE, Assasi S, Beretta L, Carreira P, Guillén A, Simeón CP, Koumakis E, Dieude P, Allanore Y, García-Hernández FJ, Espinosa G, Castellví I, Trapiella JL, Rodriguez L, González-Gay MÁ, Egurbide MV, Sáez L, Callejas-Rubio JL, Vargas-Hitos JA, Hunzelmann N, Riemekasten G, Witte T, Distler JH, Kreuter A, Lunardi C, Santaniello A, Tan FK, Shiels PG, Herrick A, Worthington J, Vonk MC, Koeleman BP, Radstake TR, Mayes MD, Martin J; Spanish Scleroderma Group.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S31-5. Epub 2015 Aug 27.

PMID:
26314374
39.

Biological Ageing, Inflammation and Nutrition: How Might They Impact on Systemic Sclerosis?

Shiels PG, Ritzau-Reid K.

Curr Aging Sci. 2015;8(2):123-30. Review.

PMID:
26212058
40.

SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.

McGlynn LM, McCluney S, Jamieson NB, Thomson J, MacDonald AI, Oien K, Dickson EJ, Carter CR, McKay CJ, Shiels PG.

PLoS One. 2015 Jun 29;10(6):e0131344. doi: 10.1371/journal.pone.0131344. eCollection 2015.

41.

Chronic kidney disease and premature ageing.

Kooman JP, Kotanko P, Schols AM, Shiels PG, Stenvinkel P.

Nat Rev Nephrol. 2014 Dec;10(12):732-42. doi: 10.1038/nrneph.2014.185. Epub 2014 Oct 7. Review.

PMID:
25287433
42.

Reproducibility of telomere length assessment: an international collaborative study.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T.

Int J Epidemiol. 2015 Oct;44(5):1673-83. doi: 10.1093/ije/dyu191. Epub 2014 Sep 19.

43.

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility.

López-Isac E, Bossini-Castillo L, Simeon CP, Egurbide MV, Alegre-Sancho JJ, Callejas JL, Roman-Ivorra JA, Freire M, Beretta L, Santaniello A, Airó P, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JH, Schuerwegh AJ, Vonk MC, Voskuyl AE, Shiels PG, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Assassi S, Koeleman BP, Mayes MD, Radstake TR, Martin J; Spanish Scleroderma Group.

Arthritis Res Ther. 2014 Jan 9;16(1):R6. doi: 10.1186/ar4432.

44.

SIRT2: tumour suppressor or tumour promoter in operable breast cancer?

McGlynn LM, Zino S, MacDonald AI, Curle J, Reilly JE, Mohammed ZM, McMillan DC, Mallon E, Payne AP, Edwards J, Shiels PG.

Eur J Cancer. 2014 Jan;50(2):290-301. doi: 10.1016/j.ejca.2013.10.005. Epub 2013 Oct 29.

PMID:
24183459
45.

Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study.

Krishnadas R, McLean J, Batty GD, Burns H, Deans KA, Ford I, McConnachie A, McGinty A, McLean JS, Millar K, Sattar N, Shiels PG, Velupillai YN, Packard CJ, Cavanagh J.

Neuroimage Clin. 2013 Apr 22;2:646-57. doi: 10.1016/j.nicl.2013.04.012. eCollection 2013. Erratum in: Neuroimage Clin. 2015;9:e1. Batty, David G [Corrected to Batty, G David].

46.

The in situ local immune response, tumour senescence and proliferation in colorectal cancer.

Roxburgh CS, Richards CH, Macdonald AI, Powell AG, McGlynn LM, McMillan DC, Horgan PG, Edwards J, Shiels PG.

Br J Cancer. 2013 Oct 15;109(8):2207-16. doi: 10.1038/bjc.2013.556. Epub 2013 Sep 10.

47.

Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing.

Pathai S, Shiels PG, Weiss HA, Gilbert CE, Peto T, Bekker LG, Wood R, Wong TY, Lawn SD.

Mech Ageing Dev. 2013 Sep;134(9):400-6. doi: 10.1016/j.mad.2013.08.002. Epub 2013 Aug 27.

48.

Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study.

Krishnadas R, McLean J, Batty GD, Burns H, Deans KA, Ford I, McConnachie A, McLean JS, Millar K, Sattar N, Shiels PG, Tannahill C, Velupillai YN, Packard CJ, Cavanagh J.

Psychosom Med. 2013 Sep;75(7):616-23. doi: 10.1097/PSY.0b013e3182a151a7. Epub 2013 Aug 24.

PMID:
23975946
49.

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease.

Robinson MW, McGuinness D, Swann R, Barclay S, Mills PR, Patel AH, McLauchlan J, Shiels PG.

Aging Cell. 2013 Dec;12(6):1141-3. doi: 10.1111/acel.12125. Epub 2013 Aug 12.

50.

Telomere length and physical performance at older ages: an individual participant meta-analysis.

Gardner MP, Martin-Ruiz C, Cooper R, Hardy R, Sayer AA, Cooper C, Deary IJ, Gallacher J, Harris SE, Shiels PG, Starr JM, Kuh D, von Zglinicki T, Ben-Shlomo Y; Halcyon study team.

PLoS One. 2013 Jul 26;8(7):e69526. doi: 10.1371/journal.pone.0069526. Print 2013.

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