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Macro- and micromechanical remodelling in the fish atrium is associated with regulation of collagen 1 alpha 3 chain expression.

Keen AN, Fenna AJ, McConnell JC, Sherratt MJ, Gardner P, Shiels HA.

Pflugers Arch. 2018 Aug;470(8):1205-1219. doi: 10.1007/s00424-018-2140-1. Epub 2018 Mar 28.


Sperm in hot water: direct and indirect thermal challenges interact to impact on brown trout sperm quality.

Fenkes M, Fitzpatrick JL, Ozolina K, Shiels HA, Nudds RL.

J Exp Biol. 2017 Jul 15;220(Pt 14):2513-2520. doi: 10.1242/jeb.156018. Epub 2017 Apr 28.


A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant.

Brette F, Shiels HA, Galli GL, Cros C, Incardona JP, Scholz NL, Block BA.

Sci Rep. 2017 Jan 31;7:41476. doi: 10.1038/srep41476.


Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention.

Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, Prehar S, Castro S, Zhang H, Ji Y, Zhang X, Xiao R, Zhang R, Lei M, Cyganek L, Guan K, Millar CB, Liao X, Jain MK, Boyett MR, Cartwright EJ, Shiels HA, Wang X.

Circulation. 2017 Feb 14;135(7):683-699. doi: 10.1161/CIRCULATIONAHA.116.022941. Epub 2016 Nov 29.


Temperature-induced cardiac remodelling in fish.

Keen AN, Klaiman JM, Shiels HA, Gillis TE.

J Exp Biol. 2017 Jan 15;220(Pt 2):147-160. doi: 10.1242/jeb.128496. Epub 2016 Nov 16. Review.


Conservation physiology of marine fishes: state of the art and prospects for policy.

McKenzie DJ, Axelsson M, Chabot D, Claireaux G, Cooke SJ, Corner RA, De Boeck G, Domenici P, Guerreiro PM, Hamer B, Jørgensen C, Killen SS, Lefevre S, Marras S, Michaelidis B, Nilsson GE, Peck MA, Perez-Ruzafa A, Rijnsdorp AD, Shiels HA, Steffensen JF, Svendsen JC, Svendsen MB, Teal LR, van der Meer J, Wang T, Wilson JM, Wilson RW, Metcalfe JD.

Conserv Physiol. 2016 Oct 18;4(1):cow046. eCollection 2016. Review.


Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis.

Galli GL, Crossley J, Elsey RM, Dzialowski EM, Shiels HA, Crossley DA 2nd.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1164-R1172. doi: 10.1152/ajpregu.00107.2016. Epub 2016 Oct 5.


Intraspecific individual variation of temperature tolerance associated with oxygen demand in the European sea bass (Dicentrarchus labrax).

Ozolina K, Shiels HA, Ollivier H, Claireaux G.

Conserv Physiol. 2016 Jan 8;4(1):cov060. doi: 10.1093/conphys/cov060. eCollection 2016.


Cardiovascular function, compliance, and connective tissue remodeling in the turtle, Trachemys scripta, following thermal acclimation.

Keen AN, Shiels HA, Crossley DA 2nd.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R133-43. doi: 10.1152/ajpregu.00510.2015. Epub 2016 Apr 13.


The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle.

Keen AN, Fenna AJ, McConnell JC, Sherratt MJ, Gardner P, Shiels HA.

Front Physiol. 2016 Jan 21;6:427. doi: 10.3389/fphys.2015.00427. eCollection 2015.


Individual variation in whole-animal hypoxia tolerance is associated with cardiac hypoxia tolerance in a marine teleost.

Joyce W, Ozolina K, Mauduit F, Ollivier H, Claireaux G, Shiels HA.

Biol Lett. 2016 Jan;12(1):20150708. doi: 10.1098/rsbl.2015.0708.


The potential impacts of migratory difficulty, including warmer waters and altered flow conditions, on the reproductive success of salmonid fishes.

Fenkes M, Shiels HA, Fitzpatrick JL, Nudds RL.

Comp Biochem Physiol A Mol Integr Physiol. 2016 Mar;193:11-21. doi: 10.1016/j.cbpa.2015.11.012. Epub 2015 Nov 18.


Kinematics and energetics of swimming performance during acute warming in brown trout Salmo trutta.

Lea JM, Keen AN, Nudds RL, Shiels HA.

J Fish Biol. 2016 Jan;88(1):403-17. doi: 10.1111/jfb.12788. Epub 2015 Nov 13.


Is there something fishy about the regulation of the ryanodine receptor in the fish heart?

Shiels HA, Sitsapesan R.

Exp Physiol. 2015 Dec;100(12):1412-20. doi: 10.1113/EP085136. Epub 2015 Aug 16. Review.


Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart.

Hassinen M, Haverinen J, Hardy ME, Shiels HA, Vornanen M.

Pflugers Arch. 2015 Dec;467(12):2437-46. doi: 10.1007/s00424-015-1710-8. Epub 2015 May 21.


Generating an in vitro 3D cell culture model from zebrafish larvae for heart research.

Grunow B, Mohamet L, Shiels HA.

J Exp Biol. 2015 Apr 15;218(Pt 8):1116-21. doi: 10.1242/jeb.118224. Epub 2015 Feb 24.


Cardiac function in an endothermic fish: cellular mechanisms for overcoming acute thermal challenges during diving.

Shiels HA, Galli GL, Block BA.

Proc Biol Sci. 2015 Feb 7;282(1800):20141989. doi: 10.1098/rspb.2014.1989.


The calcium stored in the sarcoplasmic reticulum acts as a safety mechanism in rainbow trout heart.

Cros C, Sallé L, Warren DE, Shiels HA, Brette F.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1493-501. doi: 10.1152/ajpregu.00127.2014. Epub 2014 Nov 5.


The sarcoplasmic reticulum and the evolution of the vertebrate heart.

Shiels HA, Galli GL.

Physiology (Bethesda). 2014 Nov;29(6):456-69. doi: 10.1152/physiol.00015.2014. Review.


Electrical excitability of the heart in a Chondrostei fish, the Siberian sturgeon (Acipenser baerii).

Haworth TE, Haverinen J, Shiels HA, Vornanen M.

Am J Physiol Regul Integr Comp Physiol. 2014 Nov 1;307(9):R1157-66. doi: 10.1152/ajpregu.00253.2014. Epub 2014 Aug 27.


Rainbow trout provide the first experimental evidence for adherence to a distinct Strouhal number during animal oscillatory propulsion.

Nudds RL, John EL, Keen AN, Shiels HA.

J Exp Biol. 2014 Jul 1;217(Pt 13):2244-9. doi: 10.1242/jeb.102236.


The impact of abdominal aortic aneurysm surgery on intensive care unit resources in an Irish tertiary centre.

Shiels H, Desmond AN, Parimkayala R, Cahill J.

Ir J Med Sci. 2013 Sep;182(3):371-5. doi: 10.1007/s11845-012-0891-9. Epub 2012 Dec 14.


Cardiac remodeling in fish: strategies to maintain heart function during temperature Change.

Klaiman JM, Fenna AJ, Shiels HA, Macri J, Gillis TE.

PLoS One. 2011;6(9):e24464. doi: 10.1371/journal.pone.0024464. Epub 2011 Sep 7.


Rainbow trout myocardium does not exhibit a slow inotropic response to stretch.

Patrick SM, White E, Shiels HA.

J Exp Biol. 2011 Apr 1;214(Pt 7):1118-22. doi: 10.1242/jeb.048546.


Temperature effects on Ca2+ cycling in scombrid cardiomyocytes: a phylogenetic comparison.

Galli GL, Lipnick MS, Shiels HA, Block BA.

J Exp Biol. 2011 Apr 1;214(Pt 7):1068-76. doi: 10.1242/jeb.048231.


The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares.

Patrick SM, White E, Brill RW, Shiels HA.

J Fish Biol. 2011 Feb;78(2):651-8. doi: 10.1111/j.1095-8649.2010.02869.x.


Warm fish with cold hearts: thermal plasticity of excitation-contraction coupling in bluefin tuna.

Shiels HA, Di Maio A, Thompson S, Block BA.

Proc Biol Sci. 2011 Jan 7;278(1702):18-27. doi: 10.1098/rspb.2010.1274. Epub 2010 Jul 28.


Mechano-electric feedback in the fish heart.

Patrick SM, White E, Shiels HA.

PLoS One. 2010 May 7;5(5):e10548. doi: 10.1371/journal.pone.0010548.


Enhanced length-dependent Ca2+ activation in fish cardiomyocytes permits a large operating range of sarcomere lengths.

Patrick SM, Hoskins AC, Kentish JC, White E, Shiels HA, Cazorla O.

J Mol Cell Cardiol. 2010 May;48(5):917-24. doi: 10.1016/j.yjmcc.2010.02.008. Epub 2010 Feb 17.


Hypercapnic acidosis reduces contractile function in the ventricle of the armored catfish, Pterygoplichthys pardalis.

Shiels HA, Santiago DA, Galli GL.

Physiol Biochem Zool. 2010 Mar-Apr;83(2):366-75. doi: 10.1086/644759.


The cellular force-frequency response in ventricular myocytes from the varanid lizard, Varanus exanthematicus.

Warren DE, Galli GL, Patrick SM, Shiels HA.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R567-74. doi: 10.1152/ajpregu.00650.2009. Epub 2010 Jan 6.


Ca2+ cycling in cardiomyocytes from a high-performance reptile, the varanid lizard (Varanus exanthematicus).

Galli GL, Warren DE, Shiels HA.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1636-44. doi: 10.1152/ajpregu.00381.2009. Epub 2009 Oct 7.


Temperature acclimation has no effect on ryanodine receptor expression or subcellular localization in rainbow trout heart.

Birkedal R, Christopher J, Thistlethwaite A, Shiels HA.

J Comp Physiol B. 2009 Nov;179(8):961-9. doi: 10.1007/s00360-009-0377-x. Epub 2009 Jun 21.


Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio).

Brette F, Luxan G, Cros C, Dixey H, Wilson C, Shiels HA.

Biochem Biophys Res Commun. 2008 Sep 12;374(1):143-6. doi: 10.1016/j.bbrc.2008.06.109. Epub 2008 Jul 9.


Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective.

Stecyk JA, Galli GL, Shiels HA, Farrell AP.

Comp Biochem Physiol C Toxicol Pharmacol. 2008 Nov;148(4):339-54. doi: 10.1016/j.cbpc.2008.05.016. Epub 2008 Jun 5. Review.


The Frank-Starling mechanism in vertebrate cardiac myocytes.

Shiels HA, White E.

J Exp Biol. 2008 Jul;211(Pt 13):2005-13. doi: 10.1242/jeb.003145. Review.


High [Na+]i in cardiomyocytes from rainbow trout.

Birkedal R, Shiels HA.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R861-6. Epub 2007 May 16.


Calcium flux in turtle ventricular myocytes.

Galli GL, Taylor EW, Shiels HA.

Am J Physiol Regul Integr Comp Physiol. 2006 Dec;291(6):R1781-9. Epub 2006 Aug 3.


Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat.

Shiels H, O'Connell A, Qureshi MA, Howarth FC, White E, Calaghan S.

Mol Cell Biochem. 2007 Jan;294(1-2):173-80. Epub 2006 Jul 13.


Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to order.

Birkedal R, Shiels HA, Vendelin M.

Am J Physiol Cell Physiol. 2006 Dec;291(6):C1148-58. Epub 2006 Jul 5.


The cellular basis for enhanced volume-modulated cardiac output in fish hearts.

Shiels HA, Calaghan SC, White E.

J Gen Physiol. 2006 Jul;128(1):37-44. Epub 2006 Jun 12.


The role of the sarcoplasmic reticulum in the generation of high heart rates and blood pressures in reptiles.

Galli GL, Gesser H, Taylor EW, Shiels HA, Wang T.

J Exp Biol. 2006 May;209(Pt 10):1956-63.


Temporal and spatial properties of cellular Ca2+ flux in trout ventricular myocytes.

Shiels HA, White E.

Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1756-66. Epub 2005 Jan 13.


Acute temperature change modulates the response of ICa to adrenergic stimulation in fish cardiomyocytes.

Shiels HA, Vornanen M, Farrell AP.

Physiol Biochem Zool. 2003 Nov-Dec;76(6):816-24.


Electrophysiological properties of the L-type Ca(2+) current in cardiomyocytes from bluefin tuna and Pacific mackerel.

Shiels HA, Blank JM, Farrell AP, Block BA.

Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R659-68. Epub 2003 Dec 4.


Effects of temperature on intracellular Ca2+ in trout atrial myocytes.

Shiels HA, Vornanen M, Farrell AP.

J Exp Biol. 2002 Dec;205(Pt 23):3641-50.


Temperature dependence of cardiac sarcoplasmic reticulum function in rainbow trout myocytes.

Shiels HA, Vornanen M, Farrell AP.

J Exp Biol. 2002 Dec;205(Pt 23):3631-9.


Plasticity of excitation-contraction coupling in fish cardiac myocytes.

Vornanen M, Shiels HA, Farrell AP.

Comp Biochem Physiol A Mol Integr Physiol. 2002 Aug;132(4):827-46. Review.


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