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Pharmacokinetics and Dialytic Clearance of Isavuconazole During In Vitro and In Vivo Continuous Renal Replacement Therapy.

Biagi M, Butler D, Tan X, Qasmieh S, Tejani K, Patel S, Rivosecchi RM, Nguyen MH, Clancy CJ, Shields RK, Wenzler E.

Antimicrob Agents Chemother. 2019 Sep 16. pii: AAC.01085-19. doi: 10.1128/AAC.01085-19. [Epub ahead of print]


Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.

Marsh JW, Mustapha MM, Griffith MP, Evans DR, Ezeonwuka C, Pasculle AW, Shutt KA, Sundermann A, Ayres AM, Shields RK, Babiker A, Cooper VS, Van Tyne D, Harrison LH.

MBio. 2019 Sep 3;10(5). pii: e01945-19. doi: 10.1128/mBio.01945-19.


Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS-Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis.

Wright WF, Bejou N, Shields RK, Marr K, McCarty TP, Pappas PG.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00512-19. doi: 10.1128/AAC.00512-19. Print 2019 Aug.


Patient-to-patient transmission of KPC variants with reduced ceftazidime-avibactam susceptibility.

Munoz-Price LS, Reeme AE, Buchan BW, Mettus RT, Mustapha MM, Van Tyne D, Shields RK, Doi Y.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00955-19. doi: 10.1128/AAC.00955-19. [Epub ahead of print]


Fosfomycin for treatment of multidrug-resistant pathogens causing urinary tract infection: A real-world perspective and review of the literature.

Babiker A, Clarke L, Doi Y, Shields RK.

Diagn Microbiol Infect Dis. 2019 Jun 24:114856. doi: 10.1016/j.diagmicrobio.2019.06.008. [Epub ahead of print]


Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.

Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB.

Elife. 2019 Jul 18;8. pii: e45873. doi: 10.7554/eLife.45873.


Pharmacodynamics of Ceftazidime plus Avibactam against KPC-2-Bearing Isolates of Klebsiella pneumoniae in a Hollow Fiber Infection Model.

Drusano GL, Shields RK, Mtchedlidze N, Nguyen MH, Clancy CJ, Vicciarelli M, Louie A.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00462-19. doi: 10.1128/AAC.00462-19. Print 2019 Aug.


Reduced ceftazidime and ertapenem susceptibility due to production of OXA-2 in Klebsiella pneumoniae ST258.

Iovleva A, Mettus RT, McElheny CL, Mustapha MM, Van Tyne D, Shields RK, Pasculle AW, Cooper VS, Doi Y.

J Antimicrob Chemother. 2019 Aug 1;74(8):2203-2208. doi: 10.1093/jac/dkz183.


Motor demands of cognitive testing may artificially reduce executive function scores in individuals with spinal cord injury.

Lee J, Dudley-Javoroski S, Shields RK.

J Spinal Cord Med. 2019 Apr 3:1-9. doi: 10.1080/10790268.2019.1597482. [Epub ahead of print]


Sustained submaximal contraction yields biphasic modulation of soleus Post-activation depression in healthy humans.

Oza PD, Dudley-Javoroski S, Shields RK.

Scand J Med Sci Sports. 2019 Jul;29(7):944-951. doi: 10.1111/sms.13421. Epub 2019 Apr 4.


Effects of KPC Variant and Porin Genotype on the In Vitro Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae.

Wilson WR, Kline EG, Jones CE, Morder KT, Mettus RT, Doi Y, Nguyen MH, Clancy CJ, Shields RK.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02048-18. doi: 10.1128/AAC.02048-18. Print 2019 Mar.


Age and Cognitive Stress Influences Motor Skill Acquisition, Consolidation, and Dual-Task Effect in Humans.

Cole KR, Shields RK.

J Mot Behav. 2019;51(6):622-639. doi: 10.1080/00222895.2018.1547893. Epub 2019 Jan 2.


Performance of ceftazidime/avibactam susceptibility testing methods against clinically relevant Gram-negative organisms.

Wenzler E, Lee M, Wu TJ, Meyer KA, Shields RK, Nguyen MH, Clancy CJ, Humphries RM, Harrington AT.

J Antimicrob Chemother. 2019 Mar 1;74(3):633-638. doi: 10.1093/jac/dky483.


Precision Physical Therapy: Exercise, the Epigenome, and the Heritability of Environmentally Modified Traits.

Woelfel JR, Dudley-Javoroski S, Shields RK.

Phys Ther. 2018 Nov 1;98(11):946-952. doi: 10.1093/ptj/pzy092.


Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata.

Shields RK, Kline EG, Healey KR, Kordalewska M, Perlin DS, Nguyen MH, Clancy CJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01692-18. doi: 10.1128/AAC.01692-18. Print 2019 Jan.


Whole body heat exposure modulates acute glucose metabolism.

Kimball AL, McCue PM, Petrie MA, Shields RK.

Int J Hyperthermia. 2018;35(1):644-651. doi: 10.1080/02656736.2018.1516303. Epub 2018 Oct 10.


Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients.

Wu X, Clancy CJ, Rivosecchi RM, Zhao W, Shields RK, Marini RV, Venkataramanan R, Nguyen MH.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01643-18. doi: 10.1128/AAC.01643-18. Print 2018 Dec.


Fluoroquinolone Prophylaxis Selects for Meropenem-nonsusceptible Pseudomonas aeruginosa in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.

Hakki M, Humphries RM, Hemarajata P, Tallman GB, Shields RK, Mettus RT, Doi Y, Lewis JS.

Clin Infect Dis. 2019 May 30;68(12):2045-2052. doi: 10.1093/cid/ciy825.


Hybrid stimulation enhances torque as a function of muscle fusion in human paralyzed and non-paralyzed skeletal muscle.

Cole KR, Dudley-Javoroski S, Shields RK.

J Spinal Cord Med. 2019 Sep;42(5):562-570. doi: 10.1080/10790268.2018.1485312. Epub 2018 Jun 20.


Physiotherapy education is a good financial investment, up to a certain level of student debt: an inter-professional economic analysis.

Shields RK, Dudley-Javoroski S.

J Physiother. 2018 Jul;64(3):183-191. doi: 10.1016/j.jphys.2018.05.009. Epub 2018 Jun 15.


Colistin Does Not Potentiate Ceftazidime-Avibactam Killing of Carbapenem-Resistant Enterobacteriaceae In Vitro or Suppress Emergence of Ceftazidime-Avibactam Resistance.

Shields RK, Nguyen MH, Hao B, Kline EG, Clancy CJ.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e01018-18. doi: 10.1128/AAC.01018-18. Print 2018 Aug.


Benchmarking the Physical Therapist Academic Environment to Understand the Student Experience.

Shields RK, Dudley-Javoroski S, Sass KJ, Becker M.

Phys Ther. 2018 Aug 1;98(8):658-669. doi: 10.1093/ptj/pzy051.


Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections.

Shields RK, Nguyen MH, Chen L, Press EG, Kreiswirth BN, Clancy CJ.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02497-17. doi: 10.1128/AAC.02497-17. Print 2018 May.


Modulation of H-Reflex Depression with Paired-Pulse Stimulation in Healthy Active Humans.

Oza PD, Dudley-Javoroski S, Shields RK.

Rehabil Res Pract. 2017;2017:5107097. doi: 10.1155/2017/5107097. Epub 2017 Oct 31.


Verification of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Susceptibility Testing Methods against Carbapenem-Resistant Enterobacteriaceae and Pseudomonas aeruginosa.

Shields RK, Clancy CJ, Pasculle AW, Press EG, Haidar G, Hao B, Chen L, Kreiswirth BN, Nguyen MH.

J Clin Microbiol. 2018 Jan 24;56(2). pii: e01093-17. doi: 10.1128/JCM.01093-17. Print 2018 Feb.


Limb Segment Load Inhibits the Recovery of Soleus H-Reflex After Segmental Vibration in Humans.

Tseng SC, Shields RK.

J Mot Behav. 2018 Nov-Dec;50(6):631-642. doi: 10.1080/00222895.2017.1394259. Epub 2017 Nov 15.


Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.

Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.

MBio. 2017 Oct 31;8(5). pii: e00528-17. doi: 10.1128/mBio.00528-17.


Turning Over the Hourglass.

Shields RK.

Phys Ther. 2017 Oct 1;97(10):949-963. doi: 10.1093/ptj/pzx072. No abstract available.


Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: Clinical Effectiveness and Evolution of Resistance.

Haidar G, Philips NJ, Shields RK, Snyder D, Cheng S, Potoski BA, Doi Y, Hao B, Press EG, Cooper VS, Clancy CJ, Nguyen MH.

Clin Infect Dis. 2017 Jul 1;65(1):110-120. doi: 10.1093/cid/cix182.


Professionalism Values in Health Science Education: Self- and Peer-Assessment of Faculty, Staff, and Students.

Becker M, Dudley-Javoroski S, Shields RK.

J Allied Health. 2017 Fall;46(3):178-184.


Fatigability, oxygen uptake kinetics and muscle deoxygenation in incomplete spinal cord injury during treadmill walking.

Gollie JM, Herrick JE, Keyser RE, Chin LMK, Collins JP, Shields RK, Panza GS, Guccione AA.

Eur J Appl Physiol. 2017 Oct;117(10):1989-2000. doi: 10.1007/s00421-017-3685-y. Epub 2017 Jul 25.


Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature.

Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ.

Open Forum Infect Dis. 2017 Jul 1;4(3):ofx101. doi: 10.1093/ofid/ofx101. eCollection 2017 Summer.


Risk Factors Associated With Outpatient Parenteral Antibiotic Therapy Program Failure Among Intravenous Drug Users.

Buehrle DJ, Shields RK, Shah N, Shoff C, Sheridan K.

Open Forum Infect Dis. 2017 May 23;4(3):ofx102. doi: 10.1093/ofid/ofx102. eCollection 2017 Summer.


Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients.

Rivosecchi RM, Clancy CJ, Shields RK, Ensor CR, Shullo MA, Falcione BA, Venkataramanan R, Nguyen MH.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00970-17. doi: 10.1128/AAC.00970-17. Print 2017 Sep.


Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae.

Haidar G, Clancy CJ, Chen L, Samanta P, Shields RK, Kreiswirth BN, Nguyen MH.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00642-17. doi: 10.1128/AAC.00642-17. Print 2017 Sep.


Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia.

Shields RK, Nguyen MH, Chen L, Press EG, Potoski BA, Marini RV, Doi Y, Kreiswirth BN, Clancy CJ.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00883-17. doi: 10.1128/AAC.00883-17. Print 2017 Aug.


Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum β-Lactams for Major Gram-Negative Bacterial Pathogens.

Shelburne SA, Kim J, Munita JM, Sahasrabhojane P, Shields RK, Press EG, Li X, Arias CA, Cantarel B, Jiang Y, Kim MS, Aitken SL, Greenberg DE.

Clin Infect Dis. 2017 Sep 1;65(5):738-745. doi: 10.1093/cid/cix417.


Vibration training after chronic spinal cord injury: Evidence for persistent segmental plasticity.

Yen CL, McHenry CL, Petrie MA, Dudley-Javoroski S, Shields RK.

Neurosci Lett. 2017 Apr 24;647:129-132. doi: 10.1016/j.neulet.2017.03.019. Epub 2017 Mar 16.


Defining the incidence and risk factors of colistin-induced acute kidney injury by KDIGO criteria.

Shields RK, Anand R, Clarke LG, Paronish JA, Weirich M, Perone H, Kieserman J, Freedy H, Andrzejewski C, Bonilla H.

PLoS One. 2017 Mar 7;12(3):e0173286. doi: 10.1371/journal.pone.0173286. eCollection 2017.


In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases.

Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00079-17. doi: 10.1128/AAC.00079-17. Print 2017 May.


Mutations in blaKPC-3 That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases.

Haidar G, Clancy CJ, Shields RK, Hao B, Cheng S, Nguyen MH.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02534-16. doi: 10.1128/AAC.02534-16. Print 2017 May.


Speed, resistance, and unexpected accelerations modulate feed forward and feedback control during a novel weight bearing task.

Tseng SC, Cole KR, Shaffer MA, Petrie MA, Yen CL, Shields RK.

Gait Posture. 2017 Feb;52:345-353. doi: 10.1016/j.gaitpost.2016.12.015. Epub 2016 Dec 15.


Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.

Shields RK, Chen L, Cheng S, Chavda KD, Press EG, Snyder A, Pandey R, Doi Y, Kreiswirth BN, Nguyen MH, Clancy CJ.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02097-16. doi: 10.1128/AAC.02097-16. Print 2017 Mar.


Low-Force Muscle Activity Regulates Energy Expenditure after Spinal Cord Injury.

Woelfel JR, Kimball AL, Yen CL, Shields RK.

Med Sci Sports Exerc. 2017 May;49(5):870-878. doi: 10.1249/MSS.0000000000001187.


The hidden societal cost of antibiotic resistance per antibiotic prescribed in the United States: an exploratory analysis.

Michaelidis CI, Fine MJ, Lin CJ, Linder JA, Nowalk MP, Shields RK, Zimmerman RK, Smith KJ.

BMC Infect Dis. 2016 Nov 8;16(1):655.


Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Microbiologic Treatment Failure.

Buehrle DJ, Shields RK, Clarke LG, Potoski BA, Clancy CJ, Nguyen MH.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01243-16. doi: 10.1128/AAC.01243-16. Print 2017 Jan.


Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method.

Espinel-Ingroff A, Arendrup M, Cantón E, Cordoba S, Dannaoui E, García-Rodríguez J, Gonzalez GM, Govender NP, Martin-Mazuelos E, Lackner M, Lass-Flörl C, Linares Sicilia MJ, Rodriguez-Iglesias MA, Pelaez T, Shields RK, Garcia-Effron G, Guinea J, Sanguinetti M, Turnidge J.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01792-16. doi: 10.1128/AAC.01792-16. Print 2017 Jan.


Effect of Surgery on Gait and Sensory Motor Performance in Patients With Cervical Spondylotic Myelopathy.

Abode-Iyamah KO, Viljoen SV, McHenry CL, Petrie MA, Stoner KE, Dahdaleh NS, Grosland NM, Howard MA, Shields RK.

Neurosurgery. 2016 Nov;79(5):701-707.


Dynamic Fatigue Does Not Alter Soleus H-Reflexes Conditioned by Homonymous or Heteronymous Pathways.

Oza PD, Dudley-Javoroski S, Shields RK.

Motor Control. 2017 Jul;21(3):345-358. doi: 10.1123/mc.2016-0030. Epub 2016 Oct 13.


Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections.

Shields RK, Potoski BA, Haidar G, Hao B, Doi Y, Chen L, Press EG, Kreiswirth BN, Clancy CJ, Nguyen MH.

Clin Infect Dis. 2016 Dec 15;63(12):1615-1618. Epub 2016 Sep 13.

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