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Items: 1 to 50 of 110

1.

TAF1 plays a critical role in AML1-ETO driven leukemogenesis.

Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L, Sun X, Figueroa M, Shiekhattar R, Nimer S.

Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z.

2.

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms.

Chan HL, Beckedorff F, Zhang Y, Garcia-Huidobro J, Jiang H, Colaprico A, Bilbao D, Figueroa ME, LaCava J, Shiekhattar R, Morey L.

Nat Commun. 2018 Aug 23;9(1):3377. doi: 10.1038/s41467-018-05728-x.

3.

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.

Amaral PP, Leonardi T, Han N, Viré E, Gascoigne DK, Arias-Carrasco R, Büscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T.

Genome Biol. 2018 Mar 15;19(1):32. doi: 10.1186/s13059-018-1405-5.

4.

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs.

Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R.

Genes Dev. 2017 Sep 1;31(17):1809-1820. doi: 10.1101/gad.301697.117.

5.

PAF1 regulation of promoter-proximal pause release via enhancer activation.

Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A.

Science. 2017 Sep 22;357(6357):1294-1298. doi: 10.1126/science.aan3269. Epub 2017 Aug 31.

6.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription.

Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL.

Cell. 2017 Jan 12;168(1-2):135-149.e22. doi: 10.1016/j.cell.2016.12.020. Epub 2017 Jan 12.

7.

Loss of p300 accelerates MDS-associated leukemogenesis.

Cheng G, Liu F, Asai T, Lai F, Man N, Xu H, Chen S, Greenblatt S, Hamard PJ, Ando K, Chen X, Wang L, Martinez C, Tadi M, Wang L, Xu M, Yang FC, Shiekhattar R, Nimer SD.

Leukemia. 2017 Jun;31(6):1382-1390. doi: 10.1038/leu.2016.347. Epub 2016 Nov 24.

8.

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer.

Witt AE, Lee CW, Lee TI, Azzam DJ, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick EB, Gropper AB, Wahlestedt C, Richardson AL, Shiekhattar R, Young RA, Ince TA.

Oncogene. 2017 Mar 23;36(12):1707-1720. doi: 10.1038/onc.2016.337. Epub 2016 Oct 3.

9.

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.

Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF.

Sci Adv. 2016 Sep 2;2(9):e1601167. doi: 10.1126/sciadv.1601167. eCollection 2016 Sep.

10.

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.

Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG.

Mol Cell. 2016 Aug 4;63(3):470-84. doi: 10.1016/j.molcel.2016.06.035. Epub 2016 Jul 28.

11.

Detection and Analysis of Long Noncoding RNAs.

Lai F, Blumenthal E, Shiekhattar R.

Methods Enzymol. 2016;573:421-44. doi: 10.1016/bs.mie.2016.03.010. Epub 2016 Mar 28.

PMID:
27372765
12.

Diverse regulatory interactions of long noncoding RNAs.

Kim TK, Shiekhattar R.

Curr Opin Genet Dev. 2016 Feb;36:73-82. doi: 10.1016/j.gde.2016.03.014. Epub 2016 May 3. Review.

13.

Architectural and Functional Commonalities between Enhancers and Promoters.

Kim TK, Shiekhattar R.

Cell. 2015 Aug 27;162(5):948-59. doi: 10.1016/j.cell.2015.08.008. Review.

14.

Integrator mediates the biogenesis of enhancer RNAs.

Lai F, Gardini A, Zhang A, Shiekhattar R.

Nature. 2015 Sep 17;525(7569):399-403. doi: 10.1038/nature14906. Epub 2015 Aug 26.

15.

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.

Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A.

Cell. 2015 Aug 27;162(5):1003-15. doi: 10.1016/j.cell.2015.07.042. Epub 2015 Aug 13.

16.

The many faces of long noncoding RNAs.

Gardini A, Shiekhattar R.

FEBS J. 2015 May;282(9):1647-57. doi: 10.1111/febs.13101. Epub 2014 Nov 7. Review.

17.

Regulation of transcription by long noncoding RNAs.

Bonasio R, Shiekhattar R.

Annu Rev Genet. 2014;48:433-55. doi: 10.1146/annurev-genet-120213-092323. Epub 2014 Sep 18. Review.

18.

Integrator regulates transcriptional initiation and pause release following activation.

Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R.

Mol Cell. 2014 Oct 2;56(1):128-139. doi: 10.1016/j.molcel.2014.08.004. Epub 2014 Sep 4.

19.

Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia.

Rocha-Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L.

Mol Cell Biol. 2014 Oct 1;34(19):3765-75. doi: 10.1128/MCB.00839-14. Epub 2014 Jul 28.

20.

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL.

Cell Metab. 2014 Jun 3;19(6):952-66. doi: 10.1016/j.cmet.2014.04.004. Epub 2014 May 8.

21.

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation.

Gardini A, Baillat D, Cesaroni M, Shiekhattar R.

EMBO J. 2014 Apr 16;33(8):890-905. doi: 10.1002/embj.201385567. Epub 2014 Mar 3. Erratum in: EMBO J. 2014 Sep 17;33(18):2134.

22.

Where long noncoding RNAs meet DNA methylation.

Lai F, Shiekhattar R.

Cell Res. 2014 Mar;24(3):263-4. doi: 10.1038/cr.2014.13. Epub 2014 Jan 31.

23.

Enhancer RNAs: the new molecules of transcription.

Lai F, Shiekhattar R.

Curr Opin Genet Dev. 2014 Apr;25:38-42. doi: 10.1016/j.gde.2013.11.017. Epub 2014 Jan 28. Review.

24.

PINTing for p53.

Shiekhattar R.

Genome Biol. 2013;14(9):132.

25.

Opening the Chromatin by eRNAs.

Shiekhattar R.

Mol Cell. 2013 Sep 12;51(5):557-8. doi: 10.1016/j.molcel.2013.08.033.

26.

Long noncoding RNAs usher in a new era in the biology of enhancers.

Ørom UA, Shiekhattar R.

Cell. 2013 Sep 12;154(6):1190-3. doi: 10.1016/j.cell.2013.08.028. Review.

27.

The Yin and Yang of enhancer-like RNAs.

Shiekhattar R.

EMBO J. 2013 Oct 2;32(19):2533-4. doi: 10.1038/emboj.2013.185. Epub 2013 Aug 13. No abstract available.

28.

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.

Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R.

Nature. 2013 Feb 28;494(7438):497-501. doi: 10.1038/nature11884. Epub 2013 Feb 17.

29.

Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.

Baillat D, Gardini A, Cesaroni M, Shiekhattar R.

Mol Cell Biol. 2012 Nov;32(22):4642-50. doi: 10.1128/MCB.00906-12. Epub 2012 Sep 10.

30.

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, Lagarde J, Veeravalli L, Ruan X, Ruan Y, Lassmann T, Carninci P, Brown JB, Lipovich L, Gonzalez JM, Thomas M, Davis CA, Shiekhattar R, Gingeras TR, Hubbard TJ, Notredame C, Harrow J, Guigó R.

Genome Res. 2012 Sep;22(9):1775-89. doi: 10.1101/gr.132159.111.

31.

Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila.

Herz HM, Mohan M, Garrett AS, Miller C, Casto D, Zhang Y, Seidel C, Haug JS, Florens L, Washburn MP, Yamaguchi M, Shiekhattar R, Shilatifard A.

Mol Cell Biol. 2012 May;32(9):1683-93. doi: 10.1128/MCB.06503-11. Epub 2012 Feb 21.

32.

Noncoding RNAs and enhancers: complications of a long-distance relationship.

Orom UA, Shiekhattar R.

Trends Genet. 2011 Oct;27(10):433-9. doi: 10.1016/j.tig.2011.06.009. Epub 2011 Aug 9. Review.

33.

Jarid2 regulates mouse epidermal stem cell activation and differentiation.

Mejetta S, Morey L, Pascual G, Kuebler B, Mysliwiec MR, Lee Y, Shiekhattar R, Di Croce L, Benitah SA.

EMBO J. 2011 Aug 2;30(17):3635-46. doi: 10.1038/emboj.2011.265.

34.

Human GTPases associate with RNA polymerase II to mediate its nuclear import.

Carré C, Shiekhattar R.

Mol Cell Biol. 2011 Oct;31(19):3953-62. doi: 10.1128/MCB.05442-11. Epub 2011 Jul 18.

35.

Long noncoding RNAs as enhancers of gene expression.

Ørom UA, Derrien T, Guigo R, Shiekhattar R.

Cold Spring Harb Symp Quant Biol. 2010;75:325-31. doi: 10.1101/sqb.2010.75.058. Epub 2011 Apr 18.

36.

Long non-coding RNAs and enhancers.

Ørom UA, Shiekhattar R.

Curr Opin Genet Dev. 2011 Apr;21(2):194-8. doi: 10.1016/j.gde.2011.01.020. Epub 2011 Feb 15. Review.

37.

Long noncoding RNAs with enhancer-like function in human cells.

Ørom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q, Guigo R, Shiekhattar R.

Cell. 2010 Oct 1;143(1):46-58. doi: 10.1016/j.cell.2010.09.001.

38.

Plant homeodomain fingers form a helping hand for transcription.

Fortschegger K, Shiekhattar R.

Epigenetics. 2011 Jan;6(1):4-8. doi: 10.4161/epi.6.1.13297. Epub 2011 Jan 1. Review.

39.

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

Fortschegger K, de Graaf P, Outchkourov NS, van Schaik FM, Timmers HT, Shiekhattar R.

Mol Cell Biol. 2010 Jul;30(13):3286-98. doi: 10.1128/MCB.01520-09. Epub 2010 Apr 26.

40.

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

Baillat D, Shiekhattar R.

Mol Cell Biol. 2009 Aug;29(15):4144-55. doi: 10.1128/MCB.00380-09. Epub 2009 May 26.

41.

An operational definition of epigenetics.

Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A.

Genes Dev. 2009 Apr 1;23(7):781-3. doi: 10.1101/gad.1787609.

42.

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.

Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S Jr, Shiekhattar R, Esteller M.

Nat Genet. 2009 Mar;41(3):365-70. doi: 10.1038/ng.317. Epub 2009 Feb 15. Erratum in: Nat Genet. 2010 May;42(5):464. Retraction in: Nat Genet. 2016 Feb;48(2):221.

43.

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10820-5. doi: 10.1073/pnas.0800658105. Epub 2008 Jul 31.

44.

Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein.

Messick TE, Russell NS, Iwata AJ, Sarachan KL, Shiekhattar R, Shanks JR, Reyes-Turcu FE, Wilkinson KD, Marmorstein R.

J Biol Chem. 2008 Apr 18;283(16):11038-49. doi: 10.1074/jbc.M704398200. Epub 2008 Feb 12.

45.

Thrilling transcription through threonine phosphorylation.

Di Croce L, Shiekhattar R.

Nat Cell Biol. 2008 Jan;10(1):5-6. doi: 10.1038/ncb0108-5. No abstract available.

PMID:
18172424
46.

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.

Smith ER, Lee MG, Winter B, Droz NM, Eissenberg JC, Shiekhattar R, Shilatifard A.

Mol Cell Biol. 2008 Feb;28(3):1041-6. Epub 2007 Nov 26.

47.

New nomenclature for chromatin-modifying enzymes.

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y.

Cell. 2007 Nov 16;131(4):633-6. No abstract available.

48.

Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.

Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A, Shiekhattar R, Berger SL.

Mol Cell Biol. 2007 Nov;27(22):7856-64. Epub 2007 Sep 17.

49.

p53 is regulated by the lysine demethylase LSD1.

Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL.

Nature. 2007 Sep 6;449(7158):105-8.

PMID:
17805299
50.

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R.

Science. 2007 Oct 19;318(5849):447-50. Epub 2007 Aug 30.

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