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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB.

Cancer Cell. 2019 Dec 9;36(6):690-691. doi: 10.1016/j.ccell.2019.11.008. No abstract available.


Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice.

Chen YC, Su YC, Shieh GS, Su BH, Su WC, Huang PH, Jiang ST, Shiau AL, Wu CL.

FASEB J. 2019 Nov;33(11):13051-13061. doi: 10.1096/fj.201900504R. Epub 2019 Oct 5.


Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer.

Feng YH, Su YC, Lin SF, Lin PR, Wu CL, Tung CL, Li CF, Shieh GS, Shiau AL.

BMC Cancer. 2019 Aug 9;19(1):791. doi: 10.1186/s12885-019-6014-5.


Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination.

Chen YH, Lai KY, Chiu YH, Wu YW, Shiau AL, Chen MC.

Acta Biomater. 2019 Oct 1;97:230-238. doi: 10.1016/j.actbio.2019.07.048. Epub 2019 Jul 27.


Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol.

Kuo WS, Weng CT, Chen JH, Wu CL, Shiau AL, Hsieh JL, So EC, Wu PT, Chen SY.

Nanomaterials (Basel). 2019 Jun 23;9(6). pii: E909. doi: 10.3390/nano9060909.


The irregular breathing effect on target volume and coverage for lung stereotactic body radiotherapy.

Pan CH, Shiau AC, Li KC, Hsu SH, Liang JA.

J Appl Clin Med Phys. 2019 Jul;20(7):109-120. doi: 10.1002/acm2.12663. Epub 2019 Jun 17.


Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking.

Kuo YH, Shiau AL, Tung CL, Su YC, Li CF, Su BH, Tsao CJ, Wu CL, Feng YH, Wu P.

Oncol Lett. 2019 Jun;17(6):5740-5746. doi: 10.3892/ol.2019.10248. Epub 2019 Apr 12.


Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB.

Cancer Cell. 2019 May 13;35(5):816. doi: 10.1016/j.ccell.2019.04.011. No abstract available.


Impact of body-mass factors on setup displacement during pelvic irradiation in patients with lower abdominal cancer.

Wu WC, Chang YR, Lai YL, Shiau AC, Liang JA, Chien CR, Kuo YC, Chen SW.

Radiol Oncol. 2019 Apr 5;53(2):256-264. doi: 10.2478/raon-2019-0017.


Dioxygen reacts with metal-carbon bonds in thorium dialkyls to produce bis(alkoxides).

Settineri NS, Shiau AA, Arnold J.

Dalton Trans. 2019 Apr 23;48(17):5569-5573. doi: 10.1039/c9dt00811j.


In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats.

Tai YS, Jou IM, Jung YC, Wu CL, Shiau AL, Chen CY.

World J Gastrointest Surg. 2019 Feb 27;11(2):85-92. doi: 10.4240/wjgs.v11.i2.85.


Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB.

Cancer Cell. 2019 Mar 18;35(3):504-518.e7. doi: 10.1016/j.ccell.2019.01.020. Epub 2019 Feb 28. Erratum in: Cancer Cell. 2019 May 13;35(5):816. Cancer Cell. 2019 Dec 9;36(6):690-691.


Differential effect of inhibitory strategies of the V617 mutant of JAK2 on cytokine receptor signaling.

Leroy E, Balligand T, Pecquet C, Mouton C, Colau D, Shiau AK, Dusa A, Constantinescu SN.

J Allergy Clin Immunol. 2019 Jul;144(1):224-235. doi: 10.1016/j.jaci.2018.12.1023. Epub 2019 Jan 29.


A simple method for determining dosimetric leaf gap with cross-field dose width for rounded leaf-end multileaf collimator systems.

Lin CY, Shiau AC, Ji JH, Lee CJ, Wang TH, Hsu SH, Liang JA.

Radiat Oncol. 2018 Nov 13;13(1):222. doi: 10.1186/s13014-018-1164-1.


Tetranuclear [MnIIIMn3IVO4] Complexes as Spectroscopic Models of the S2 State of the Oxygen Evolving Complex in Photosystem II.

Lee HB, Shiau AA, Oyala PH, Marchiori DA, Gul S, Chatterjee R, Yano J, Britt RD, Agapie T.

J Am Chem Soc. 2018 Dec 12;140(49):17175-17187. doi: 10.1021/jacs.8b09961. Epub 2018 Nov 30.


CFI-400945 is not a selective cellular PLK4 inhibitor.

Oegema K, Davis RL, Lara-Gonzalez P, Desai A, Shiau AK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10808-E10809. doi: 10.1073/pnas.1813310115. Epub 2018 Oct 30. No abstract available.


Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy.

Hsieh JL, Jou IM, Wu CL, Wu PT, Shiau AL, Chong HE, Lo YT, Shen PC, Chen SY.

PLoS One. 2018 Oct 8;13(10):e0204603. doi: 10.1371/journal.pone.0204603. eCollection 2018.


Two-electron oxidation of a homoleptic U(iii) guanidinate complex by diphenyldiazomethane.

Settineri NS, Shiau AA, Arnold J.

Chem Commun (Camb). 2018 Sep 25;54(77):10913-10916. doi: 10.1039/c8cc06514d.


Phenotypic Screening for Inhibitors of a Mutant Thrombopoietin Receptor.

Ngo A, Koay A, Pecquet C, Diaconu CC, Jenkins DA, Shiau AK, Constantinescu SN, Choong ML.

Methods Mol Biol. 2018;1787:53-66. doi: 10.1007/978-1-4939-7847-2_4.


Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression.

Su YC, Feng YH, Wu HT, Huang YS, Tung CL, Wu P, Chang CJ, Shiau AL, Wu CL.

Sci Rep. 2018 Apr 26;8(1):6586. doi: 10.1038/s41598-018-24633-3.


P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint.

Chen SY, Shiau AL, Wu CL, Wang CR.

Oncotarget. 2017 Dec 15;8(70):115413-115419. doi: 10.18632/oncotarget.23268. eCollection 2017 Dec 29.


Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+ TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy.

Huang CY, Chiang SF, Ke TW, Chen TW, Lan YC, You YS, Shiau AC, Chen WT, Chao KSC.

Cancer Immunol Immunother. 2018 Apr;67(4):551-562. doi: 10.1007/s00262-017-2109-5. Epub 2017 Dec 21.


Identification of H3K4me1-associated proteins at mammalian enhancers.

Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B.

Nat Genet. 2018 Jan;50(1):73-82. doi: 10.1038/s41588-017-0015-6. Epub 2017 Dec 18.


Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.

Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB.

Genes Dev. 2017 Jun 15;31(12):1212-1227. doi: 10.1101/gad.300079.117. Epub 2017 Jul 19.


mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS.

Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22.


Evaluation of Clinical Application and Dosimetric Comparison of Treatment Plans of Gamma Knife and CyberKnife in Treating Arteriovenous Malformations.

Kuo CY, Tsai YC, Shiau AC, Cheng HW, Yu HW, Su YK, Tsai JT.

Stereotact Funct Neurosurg. 2017;95(3):142-148. doi: 10.1159/000460259. Epub 2017 May 10.


One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis.

Chen YF, Shiau AL, Chang SJ, Fan NS, Wang CT, Wu CL, Jan JS.

Acta Biomater. 2017 Jun;55:283-295. doi: 10.1016/j.actbio.2017.04.009. Epub 2017 Apr 13.


Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation.

Hsieh JL, Shen PC, Wu PT, Jou IM, Wu CL, Shiau AL, Wang CR, Chong HE, Chuang SH, Peng JS, Chen SY.

Sci Rep. 2017 Apr 10;7:46050. doi: 10.1038/srep46050.


A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy.

Lee PY, Lin CY, Chen SW, Chien CR, Chu CN, Hsu HT, Liang JA, Lin YJ, Shiau AC.

Radiat Oncol. 2017 Mar 20;12(1):55. doi: 10.1186/s13014-017-0801-4.


IL-6 ameliorates acute lung injury in influenza virus infection.

Yang ML, Wang CT, Yang SJ, Leu CH, Chen SH, Wu CL, Shiau AL.

Sci Rep. 2017 Mar 6;7:43829. doi: 10.1038/srep43829.


A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms.

Ngo A, Koay AZ, Pecquet C, Diaconu CC, Ould-Amer Y, Huang Q, Kang C, Poulsen A, Lee MA, Jenkins D, Shiau A, Constantinescu SN, Choong ML.

Comb Chem High Throughput Screen. 2016;19(10):824-833. doi: 10.2174/1386207319666161010163825.


An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS.

Cancer Cell. 2016 Nov 14;30(5):683-693. doi: 10.1016/j.ccell.2016.09.008. Epub 2016 Oct 13.


Intraarticular overexpression of Smad7 ameliorates experimental arthritis.

Chen SY, Shiau AL, Wu CL, Wang CR.

Sci Rep. 2016 Oct 12;6:35163. doi: 10.1038/srep35163.


GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.

Xing M, Peterman MC, Davis RL, Oegema K, Shiau AK, Field SJ.

Mol Biol Cell. 2016 Dec 1;27(24):3828-3840. Epub 2016 Oct 5.


53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K.

J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081.


Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C, Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.

Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868.


Elovl6 is a poor prognostic predictor in breast cancer.

Feng YH, Chen WY, Kuo YH, Tung CL, Tsao CJ, Shiau AL, Wu CL.

Oncol Lett. 2016 Jul;12(1):207-212. Epub 2016 May 16.


Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer.

Lu CS, Shieh GS, Wang CT, Su BH, Su YC, Chen YC, Su WC, Wu P, Yang WH, Shiau AL, Wu CL.

Oncotarget. 2017 May 9;8(19):30844-30858. doi: 10.18632/oncotarget.9602.


Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.

Leroy E, Dusa A, Colau D, Motamedi A, Cahu X, Mouton C, Huang LJ, Shiau AK, Constantinescu SN.

Biochem J. 2016 Jun 1;473(11):1579-91. doi: 10.1042/BCJ20160085. Epub 2016 Mar 30.


Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Tögel L, Nightingale R, Chueh AC, Jayachandran A, Tran H, Phesse T, Wu R, Sieber OM, Arango D, Dhillon AS, Dawson MA, Diez-Dacal B, Gahman TC, Filippakopoulos P, Shiau AK, Mariadason JM.

Mol Cancer Ther. 2016 Jun;15(6):1217-26. doi: 10.1158/1535-7163.MCT-15-0724. Epub 2016 Mar 16.


A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.

de Groot CO, Hsia JE, Anzola JV, Motamedi A, Yoon M, Wong YL, Jenkins D, Lee HJ, Martinez MB, Davis RL, Gahman TC, Desai A, Shiau AK.

Front Oncol. 2015 Dec 21;5:285. doi: 10.3389/fonc.2015.00285. eCollection 2015.


HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator.

Wu CH, Liao YJ, Shiau AC, Lin HY, Hsueh Liu YW, Hsu SM.

Sci Rep. 2015 Dec 11;5:17863. doi: 10.1038/srep17863.


Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity.

Su BH, Shieh GS, Tseng YL, Shiau AL, Wu CL.

Oncotarget. 2015 Nov 10;6(35):38308-26. doi: 10.18632/oncotarget.5702.


Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema.

Su BH, Tseng YL, Shieh GS, Chen YC, Wu P, Shiau AL, Wu CL.

J Pathol. 2016 Feb;238(3):412-22. doi: 10.1002/path.4664. Epub 2015 Nov 28.


Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p.

Peng JS, Chen SY, Wu CL, Chong HE, Ding YC, Shiau AL, Wang CR.

Arthritis Rheumatol. 2016 Feb;68(2):370-81. doi: 10.1002/art.39446.


EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS.

Mol Cell. 2015 Oct 15;60(2):307-18. doi: 10.1016/j.molcel.2015.09.002. Epub 2015 Oct 8.


Erratum to: Brief histories of medical physics in Asia-Oceania.

Round WH, Jafari S, Kron T, Azhari HA, Chhom S, Hu Y, Mauldon GF, Cheung KY, Kuppusamy T, Pawiro SA, Lubis LE, Soejoko DS, Haryanto F, Endo M, Han Y, Suh TS, Ng KH, Luvsan-Ish A, Maung SO, Chaurasia PP, Jafri SM, Farrukh S, Peralta A, Toh HJ, Sarasanandarajah S, Shiau AC, Krisanachinda A, Suriyapee S, Vinijsorn S, Nguyen TC.

Australas Phys Eng Sci Med. 2015 Sep;38(3):525. doi: 10.1007/s13246-015-0370-5. Epub 2015 Sep 8. No abstract available.


Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance.

Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Shiau AL, Chang CJ, Wu CL.

J Clin Endocrinol Metab. 2015 Nov;100(11):4114-23. doi: 10.1210/jc.2015-2277. Epub 2015 Sep 8.


Amelioration of experimental arthritis by intra-articular injection of an epidermal growth factor receptor tyrosine kinase inhibitor.

Chen SY, Shiau AL, Wu CL, Wang CR.

Clin Exp Rheumatol. 2015 Nov-Dec;33(6):839-43. Epub 2015 Aug 27.


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